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The map label for this gene is cvrA [H]

Identifier: 37521328

GI number: 37521328

Start: 1865300

End: 1866613

Strand: Reverse

Name: cvrA [H]

Synonym: gll1759

Alternate gene names: 37521328

Gene position: 1866613-1865300 (Counterclockwise)

Preceding gene: 37521330

Following gene: 37521325

Centisome position: 40.06

GC content: 60.96

Gene sequence:

>1314_bases
ATGACCTTTAACTTGTGGTTTGTGATCGTTGGGGCGCTATTTATCGTTATGGCGCTCTCCAACTCGATTCTGCGTCGTCT
ACCGCTCACCACTTCGTTGCTGTATCTTCTGGTGGGATTGGTGCTCGGCCCCGTCGGCCTGGGGCTCATACGGCTCGATG
CCATTGAGCAAGCCGGGTTGCTCGAACGAATCACAGAGGTGGCAGTGATCATTTCGCTGTTTACCTCCGGGCTGAAGCTG
CGCACACCGCTGTCGAAGAAACGCTGGCAACTGCCCGTGCGCCTCGCCTTCATCTCGATGACGGTCACTGTCGCCTTGAT
TGCTTGTGCAGGAGTGTTCTGGCTGGGATTGCCCCTGGGAGCGGCGATTTTGCTTGGGGGGGTGCTTGCCCCAACTGATC
CGGTGCTTGCTTCCGACGTGCAACTAGAAGATCCGTTCGACAGCGATCGATTGCGCTTCAGCCTCACCGGCGAAGCGGGC
CTCAATGACGGCACCGCCTTTCCGTTTGTGATGTTGGGGTTGGGACTGCTGGGCCTGCACGAGCTGGGTGAGGGAGGTTG
GCGCTGGGTTGCGGTCGATGTCCTCTGGGCAACGGCTGCCGGGTTGGGTGTGGGATGGCTTTGCGGCCTGCTGGTGGGCA
GACTGGTGCTCTATCTGCGCAGTCGCCGCGAGGAGGCCGTCCAACTCGACGATTTTCTGGCCCTGGGATTGATCGCCCTG
TCGTACGGAGCGGCGCTGTTGGTAGCCGGCTATGGATTCCTTGCCGTCTTCGCCGCCGGATTGGCGTTGCGCAGCATTGA
ACTGCAAGCCGCCGGCGAAAAGCCCTCCGAGGACGTTCAGGCGATGGCCCGCCAGGGTGCTAAGGAGGAAGTACCCCCGG
GCTCCGAGTCGGCGCCGCTGTTTATGGCCCAGGCGGTGCTCGAATTCAACGAACAACTCGAGCGCATCGGGGAGGTGGTG
ATCGTGGTGCTGGTGGGCGGATTGCTCGCTACTTTCTTGCCGCCGCCTGCCGCTTTGCTGTGGTTTGTGCCGCTGTTGTT
TCTGGTGATCCGGCCGATCTCGGTGTGGATCGGACTGTTGGGCTCCAACACCTCCGGACTGCAGCGCCGGTTGATGGCCT
GGTTCGGCATTCGCGGCATCGGCTCCATTTACTATTTGATGTTTGCGATTACCCACGGTCTACCCGGGGACATCGCCCGC
ACCCTAACGGCGATCACCCTTATGGTGGTGGCGATTTCGATCGTCGTGCACGGCATCTCAGTGACGCCGTTGATGAGTCT
TTACGGCCGCCGCAGCGAGGGCAAGCCCGCATAA

Upstream 100 bases:

>100_bases
TCCCAACAGGGAGATGTACTGCGCCATATTGTCTGCAAAGATGGGCGGGCCGGACTCCGACTGTCCAGGCGGTCGCCAGA
AAACTTTCGTTGATTCAGTC

Downstream 100 bases:

>100_bases
TTCAAGACGTCTAACCCTTGTGCAGTCGAACTTGAGATTCAGTGATCCAGGTAATGCAACTGCCGCACAAGCAAGCTCAA
GAACAGACCGACGTCGGTGA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTFNLWFVIVGALFIVMALSNSILRRLPLTTSLLYLLVGLVLGPVGLGLIRLDAIEQAGLLERITEVAVIISLFTSGLKL
RTPLSKKRWQLPVRLAFISMTVTVALIACAGVFWLGLPLGAAILLGGVLAPTDPVLASDVQLEDPFDSDRLRFSLTGEAG
LNDGTAFPFVMLGLGLLGLHELGEGGWRWVAVDVLWATAAGLGVGWLCGLLVGRLVLYLRSRREEAVQLDDFLALGLIAL
SYGAALLVAGYGFLAVFAAGLALRSIELQAAGEKPSEDVQAMARQGAKEEVPPGSESAPLFMAQAVLEFNEQLERIGEVV
IVVLVGGLLATFLPPPAALLWFVPLLFLVIRPISVWIGLLGSNTSGLQRRLMAWFGIRGIGSIYYLMFAITHGLPGDIAR
TLTAITLMVVAISIVVHGISVTPLMSLYGRRSEGKPA

Sequences:

>Translated_437_residues
MTFNLWFVIVGALFIVMALSNSILRRLPLTTSLLYLLVGLVLGPVGLGLIRLDAIEQAGLLERITEVAVIISLFTSGLKL
RTPLSKKRWQLPVRLAFISMTVTVALIACAGVFWLGLPLGAAILLGGVLAPTDPVLASDVQLEDPFDSDRLRFSLTGEAG
LNDGTAFPFVMLGLGLLGLHELGEGGWRWVAVDVLWATAAGLGVGWLCGLLVGRLVLYLRSRREEAVQLDDFLALGLIAL
SYGAALLVAGYGFLAVFAAGLALRSIELQAAGEKPSEDVQAMARQGAKEEVPPGSESAPLFMAQAVLEFNEQLERIGEVV
IVVLVGGLLATFLPPPAALLWFVPLLFLVIRPISVWIGLLGSNTSGLQRRLMAWFGIRGIGSIYYLMFAITHGLPGDIAR
TLTAITLMVVAISIVVHGISVTPLMSLYGRRSEGKPA
>Mature_436_residues
TFNLWFVIVGALFIVMALSNSILRRLPLTTSLLYLLVGLVLGPVGLGLIRLDAIEQAGLLERITEVAVIISLFTSGLKLR
TPLSKKRWQLPVRLAFISMTVTVALIACAGVFWLGLPLGAAILLGGVLAPTDPVLASDVQLEDPFDSDRLRFSLTGEAGL
NDGTAFPFVMLGLGLLGLHELGEGGWRWVAVDVLWATAAGLGVGWLCGLLVGRLVLYLRSRREEAVQLDDFLALGLIALS
YGAALLVAGYGFLAVFAAGLALRSIELQAAGEKPSEDVQAMARQGAKEEVPPGSESAPLFMAQAVLEFNEQLERIGEVVI
VVLVGGLLATFLPPPAALLWFVPLLFLVIRPISVWIGLLGSNTSGLQRRLMAWFGIRGIGSIYYLMFAITHGLPGDIART
LTAITLMVVAISIVVHGISVTPLMSLYGRRSEGKPA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 46686; Mature: 46555

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFNLWFVIVGALFIVMALSNSILRRLPLTTSLLYLLVGLVLGPVGLGLIRLDAIEQAGL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERITEVAVIISLFTSGLKLRTPLSKKRWQLPVRLAFISMTVTVALIACAGVFWLGLPLG
HHHHHHHHHHHHHHHCCCEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAILLGGVLAPTDPVLASDVQLEDPFDSDRLRFSLTGEAGLNDGTAFPFVMLGLGLLGLH
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
ELGEGGWRWVAVDVLWATAAGLGVGWLCGLLVGRLVLYLRSRREEAVQLDDFLALGLIAL
HHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYGAALLVAGYGFLAVFAAGLALRSIELQAAGEKPSEDVQAMARQGAKEEVPPGSESAPL
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHH
FMAQAVLEFNEQLERIGEVVIVVLVGGLLATFLPPPAALLWFVPLLFLVIRPISVWIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSNTSGLQRRLMAWFGIRGIGSIYYLMFAITHGLPGDIARTLTAITLMVVAISIVVHGIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
VTPLMSLYGRRSEGKPA
HHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TFNLWFVIVGALFIVMALSNSILRRLPLTTSLLYLLVGLVLGPVGLGLIRLDAIEQAGL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERITEVAVIISLFTSGLKLRTPLSKKRWQLPVRLAFISMTVTVALIACAGVFWLGLPLG
HHHHHHHHHHHHHHHCCCEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAILLGGVLAPTDPVLASDVQLEDPFDSDRLRFSLTGEAGLNDGTAFPFVMLGLGLLGLH
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
ELGEGGWRWVAVDVLWATAAGLGVGWLCGLLVGRLVLYLRSRREEAVQLDDFLALGLIAL
HHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYGAALLVAGYGFLAVFAAGLALRSIELQAAGEKPSEDVQAMARQGAKEEVPPGSESAPL
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHH
FMAQAVLEFNEQLERIGEVVIVVLVGGLLATFLPPPAALLWFVPLLFLVIRPISVWIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSNTSGLQRRLMAWFGIRGIGSIYYLMFAITHGLPGDIARTLTAITLMVVAISIVVHGIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
VTPLMSLYGRRSEGKPA
HHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]