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The map label for this gene is serS

Identifier: 30062380

GI number: 30062380

Start: 885647

End: 886939

Strand: Direct

Name: serS

Synonym: S0893

Alternate gene names: 30062380

Gene position: 885647-886939 (Clockwise)

Preceding gene: 30062379

Following gene: 30062381

Centisome position: 19.26

GC content: 52.75

Gene sequence:

>1293_bases
ATGCTCGATCCCAATCTGCTGCGTAATGAGCCAGACGCAGTCGCTGAAAAACTGGCACGCCGGGGCTTTAAGCTGGATGT
AGATAAGCTGGGCGCTCTTGAAGAGCGTCGTAAAGTATTGCAGGTCAAAACGGAAAACCTGCAAGCGGAGCGTAACTCCC
GATCGAAATCCATTGGCCAGGCGAAAGCGCGCGGGGAAGATATCGAGCCTTTACGTCTGGAAGTGAACAAACTGGGCGAA
GAGCTGGATGCAGCAAAAGCCGAGCTGGATGCTTTACAGGCTGAAATTCGCGATATCGCGCTGACCATCCCTAACCTGCC
TGCAGATGAAGTGCCGGTAGGTAAAGACGAAAATGACAACGTTGAAGTCAGCCGCTGGGGTACCCCGCGTGAGTTTGACT
TTGAAGTTCGTGACCACGTGACGCTGGGTGAAATGCACTCTGGCCTCGACTTTGCAGCTGCAGTTAAGCTGACTGGTTCC
CGCTTTGTGGTAATGAAAGGGCAGATTGCTCGCATGCACCGCGCACTGTCGCAGTTTATGCTGGATCTGCATACCGAACA
GCATGGCTACAGTGAGAACTATGTTCCGTACCTGGTTAACCAGGACACGCTGTACGGTACGGGTCAGCTGCCGAAATTTG
CTGGCGATCTGTTCCATACTCGTCCGCTGGAAGAAGAAGCAGACACCAGTAACTATGCGCTGATCCCAACGGCAGAAGTT
CCGCTGACTAACCTGGTGCGCGGTGAAATCATCGATGAAGATGATCTGCCAATTAAGATGACCGCCCACACCCCATGCTT
CCGTTCTGAAGCCGGTTCATATGGTCGTGACACCCGTGGTCTGATCCGTATGCACCAGTTCGACAAAGTTGAAATGGTGC
AGATCGTGCGCCCAGAAGACTCAATGGCGGCGCTGGAAGAGATGACTGGTCATGCAGAAAAAGTCCTGCAGTTGCTGGGC
CTGCCGTACCGTAAAATCATCCTTTGCACTGGCGACATGGGCTTTGGCGCTTGCAAAACTTACGACCTGGAAGTATGGAT
CCCGGCACAGAACACCTACCGTGAGATCTCTTCCTGCTCCAACGTTTGGGATTTCCAGGCACGTCGTATGCAGGCACGTT
GCCGCAGCAAGTCGGACAAGAAAACCCGTCTGGTTCATACCCTGAACGGTTCTGGTCTGGCTGTTGGTCGTACGCTGGTT
GCAGTAATGGAAAACTATCAGCAGGCTGATGGTCGTATTGAAGTACCAGAAGTTCTGCGTCCGTATATGAACGGACTGGA
ATATATTGGCTAA

Upstream 100 bases:

>100_bases
CTACCGTTAATGTTATCGTTGCGGTAATGTTGTTACTGTATCCCTGTGGTCGCAGGCTGTGGCCACATCTCCCATTTAAT
TCGATAAGCACAGGATAAGC

Downstream 100 bases:

>100_bases
TACCCAATTTTTCTGAATCTAAAAAGCGCCTTTAGGGCGCTTTTTTTGTCTCCCTTTGATACCGAACAATAATTACTCCT
CACTTACACGTAATACTACT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
ELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGS
RFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIEVPEVLRPYMNGLEYIG

Sequences:

>Translated_430_residues
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
ELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGS
RFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIEVPEVLRPYMNGLEYIG
>Mature_430_residues
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
ELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGS
RFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIEVPEVLRPYMNGLEYIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=439, Percent_Identity=32.8018223234624, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI8923421, Length=344, Percent_Identity=30.2325581395349, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI225579074, Length=344, Percent_Identity=30.2325581395349, Blast_Score=155, Evalue=7e-38,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=100, Blast_Score=891, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=31.0344827586207, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17542084, Length=335, Percent_Identity=31.044776119403, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321799, Length=389, Percent_Identity=31.3624678663239, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320226, Length=395, Percent_Identity=30.8860759493671, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=31.1965811965812, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17737985, Length=366, Percent_Identity=32.2404371584699, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48415; Mature: 48415

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQ
CCCCCCCCCCHHHHHHHHHHCCCEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
VEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFM
EEEEECCCCCCCCCHHHCCEEHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
HHHHHHCCCCCCCCCCEEECCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCC
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
CHHHHHHCCCCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCH
SMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCS
HHHHHHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHH
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLR
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHH
PYMNGLEYIG
HHHHHHHCCC
>Mature Secondary Structure
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQ
CCCCCCCCCCHHHHHHHHHHCCCEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
VEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFM
EEEEECCCCCCCCCHHHCCEEHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
HHHHHHCCCCCCCCCCEEECCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCC
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
CHHHHHHCCCCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCH
SMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCS
HHHHHHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHH
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLR
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHH
PYMNGLEYIG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA