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The map label for this gene is hycC

Identifier: 30064077

GI number: 30064077

Start: 2810368

End: 2812161

Strand: Reverse

Name: hycC

Synonym: S2932

Alternate gene names: 30064077

Gene position: 2812161-2810368 (Counterclockwise)

Preceding gene: 30064078

Following gene: 30064076

Centisome position: 61.14

GC content: 58.19

Gene sequence:

>1794_bases
TTGTCGCCGCCGCTGTTCTGGCATTTCTCTTTTCAAAAAGCGCTAAGTGGCTGGATAGCCGGAATTGGCGGCGCGGTTGG
TAGTCTGTATACGGCAGCCGCGGGCTTCACTGTACTGACTGGCGCGGTTGGCGTGAGCGGTGCGCTGTCGCTGGTAAGCT
ACGATGTGCAAATCTCCCCGCTTAACGCGATTTGGCTGATTACCCTCGGCCTTTGCGGTCTGTTTGTCAGCCTCTATAAC
ATTGACTGGCATCGCCACGCGCAGGTGAAGTGCAACGGCTTGCAGATCAATATGTTGATGGCTGCCGCCGTCTGCGCCGT
CATCGCCAGCAACCTCGGCATGTTCGTGGTAATGGCCGAAGTCATGGCCTTGTGTGCGGTGTTCCTCACCAGCAACAGCA
AAGAGGGCAAACTGTGGTTTGCGCTGAGGCGTCTTGGCACTCTGCTGCTGGTGATTGCTTGCTGGCTGCTGTGGCAGCGT
TATGGCACGCTGGATCTGCGCCTGCTGGATATGCGTATGCAACAGCTGCCGCTCGGTTCCGATATCTGGCTGCTCGGTGT
GATTGGCTTTGGCCTGCTGGCTGGGATTATTCCGCTGCACGGCTGGGTGCCGCAGGCACATGCTAACGCCTCTGCGCCAG
CTGCCGCGTTGTTTTCTACGGTAGTCATGAAAATTGGCCTGCTGGGCATGTTAACCCTGTCACTGCTGGGCGGTAATGCA
CCGCTGTGGTGGGGGATCGCGCTGCTGGTGCTCGGCATGATCACCGCGTTCGTCGGTGGTCTGTATGCGTTGATGGAACA
CAACATCCAGCGCCTGCTGGCTTACCACACCCTGGAAAATATCGGCATTATCCTGCTGGGGCTGGGGCTGGGGCTGGGCG
CTGGCGTAACGGGTATCGCGCTCGAACAACCGGCGCTGATTGCTCTTGGCCTGGTCGGTGGTCTGTACCATCTGCTTAAC
CATAGCCTGTTCAAAAGCGTACTGTTCCTCGGGGCGGGGAGCGTCTGGTTCCGTACCGGTCATCGCGATATCGAAAAACT
CGGTGGTATTGGCAAGAAAATGCCGGTTATCTCCATCGCCATGTTAGTCGGGTTGATGGCAATGGCTGCGCTGCCGCCAC
TGAACGGGTTTGCCGGGGAATGGGTTATCTATCAATCCTTCTTCAAACTGAGCAATAGCGGCGCGTTTGTTGCCCGTCTG
CTGGGGCCGCTGCTCGCTGTGGGTCTGGCAATTACCGGTGCGCTGGCGGTGATGTGTATGGCGAAAGTCTATGGCGTCAC
GTTCCTCGGCGCGCCGCGTACCAAAGAAGCCGAAAACGCCACCTGTGCGCCGCTCCTGATGAGCGTAAGCGTAGTGGCAC
TGGCGATTTGCTGCGTAATTGGCGGTGTTGCTGCGCCGTGGCTGCTGCCGATGCTCTCTGCTGCTGTACCTCTGCCTCTG
GAGCCTGCTAACACCACCGTTTCTCAACCAATGATCACATTGCTGCTGATTGCCTGCCCGCTGCTGCCATTCATCATTAT
GGCGATTTGCAAAGGCGACCGCCTGCCGTCACGTTCCCGCGGTGCGGCCTGGGTGTGCGGCTACGACCATGAAAAATCAA
TGGTGATTACCGCTCACGGTTTTGCCATGCCGGTTAAACAGGCGTTTGCGCCAGTGCTGAAACTGCGCAAATGGCTGAAT
CCGGTGTCGCTAGTGCCGGGCTGGCAGTGCGAAGGTAGTGCGTTGCTGTTCCGCCGGATGGCGCTGGTTGAACTGGCGGT
ACTGGTGGTGATTATTGTTTCACGAGGAGCCTGA

Upstream 100 bases:

>100_bases
CTTTAACACGGACTTTGGCGATCTCACCTTGTTTCAGCAGGCTCAAAGTGGAGAGGCTAAATGAGCGCAATTTCCCTGAT
CAATAGCGGCGTGGCATGGT

Downstream 100 bases:

>100_bases
GAATGAGTGTTTTATATCCGTTAATTCAGGCGCTGGTGTTATTTGCCGTTGCGCCGCTGCTCTCCGGTATTACCCGCGTG
GCGCGCGCCCGTCTGCATAA

Product: formate hydrogenlyase subunit 3

Products: NA

Alternate protein names: FHL subunit 3; Hydrogenase-3 component C [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MSPPLFWHFSFQKALSGWIAGIGGAVGSLYTAAAGFTVLTGAVGVSGALSLVSYDVQISPLNAIWLITLGLCGLFVSLYN
IDWHRHAQVKCNGLQINMLMAAAVCAVIASNLGMFVVMAEVMALCAVFLTSNSKEGKLWFALRRLGTLLLVIACWLLWQR
YGTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGMLTLSLLGGNA
PLWWGIALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGLGLGAGVTGIALEQPALIALGLVGGLYHLLN
HSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARL
LGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSAAVPLPL
EPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEKSMVITAHGFAMPVKQAFAPVLKLRKWLN
PVSLVPGWQCEGSALLFRRMALVELAVLVVIIVSRGA

Sequences:

>Translated_597_residues
MSPPLFWHFSFQKALSGWIAGIGGAVGSLYTAAAGFTVLTGAVGVSGALSLVSYDVQISPLNAIWLITLGLCGLFVSLYN
IDWHRHAQVKCNGLQINMLMAAAVCAVIASNLGMFVVMAEVMALCAVFLTSNSKEGKLWFALRRLGTLLLVIACWLLWQR
YGTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGMLTLSLLGGNA
PLWWGIALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGLGLGAGVTGIALEQPALIALGLVGGLYHLLN
HSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARL
LGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSAAVPLPL
EPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEKSMVITAHGFAMPVKQAFAPVLKLRKWLN
PVSLVPGWQCEGSALLFRRMALVELAVLVVIIVSRGA
>Mature_596_residues
SPPLFWHFSFQKALSGWIAGIGGAVGSLYTAAAGFTVLTGAVGVSGALSLVSYDVQISPLNAIWLITLGLCGLFVSLYNI
DWHRHAQVKCNGLQINMLMAAAVCAVIASNLGMFVVMAEVMALCAVFLTSNSKEGKLWFALRRLGTLLLVIACWLLWQRY
GTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGMLTLSLLGGNAP
LWWGIALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGLGLGAGVTGIALEQPALIALGLVGGLYHLLNH
SLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARLL
GPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSAAVPLPLE
PANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEKSMVITAHGFAMPVKQAFAPVLKLRKWLNP
VSLVPGWQCEGSALLFRRMALVELAVLVVIIVSRGA

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=243, Percent_Identity=26.3374485596708, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI2367154, Length=589, Percent_Identity=98.471986417657, Blast_Score=1086, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=513, Percent_Identity=39.1812865497076, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1788831, Length=201, Percent_Identity=34.8258706467662, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788614, Length=302, Percent_Identity=26.4900662251656, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1788829, Length=195, Percent_Identity=27.6923076923077, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788613, Length=197, Percent_Identity=27.4111675126904, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: NA

Molecular weight: Translated: 63244; Mature: 63113

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPLFWHFSFQKALSGWIAGIGGAVGSLYTAAAGFTVLTGAVGVSGALSLVSYDVQISP
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEECC
LNAIWLITLGLCGLFVSLYNIDWHRHAQVKCNGLQINMLMAAAVCAVIASNLGMFVVMAE
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEHHHHHHHHHHHHHHHCCHHHHHHHH
VMALCAVFLTSNSKEGKLWFALRRLGTLLLVIACWLLWQRYGTLDLRLLDMRMQQLPLGS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
DIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGMLTLSLLGGNA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLWWGIALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGLGLGAGVTGIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEE
LEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIA
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCHHHHHHCCCCCCCHHHHHH
MLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGALAVMCM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSAAVPLPL
HHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEKSMVITAHG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECC
FAMPVKQAFAPVLKLRKWLNPVSLVPGWQCEGSALLFRRMALVELAVLVVIIVSRGA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPPLFWHFSFQKALSGWIAGIGGAVGSLYTAAAGFTVLTGAVGVSGALSLVSYDVQISP
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEECC
LNAIWLITLGLCGLFVSLYNIDWHRHAQVKCNGLQINMLMAAAVCAVIASNLGMFVVMAE
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEHHHHHHHHHHHHHHHCCHHHHHHHH
VMALCAVFLTSNSKEGKLWFALRRLGTLLLVIACWLLWQRYGTLDLRLLDMRMQQLPLGS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
DIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGMLTLSLLGGNA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLWWGIALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGLGLGAGVTGIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEE
LEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIA
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCHHHHHHCCCCCCCHHHHHH
MLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGALAVMCM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSAAVPLPL
HHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEKSMVITAHG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECC
FAMPVKQAFAPVLKLRKWLNPVSLVPGWQCEGSALLFRRMALVELAVLVVIIVSRGA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]