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The map label for this gene is lldR

Identifier: 30065120

GI number: 30065120

Start: 4022789

End: 4023565

Strand: Reverse

Name: lldR

Synonym: S4125

Alternate gene names: 30065120

Gene position: 4023565-4022789 (Counterclockwise)

Preceding gene: 30065121

Following gene: 30065119

Centisome position: 87.48

GC content: 54.18

Gene sequence:

>777_bases
ATGATTGTTTTACCCAGACGCCTGTCAGACGAGGTTGCCGATCGTGTGCGGGCGCTGATTGATGAAAAAAACCTGGAAGC
GGGCATGAAGTTGCCCGCTGAGCGCCAACTGGCGATGCAACTCGGCGTATCACGTAATTCACTACGCGAGGCGCTGGCAA
AACTGGTGAGCGAAGGCGTGCTGCTCAGTCGACGCGGCGGCGGGACGTTTATTCGCTGGCGTCATGACACATGGTCGGAG
CAAAACATCGTCCAGCCGCTAAAAACGCTGATGGCCGATGATCCGGATTACAGTTTCGATATTCTGGAAGCCCGCTACGC
CATTGAAGCCAGCACCGCATGGCATGCGGCAATGCGCGCCACACCTGGCGACAAAGAAAAGATTCAGCTTTGCTTTGAAG
CAACGCTAAGTGAAGACCCGGATATCGCCTCACAAGCGGACGTTCGTTTTCATCTGGCGATTGCCGAAGCCTCACATAAC
ATCGTGCTGCTGCAAACCATGCGCGGTTTCTTCGATGTCCTGCAATCCTCAGTGAAGCATAGCCGTCAGCGGATGTATCT
GGTGCCACCGGTTTTTTCACAACTGACCGAACAACATCAGGCTGTCATTGACGCCATTTTTGCTGGTGATGCCGACGGGG
CGCGTAAAGCAATGATGGCGCACCTTAGTTTTGTTCACACCACCATGAAACGATTCGATGAAGATCAGGCTCGCCACGCA
CGGATTACCCGCCTGCCCGGTGAGCATAATGAGCATTCGAGGGAGAAAAACGCATGA

Upstream 100 bases:

>100_bases
ATTTGTTCCGCTTTACTGTCAAACACAGCCTGATCTTCACCTGTATGGTGGGCGTGATCACCACGCTTCAGGCTTATGTC
TTAACGTGGATGATTCCTTA

Downstream 100 bases:

>100_bases
TTATTTCCGCAGCCAGCGATTATCGCGCCGCAGCGCAACGCATTCTGCCGCCGTTCCTGTTCCACTATATGGATGGTGGT
GCATATTCTGAATACACGCT

Product: DNA-binding transcriptional repressor LldR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSE
QNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHN
IVLLQTMRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
RITRLPGEHNEHSREKNA

Sequences:

>Translated_258_residues
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSE
QNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHN
IVLLQTMRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
RITRLPGEHNEHSREKNA
>Mature_258_residues
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSE
QNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHN
IVLLQTMRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
RITRLPGEHNEHSREKNA

Specific function: May be a regulatory protein for the LCT genes

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790032, Length=258, Percent_Identity=100, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1786303, Length=231, Percent_Identity=38.0952380952381, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789353, Length=234, Percent_Identity=31.1965811965812, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790780, Length=232, Percent_Identity=30.1724137931034, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI87082208, Length=237, Percent_Identity=27.0042194092827, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDR_ECOLI (P0ACL7)

Other databases:

- EMBL:   L13970
- EMBL:   U00039
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   B49904
- RefSeq:   AP_004187.1
- RefSeq:   NP_418061.1
- ProteinModelPortal:   P0ACL7
- SMR:   P0ACL7
- STRING:   P0ACL7
- EnsemblBacteria:   EBESCT00000002630
- EnsemblBacteria:   EBESCT00000002631
- EnsemblBacteria:   EBESCT00000017901
- GeneID:   948122
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3579
- KEGG:   eco:b3604
- EchoBASE:   EB1905
- EcoGene:   EG11962
- eggNOG:   COG2186
- GeneTree:   EBGT00050000009602
- HOGENOM:   HBG700007
- OMA:   PNYSFDI
- ProtClustDB:   PRK10421
- BioCyc:   EcoCyc:EG11962-MONOMER
- Genevestigator:   P0ACL7
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 29167; Mature: 29167

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGV
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCE
LLSRRGGGTFIRWRHDTWSEQNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRA
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
TPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSSVKH
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHH
SRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
HHHCEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RITRLPGEHNEHSREKNA
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGV
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCE
LLSRRGGGTFIRWRHDTWSEQNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRA
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
TPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSSVKH
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHH
SRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
HHHCEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RITRLPGEHNEHSREKNA
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407843; 8041620; 9278503