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The map label for this gene is dmsA

Identifier: 30062381

GI number: 30062381

Start: 887266

End: 889623

Strand: Direct

Name: dmsA

Synonym: S0894

Alternate gene names: 30062381

Gene position: 887266-889623 (Clockwise)

Preceding gene: 30062380

Following gene: 30062382

Centisome position: 19.29

GC content: 52.46

Gene sequence:

>2358_bases
ATGGCCAGCAGCGCATTAACATTACCTTTTAGTCGGATTGCGCACGCTGTCGATAGCGCCATTCCAACAAAATCAGACGA
AAAGGTTATCTGGAGCGCCTGTACAGTTAACTGTGGTAGTCGCTGCCCGCTACGTATGCACGTCGTGGACGGTGAAATCA
AATATGTCGAAACAGACAATACCGGCGATGACAATTACGACGGCCTGCACCAGGTTCGCGCCTGCCTGCGTGGGCGTTCC
ATGCGTCGCCGTGTCTACAATCCGGACCGCCTGAAATATCCGATGAAACGAGTCGGGGCGCGCGGTGAAGGCAAATTCGA
GCGCATTAGCTGGGAAGAAGCCTACGACATCATCGCGACCAATATGCAGCGCCTGATCAAAGAGTACGGCAACGAGTCTA
TCTATCTGAACTATGGCACCGGTACGCTGGGCGGCACCATGACCCGCTCCTGGCCGCCGGGAAATACCCTGGTCGCGCGC
CTGATGAACTGCTGCGGCGGTTATCTTAACCATTACGGTGACTACTCTTCCGCGCAAATTGCGGAAGGTTTGAACCATAC
CTACGGCGGCTGGGCAGATGGTAACAGCCCGTCGGATATCGAAAACAGTAAATTGGTAGTGCTGTTTGGTAATAACCCAG
GCGAAACGCGAATGAGTGGCGGTGGGGTGACTTACTATCTTGAACAGGCACGCCAGAAATCTAATGCTCGCATGATCATC
ATCGATCCGCGCTATACCGACACCGGTGCCGGGCGCGAAGATGAGTGGATCCCTATTCGTCCAGGAACAGATGCCGCACT
GGTTAACGGTCTGGCGTACGTCATGATCACTAAAAACCTGGTGGATCAGGCATTCCTCGATAAATATTGCGTTGGCTATG
ACGAGAAAACCCTGCCCGCCAGTGCGCCGAAAAATGGTCATTATAAAGCTTATATTCTGGGTGAAGGGCCAGATGGCGTG
GCTAAAACACCGGAATGGGCCTCGCAAATCACCGGTGTTCCGGCAGACAAAATCATCAAACTGGCTCGTGAAATCGGCAG
TACCAAACCGGCGTTTATCAGCCAGGGATGGGGCCCGCAGCGTCACGCTAACGGTGAAATCGCAACCCGTGCTATCTCGA
TGCTGGCGATTCTGACCGGTAACGTTGGTATTAATGGAGGGAACAGCGGCGCGCGTGAAGGTTCATACAGCTTACCGTTT
GTCCGTATGCCGACCTTGGAAAACCCGATCCAGACCAGCATTTCGATGTTTATGTGGACCGATGCCATTGAACGTGGCCC
GGAAATGACGGCGCTGCGTGATGGTGTGCGCGGGAAAGATAAGCTGGATGTGCCGATCAAAATGATCTGGAACTATGCCG
GTAACTGCCTGATTAACCAGCATTCTGAAATCAACCGTACCCATGAAATCCTCCAGGATGATAAGAAGTGCGAGCTGATT
GTGGTTATCGACTGCCACATGACCTCATCGGCGAAATATGCTGACATCCTGCTGCCTGACTGCACCGCTTCCGAACAGAT
GGACTTTGCACTGGATGCATCCTGCGGGAATATGTCTTACGTGATTTTCAACGATCAGGTGATTAAACCGCGCTTTGAAT
GTAAGACCATCTATGAAATGACCAGCGAACTGGCAAAACGTCTTGGCGTTGAGCAACAGTTTACTGAAGGCCGTACCCAG
GAAGAGTGGATGCGGCATCTGTATGCCCAGTCGCGGGAAGCGATTCCTGAACTGCCAACGTTTGAAGAGTTCCGCAAGCA
GGGGATCTTTAAAAAGCGCGACCCACAAGGGCATCACGTTGCTTATAAAGCCTTCCGTGAAGATCCGCAGGCAAACCCAC
TGACTACGCCATCGGGCAAAATTGAGATTTATTCGCAGGCGCTGGCTGACATTGCCGCTACCTGGGAATTGCCAGAAGGC
GATGTGATCGATCCACTGCCGATCTACACGCCGGGCTTTGAAAGTTATCAGGATCCGCTGAACAAACAGTATCCGCTGCA
GCTTACAGGTTTCCACTATAAATCTCGCGTTCACTCAACTTACGGCAACGTTGATGTGCTGAAAGCGGCTTGCCGTCAGG
AAATGTGGATCAACCCGCTTGATGCCCAAAAACGCGGTATCCACAACGGCGATAAAGTCAGGATCTTTAACGATCGTGGT
GAGGTTCATATTGAGGCGAAAGTGACGCCACGAATGATGCCGGGCGTGGTCGCACTGGGTGAAGGCGCCTGGTATGACCC
GGATGCAAAACGTGTCGATAAGGGCGGTTGTATCAACGTACTGACCACTCAACGTCCGTCTCCTCTCGCTAAGGGGAATC
CGTCACATACAAACCTTGTTCAGGTTGAAAAGGTGTAA

Upstream 100 bases:

>100_bases
TGAGTGAGCCATTATGAAAACGAAAATCCCTGATGCGGTATTGGCTGCTGAGGAGAGTCGCCGTGGTTTGGTAAAAACGA
CAGCGATCGGCGGCCTGGCA

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACCCAGTATGGATTTTTTATTGATTCCAGCCGTTGCACCGGTTGCAAAACCTGCGAGCTGGCTT
GTAAAGACTACAAAGATTTG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRS
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVAR
LMNCCGGYLNHYGDYSSAQIAEGLNHTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMII
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITKNLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPF
VRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQALADIAATWELPEG
DVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGIHNGDKVRIFNDRG
EVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV

Sequences:

>Translated_785_residues
MASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRS
MRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVAR
LMNCCGGYLNHYGDYSSAQIAEGLNHTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMII
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITKNLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGV
AKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPF
VRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQ
EEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQALADIAATWELPEG
DVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGIHNGDKVRIFNDRG
EVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV
>Mature_784_residues
ASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRSM
RRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVARL
MNCCGGYLNHYGDYSSAQIAEGLNHTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMIII
DPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITKNLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGVA
KTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPFV
RMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELIV
VIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQE
EWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQALADIAATWELPEGD
VIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGIHNGDKVRIFNDRGE
VHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=785, Percent_Identity=99.7452229299363, Blast_Score=1643, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=789, Percent_Identity=66.7934093789607, Blast_Score=1123, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=789, Percent_Identity=65.7794676806084, Blast_Score=1101, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=757, Percent_Identity=32.1003963011889, Blast_Score=305, Evalue=7e-84,
Organism=Escherichia coli, GI1787231, Length=760, Percent_Identity=31.9736842105263, Blast_Score=304, Evalue=1e-83,
Organism=Escherichia coli, GI87081994, Length=752, Percent_Identity=31.5159574468085, Blast_Score=278, Evalue=1e-75,
Organism=Escherichia coli, GI3868721, Length=783, Percent_Identity=24.904214559387, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI3868720, Length=417, Percent_Identity=26.378896882494, Blast_Score=104, Evalue=3e-23,
Organism=Escherichia coli, GI1788534, Length=838, Percent_Identity=23.2696897374702, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI3868719, Length=420, Percent_Identity=25.952380952381, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787477, Length=350, Percent_Identity=24.5714285714286, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 87423; Mature: 87292

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDN
CCCCCEECCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEECCEEEEEECCC
TGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIAT
CCCCCCHHHHHHHHHHHCHHHHHHCCCCHHHCCCHHHCCCCCCCCEEECCHHHHHHHHHH
NMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQI
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
AEGLNHTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMII
HHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCEEHHHHHHHHHCCCEEEE
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITKNLVDQAFLDKYCVGYDEKTLPA
ECCCCCCCCCCCCCCEEECCCCCCHHHHCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCC
SAPKNGHYKAYILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQ
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCCCCCC
RHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWT
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHH
DAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
HHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEE
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEM
EEEEECCCCCCCEEEEECCCCCCCCCCCEEEECCCCCEEEEEECCCEECCCHHHHHHHHH
TSELAKRLGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHV
HHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHH
AYKAFREDPQANPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPL
HHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCC
NKQYPLQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGIHNGDKVRIFNDRG
CCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCC
EVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDKGGCINVLTTQRPSPLAKGNPSHTNLV
CEEEEEEECCCCCCCEEEECCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEE
QVEKV
EEECC
>Mature Secondary Structure 
ASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDN
CCCCEECCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEECCEEEEEECCC
TGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIAT
CCCCCCHHHHHHHHHHHCHHHHHHCCCCHHHCCCHHHCCCCCCCCEEECCHHHHHHHHHH
NMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQI
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
AEGLNHTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMII
HHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCEEHHHHHHHHHCCCEEEE
IDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITKNLVDQAFLDKYCVGYDEKTLPA
ECCCCCCCCCCCCCCEEECCCCCCHHHHCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCC
SAPKNGHYKAYILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQ
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCCCCCC
RHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWT
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHH
DAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELI
HHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEE
VVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEM
EEEEECCCCCCCEEEEECCCCCCCCCCCEEEECCCCCEEEEEECCCEECCCHHHHHHHHH
TSELAKRLGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHV
HHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHH
AYKAFREDPQANPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPL
HHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCC
NKQYPLQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGIHNGDKVRIFNDRG
CCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCC
EVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDKGGCINVLTTQRPSPLAKGNPSHTNLV
CEEEEEEECCCCCCCEEEECCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEE
QVEKV
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]