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The map label for this gene is lon [H]

Identifier: 34498010

GI number: 34498010

Start: 2747950

End: 2750364

Strand: Reverse

Name: lon [H]

Synonym: CV_2555

Alternate gene names: 34498010

Gene position: 2750364-2747950 (Counterclockwise)

Preceding gene: 34498012

Following gene: 34498009

Centisome position: 57.89

GC content: 64.06

Gene sequence:

>2415_bases
ATGCCGCAACCCGCAGAAATCAGAGAAGAGACCTCGCTGCCGCTGCTTCCGCTGCGCGATGTGGTGGTCTTTCCGCACAT
GGTCATTCCGCTGTTCGTCGGACGGGCCAAGTCGATCCGTGCGCTGGAACTGGCCATGGACGAAGGCAAGCAGATCCTGC
TGGTCGCCCAGCGCTCGGCCTCCAAGGACGAACCGTCGGCCGAGGACCTGTACGGCGTGGGCACCATCGCAGCGGTGCTG
CAGATGCTCAAGCTGCCCGACGGCACGGTGAAGGTGCTGGTAGAGGGCCGTCAGCGCGCCACCATCAAGGAAGTGGGCGA
GGAGGACGGCTGCTTCGTCGCCGAGTTCTCGCCGCTGTCCAGCGAACTGGAAGAGTCCAACGAGACCGAGGCGATGCGCC
GCGCGCTGCTCGCGCAGTTCGAGCAGTACGTGAAGCTGAACAAGAAGATCCCGCCTGAGGTGCTGAACTCGCTGGCCGGC
ATCGACCGCGCCGGCCGCATGGCCGACAGCATCATCGCCCACCTGCCCTTGAAGCTGGAGCAGAAGCAGGAAGTGCTGGA
GATGTTCGACGTGCAGACCCGCCTCGAGCATCTGATGTCGCAGCTGGAAGGCGAGATCGACATCCTGCAGGTGGAAAAGC
GCATCCGCGGCCGCGTCAAGCGCCAGATGGAGAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCCATCCAG
AAAGAGCTGGGCGAGATGGACGAGGCCAGCGACCACGACGAGCTGGAGCGCCGCATCAAGGCCGCGGGCATGAGCAAGGA
AGGCCGCGAAAAGGCATTGTCGGAGCTGAAGAAGCTGAAGATGATGTCGCCGATGTCGGCCGAAGCCACCGTGGTGCGCA
ACTACATCGACACGCTGCTCGAGCTGCCGTGGAAGAAAAAGACCAAGATCAGCAAGGATGTGGCCGCCGCCGACGCCGTG
CTGGACGAGGATCACTTCGGCCTGGAGAAGGTCAAGGAACGCATTCTGGAGTACCTGGCGGTGCAGCAGCGCGTCGACCG
CCTGAAAGCGCCCATCTTGTGCCTGGTGGGCCCTCCGGGCGTGGGCAAGACCTCGCTGGGGCAGTCCATCGCCCGCGCCA
CTAACCGCAAGTTCGTGCGGATGGCGCTGGGCGGCGTGCGCGACGAGTCCGAGATCCGCGGCCACCGCCGCACCTACATC
GGTTCCATGCCGGGCAAGGTGCTGCAGAACATGGCCAAGATCGGCGTCAAGAACCCGCTGTTCCTGCTGGACGAAGTGGA
CAAGCTGGGTGCCGACTTCCGCGGCGACCCGTCCTCCGCGCTGCTGGAGGTGCTGGATCCCGAACAGAACCACGCCTTCA
TCGACCATTACGCCGAGGTTGAGTACGATCTGTCCGACGTGATGTTCGTCGCGACCGCCAACTCGCTGAATATCCCGCCG
GCGCTGCTCGACCGGATGGAAATCATTCGTCTTTCCGGCTATACCGAGGACGAAAAGGTGAACATCGCGCTGAAGTACCT
GTTGCCCAAGCAGATGGAGGCCAACGGCGTGCGAGACGGCGAGCTGGTGGTGCAGGAATCGGCGATCCGCGACATCGTCC
GCTACTACACCCGCGAAGCCGGCGTGCGCAGCCTGGACCGCGAAGTGGCCAAGATCTGCCGCAAGGTGGTGACCGGCGCG
CTGCTGAAGCCGGCCAAAGCCGGCAAGGTGACGGTGTCCGCCAAGAATCTGGACAAGTATCTGGGCGTGCGCCGCTTCGA
CTACGGCCTGGCCGAGGAGCAGAATCGCATCGGCCAGGTGACCGGCCTCGCGTGGACCGAGGTGGGCGGCGAGTTGCTGA
CCATCGAGGCGGTGTCGCTGCCGGGCAAGGGCAATATCGTGCGCACCGGCCAGTTGGGCGAGGTGATGCAGGAGTCGATC
ACCGCGGCGATGAGCGTGGTGCGCAGCAGAGCCAGAAGCCTCGGCGTGAAGCCCGACTTCTACGAGAAGAGCGACATGCA
CATCCACGTGCCGGAAGGCGCAACGCCGAAGGATGGCCCCAGCGCGGGCATCGCGATGACCACGGCCATCGTGTCGGTGC
TGACCGGCATTCCGGTCCGCGCCGACGTGGCGATGACCGGGGAGATCACGCTGCGCGGCGAGGTGCTGCCGATCGGCGGC
CTGAAGGAGAAGTTGCTGGCGGCGCATCGAGGCGGCATCCGCCACGTGCTGATTCCAAAGGGCAACGAGAAGGATCTGGT
GGATATCCCGGCCAACATCAAGCAGAAGCTGGAAATCCATCCGGTCAAGTGGATCGACGAGGTGCTGGCGCTCGCGCTGG
AGCGTCAACCGGAAGAACTGTCGCAAGAAGAACAATCTGGCGACATTCCGCCGACTCAGGATGCGGGCAGCAATGTGCCG
GTCCTGAAGCATTAA

Upstream 100 bases:

>100_bases
GTCACGTGCTACTCAATACCGGGGGGACGTCGGGGTGTTGATATTCTGGCCTTTCGCCCCATTTTCCAAGCATTGTTTCC
CCAAGCTAAGGTTAGGTGAT

Downstream 100 bases:

>100_bases
GAATCATGGTCTTACCGAAGCCGTGAATAAGCTGTGTTTTCGCGGCTTCCCGTTGTGCTTGCGAATTAGCAAAATGGCCG
TGGAAGCCGCTTGACACAAG

Product: endopeptidase La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MPQPAEIREETSLPLLPLRDVVVFPHMVIPLFVGRAKSIRALELAMDEGKQILLVAQRSASKDEPSAEDLYGVGTIAAVL
QMLKLPDGTVKVLVEGRQRATIKEVGEEDGCFVAEFSPLSSELEESNETEAMRRALLAQFEQYVKLNKKIPPEVLNSLAG
IDRAGRMADSIIAHLPLKLEQKQEVLEMFDVQTRLEHLMSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEMDEASDHDELERRIKAAGMSKEGREKALSELKKLKMMSPMSAEATVVRNYIDTLLELPWKKKTKISKDVAAADAV
LDEDHFGLEKVKERILEYLAVQQRVDRLKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYI
GSMPGKVLQNMAKIGVKNPLFLLDEVDKLGADFRGDPSSALLEVLDPEQNHAFIDHYAEVEYDLSDVMFVATANSLNIPP
ALLDRMEIIRLSGYTEDEKVNIALKYLLPKQMEANGVRDGELVVQESAIRDIVRYYTREAGVRSLDREVAKICRKVVTGA
LLKPAKAGKVTVSAKNLDKYLGVRRFDYGLAEEQNRIGQVTGLAWTEVGGELLTIEAVSLPGKGNIVRTGQLGEVMQESI
TAAMSVVRSRARSLGVKPDFYEKSDMHIHVPEGATPKDGPSAGIAMTTAIVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIRHVLIPKGNEKDLVDIPANIKQKLEIHPVKWIDEVLALALERQPEELSQEEQSGDIPPTQDAGSNVP
VLKH

Sequences:

>Translated_804_residues
MPQPAEIREETSLPLLPLRDVVVFPHMVIPLFVGRAKSIRALELAMDEGKQILLVAQRSASKDEPSAEDLYGVGTIAAVL
QMLKLPDGTVKVLVEGRQRATIKEVGEEDGCFVAEFSPLSSELEESNETEAMRRALLAQFEQYVKLNKKIPPEVLNSLAG
IDRAGRMADSIIAHLPLKLEQKQEVLEMFDVQTRLEHLMSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEMDEASDHDELERRIKAAGMSKEGREKALSELKKLKMMSPMSAEATVVRNYIDTLLELPWKKKTKISKDVAAADAV
LDEDHFGLEKVKERILEYLAVQQRVDRLKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYI
GSMPGKVLQNMAKIGVKNPLFLLDEVDKLGADFRGDPSSALLEVLDPEQNHAFIDHYAEVEYDLSDVMFVATANSLNIPP
ALLDRMEIIRLSGYTEDEKVNIALKYLLPKQMEANGVRDGELVVQESAIRDIVRYYTREAGVRSLDREVAKICRKVVTGA
LLKPAKAGKVTVSAKNLDKYLGVRRFDYGLAEEQNRIGQVTGLAWTEVGGELLTIEAVSLPGKGNIVRTGQLGEVMQESI
TAAMSVVRSRARSLGVKPDFYEKSDMHIHVPEGATPKDGPSAGIAMTTAIVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIRHVLIPKGNEKDLVDIPANIKQKLEIHPVKWIDEVLALALERQPEELSQEEQSGDIPPTQDAGSNVP
VLKH
>Mature_803_residues
PQPAEIREETSLPLLPLRDVVVFPHMVIPLFVGRAKSIRALELAMDEGKQILLVAQRSASKDEPSAEDLYGVGTIAAVLQ
MLKLPDGTVKVLVEGRQRATIKEVGEEDGCFVAEFSPLSSELEESNETEAMRRALLAQFEQYVKLNKKIPPEVLNSLAGI
DRAGRMADSIIAHLPLKLEQKQEVLEMFDVQTRLEHLMSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQK
ELGEMDEASDHDELERRIKAAGMSKEGREKALSELKKLKMMSPMSAEATVVRNYIDTLLELPWKKKTKISKDVAAADAVL
DEDHFGLEKVKERILEYLAVQQRVDRLKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYIG
SMPGKVLQNMAKIGVKNPLFLLDEVDKLGADFRGDPSSALLEVLDPEQNHAFIDHYAEVEYDLSDVMFVATANSLNIPPA
LLDRMEIIRLSGYTEDEKVNIALKYLLPKQMEANGVRDGELVVQESAIRDIVRYYTREAGVRSLDREVAKICRKVVTGAL
LKPAKAGKVTVSAKNLDKYLGVRRFDYGLAEEQNRIGQVTGLAWTEVGGELLTIEAVSLPGKGNIVRTGQLGEVMQESIT
AAMSVVRSRARSLGVKPDFYEKSDMHIHVPEGATPKDGPSAGIAMTTAIVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIRHVLIPKGNEKDLVDIPANIKQKLEIHPVKWIDEVLALALERQPEELSQEEQSGDIPPTQDAGSNVPV
LKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=841, Percent_Identity=38.0499405469679, Blast_Score=531, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=616, Percent_Identity=42.5324675324675, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=68.8227684346701, Blast_Score=1075, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=697, Percent_Identity=38.5939741750359, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17556486, Length=792, Percent_Identity=34.0909090909091, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=708, Percent_Identity=38.7005649717514, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI221513036, Length=607, Percent_Identity=42.833607907743, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24666867, Length=607, Percent_Identity=42.833607907743, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89019; Mature: 88888

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPAEIREETSLPLLPLRDVVVFPHMVIPLFVGRAKSIRALELAMDEGKQILLVAQRSA
CCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCC
SKDEPSAEDLYGVGTIAAVLQMLKLPDGTVKVLVEGRQRATIKEVGEEDGCFVAEFSPLS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECCHHH
SELEESNETEAMRRALLAQFEQYVKLNKKIPPEVLNSLAGIDRAGRMADSIIAHLPLKLE
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QKQEVLEMFDVQTRLEHLMSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGEMDEASDHDELERRIKAAGMSKEGREKALSELKKLKMMSPMSAEATVVRNYIDTLL
HHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ELPWKKKTKISKDVAAADAVLDEDHFGLEKVKERILEYLAVQQRVDRLKAPILCLVGPPG
HCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYIGSMPGKVLQNMAKIGVKNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCH
FLLDEVDKLGADFRGDPSSALLEVLDPEQNHAFIDHYAEVEYDLSDVMFVATANSLNIPP
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCEECHHHEEEEEECCCCCCCH
ALLDRMEIIRLSGYTEDEKVNIALKYLLPKQMEANGVRDGELVVQESAIRDIVRYYTREA
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GVRSLDREVAKICRKVVTGALLKPAKAGKVTVSAKNLDKYLGVRRFDYGLAEEQNRIGQV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCHHHCCCHHHHHHHHHHH
TGLAWTEVGGELLTIEAVSLPGKGNIVRTGQLGEVMQESITAAMSVVRSRARSLGVKPDF
HCCCHHHCCCEEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YEKSDMHIHVPEGATPKDGPSAGIAMTTAIVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIRHVLIPKGNEKDLVDIPANIKQKLEIHPVKWIDEVLALALERQPEEL
HHHHHHHHHCCCCEEEEECCCCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHHCCHHHH
SQEEQSGDIPPTQDAGSNVPVLKH
HHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQPAEIREETSLPLLPLRDVVVFPHMVIPLFVGRAKSIRALELAMDEGKQILLVAQRSA
CCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCC
SKDEPSAEDLYGVGTIAAVLQMLKLPDGTVKVLVEGRQRATIKEVGEEDGCFVAEFSPLS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECCHHH
SELEESNETEAMRRALLAQFEQYVKLNKKIPPEVLNSLAGIDRAGRMADSIIAHLPLKLE
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QKQEVLEMFDVQTRLEHLMSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGEMDEASDHDELERRIKAAGMSKEGREKALSELKKLKMMSPMSAEATVVRNYIDTLL
HHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ELPWKKKTKISKDVAAADAVLDEDHFGLEKVKERILEYLAVQQRVDRLKAPILCLVGPPG
HCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYIGSMPGKVLQNMAKIGVKNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCH
FLLDEVDKLGADFRGDPSSALLEVLDPEQNHAFIDHYAEVEYDLSDVMFVATANSLNIPP
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCEECHHHEEEEEECCCCCCCH
ALLDRMEIIRLSGYTEDEKVNIALKYLLPKQMEANGVRDGELVVQESAIRDIVRYYTREA
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GVRSLDREVAKICRKVVTGALLKPAKAGKVTVSAKNLDKYLGVRRFDYGLAEEQNRIGQV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCHHHCCCHHHHHHHHHHH
TGLAWTEVGGELLTIEAVSLPGKGNIVRTGQLGEVMQESITAAMSVVRSRARSLGVKPDF
HCCCHHHCCCEEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YEKSDMHIHVPEGATPKDGPSAGIAMTTAIVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIRHVLIPKGNEKDLVDIPANIKQKLEIHPVKWIDEVLALALERQPEEL
HHHHHHHHHCCCCEEEEECCCCCCCEEECCCCHHHCCCCCCHHHHHHHHHHHHHCCHHHH
SQEEQSGDIPPTQDAGSNVPVLKH
HHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]