Click here to switch to the map view.

The map label for this gene is ppiB [C]

Identifier: 33863447

GI number: 33863447

Start: 1268268

End: 1268972

Strand: Reverse

Name: ppiB [C]

Synonym: PMT1177

Alternate gene names: 33863447

Gene position: 1268972-1268268 (Counterclockwise)

Preceding gene: 33863448

Following gene: 33863444

Centisome position: 52.64

GC content: 50.5

Gene sequence:

>705_bases
TTGTTGCTCTCATCCCTTGCGCGTTTGATTCGGCGTCAAAACATCTGGGGAATTCTGCTTTGTGTGCCCTTATTGGTTGG
CTGCAGCAAGTCCACTACGGCATCGATCAAGGCGGTTTGTTCCTCGCTGACTAGCCCCTGCTTGCAAGGCAAAGCCAATG
TGCTGATGAGTACGAATCGAGGCGCAATCACCCTTGAGGTGGATGGTGATGCTGCTCCTGTTACCGCAGGTAATTTCGTC
GATCTTGTTAAACGTGGTGTCTATAACGGCACTGTTTTTCATCGGGTCGTGAAAGAGCCCGTTCCCTTTGTTATTCAGGG
CGGTGATCCTGCTTCAAAGGATCCTAAAACGCTCAAGATCAATTACGGGAAGGGTAGTTTCATCGATCCCGCCAGTGCTC
AGGCCCGCTTCATTCCCTTTGAAGTGAAGTTGAAAACAGATGACCAGCCTCGCTATGGAAAGTTGATCACCAACCCCAGA
GAGTTGCTGCAATTGCAATTGACTCATAAGAAGGGGGCTCTGGCTATGGCTCGTTCTCCGGCGCCGGATTCAGCCAGTGC
TCAGTTTTACATTGCTTTGCGCCCTTTGCCCGAACTTGATGGCCGTTATGCTGTTTTTGGCAGGGTGATCAAGGGGTTGG
AGGTGGTGGATTCGATTCAGCAGGGTGATCGTATTTTTAAAGCCAGCCTGGTAATGGCGAAATAA

Upstream 100 bases:

>100_bases
TCTTACCCGCGTCGGTCAGCCTCTCCCCCTCGCACAGTTAGAACAGGATGGTGCTGAGCTAGCGCGTTTTCTTGACGTGA
ATCTTGAAGGGCTCTGAATT

Downstream 100 bases:

>100_bases
AAACCCTTAAGACATTGCCAATCACTTAGGCCGGTATTCGGCTCCCGCTCGGAGAGACCTTTAAGAGTTCGGTGTTTACC
CCTGAGGCCCTTACCAGAGC

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLLSSLARLIRRQNIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNRGAITLEVDGDAAPVTAGNFV
DLVKRGVYNGTVFHRVVKEPVPFVIQGGDPASKDPKTLKINYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPR
ELLQLQLTHKKGALAMARSPAPDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDSIQQGDRIFKASLVMAK

Sequences:

>Translated_234_residues
MLLSSLARLIRRQNIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNRGAITLEVDGDAAPVTAGNFV
DLVKRGVYNGTVFHRVVKEPVPFVIQGGDPASKDPKTLKINYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPR
ELLQLQLTHKKGALAMARSPAPDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDSIQQGDRIFKASLVMAK
>Mature_234_residues
MLLSSLARLIRRQNIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNRGAITLEVDGDAAPVTAGNFV
DLVKRGVYNGTVFHRVVKEPVPFVIQGGDPASKDPKTLKINYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPR
ELLQLQLTHKKGALAMARSPAPDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDSIQQGDRIFKASLVMAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789763, Length=201, Percent_Identity=34.3283582089552, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17551282, Length=133, Percent_Identity=34.5864661654135, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=133, Percent_Identity=34.5864661654135, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25307; Mature: 25307

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSSLARLIRRQNIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNR
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
GAITLEVDGDAAPVTAGNFVDLVKRGVYNGTVFHRVVKEPVPFVIQGGDPASKDPKTLKI
CEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEE
NYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPRELLQLQLTHKKGALAMARSP
ECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHEEEECCCCCCEEEECCC
APDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDSIQQGDRIFKASLVMAK
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHEEEECC
>Mature Secondary Structure
MLLSSLARLIRRQNIWGILLCVPLLVGCSKSTTASIKAVCSSLTSPCLQGKANVLMSTNR
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
GAITLEVDGDAAPVTAGNFVDLVKRGVYNGTVFHRVVKEPVPFVIQGGDPASKDPKTLKI
CEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEE
NYGKGSFIDPASAQARFIPFEVKLKTDDQPRYGKLITNPRELLQLQLTHKKGALAMARSP
ECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHEEEECCCCCCEEEECCC
APDSASAQFYIALRPLPELDGRYAVFGRVIKGLEVVDSIQQGDRIFKASLVMAK
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]