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The map label for this gene is clpX

Identifier: 34498012

GI number: 34498012

Start: 2751716

End: 2752996

Strand: Reverse

Name: clpX

Synonym: CV_2557

Alternate gene names: 34498012

Gene position: 2752996-2751716 (Counterclockwise)

Preceding gene: 34498013

Following gene: 34498010

Centisome position: 57.94

GC content: 62.37

Gene sequence:

>1281_bases
ATGGCTGACAAAAACAGCAACGAGAAGCTCCTCTACTGCTCTTTCTGCGGAAAGAGCCAGCATGAGGTGCAGCGGCTGAT
CGCCGGACCGCAGGTGTTCATCTGCAACGAGTGCGTCGAGCTGTGCAACGACATCATCCGCGAGGAGCTGGAAAAAGGCA
CTGGCGGCGAAGTGATCGGCGGCGCGTCCGCCGACCATCCGCTGCCGACCCCGCAGGAGATCCGCGCGGACCTTGACCAG
TACATCATCGGCCAGGACTTTGCCAAGAAGACCCTGTCGGTGGCGGTGTACAACCACTACAAGCGGCTGTACAACAAGGG
CGGCAAGGACGATGTCGAGCTGGCCAAGAGCAACATCCTCTTGATCGGCCCGACCGGCTCCGGTAAGACGCTGCTGGCGC
AGTCGCTGGCGCGCCTCTTGGACGTGCCCTTCGTCATCGCCGACGCCACCACGCTGACCGAGGCGGGGTATGTGGGCGAG
GATGTCGAGCACATCATCCAGAAGCTGCTGCAGAAGTGCGACTACGATGTCGACAAGGCCCAGCGCGGCATCGTCTACAT
CGACGAGATCGACAAGATCTCCCGCAAGTCGGAAAACCCGTCCATCACCCGCGACGTGTCGGGCGAGGGCGTGCAGCAGG
CGTTGCTGAAGCTGATCGAGGGCACGGTGGCTTCGGTGCCTCCGCAAGGCGGCCGCAAGCACCCGAACCAGGAATTCATC
CAGGTCGACACCACCAATATCCTGTTCATCTGCGGCGGGGCTTTCGATGGTCTGGACAAGATCATCCGCCAGCGTTCCGA
GAAGGGCGGCATCGGCTTCGGCGCCGAGGTCTCTTCCAAGGACGATGGCAAGAGCCTGACCAAGCTGTTCCAGGAAGTGG
AGCCGCAGGACATCATCCGTTTCGGCCTGATTCCGGAACTGATCGGTCGTCTGCCGGTGGTGGCCACGCTGGAGGAGCTG
GACGAGGAGGCGCTGGTTTCCATCCTGACCCAGCCGAAGAACGCGCTGATCAAGCAATACCAGAAGCTGTTCTCGCTGGA
AACGGTGGAGCTGGAAGTGCGTCCGTCGGCGCTGCGCGTGATCGCCAAGCAGGCGCTCGCCCGCAAGACCGGCGCCCGCG
GCCTGCGCTCCATCCTGGAGCGCGCGCTGCTCGATACCATGTACGAGCTGCCGTCGATGCAGGACGTGGAAAAAGTCGTC
GTCGACGAGAAGGTGATCGAGAAGGGCGACAAGCCGCTTTTCATCTATCGCGAAGGCGGCGGTGTGGCACAATCCGCCTG
A

Upstream 100 bases:

>100_bases
GACAATTTCATGTCCGCCGAAGAGGCCCGCGCCTACGGTATGATCGATAAAGTGCTGTCTTCCCGCCGGGATGTGACGGC
CTAAGTAGTGGAATGGGCTA

Downstream 100 bases:

>100_bases
CGGCCTGGCCTGAATGACTGAACCGCCCGTCAGGGCGGTTTTTTATTTGTCGCCGACGTAATCTGTTTTAGTATGGGGTC
GACGTCCCCCCACTTTCAGT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MADKNSNEKLLYCSFCGKSQHEVQRLIAGPQVFICNECVELCNDIIREELEKGTGGEVIGGASADHPLPTPQEIRADLDQ
YIIGQDFAKKTLSVAVYNHYKRLYNKGGKDDVELAKSNILLIGPTGSGKTLLAQSLARLLDVPFVIADATTLTEAGYVGE
DVEHIIQKLLQKCDYDVDKAQRGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFI
QVDTTNILFICGGAFDGLDKIIRQRSEKGGIGFGAEVSSKDDGKSLTKLFQEVEPQDIIRFGLIPELIGRLPVVATLEEL
DEEALVSILTQPKNALIKQYQKLFSLETVELEVRPSALRVIAKQALARKTGARGLRSILERALLDTMYELPSMQDVEKVV
VDEKVIEKGDKPLFIYREGGGVAQSA

Sequences:

>Translated_426_residues
MADKNSNEKLLYCSFCGKSQHEVQRLIAGPQVFICNECVELCNDIIREELEKGTGGEVIGGASADHPLPTPQEIRADLDQ
YIIGQDFAKKTLSVAVYNHYKRLYNKGGKDDVELAKSNILLIGPTGSGKTLLAQSLARLLDVPFVIADATTLTEAGYVGE
DVEHIIQKLLQKCDYDVDKAQRGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFI
QVDTTNILFICGGAFDGLDKIIRQRSEKGGIGFGAEVSSKDDGKSLTKLFQEVEPQDIIRFGLIPELIGRLPVVATLEEL
DEEALVSILTQPKNALIKQYQKLFSLETVELEVRPSALRVIAKQALARKTGARGLRSILERALLDTMYELPSMQDVEKVV
VDEKVIEKGDKPLFIYREGGGVAQSA
>Mature_425_residues
ADKNSNEKLLYCSFCGKSQHEVQRLIAGPQVFICNECVELCNDIIREELEKGTGGEVIGGASADHPLPTPQEIRADLDQY
IIGQDFAKKTLSVAVYNHYKRLYNKGGKDDVELAKSNILLIGPTGSGKTLLAQSLARLLDVPFVIADATTLTEAGYVGED
VEHIIQKLLQKCDYDVDKAQRGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFIQ
VDTTNILFICGGAFDGLDKIIRQRSEKGGIGFGAEVSSKDDGKSLTKLFQEVEPQDIIRFGLIPELIGRLPVVATLEELD
EEALVSILTQPKNALIKQYQKLFSLETVELEVRPSALRVIAKQALARKTGARGLRSILERALLDTMYELPSMQDVEKVVV
DEKVIEKGDKPLFIYREGGGVAQSA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=329, Percent_Identity=53.1914893617021, Blast_Score=327, Evalue=1e-89,
Organism=Escherichia coli, GI1786642, Length=414, Percent_Identity=73.6714975845411, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1790366, Length=101, Percent_Identity=46.5346534653465, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=307, Percent_Identity=48.2084690553746, Blast_Score=273, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI71982908, Length=307, Percent_Identity=48.2084690553746, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71988663, Length=399, Percent_Identity=39.0977443609023, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71988660, Length=259, Percent_Identity=40.1544401544402, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319704, Length=426, Percent_Identity=38.7323943661972, Blast_Score=268, Evalue=8e-73,
Organism=Drosophila melanogaster, GI24648289, Length=320, Percent_Identity=45.9375, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24648291, Length=320, Percent_Identity=45.9375, Blast_Score=284, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_CHRVO (Q7NUZ0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902227.1
- ProteinModelPortal:   Q7NUZ0
- GeneID:   2547799
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2557
- NMPDR:   fig|243365.1.peg.2557
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q7NUZ0
- ProtClustDB:   PRK05342
- BioCyc:   CVIO243365:CV_2557-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: 3.4.21.92

Molecular weight: Translated: 46791; Mature: 46660

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKNSNEKLLYCSFCGKSQHEVQRLIAGPQVFICNECVELCNDIIREELEKGTGGEVIG
CCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEC
GASADHPLPTPQEIRADLDQYIIGQDFAKKTLSVAVYNHYKRLYNKGGKDDVELAKSNIL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCEE
LIGPTGSGKTLLAQSLARLLDVPFVIADATTLTEAGYVGEDVEHIIQKLLQKCDYDVDKA
EEECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
QRGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFI
CCCEEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEE
QVDTTNILFICGGAFDGLDKIIRQRSEKGGIGFGAEVSSKDDGKSLTKLFQEVEPQDIIR
EEECCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHH
FGLIPELIGRLPVVATLEELDEEALVSILTQPKNALIKQYQKLFSLETVELEVRPSALRV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECHHHHHH
IAKQALARKTGARGLRSILERALLDTMYELPSMQDVEKVVVDEKVIEKGDKPLFIYREGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCC
GVAQSA
CCCCCC
>Mature Secondary Structure 
ADKNSNEKLLYCSFCGKSQHEVQRLIAGPQVFICNECVELCNDIIREELEKGTGGEVIG
CCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEC
GASADHPLPTPQEIRADLDQYIIGQDFAKKTLSVAVYNHYKRLYNKGGKDDVELAKSNIL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCEE
LIGPTGSGKTLLAQSLARLLDVPFVIADATTLTEAGYVGEDVEHIIQKLLQKCDYDVDKA
EEECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
QRGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQEFI
CCCEEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEE
QVDTTNILFICGGAFDGLDKIIRQRSEKGGIGFGAEVSSKDDGKSLTKLFQEVEPQDIIR
EEECCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHH
FGLIPELIGRLPVVATLEELDEEALVSILTQPKNALIKQYQKLFSLETVELEVRPSALRV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECHHHHHH
IAKQALARKTGARGLRSILERALLDTMYELPSMQDVEKVVVDEKVIEKGDKPLFIYREGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCC
GVAQSA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782