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The map label for this gene is pth [H]

Identifier: 30410817

GI number: 30410817

Start: 206033

End: 206581

Strand: Direct

Name: pth [H]

Synonym: BUsg184

Alternate gene names: 30410817

Gene position: 206033-206581 (Clockwise)

Preceding gene: 21672470

Following gene: 21672472

Centisome position: 32.12

GC content: 23.32

Gene sequence:

>549_bases
TTGAATAAAATAAAAATGATAGTAGGATTATCTAATCCTAAAAAAAAATATCATAAAACGCGTCATAACGTTGGATCTTG
GTATATTTATTCGTTAGCAAAAAATTATTTGAGTATTTTAAAAGAAGAAAAAAAATTTTTTGGTTTTACTGGTTGTTTAA
ATATCAAATCAAATTTTATTCGTTTACTCATACCTGATATTTTTATGAATATAAATGGTTTTTCCGTACATAGAATGGCT
TCATTTTATAATATAAGTTTAAATCAAATATTAATAGTACATGATGATCTTGATTTAGCACCTGGAATTATAAAATATAA
ATATAGTTACGGGCATAGTGGTCACAACGGATTAAGACATATTATTAAAGAATTTAATACTAAAGTGAATTTTTATCGAT
TGAGAATTGGCATTGGTCGTCCAAAAAATAAAAATGAAATATCATCGTTTGTACTTTCTATACCTGATTTCAAGGAAATG
AAGTTAATTAAGAAATCTATTTCATATGCAATAAAAGAAAATTTTACATTATTAAATTTGATACAATAG

Upstream 100 bases:

>100_bases
AATCTTTAATTAATAAATGTTTTAAAATAAAAACATATAATATTTAATATTATATGTTTTTCATTTTTTATATAAATCTG
AAAATGTTAAAGGATTTTTT

Downstream 100 bases:

>100_bases
TCAGATATAAAAATTTTTTTATATTTTTTAAATCAATTTTGTGTAATTGTTCATTTTTTAAGGCGTATAAAATATGGGTT
TTAAATGTGGAATTATAGGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MNKIKMIVGLSNPKKKYHKTRHNVGSWYIYSLAKNYLSILKEEKKFFGFTGCLNIKSNFIRLLIPDIFMNINGFSVHRMA
SFYNISLNQILIVHDDLDLAPGIIKYKYSYGHSGHNGLRHIIKEFNTKVNFYRLRIGIGRPKNKNEISSFVLSIPDFKEM
KLIKKSISYAIKENFTLLNLIQ

Sequences:

>Translated_182_residues
MNKIKMIVGLSNPKKKYHKTRHNVGSWYIYSLAKNYLSILKEEKKFFGFTGCLNIKSNFIRLLIPDIFMNINGFSVHRMA
SFYNISLNQILIVHDDLDLAPGIIKYKYSYGHSGHNGLRHIIKEFNTKVNFYRLRIGIGRPKNKNEISSFVLSIPDFKEM
KLIKKSISYAIKENFTLLNLIQ
>Mature_182_residues
MNKIKMIVGLSNPKKKYHKTRHNVGSWYIYSLAKNYLSILKEEKKFFGFTGCLNIKSNFIRLLIPDIFMNINGFSVHRMA
SFYNISLNQILIVHDDLDLAPGIIKYKYSYGHSGHNGLRHIIKEFNTKVNFYRLRIGIGRPKNKNEISSFVLSIPDFKEM
KLIKKSISYAIKENFTLLNLIQ

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=161, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI1787455, Length=169, Percent_Identity=47.9289940828402, Blast_Score=163, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21236; Mature: 21236

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIKMIVGLSNPKKKYHKTRHNVGSWYIYSLAKNYLSILKEEKKFFGFTGCLNIKSNFI
CCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECHHHHH
RLLIPDIFMNINGFSVHRMASFYNISLNQILIVHDDLDLAPGIIKYKYSYGHSGHNGLRH
HHEEHHHHHCCCCCCHHHHHHHEEEEEEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHH
IIKEFNTKVNFYRLRIGIGRPKNKNEISSFVLSIPDFKEMKLIKKSISYAIKENFTLLNL
HHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEE
IQ
CC
>Mature Secondary Structure
MNKIKMIVGLSNPKKKYHKTRHNVGSWYIYSLAKNYLSILKEEKKFFGFTGCLNIKSNFI
CCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECHHHHH
RLLIPDIFMNINGFSVHRMASFYNISLNQILIVHDDLDLAPGIIKYKYSYGHSGHNGLRH
HHEEHHHHHCCCCCCHHHHHHHEEEEEEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHH
IIKEFNTKVNFYRLRIGIGRPKNKNEISSFVLSIPDFKEMKLIKKSISYAIKENFTLLNL
HHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEE
IQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]