Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 30995438

GI number: 30995438

Start: 1374341

End: 1375534

Strand: Reverse

Name: csd [H]

Synonym: HI1295

Alternate gene names: 30995438

Gene position: 1375534-1374341 (Counterclockwise)

Preceding gene: 30995439

Following gene: 16273207

Centisome position: 75.16

GC content: 41.37

Gene sequence:

>1194_bases
TTGATTATCAAACGTTCCCGTCAAGCATTTCCCTATTTCCAACGTGAAGATGCGGTTATTTATTTAGATAACGCCGCCAC
CACGTTGAAACCTCAAGTATTAATTGATCGCACCGCTGAATTTTATGCGTCTGCAGGTTCGGTGCATCGCAGCCAATATG
ATGCTGCCCAAACTGTGCAATATGAACAGGCTCGCACACAAGTTAAAGAATGGGTTCATGCAGAAGATAAACACGCTGTT
ATTTGGACTTCGGGTACAACTCACGCAATAAACTTAGTGGCAAATGGATTGATGCCGCAATTAAACGCCGAAGATGAAAT
TCTGATTAGCCAAGCAGATCATCATGCCAATTTTGTCACTTGGCATGAAACGGCGAAAAAGTGCGGTGCAAAAATTCAAG
TTTTACCGATTTTAGATAATTGGCTAATTGATGAAAATGCGCTGATTTCAGCCCTTTCTGAAAAAACAAAACTCGTTGCG
CTAAATTTTGTTTCAAATGTCACTGGCACAGAACAGCCGATTAAACGCCTGATTCAACTTATTAGAAAACATAGCAATGC
CTTGGTTTTAGTGGATGCAGCACAAGCGATTAGTCATATCAAAATTGATTTACAAGATTTAGATGCCGATTTCCTCGCAT
TTTCTGCCCATAAAATTTATGGCCCAAATGGGCTTGGCGTTTTAACAGGAAAATTGACCGCACTTTCTCAACTTCAACCG
CTCTTTTTCGGTGGAAAAATGGTTGATCGTGTATCAAATGATCGTATTACTTTTGCCGAATTGCCTTATCGTTTAGAAGC
TGGCACACCCAATATTGCTGGGGTTATTGGCTTTAATGCGGTGCTGGATTGGCTACAAAAATGGGATTTTACCGCTGCAG
AACAGTACGCTATATCCTTGGCTGAATCCGTCAAAGTGCGGTTAAAATCTTACGAGAATTGCCGATTATTCAATTCTCCT
CAAGCAAGCACCGTTGTTTGCTTTGTATTTGATGGCATTGACTGTTCTGATCTTTCTACACTTTTGAGCGAACAAAATAT
TGCGCTTCGTGTGGGCGAACATTGTGCCCAGCCTTATTTAGCACGCTTAGGCGAACGCACCACATTACGCCTGTCTTTTG
CCCCTTATAATACACAAGAAGATGTAGAGGCATTCTTCACCGCCTTAGATAAAGCACTGGATTTATTACAATGA

Upstream 100 bases:

>100_bases
GCACAAGAAAATGCACAAGCCAAAGGAATTGGTCTTTGGGCAGACAATAATCCAATTGAACCAAGTCAATGGCGCAGACA
AGAGAAAATTAATATGGCTT

Downstream 100 bases:

>100_bases
TAGAACAATTAAAACAAGCTAAAAATTGGGAAGATCGCTATCGCCTGATTATTCAAGCAGGCAAAAATTTACCTCGCCCA
AGCGATAATGAACTCGCTCA

Product: putative selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MIIKRSRQAFPYFQREDAVIYLDNAATTLKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQYEQARTQVKEWVHAEDKHAV
IWTSGTTHAINLVANGLMPQLNAEDEILISQADHHANFVTWHETAKKCGAKIQVLPILDNWLIDENALISALSEKTKLVA
LNFVSNVTGTEQPIKRLIQLIRKHSNALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQP
LFFGGKMVDRVSNDRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQYAISLAESVKVRLKSYENCRLFNSP
QASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYLARLGERTTLRLSFAPYNTQEDVEAFFTALDKALDLLQ

Sequences:

>Translated_397_residues
MIIKRSRQAFPYFQREDAVIYLDNAATTLKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQYEQARTQVKEWVHAEDKHAV
IWTSGTTHAINLVANGLMPQLNAEDEILISQADHHANFVTWHETAKKCGAKIQVLPILDNWLIDENALISALSEKTKLVA
LNFVSNVTGTEQPIKRLIQLIRKHSNALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQP
LFFGGKMVDRVSNDRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQYAISLAESVKVRLKSYENCRLFNSP
QASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYLARLGERTTLRLSFAPYNTQEDVEAFFTALDKALDLLQ
>Mature_397_residues
MIIKRSRQAFPYFQREDAVIYLDNAATTLKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQYEQARTQVKEWVHAEDKHAV
IWTSGTTHAINLVANGLMPQLNAEDEILISQADHHANFVTWHETAKKCGAKIQVLPILDNWLIDENALISALSEKTKLVA
LNFVSNVTGTEQPIKRLIQLIRKHSNALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQP
LFFGGKMVDRVSNDRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQYAISLAESVKVRLKSYENCRLFNSP
QASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYLARLGERTTLRLSFAPYNTQEDVEAFFTALDKALDLLQ

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=24.9343832020997, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156713448, Length=257, Percent_Identity=25.2918287937743, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789175, Length=395, Percent_Identity=46.8354430379747, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI1787970, Length=402, Percent_Identity=36.0696517412935, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI48994898, Length=234, Percent_Identity=30.3418803418803, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=233, Percent_Identity=30.4721030042918, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=353, Percent_Identity=27.1954674220963, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=27.5510204081633, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI20129463, Length=237, Percent_Identity=30.8016877637131, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44236; Mature: 44236

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKRSRQAFPYFQREDAVIYLDNAATTLKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQ
CCCCCCCCCCCCEECCCCEEEECCCCCCCCCHHEEHHHHHHHHCCCCHHHHHHHHHHHHH
YEQARTQVKEWVHAEDKHAVIWTSGTTHAINLVANGLMPQLNAEDEILISQADHHANFVT
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEE
WHETAKKCGAKIQVLPILDNWLIDENALISALSEKTKLVALNFVSNVTGTEQPIKRLIQL
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHH
IRKHSNALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQP
HHHCCCEEEEEEHHHHHHHEEEEHHHCCCHHHEEEHHEEECCCCCEEEEHHHHHHHHCCH
LFFGGKMVDRVSNDRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQYAISL
HHCCCHHHHHCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AESVKVRLKSYENCRLFNSPQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYL
HHHHHHHHHCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEHHHHHCCHHH
ARLGERTTLRLSFAPYNTQEDVEAFFTALDKALDLLQ
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIKRSRQAFPYFQREDAVIYLDNAATTLKPQVLIDRTAEFYASAGSVHRSQYDAAQTVQ
CCCCCCCCCCCCEECCCCEEEECCCCCCCCCHHEEHHHHHHHHCCCCHHHHHHHHHHHHH
YEQARTQVKEWVHAEDKHAVIWTSGTTHAINLVANGLMPQLNAEDEILISQADHHANFVT
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEE
WHETAKKCGAKIQVLPILDNWLIDENALISALSEKTKLVALNFVSNVTGTEQPIKRLIQL
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHH
IRKHSNALVLVDAAQAISHIKIDLQDLDADFLAFSAHKIYGPNGLGVLTGKLTALSQLQP
HHHCCCEEEEEEHHHHHHHEEEEHHHCCCHHHEEEHHEEECCCCCEEEEHHHHHHHHCCH
LFFGGKMVDRVSNDRITFAELPYRLEAGTPNIAGVIGFNAVLDWLQKWDFTAAEQYAISL
HHCCCHHHHHCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
AESVKVRLKSYENCRLFNSPQASTVVCFVFDGIDCSDLSTLLSEQNIALRVGEHCAQPYL
HHHHHHHHHCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEHHHHHCCHHH
ARLGERTTLRLSFAPYNTQEDVEAFFTALDKALDLLQ
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]