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The map label for this gene is gmd [C]

Identifier: 308535385

GI number: 308535385

Start: 4249699

End: 4250682

Strand: Direct

Name: gmd [C]

Synonym: NA

Alternate gene names: 308535385

Gene position: 4249699-4250682 (Clockwise)

Preceding gene: 197120082

Following gene: 197120084

Centisome position: 92.08

GC content: 63.92

Gene sequence:

>984_bases
TTGGTCACCGGCGCCGATGGCTTCATCGGCTCCCACCTTACCGAGACGCTGGTACGGCAGGGTTACGAGGTCCGGCCCTT
CGTCTTTTACAACTCCTTCAACTCCTGGGGCTGGCTCGACCAGGCGCCGGAGGAGATCCGGAAGAACCTCGACGTCTTCG
CCGGCGACATCCGCGACCCGCACGGCGTCCGGACCGCCATGAAGGGGTGCGGCTCGGTATTGCACCTGGCTGCGCTGATC
GGGATTCCCTACTCCTACCACTCCCCAGACACTTACGTCGACACCAACATCAGGGGGACGCTCAACATCGTGCAGGCCGC
CCGGGAAGAGGGGGTGGAGAAGGTGATCCACACCTCGACCAGCGAGGTCTACGGCACGGCGCGCTTCGTTCCCATCACCG
AAGAACACCCGCTCCATGGGCAGTCCCCCTACTCCGCTTCGAAGATCGGCGCCGACCAGATCGCACTCTCCTTTTACAGC
TCCTTCGGCACGCCGGTCACCGTAGTGCGCCCCTTCAACACCTACGGCCCCCGGCAGTCGGCGCGGGCGGTGATCCCGAC
CATCATCACCCAGATCGCCGCGGGGAGGGAGGAGATCAGGCTGGGCTCGCTGCACCCCACCCGCGACTTCAACTTCGTCT
CGGACACGGTGGGGGGCTTCATCGCCGCGCTCAACTCGAATGCGGGAACCGGCGAGGTGGTGAATATCGGCAGCAACTTC
GAGATCTCCATCGGCGAGACGGTCGACATGATCGCACAGCTGATGGGGGCGAAGCTCAAGGTCGTCTCGGACGACGTGCG
GATCAGGCCGGAGAAGAGCGAGGTGGAAAGGCTTTGGGCAGACAACGCCAAGGCCGAGCGGCTTTTGGGGTGGAGCCCCG
CGTACGCGGGAAAAGAAGGGCTGCGCCGCGGCCTCGAAGAAACGATCCAGTGGTTCAAGGACCCGGCCAACCTGAGCCGG
TACAAGATGCAGTACAACGTATAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:
NA

Sequences:

>Translated_327_residues
MVTGADGFIGSHLTETLVRQGYEVRPFVFYNSFNSWGWLDQAPEEIRKNLDVFAGDIRDPHGVRTAMKGCGSVLHLAALI
GIPYSYHSPDTYVDTNIRGTLNIVQAAREEGVEKVIHTSTSEVYGTARFVPITEEHPLHGQSPYSASKIGADQIALSFYS
SFGTPVTVVRPFNTYGPRQSARAVIPTIITQIAAGREEIRLGSLHPTRDFNFVSDTVGGFIAALNSNAGTGEVVNIGSNF
EISIGETVDMIAQLMGAKLKVVSDDVRIRPEKSEVERLWADNAKAERLLGWSPAYAGKEGLRRGLEETIQWFKDPANLSR
YKMQYNV
>Mature_327_residues
MVTGADGFIGSHLTETLVRQGYEVRPFVFYNSFNSWGWLDQAPEEIRKNLDVFAGDIRDPHGVRTAMKGCGSVLHLAALI
GIPYSYHSPDTYVDTNIRGTLNIVQAAREEGVEKVIHTSTSEVYGTARFVPITEEHPLHGQSPYSASKIGADQIALSFYS
SFGTPVTVVRPFNTYGPRQSARAVIPTIITQIAAGREEIRLGSLHPTRDFNFVSDTVGGFIAALNSNAGTGEVVNIGSNF
EISIGETVDMIAQLMGAKLKVVSDDVRIRPEKSEVERLWADNAKAERLLGWSPAYAGKEGLRRGLEETIQWFKDPANLSR
YKMQYNV

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=325, Percent_Identity=31.0769230769231, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI42516563, Length=322, Percent_Identity=30.7453416149068, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI56237023, Length=350, Percent_Identity=27.4285714285714, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI56118217, Length=350, Percent_Identity=27.4285714285714, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI189083684, Length=350, Percent_Identity=27.4285714285714, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4504031, Length=347, Percent_Identity=26.8011527377522, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI193211614, Length=228, Percent_Identity=27.6315789473684, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI8393516, Length=228, Percent_Identity=27.6315789473684, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788366, Length=340, Percent_Identity=27.9411764705882, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI48994969, Length=347, Percent_Identity=27.0893371757925, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786974, Length=317, Percent_Identity=27.1293375394322, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=26.4705882352941, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788365, Length=256, Percent_Identity=25.390625, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=332, Percent_Identity=26.8072289156627, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17568069, Length=323, Percent_Identity=25.3869969040248, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17507723, Length=323, Percent_Identity=24.7678018575851, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71982038, Length=361, Percent_Identity=25.4847645429363, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=323, Percent_Identity=25.3869969040248, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=357, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=23.0061349693252, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71987463, Length=189, Percent_Identity=30.6878306878307, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=327, Percent_Identity=27.82874617737, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=30.5135951661631, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19923002, Length=339, Percent_Identity=28.3185840707965, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24158427, Length=321, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36013; Mature: 36013

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTGADGFIGSHLTETLVRQGYEVRPFVFYNSFNSWGWLDQAPEEIRKNLDVFAGDIRDP
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCC
HGVRTAMKGCGSVLHLAALIGIPYSYHSPDTYVDTNIRGTLNIVQAAREEGVEKVIHTST
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCC
SEVYGTARFVPITEEHPLHGQSPYSASKIGADQIALSFYSSFGTPVTVVRPFNTYGPRQS
HHHCCCEEEEECCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
ARAVIPTIITQIAAGREEIRLGSLHPTRDFNFVSDTVGGFIAALNSNAGTGEVVNIGSNF
HHHHHHHHHHHHHCCHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCE
EISIGETVDMIAQLMGAKLKVVSDDVRIRPEKSEVERLWADNAKAERLLGWSPAYAGKEG
EEECCCHHHHHHHHHCCEEEEECCCCEECCCHHHHHHHHHCCCHHHHHCCCCCCCCCHHH
LRRGLEETIQWFKDPANLSRYKMQYNV
HHHHHHHHHHHHHCCCCHHHEEEEECC
>Mature Secondary Structure
MVTGADGFIGSHLTETLVRQGYEVRPFVFYNSFNSWGWLDQAPEEIRKNLDVFAGDIRDP
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCC
HGVRTAMKGCGSVLHLAALIGIPYSYHSPDTYVDTNIRGTLNIVQAAREEGVEKVIHTST
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCC
SEVYGTARFVPITEEHPLHGQSPYSASKIGADQIALSFYSSFGTPVTVVRPFNTYGPRQS
HHHCCCEEEEECCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
ARAVIPTIITQIAAGREEIRLGSLHPTRDFNFVSDTVGGFIAALNSNAGTGEVVNIGSNF
HHHHHHHHHHHHHCCHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCE
EISIGETVDMIAQLMGAKLKVVSDDVRIRPEKSEVERLWADNAKAERLLGWSPAYAGKEG
EEECCCHHHHHHHHHCCEEEEECCCCEECCCHHHHHHHHHCCCHHHHHCCCCCCCCCHHH
LRRGLEETIQWFKDPANLSRYKMQYNV
HHHHHHHHHHHHHCCCCHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]