Click here to switch to the map view.

The map label for this gene is pabB [H]

Identifier: 37680264

GI number: 37680264

Start: 2085215

End: 2086615

Strand: Direct

Name: pabB [H]

Synonym: VV2080

Alternate gene names: 37680264

Gene position: 2085215-2086615 (Clockwise)

Preceding gene: 37680252

Following gene: 37680267

Centisome position: 62.16

GC content: 48.61

Gene sequence:

>1401_bases
ATGCAGCAATCGAACTCTTTGTCACAAATTAAACAAATGAATAACAGCATAAATACGGCCATTTCTTCAAAAACACTGCC
TTATCAAACGGACCTTGCCCAACAGTGGTTTGACGCCATCCAACATCAACCTTGGGCAATGCTGTTGCGTTCGGCATCAC
CAACACATGTTGACAGCCGTTTTGACATTCTCGTCGCAAAGCCCGTTGCGACATTAGAAACACGTGGTGCGGTAACTGAG
ATCAATACCAATGACGAAGTCATTGAAAGTAAAGATGATCCTTTCACGCTTCTTGCGCGTTATCAACAGCGTTTTACCCC
TGCTCTATCCTGTGATGAAGAGATTCCTTTTATGGGTGGTGCTCTGGGTTACTTTAGCTACGATTTAGGTCGTCGCGTTG
AAAAACTGCCTGAGATTGCAACACAAGATATTGCTGCGCCCGACATGGCGGTGGGCATCTACACATGGGCATTGATTGTC
GACAATCAGACGCAGACAGCGCAACTGGTTGGCCAAGACGTAGAACAAGCTTATCAATGGCTGAGCACGCAAACAAAAGC
AAACGAAGCGACGTTTGCCCTTACCAGTGATTGGCAATCCAACATGAATCGTCGCGATTACCAAGGTAAGTTTGATTGCG
TACAGGAGTACTTGCTCAGTGGTGACTGCTACCAAATTAACTTAGCGCAGCGCTTTCATGCCAATTACCAAGGCAGCGAA
TGGCAAGCTTACCAGAAGCTAGAGCAGAGCAACCAAGCACCATTTTCTGCTTTCATTCGTTTGGAGGACGCGGCGATTTT
AAGTGTGTCGCCGGAGCGTTTTCTCGAGCTCAAAAAACGTGTCATTGAAACCAAGCCGATCAAAGGAACTCGTCCTCGTC
ATAATGATGAACAACAGGACAAACAGGCGGCACTTGAGCTTGCCAATGCCGAAAAAGATCAAGCGGAAAATCTGATGATC
GTCGATCTGCTGCGCAACGATATTGGCCGTGTCGCCAAACCGGGCAGTGTGCATGTTCCTAAACTGTTTGACATCGAAAG
CTTTCCCGCCGTGCATCACTTAGTCAGCACGATTCGAGCGGAGTTGGCAGCGCAGTATACTGCCGCTGACTTACTGCGAG
CGTGTTTCCCGGGAGGCTCGATTACCGGCGCGCCGAAAGTGCGCGCAATGGAAATCATTGAAGAGCTTGAGCCTCATCGA
CGCTCAGCCTATTGCGGTAGTATCGGTTACATCAGTCGCCATGGTCGCATGGATACCAGCATTACAATTCGTACCTTAGT
GGCGGAGCAAGGTAAGTTGTTCGCTTGGGCTGGGGGCGGTGTAGTGGCTGACAGTCAATGCGATGCGGAATATCAAGAGA
CGTTAGATAAACTGTCGAAAATTCTGCCTACGTTGCAATAA

Upstream 100 bases:

>100_bases
AGTGATCGAAAGAATCCATCCGATTTTTTATGAGTTCCCGACTGAACTAAGTAAGCGAAATTGTTTCGTTTTATGATACT
CTTGCTTTCCATCACGCGCT

Downstream 100 bases:

>100_bases
TCGCCGTCACAGCACATTGGATAATTAGCGCGAAGTCGCCCTTTTGTTCTGTATCGCTTTGTTCGACAGTGCGATTTCAA
ACAATGCAAAGAAGAGAGAC

Product: para-aminobenzoate synthase component I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MQQSNSLSQIKQMNNSINTAISSKTLPYQTDLAQQWFDAIQHQPWAMLLRSASPTHVDSRFDILVAKPVATLETRGAVTE
INTNDEVIESKDDPFTLLARYQQRFTPALSCDEEIPFMGGALGYFSYDLGRRVEKLPEIATQDIAAPDMAVGIYTWALIV
DNQTQTAQLVGQDVEQAYQWLSTQTKANEATFALTSDWQSNMNRRDYQGKFDCVQEYLLSGDCYQINLAQRFHANYQGSE
WQAYQKLEQSNQAPFSAFIRLEDAAILSVSPERFLELKKRVIETKPIKGTRPRHNDEQQDKQAALELANAEKDQAENLMI
VDLLRNDIGRVAKPGSVHVPKLFDIESFPAVHHLVSTIRAELAAQYTAADLLRACFPGGSITGAPKVRAMEIIEELEPHR
RSAYCGSIGYISRHGRMDTSITIRTLVAEQGKLFAWAGGGVVADSQCDAEYQETLDKLSKILPTLQ

Sequences:

>Translated_466_residues
MQQSNSLSQIKQMNNSINTAISSKTLPYQTDLAQQWFDAIQHQPWAMLLRSASPTHVDSRFDILVAKPVATLETRGAVTE
INTNDEVIESKDDPFTLLARYQQRFTPALSCDEEIPFMGGALGYFSYDLGRRVEKLPEIATQDIAAPDMAVGIYTWALIV
DNQTQTAQLVGQDVEQAYQWLSTQTKANEATFALTSDWQSNMNRRDYQGKFDCVQEYLLSGDCYQINLAQRFHANYQGSE
WQAYQKLEQSNQAPFSAFIRLEDAAILSVSPERFLELKKRVIETKPIKGTRPRHNDEQQDKQAALELANAEKDQAENLMI
VDLLRNDIGRVAKPGSVHVPKLFDIESFPAVHHLVSTIRAELAAQYTAADLLRACFPGGSITGAPKVRAMEIIEELEPHR
RSAYCGSIGYISRHGRMDTSITIRTLVAEQGKLFAWAGGGVVADSQCDAEYQETLDKLSKILPTLQ
>Mature_466_residues
MQQSNSLSQIKQMNNSINTAISSKTLPYQTDLAQQWFDAIQHQPWAMLLRSASPTHVDSRFDILVAKPVATLETRGAVTE
INTNDEVIESKDDPFTLLARYQQRFTPALSCDEEIPFMGGALGYFSYDLGRRVEKLPEIATQDIAAPDMAVGIYTWALIV
DNQTQTAQLVGQDVEQAYQWLSTQTKANEATFALTSDWQSNMNRRDYQGKFDCVQEYLLSGDCYQINLAQRFHANYQGSE
WQAYQKLEQSNQAPFSAFIRLEDAAILSVSPERFLELKKRVIETKPIKGTRPRHNDEQQDKQAALELANAEKDQAENLMI
VDLLRNDIGRVAKPGSVHVPKLFDIESFPAVHHLVSTIRAELAAQYTAADLLRACFPGGSITGAPKVRAMEIIEELEPHR
RSAYCGSIGYISRHGRMDTSITIRTLVAEQGKLFAWAGGGVVADSQCDAEYQETLDKLSKILPTLQ

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=443, Percent_Identity=60.2708803611738, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1787518, Length=375, Percent_Identity=32.8, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786809, Length=219, Percent_Identity=26.4840182648402, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082077, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=438, Percent_Identity=31.7351598173516, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6324361, Length=396, Percent_Identity=26.5151515151515, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 52228; Mature: 52228

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSNSLSQIKQMNNSINTAISSKTLPYQTDLAQQWFDAIQHQPWAMLLRSASPTHVDSR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
FDILVAKPVATLETRGAVTEINTNDEVIESKDDPFTLLARYQQRFTPALSCDEEIPFMGG
CEEEEECCHHHHHCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
ALGYFSYDLGRRVEKLPEIATQDIAAPDMAVGIYTWALIVDNQTQTAQLVGQDVEQAYQW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHH
LSTQTKANEATFALTSDWQSNMNRRDYQGKFDCVQEYLLSGDCYQINLAQRFHANYQGSE
HHHHCCCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCH
WQAYQKLEQSNQAPFSAFIRLEDAAILSVSPERFLELKKRVIETKPIKGTRPRHNDEQQD
HHHHHHHHHCCCCCCEEEEEEECCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
KQAALELANAEKDQAENLMIVDLLRNDIGRVAKPGSVHVPKLFDIESFPAVHHLVSTIRA
HHHHHHHHCCCHHHHCCEEHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHH
ELAAQYTAADLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIGYISRHGRMDTS
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHCCCCCCC
ITIRTLVAEQGKLFAWAGGGVVADSQCDAEYQETLDKLSKILPTLQ
EEHEEEHHCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQQSNSLSQIKQMNNSINTAISSKTLPYQTDLAQQWFDAIQHQPWAMLLRSASPTHVDSR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
FDILVAKPVATLETRGAVTEINTNDEVIESKDDPFTLLARYQQRFTPALSCDEEIPFMGG
CEEEEECCHHHHHCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
ALGYFSYDLGRRVEKLPEIATQDIAAPDMAVGIYTWALIVDNQTQTAQLVGQDVEQAYQW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHH
LSTQTKANEATFALTSDWQSNMNRRDYQGKFDCVQEYLLSGDCYQINLAQRFHANYQGSE
HHHHCCCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCH
WQAYQKLEQSNQAPFSAFIRLEDAAILSVSPERFLELKKRVIETKPIKGTRPRHNDEQQD
HHHHHHHHHCCCCCCEEEEEEECCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
KQAALELANAEKDQAENLMIVDLLRNDIGRVAKPGSVHVPKLFDIESFPAVHHLVSTIRA
HHHHHHHHCCCHHHHCCEEHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHH
ELAAQYTAADLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIGYISRHGRMDTS
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCHHHHCCCCCCC
ITIRTLVAEQGKLFAWAGGGVVADSQCDAEYQETLDKLSKILPTLQ
EEHEEEHHCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6330050; 9097040; 9278503; 7896119; 2251281; 7592344 [H]