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The map label for this gene is mpg1 [H]

Identifier: 197120084

GI number: 197120084

Start: 4250694

End: 4251416

Strand: Direct

Name: mpg1 [H]

Synonym: Gbem_3723

Alternate gene names: 197120084

Gene position: 4250694-4251416 (Clockwise)

Preceding gene: 308535385

Following gene: 197120085

Centisome position: 92.1

GC content: 59.34

Gene sequence:

>723_bases
ATGCGGGCAGTCATTCTGGCAGGCGGCAGGGGGACGAGGCTGCGCCCCTACACCGTGGTGCTTCCCAAACCCCTCATGCC
GATAGGCGAGTATCCCATCCTCGAGGTGATCGTGCGCCAACTGGTACACTGCGGCTTCACGCACATCACCATGGCGGTGA
ACCACCAGGCGAAGATCATCCAGGCCTTCTTCGGCAACGGCGAACGCTGGGGCATCACCATCGACTATTCGCTGGAAACC
AAGCCGCTGAGCACCATGGGGCCTCTCAGGCTCATCGACGATCTGCCGGAAAACTTCCTGGTGATGAACGGCGACATCCT
CACCGACCTGAACTTCAGGGAATTCCACGATTACCACGTGAGGGTAAAAAACAACTTCACCATCGCCGCATACCAAAGGG
TGCTCAAGTCCGAATACGGCGTGCTGAAGATCAACCGGCAGAAAAAGCTCTGCGGCTTCGAGGAGAAGCCCGAGTACCTT
TTGGACGTCAGCATGGGGGTCTACATGGTGAACCGCGACACGATGCGGCACATCCCCGCGGACACCCCCTACGGGTTCGA
CCACCTGATGCTCGACCTCCTGGCTGAGGGGCACCCGGCCTCGGTGAAGATCCACAAGGGATTCTGGCTCGACATCGGCC
GCCCCGACGATTACATGCAGGCGATCGAGGAGTTCGACTCGCTGAAGGGGAAGTTCCTCCCCTACGAAGGAACAGTGCAA
TGA

Upstream 100 bases:

>100_bases
AAGGGCTGCGCCGCGGCCTCGAAGAAACGATCCAGTGGTTCAAGGACCCGGCCAACCTGAGCCGGTACAAGATGCAGTAC
AACGTATAAGGAGCGGATAG

Downstream 100 bases:

>100_bases
GCAACGTCCCGATCAACAAGGGGAACTACGAACTCGAGACCCCGGAGCGCGAGACGCTCTTCGAAAAGTACCGCGGCGAG
GGGTGGGAAGAGGAATACGC

Product: nucleotidyltransferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MRAVILAGGRGTRLRPYTVVLPKPLMPIGEYPILEVIVRQLVHCGFTHITMAVNHQAKIIQAFFGNGERWGITIDYSLET
KPLSTMGPLRLIDDLPENFLVMNGDILTDLNFREFHDYHVRVKNNFTIAAYQRVLKSEYGVLKINRQKKLCGFEEKPEYL
LDVSMGVYMVNRDTMRHIPADTPYGFDHLMLDLLAEGHPASVKIHKGFWLDIGRPDDYMQAIEEFDSLKGKFLPYEGTVQ

Sequences:

>Translated_240_residues
MRAVILAGGRGTRLRPYTVVLPKPLMPIGEYPILEVIVRQLVHCGFTHITMAVNHQAKIIQAFFGNGERWGITIDYSLET
KPLSTMGPLRLIDDLPENFLVMNGDILTDLNFREFHDYHVRVKNNFTIAAYQRVLKSEYGVLKINRQKKLCGFEEKPEYL
LDVSMGVYMVNRDTMRHIPADTPYGFDHLMLDLLAEGHPASVKIHKGFWLDIGRPDDYMQAIEEFDSLKGKFLPYEGTVQ
>Mature_240_residues
MRAVILAGGRGTRLRPYTVVLPKPLMPIGEYPILEVIVRQLVHCGFTHITMAVNHQAKIIQAFFGNGERWGITIDYSLET
KPLSTMGPLRLIDDLPENFLVMNGDILTDLNFREFHDYHVRVKNNFTIAAYQRVLKSEYGVLKINRQKKLCGFEEKPEYL
LDVSMGVYMVNRDTMRHIPADTPYGFDHLMLDLLAEGHPASVKIHKGFWLDIGRPDDYMQAIEEFDSLKGKFLPYEGTVQ

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=241, Percent_Identity=31.9502074688797, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI11761619, Length=241, Percent_Identity=31.9502074688797, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1788351, Length=249, Percent_Identity=23.6947791164659, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=234, Percent_Identity=31.6239316239316, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17509979, Length=205, Percent_Identity=24.390243902439, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=230, Percent_Identity=31.7391304347826, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21355443, Length=241, Percent_Identity=29.8755186721992, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24644084, Length=241, Percent_Identity=29.8755186721992, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 27527; Mature: 27527

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVILAGGRGTRLRPYTVVLPKPLMPIGEYPILEVIVRQLVHCGFTHITMAVNHQAKII
CEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHH
QAFFGNGERWGITIDYSLETKPLSTMGPLRLIDDLPENFLVMNGDILTDLNFREFHDYHV
HHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHHCCCCEEEECCCEEECCCHHHCCEEEE
RVKNNFTIAAYQRVLKSEYGVLKINRQKKLCGFEEKPEYLLDVSMGVYMVNRDTMRHIPA
EEECCEEHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEECCEEEECCCHHHCCCC
DTPYGFDHLMLDLLAEGHPASVKIHKGFWLDIGRPDDYMQAIEEFDSLKGKFLPYEGTVQ
CCCCCHHHHHHHHHHCCCCCEEEEECCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRAVILAGGRGTRLRPYTVVLPKPLMPIGEYPILEVIVRQLVHCGFTHITMAVNHQAKII
CEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHH
QAFFGNGERWGITIDYSLETKPLSTMGPLRLIDDLPENFLVMNGDILTDLNFREFHDYHV
HHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHHCCCCEEEECCCEEECCCHHHCCEEEE
RVKNNFTIAAYQRVLKSEYGVLKINRQKKLCGFEEKPEYLLDVSMGVYMVNRDTMRHIPA
EEECCEEHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEECCEEEECCCHHHCCCC
DTPYGFDHLMLDLLAEGHPASVKIHKGFWLDIGRPDDYMQAIEEFDSLKGKFLPYEGTVQ
CCCCCHHHHHHHHHHCCCCCEEEEECCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]