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The map label for this gene is lldP

Identifier: 30065121

GI number: 30065121

Start: 4023565

End: 4025220

Strand: Reverse

Name: lldP

Synonym: S4126

Alternate gene names: 30065121

Gene position: 4025220-4023565 (Counterclockwise)

Preceding gene: 30065124

Following gene: 30065120

Centisome position: 87.52

GC content: 55.07

Gene sequence:

>1656_bases
ATGAATCTCTGGCAACAAAACTACGATCCCGCCGGGAATATCTGGCTTTCCAGTCTGATAGCATCGCTTCCCATCCTGTT
TTTCTTCTTTGCGCTGATTAAGCTCAAACTGAAAGGATACGTCGCCGCCTCATGGACGGTAGCAATCGCCCTTGCCGTGG
CTTTGCTGTTCTATAAAATGCCGGTCGCTAACGCGCTGGCCTCGGTGGTTTATGGCTTCTTCTATGGTTTGTGGCCCATC
GCGTGGATCATTATTGCAGCAGTGTTCGTCTATAAGATCTCGGTGAAAACCGGGCAGTTTGACATCATTCGCTCGTCTAT
TCTTTCGATAACCCCTGACCAGCGTCTGCAAATGCTGATCGTCGGTTTCTGTTTCGGCGCTTTCCTTGAAGGAGCCGCAG
GCTTTGGCGCACCGGTAGCAATTACCGCCGCATTGCTGGTCGGCCTGGGTTTTAAACCGCTGTACGCCGCCGGACTGTGC
CTGATTGTTAACACCGCGCCAGTGGCATTTGGCGCGATGGGCATTCCAATCCTGGTTGCCGGACAAGTAACAGGCATCGA
CAGCTTTGAGATTGGCCAGATGGTGGGGCGTCAGCTACCGTTTATGACCATTATCGTGCTGTTCTGGATCATGGCGATTA
TGGACGGCTGGCGCGGTATCAAAGAGACGTGGCCTGCGGTCGTGGTTGCAGGCGGCTCGTTTGCCATCGCTCAGTACCTT
AGCTCTAACTTCATTGGGCCGGAGCTGCCGGACATTATCTCTTCGCTGGTATCACTGCTCTGCCTGACGCTGTTCCTCAA
ACGCTGGCAACCAGTTCGCGTATTCCGCTTCGGTGACTTGGGGGCGTCACAGGTTGATATGACGCTGGCCCACACCGGTT
ACACCGCGGGTCAGGTGTTACGTGCCTGGACACCGTTCCTGTTCCTGACCGCTACCGTAACACTGTGGAGCATCCCGCCG
TTTAAAGCCCTGTTCGCATCGGGTGGTGCGCTGTATGAGTGGGTGATCAACATTCCGGTGCCGTACCTCAATAAACTGGT
TGCCCGTATGCCACCAGTGGTCAGCGAGGCTACAGCCTATGCCGCCGTGTTTAAGTTTGACTGGTTCTCTGCCACCGGCA
CCGCCATTCTGTTTGCTGCACTGCTCTCGATTGTCTGGCTGAAGATGAAACCGTCTGACGCTATCAGCACCTTCGGCAGC
ACGCTGAAAGAACTGGCTCTACCCATCTACTCCATCGGCATGGTGCTGGCGTTCGCCTTTATCTCGAACTATTCCGGACT
GTCATCAACACTGGCACTGGCACTGGCGCACACCGGTCATGCATTCACCTTCTTCTCGCCGTTCCTCGGCTGGCTGGGGG
TATTCCTGACCGGGTCGGATACCTCATCTAACGCCCTGTTCGCCGCGCTGCAAGCCACCGCAGCACAACAAATTGGCGTC
TCTGATCTGTTGCTGGTTGCCGCCAATACCACCGGTGGCGTCACCGGTAAGATGATCTCCCCGCAATCTATCGCTATCGC
CTGTGCGGCGGTAGGCCTGGTGGGCAAAGAGTCTGATTTGTTCCGCTTTACTGTCAAACACAGCCTGATCTTCACCTGTA
TGGTGGGCGTGATCACCACGCTTCAGGCTTATGTCTTAACGTGGATGATTCCTTAA

Upstream 100 bases:

>100_bases
CTACACAACACAATTGGCAGTGCCACTTTTACACAACGTGTGACAAGGAGATGAGCAACAGACTCATTACACGATGTGCG
TGGACTCTAGGAGACCTGCA

Downstream 100 bases:

>100_bases
TGATTGTTTTACCCAGACGCCTGTCAGACGAGGTTGCCGATCGTGTGCGGGCGCTGATTGATGAAAAAAACCTGGAAGCG
GGCATGAAGTTGCCCGCTGA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYL
SSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATVTLWSIPP
FKALFASGGALYEWVINIPVPYLNKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
SDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Sequences:

>Translated_551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYL
SSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATVTLWSIPP
FKALFASGGALYEWVINIPVPYLNKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
SDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP
>Mature_551_residues
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPI
AWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLC
LIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYL
SSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATVTLWSIPP
FKALFASGGALYEWVINIPVPYLNKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGS
TLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
SDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=99.6370235934664, Blast_Score=1085, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=63.0824372759857, Blast_Score=686, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59186; Mature: 59186

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHH
VGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPILVA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEEEECCCHHHCCCCCCEEEE
GQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYL
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHHH
SSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHEEEHEECCCHHHHHH
RAWTPFLFLTATVTLWSIPPFKALFASGGALYEWVINIPVPYLNKLVARMPPVVSEATAY
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEHEEECCHHHHHHHHHHCCCHHHHHHHH
AAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGSTLKELALPIYSIGMVLAFAF
HHHHEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCC
SDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITT
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHH
LQAYVLTWMIP
HHHHHHHHCCC
>Mature Secondary Structure
MNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHH
VGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPILVA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEEEECCCHHHCCCCCCEEEE
GQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYL
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHHH
SSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHEEEHEECCCHHHHHH
RAWTPFLFLTATVTLWSIPPFKALFASGGALYEWVINIPVPYLNKLVARMPPVVSEATAY
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEHEEECCHHHHHHHHHHCCCHHHHHHHH
AAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGSTLKELALPIYSIGMVLAFAF
HHHHEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGV
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCC
SDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITT
HHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHH
LQAYVLTWMIP
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]