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The map label for this gene is ylcA

Identifier: 30062021

GI number: 30062021

Start: 488467

End: 489150

Strand: Reverse

Name: ylcA

Synonym: S0480

Alternate gene names: 30062021

Gene position: 489150-488467 (Counterclockwise)

Preceding gene: 30062025

Following gene: 30062020

Centisome position: 10.64

GC content: 54.39

Gene sequence:

>684_bases
ATGAAACTGTTGATTGTCGAAGATGAAAAGAAAACCGGAGAATACTTGACCAAAGGGTTAACCGAAGCCGGTTTTGTGGT
CGATTTGGCCGACAACGGGCTGAATGGCTACCATCTGGCGATGACCGGTGATTATGACCTGATAATCCTCGATATTATGC
TGCCAGACGTGAACGGCTGGGATATCGTGCGCATGTTGCGCTCCGCCAATAAAGGGATGCCGATTCTGTTGCTTACCGCG
CTTGGCACCATTGAACATCGCGTCAAGGGGCTGGAGTTGGGGGCAGATGACTACCTGGTGAAACCGTTCGCTTTTGCTGA
ACTGCTGGCGCGGGTGCGCACTCTCCTGCGGCGCGGGGCGGCGGTGATTATCGAAAGTCAGTTTCAGGTTGCCGATCTGA
TGGTCGATCTCGTCAGCCGCAAAGTCACCCGCAGCGGCACGCGCATCACTCTGACCAGTAAAGAATTTACTCTGCTGGAG
TTTTTTCTCCGCCATCAGGGCGAAGTGCTGCCCCGCTCGCTTATCGCCTCGCAGGTATGGGACATGAATTTCGACAGCGA
CACTAACGCCATTGATGTGGCGGTGAAGCTGCTACGCGGCAAAATCGACAACGACTTTGAGCCGAAGCTGATTCAAACCG
TGCGCGGCGTGGGTTACATGCTTGAGGTGCCGGATGGTCAGTAA

Upstream 100 bases:

>100_bases
TTCCGGTGACAGGAAAATGACAAAATTGTCATTTTGCCAATAAGCGATTGCCATCTGATCCCGCTACTCTAGAATTGCCC
GGGCAACATGCGGAGGAAAT

Downstream 100 bases:

>100_bases
GCCATTTCAGCGCCCGTTTTCGCTGGCAACCCGCCTGACCTTTTTTATCAGCCTGGCCACCATCGCGGCGTTTTTCGCCT
TTGCATGGATCATAATCCAC

Product: DNA-binding transcriptional activator CusR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKLLRGKIDNDFEPKLIQTVRGVGYMLEVPDGQ

Sequences:

>Translated_227_residues
MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKLLRGKIDNDFEPKLIQTVRGVGYMLEVPDGQ
>Mature_227_residues
MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKLLRGKIDNDFEPKLIQTVRGVGYMLEVPDGQ

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=99.5594713656388, Blast_Score=453, Evalue=1e-129,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=51.1415525114155, Blast_Score=234, Evalue=3e-63,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.9103139013453, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=37.0689655172414, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.6363636363636, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=35.2941176470588, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.7466063348416, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.0357142857143, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=35.4545454545455, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=34.0807174887892, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.061135371179, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=31.7180616740088, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.3030303030303, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.3185840707965, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=32.1739130434783, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=27.4193548387097, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25352; Mature: 25352

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGW
CEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEEECCCCCH
DIVRMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGA
HHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
AVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVW
EEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNAIDVAVKLLRGKIDNDFEPKLIQTVRGVGYMLEVPDGQ
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure
MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGW
CEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEEECCCCCH
DIVRMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGA
HHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
AVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVW
EEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNAIDVAVKLLRGKIDNDFEPKLIQTVRGVGYMLEVPDGQ
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]