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The map label for this gene is sipB [H]

Identifier: 34498074

GI number: 34498074

Start: 2826967

End: 2828718

Strand: Reverse

Name: sipB [H]

Synonym: CV_2619

Alternate gene names: 34498074

Gene position: 2828718-2826967 (Counterclockwise)

Preceding gene: 34498075

Following gene: 34498073

Centisome position: 59.54

GC content: 66.55

Gene sequence:

>1752_bases
ATGAGTGACGCAAGCGCAATCAGCCGCAGCGCATACCTGCACAATCCCAAGCTGGCCGAAACCGCGTTCGAGAGCGTCCG
CAAGGACGGCACCTTCCTCGACGCCGCGGACAAGGCGCTCAAGGCGGTGCTGGCCACCAAGGCCGGCGAGGCCGATGGCA
AGGCGCCGATCCGCGAGCGCGACCTCGCGACGCCCGCGTTGACCCAGCCCACGGCCAAGGCCAAGGAAGAGCTGGACGGC
GCCGGCAAGCTGACGCTGTTGCTGGGGCAGTTGATGTCCCTGCTCGGCAATGTTTCGCTGTCGCAGCTGGAAAGCCGCAT
CGCCACCTGGCGCGCGATGATGGAAGCGCAAGTGGCGATGGGCGAGAAACTGTCCCAAGAGTTCCAGGACGCGTTCAAGG
CGGCGAGCGAAGCCACCGAGGCGCTGAAAGACGCCGTGGGCAACTACGACAGCGCCAAACAGGCCGCGGACGCAGCCCAG
AAGAAAGCTGACGCCGCCCAGGCCAAGGTGGACGGAATGTCGCCGGACGAGCCCGGCTACGCCGAAGCCCAGGCCGCCAG
CCAGCAGGCCGCCGCCGACGCGCTGCAGGCCAAACAGAAGGCGGACAAGGCTTACGACGCCGCTGAAAAGGCCCGCGTCG
TCGCCGTGGAGAAGGGCAAGGTCGCGGACGATCTGGCCGGCAAGGTGCAGGGCGCCAACGTCAACGCCGACGTCGCGCGC
AAGACCGGCGAGGACAACCTCTCCAACGTCGCCAAGCTGACCTTGCTGATGGCGATGTTCGTCGAGCTGGTGGGCAAGAA
CAGCGAAGAGAGCCTGAAAAACGACCTCGCCTTGTTCCAGGCCTTGCAGGAAGGCCGTCAGAAGGAAATGGACAAGAAGT
CCGCCGAGTACCAGGAAGAGGTGCGCAAGGCGGAGGAGCTCAATCGCACCATGGGGTGCATTGGCAAGATTCTGGGCGCG
CTGCTGACGGTGGTCAGCGTCGTGGCCGCGGCATTCACCGGCGGCGCCAGCCTGGCGCTGGCCGCGGTGGGCGTCGCGCT
GATGGTGGCCGACGAAGTGGTCAAGGCCGCCACCGGGGTGTCCTTCATGCAGGAGGCGTTGAAGCCGCTGATGGACAAGG
TCCTCAAACCCTTGATGGACCTGATAGGCAAGGCCATCACCAAGGCGCTGGAAGGCATGGGGGTGGACAAGAAGACCGCC
GAGCTGGCTGGCTCCATCGCCGGCGCGGTACTGGCCGCCGTCGCCATGGTGGTGGTGATGGTGGTGGTGGCCGTGGTGGG
CAAGGGCGCCGCCGGCAAGCTCGGCGGGGCGCTCAGCAAGCTGCTGGGCGACGCCATCAAGAAGATCGTGCCCAATGTGC
TGAAGGAACTGGCCAAGGGCGGCAGCAAGATGCTGACCCAGGGCTTCCAGCGTCTGGCCAACAGCCTGGGCCTGCAGACC
GACGCCGCCGCCAAACAGATGATGGCCAACACGCTGGGCCGCGTGGTGGTGGGCGGCGAGGTGGCGCAAGCCACTTCGCA
GGCCGGCGGCAACGTGGCGCAAGGCGTGTTCATGAAGAACGCCAGCGACGCCCTGGCCGATTTCACCCTGGCGCGCGCCG
CCATGGAACAGATCGAGCAATGGCTGAAGCAAGCGGTGGAAGTGTTCGCCAGCACCCAGAAAGTCACCCAGGAGCTGACC
ACGGCCATGTCCGCCGCGGTGCAGCAGAACGCCGAGGCCGGCCGTTTCGTGCTGCGCCAGAGCCACGCCTGA

Upstream 100 bases:

>100_bases
AAAGCGGCGACGAGTCGCTGCGCGACAAGGCGCAGGTGTATCTCGACAGCTTGCAGGAAGCGGAGGCCGAGCAGTCCCGT
CAGCAGGAAAAGGAACAAGC

Downstream 100 bases:

>100_bases
AGAATATGAGGAATCCATCATGACTGCCATTACCTCTTCCCCGTTGTTCCCGTCCCGCCCGGCGCTGGGCGGCGCCGATC
TCGCCGACGGCGCGGGCAAG

Product: cell invasion protein

Products: NA

Alternate protein names: Effector protein sipB [H]

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSDASAISRSAYLHNPKLAETAFESVRKDGTFLDAADKALKAVLATKAGEADGKAPIRERDLATPALTQPTAKAKEELDG
AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQ
KKADAAQAKVDGMSPDEPGYAEAQAASQQAAADALQAKQKADKAYDAAEKARVVAVEKGKVADDLAGKVQGANVNADVAR
KTGEDNLSNVAKLTLLMAMFVELVGKNSEESLKNDLALFQALQEGRQKEMDKKSAEYQEEVRKAEELNRTMGCIGKILGA
LLTVVSVVAAAFTGGASLALAAVGVALMVADEVVKAATGVSFMQEALKPLMDKVLKPLMDLIGKAITKALEGMGVDKKTA
ELAGSIAGAVLAAVAMVVVMVVVAVVGKGAAGKLGGALSKLLGDAIKKIVPNVLKELAKGGSKMLTQGFQRLANSLGLQT
DAAAKQMMANTLGRVVVGGEVAQATSQAGGNVAQGVFMKNASDALADFTLARAAMEQIEQWLKQAVEVFASTQKVTQELT
TAMSAAVQQNAEAGRFVLRQSHA

Sequences:

>Translated_583_residues
MSDASAISRSAYLHNPKLAETAFESVRKDGTFLDAADKALKAVLATKAGEADGKAPIRERDLATPALTQPTAKAKEELDG
AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQ
KKADAAQAKVDGMSPDEPGYAEAQAASQQAAADALQAKQKADKAYDAAEKARVVAVEKGKVADDLAGKVQGANVNADVAR
KTGEDNLSNVAKLTLLMAMFVELVGKNSEESLKNDLALFQALQEGRQKEMDKKSAEYQEEVRKAEELNRTMGCIGKILGA
LLTVVSVVAAAFTGGASLALAAVGVALMVADEVVKAATGVSFMQEALKPLMDKVLKPLMDLIGKAITKALEGMGVDKKTA
ELAGSIAGAVLAAVAMVVVMVVVAVVGKGAAGKLGGALSKLLGDAIKKIVPNVLKELAKGGSKMLTQGFQRLANSLGLQT
DAAAKQMMANTLGRVVVGGEVAQATSQAGGNVAQGVFMKNASDALADFTLARAAMEQIEQWLKQAVEVFASTQKVTQELT
TAMSAAVQQNAEAGRFVLRQSHA
>Mature_582_residues
SDASAISRSAYLHNPKLAETAFESVRKDGTFLDAADKALKAVLATKAGEADGKAPIRERDLATPALTQPTAKAKEELDGA
GKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQK
KADAAQAKVDGMSPDEPGYAEAQAASQQAAADALQAKQKADKAYDAAEKARVVAVEKGKVADDLAGKVQGANVNADVARK
TGEDNLSNVAKLTLLMAMFVELVGKNSEESLKNDLALFQALQEGRQKEMDKKSAEYQEEVRKAEELNRTMGCIGKILGAL
LTVVSVVAAAFTGGASLALAAVGVALMVADEVVKAATGVSFMQEALKPLMDKVLKPLMDLIGKAITKALEGMGVDKKTAE
LAGSIAGAVLAAVAMVVVMVVVAVVGKGAAGKLGGALSKLLGDAIKKIVPNVLKELAKGGSKMLTQGFQRLANSLGLQTD
AAAKQMMANTLGRVVVGGEVAQATSQAGGNVAQGVFMKNASDALADFTLARAAMEQIEQWLKQAVEVFASTQKVTQELTT
AMSAAVQQNAEAGRFVLRQSHA

Specific function: Required for entry into the host cell through presentation or delivery of sipC at the host cell plasma membrane. Along with sipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (By similarity). Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) and inserted into the host cell plasma membrane (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the invasin protein B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006972
- InterPro:   IPR003895 [H]

Pfam domain/function: PF04888 SseC [H]

EC number: NA

Molecular weight: Translated: 60608; Mature: 60477

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDASAISRSAYLHNPKLAETAFESVRKDGTFLDAADKALKAVLATKAGEADGKAPIRER
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DLATPALTQPTAKAKEELDGAGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAM
HCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQKKADAAQAKVDGMSPDEPGY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AEAQAASQQAAADALQAKQKADKAYDAAEKARVVAVEKGKVADDLAGKVQGANVNADVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCCCCHHHHH
KTGEDNLSNVAKLTLLMAMFVELVGKNSEESLKNDLALFQALQEGRQKEMDKKSAEYQEE
HCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKAEELNRTMGCIGKILGALLTVVSVVAAAFTGGASLALAAVGVALMVADEVVKAATGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SFMQEALKPLMDKVLKPLMDLIGKAITKALEGMGVDKKTAELAGSIAGAVLAAVAMVVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VVVAVVGKGAAGKLGGALSKLLGDAIKKIVPNVLKELAKGGSKMLTQGFQRLANSLGLQT
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DAAAKQMMANTLGRVVVGGEVAQATSQAGGNVAQGVFMKNASDALADFTLARAAMEQIEQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
WLKQAVEVFASTQKVTQELTTAMSAAVQQNAEAGRFVLRQSHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDASAISRSAYLHNPKLAETAFESVRKDGTFLDAADKALKAVLATKAGEADGKAPIRER
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DLATPALTQPTAKAKEELDGAGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAM
HCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GEKLSQEFQDAFKAASEATEALKDAVGNYDSAKQAADAAQKKADAAQAKVDGMSPDEPGY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AEAQAASQQAAADALQAKQKADKAYDAAEKARVVAVEKGKVADDLAGKVQGANVNADVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCCCCHHHHH
KTGEDNLSNVAKLTLLMAMFVELVGKNSEESLKNDLALFQALQEGRQKEMDKKSAEYQEE
HCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRKAEELNRTMGCIGKILGALLTVVSVVAAAFTGGASLALAAVGVALMVADEVVKAATGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SFMQEALKPLMDKVLKPLMDLIGKAITKALEGMGVDKKTAELAGSIAGAVLAAVAMVVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VVVAVVGKGAAGKLGGALSKLLGDAIKKIVPNVLKELAKGGSKMLTQGFQRLANSLGLQT
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DAAAKQMMANTLGRVVVGGEVAQATSQAGGNVAQGVFMKNASDALADFTLARAAMEQIEQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
WLKQAVEVFASTQKVTQELTTAMSAAVQQNAEAGRFVLRQSHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA