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The map label for this gene is clpP

Identifier: 34498013

GI number: 34498013

Start: 2753013

End: 2753645

Strand: Reverse

Name: clpP

Synonym: CV_2558

Alternate gene names: 34498013

Gene position: 2753645-2753013 (Counterclockwise)

Preceding gene: 34498014

Following gene: 34498012

Centisome position: 57.96

GC content: 61.93

Gene sequence:

>633_bases
ATGAAATCTATGATGGAACCGCAAGGTCTGGGCCTGGTGCCCATGGTGGTGGAGCAGAGTGGCCGCGGCGAACGCGCCTA
TGACATCTACTCTCGCCTGCTGAAGGAGCGCATCGTCTTCCTGGTCGGCCCCGTCACCGACGAGTCGGCCAACCTGGTTG
TGGCGCAGATGCTGTTCCTGGAGTCGGAAAATCCGGACAAGGACATCCATTTCTACATCAACTCGCCGGGCGGCTCGATT
ACCGCCGGCATGTCGATCTACGATACGATGAACTTCATCAAGCCGGACGTTTCCACGCTGTGCATCGGGCAGGCGGCCAG
CATGGGCGCCTTCCTGCTGGCGGCGGGCACTCACGGCAAGCGCTTCGCGCTGGAGAACAGCCGGGTGATGATCCACCAGC
CGCTGCTGTACGGCGGCGGCCTGTCCGGCCAGGTGACCGACATCGAAATCCATGCCCGCGAGCTGGTCAAGGTGAAGGCC
AAGATGAACGAGCTGTTGGCCAAGCATTCCGGCCAGACGCTGGAGCGGGTGCAGTCCGACACCGAGCGCGACAATTTCAT
GTCCGCCGAAGAGGCCCGCGCCTACGGTATGATCGATAAAGTGCTGTCTTCCCGCCGGGATGTGACGGCCTAA

Upstream 100 bases:

>100_bases
GGTTGAATTTGTGCTGTCTCAGGCCAATGTTGTAGCCAAGGACCTGTCCTTCGACGAACTGATGGGCAGCCAAGCCTGAT
AACAACTTTCGGAGTGGCCG

Downstream 100 bases:

>100_bases
GTAGTGGAATGGGCTAATGGCTGACAAAAACAGCAACGAGAAGCTCCTCTACTGCTCTTTCTGCGGAAAGAGCCAGCATG
AGGTGCAGCGGCTGATCGCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKSMMEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERIVFLVGPVTDESANLVVAQMLFLESENPDKDIHFYINSPGGSI
TAGMSIYDTMNFIKPDVSTLCIGQAASMGAFLLAAGTHGKRFALENSRVMIHQPLLYGGGLSGQVTDIEIHARELVKVKA
KMNELLAKHSGQTLERVQSDTERDNFMSAEEARAYGMIDKVLSSRRDVTA

Sequences:

>Translated_210_residues
MKSMMEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERIVFLVGPVTDESANLVVAQMLFLESENPDKDIHFYINSPGGSI
TAGMSIYDTMNFIKPDVSTLCIGQAASMGAFLLAAGTHGKRFALENSRVMIHQPLLYGGGLSGQVTDIEIHARELVKVKA
KMNELLAKHSGQTLERVQSDTERDNFMSAEEARAYGMIDKVLSSRRDVTA
>Mature_210_residues
MKSMMEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERIVFLVGPVTDESANLVVAQMLFLESENPDKDIHFYINSPGGSI
TAGMSIYDTMNFIKPDVSTLCIGQAASMGAFLLAAGTHGKRFALENSRVMIHQPLLYGGGLSGQVTDIEIHARELVKVKA
KMNELLAKHSGQTLERVQSDTERDNFMSAEEARAYGMIDKVLSSRRDVTA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=195, Percent_Identity=57.948717948718, Blast_Score=242, Evalue=1e-64,
Organism=Escherichia coli, GI1786641, Length=196, Percent_Identity=70.9183673469388, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=50.7936507936508, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129427, Length=195, Percent_Identity=56.9230769230769, Blast_Score=246, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CHRVO (Q7NUY9)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902228.1
- ProteinModelPortal:   Q7NUY9
- SMR:   Q7NUY9
- MEROPS:   S14.001
- GeneID:   2547230
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2558
- NMPDR:   fig|243365.1.peg.2558
- HOGENOM:   HBG558421
- OMA:   PTHANIV
- PhylomeDB:   Q7NUY9
- BioCyc:   CVIO243365:CV_2558-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23086; Mature: 23086

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 107-107 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSMMEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERIVFLVGPVTDESANLVVAQMLFL
CCCCCCCCCCCEEHHEECCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHH
ESENPDKDIHFYINSPGGSITAGMSIYDTMNFIKPDVSTLCIGQAASMGAFLLAAGTHGK
CCCCCCCEEEEEEECCCCCEEECHHHHHHHHHCCCCHHHHHHCCHHCCCEEEEEECCCCC
RFALENSRVMIHQPLLYGGGLSGQVTDIEIHARELVKVKAKMNELLAKHSGQTLERVQSD
EEEECCCEEEEECCEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TERDNFMSAEEARAYGMIDKVLSSRRDVTA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSMMEPQGLGLVPMVVEQSGRGERAYDIYSRLLKERIVFLVGPVTDESANLVVAQMLFL
CCCCCCCCCCCEEHHEECCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHH
ESENPDKDIHFYINSPGGSITAGMSIYDTMNFIKPDVSTLCIGQAASMGAFLLAAGTHGK
CCCCCCCEEEEEEECCCCCEEECHHHHHHHHHCCCCHHHHHHCCHHCCCEEEEEECCCCC
RFALENSRVMIHQPLLYGGGLSGQVTDIEIHARELVKVKAKMNELLAKHSGQTLERVQSD
EEEECCCEEEEECCEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TERDNFMSAEEARAYGMIDKVLSSRRDVTA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782