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The map label for this gene is sipC [H]

Identifier: 34498073

GI number: 34498073

Start: 2825691

End: 2826758

Strand: Reverse

Name: sipC [H]

Synonym: CV_2618

Alternate gene names: 34498073

Gene position: 2826758-2825691 (Counterclockwise)

Preceding gene: 34498074

Following gene: 34498072

Centisome position: 59.5

GC content: 68.63

Gene sequence:

>1068_bases
CTGGCCCAGCCCAAGAGCCTGCTGAAGCCGGAAGACGCCGGCGTGCTGCATAGCTGGCTGGCCGCCAAGCGCGAGGACGC
GGGCTTCACCGCCGGCGTCGAGCACACCGCCAACAAGCTGGAACAGATCATCGACAAGGAGCTGGAACAGCGCGGCGCCG
AGCAGGACCCCGGCTTCGACATCAGCGGCCTGTCCACCCGGATGGCGGCGCTGCTGTCCCAGGCCATCGTGCTGATGTCG
GCGCTGCGCACCGCGGACAACGCGCTGAGCACCAAGCTGTCGCTGGTCAGCTTCGACGCCACCAAGGCCACCGCGGCATC
GATGGTGCGCGAGGGCATCGCCAACCTGTCCAGCAGCATCGTGCAGAGCGTGGGCCAGGTGGCCATCACCGGCGTCGGGG
CCAAGAAGAGCCTGAACGGCCTCAACGCCGAGCGCGGCGCGCTGAAGAACAACGCCCCCAAGCTCGGCAAGCTGGGCGAC
GAGGGCCGCAACGTTCAGGCCACGCTGAGCCGCCAGAACACGGTCAAACTGGCTGCTGATGCCGATGGCCTGAAGCAGGT
GGGCCTGAAGCCGCAGAACGGCGCGGCAAGGCCCGAAGTGGCCGAGCTGAGCGCGCAGCCGAATGCGGCCGCCAGCGTGG
CCGACGGCATGGCCGGCGACAAGATCAGCCTGCAGTCCAGCAATTCGAAGCTGGCCAGGCAGCATGAGGCCGCGCTGGGC
AGCAGCACCGAGGACCTGACGGCCAAGAGCCAGGCCGAGCAGCTGGCGATGGACGATACCAAGCTCAAGGCGCAGGCCAA
GCAGACCACCGGCAAGGCGATCATGGACAGCTCGGCCGCGGCCGGCAACATCGCCGGCGGCTCCGGCCGCTACGCCGCCA
CGCTGGAACAGTCCGAGCAGCAGATCAGCCAGGCTTCCAGCCGCGTGGCCAGCACGGCTTCCGAGGAGACCCGCGAAAGC
AGCCGCAAGGCCGACAGCATCATCCAGGAGCTGCTGCGCACGCTGGAAGGCATCAGCCAGTCCAAGAGCTCGGCCATGGC
CGCGATCGCCGGCAACATCCGCGTCTGA

Upstream 100 bases:

>100_bases
GCAGGACGGACTGATATCGGTCGGCACCCTGCAGTCCATCCTGAGCCAGAGCGGCGGAGTCGGCCGCGAGTTGGCCGGCG
CGCTGGCGGGCAAGCCGGAC

Downstream 100 bases:

>100_bases
TCCGCCAGCAGGAAGGCGGGAGCATCCGCTCTCCGCCTGTCGCCCCGGCTTTCGCGGCCGGGGCGGCTTTCCGCACCATT
CATCCCGCCAGCGTCGCCGT

Product: cell invasion protein

Products: NA

Alternate protein names: Effector protein sipC [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MAQPKSLLKPEDAGVLHSWLAAKREDAGFTAGVEHTANKLEQIIDKELEQRGAEQDPGFDISGLSTRMAALLSQAIVLMS
ALRTADNALSTKLSLVSFDATKATAASMVREGIANLSSSIVQSVGQVAITGVGAKKSLNGLNAERGALKNNAPKLGKLGD
EGRNVQATLSRQNTVKLAADADGLKQVGLKPQNGAARPEVAELSAQPNAAASVADGMAGDKISLQSSNSKLARQHEAALG
SSTEDLTAKSQAEQLAMDDTKLKAQAKQTTGKAIMDSSAAAGNIAGGSGRYAATLEQSEQQISQASSRVASTASEETRES
SRKADSIIQELLRTLEGISQSKSSAMAAIAGNIRV

Sequences:

>Translated_355_residues
MAQPKSLLKPEDAGVLHSWLAAKREDAGFTAGVEHTANKLEQIIDKELEQRGAEQDPGFDISGLSTRMAALLSQAIVLMS
ALRTADNALSTKLSLVSFDATKATAASMVREGIANLSSSIVQSVGQVAITGVGAKKSLNGLNAERGALKNNAPKLGKLGD
EGRNVQATLSRQNTVKLAADADGLKQVGLKPQNGAARPEVAELSAQPNAAASVADGMAGDKISLQSSNSKLARQHEAALG
SSTEDLTAKSQAEQLAMDDTKLKAQAKQTTGKAIMDSSAAAGNIAGGSGRYAATLEQSEQQISQASSRVASTASEETRES
SRKADSIIQELLRTLEGISQSKSSAMAAIAGNIRV
>Mature_354_residues
AQPKSLLKPEDAGVLHSWLAAKREDAGFTAGVEHTANKLEQIIDKELEQRGAEQDPGFDISGLSTRMAALLSQAIVLMSA
LRTADNALSTKLSLVSFDATKATAASMVREGIANLSSSIVQSVGQVAITGVGAKKSLNGLNAERGALKNNAPKLGKLGDE
GRNVQATLSRQNTVKLAADADGLKQVGLKPQNGAARPEVAELSAQPNAAASVADGMAGDKISLQSSNSKLARQHEAALGS
STEDLTAKSQAEQLAMDDTKLKAQAKQTTGKAIMDSSAAAGNIAGGSGRYAATLEQSEQQISQASSRVASTASEETRESS
RKADSIIQELLRTLEGISQSKSSAMAAIAGNIRV

Specific function: Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates sipC activity and both are required for an efficient bacterial internalization

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the invasin protein C family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005427 [H]

Pfam domain/function: PF09599 IpaC_SipC [H]

EC number: NA

Molecular weight: Translated: 36705; Mature: 36574

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPKSLLKPEDAGVLHSWLAAKREDAGFTAGVEHTANKLEQIIDKELEQRGAEQDPGFD
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ISGLSTRMAALLSQAIVLMSALRTADNALSTKLSLVSFDATKATAASMVREGIANLSSSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHH
VQSVGQVAITGVGAKKSLNGLNAERGALKNNAPKLGKLGDEGRNVQATLSRQNTVKLAAD
HHHHHHHEEECCCCHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECC
ADGLKQVGLKPQNGAARPEVAELSAQPNAAASVADGMAGDKISLQSSNSKLARQHEAALG
CCHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHC
SSTEDLTAKSQAEQLAMDDTKLKAQAKQTTGKAIMDSSAAAGNIAGGSGRYAATLEQSEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
QISQASSRVASTASEETRESSRKADSIIQELLRTLEGISQSKSSAMAAIAGNIRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQPKSLLKPEDAGVLHSWLAAKREDAGFTAGVEHTANKLEQIIDKELEQRGAEQDPGFD
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ISGLSTRMAALLSQAIVLMSALRTADNALSTKLSLVSFDATKATAASMVREGIANLSSSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHH
VQSVGQVAITGVGAKKSLNGLNAERGALKNNAPKLGKLGDEGRNVQATLSRQNTVKLAAD
HHHHHHHEEECCCCHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECC
ADGLKQVGLKPQNGAARPEVAELSAQPNAAASVADGMAGDKISLQSSNSKLARQHEAALG
CCHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHC
SSTEDLTAKSQAEQLAMDDTKLKAQAKQTTGKAIMDSSAAAGNIAGGSGRYAATLEQSEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
QISQASSRVASTASEETRESSRKADSIIQELLRTLEGISQSKSSAMAAIAGNIRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8801431; 11677608; 12644504 [H]