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The map label for this gene is zwf [H]

Identifier: 29346631

GI number: 29346631

Start: 1518212

End: 1519708

Strand: Reverse

Name: zwf [H]

Synonym: BT_1221

Alternate gene names: 29346631

Gene position: 1519708-1518212 (Counterclockwise)

Preceding gene: 29346632

Following gene: 29346630

Centisome position: 24.28

GC content: 48.9

Gene sequence:

>1497_bases
ATGGATAAATTTGCAATGATTATTTTTGGTGCTTCGGGCGACTTGACTAAACGCAAGTTGATGCCCGCATTGTACTCTCT
GTATCGGGATAAACGGCTGACGGGGAGTTTTACTGTTCTGGGAATTGGGCGTACTGTCTATTCTGATGAAGATTACCGTT
CATATATACTTGGGGAGTTGCAGCAGTTTGTAAAGGCTGAAGAGCAGAATTTGGAGCTGATGTCTTCTTTTGTGTCTCAT
TTGTATTATTTGCCGATGGATCCTGCGAAAGTGGAGGGATATTCGCAGTTGCGGGAGCGTTTGGTAGAGCTTACGAAGGA
GGTCGATCCGGATAATTTGTTGTTCTATCTGGCTACTCCGCCTTCGCTGTATGGGGTGGTGCCTTTGCATTTGAAGGCGG
CCGGGCTGAATACTCCTCATTCTCGTATTATTGTTGAGAAGCCGTTCGGGTATGATCTGGAGTCGGCGCTTGAGTTGAAT
AAGATTTACTCTTCTGTGTTTGATGAGCATCAGATTTATCGTATCGATCATTTTCTGGGCAAGGAGACGGCGCAGAATGT
GCTTGCTTTCCGTTTCGCCAATGGTATTTTTGAGCCGTTATGGAATCGTAATTATATTGATTATGTGGAGATTACTGCTG
TAGAGAATCTGGGTATTGAGCAGCGCGGAGGTTTTTACGAGACGGCGGGGGCTTTGCGGGATATGGTGCAGAATCACCTG
ATTCAGCTCGTAGCTCTTACGGCTATGGAGCCGCCGGCGGTATTCAATGCGGATAATTTCCGGAATGAGGTAGTGAAGGT
TTATGAGTCGCTGACTCCGCTTACGGAGACGGACTTGAATGAACATATCGTTCGCGGACAATATACGGCTTCGGGCAATA
AGAAGGGGTATCGTGAGGAAAAGGGAGTGGCTCCCGACTCGCGTACGGAGACTTATATTGCGATGAAGCTGGGCATCAGT
AACTGGCGTTGGAGCGGGGTACCGTTCTACATCCGCACCGGTAAGCAGATGCCGACGAAGGTGACGGAAATTGTCGTTCA
CTTCCGCGAGACGCCCCATCAGATGTTCCGCTGTTCCGGCGGTAACTGTCCGAGGGCTAATAAGTTGATCCTTCGTTTGC
AACCAAACGAGGGTATTGTGTTGAAGATCGGAATGAAGGTTCCGGGTGCAGGTTTCGAAGTCCGTCAGGTGACGATGGAT
TTCAGTTACGCACAGTTGGGCGGCGTGCCGAGCGGTGACGCTTATGCCCGTCTGATTGACGACTGCATTCAGGGAGATCC
GACCTTATTTACTCGAAGTGATGCTGTAGAGGCTTCCTGGAACTTCTTTGATCCGGTCTTACGTTATTGGAAAGATAATC
CGGACGCACCTTTGTACGGCTATCCGGCAGGTACGTGGGGACCTCTCGAAAGTGAAGCTATGATGCACGAGCATGGGGCA
GACTGGACCAATCCGTGTAAGAATTTAACAAATACAGACCAATATTGCGAACTATGA

Upstream 100 bases:

>100_bases
GGGCGGTTGGTTGAGATTGGTCGGTTTGTCGGTTGGTTGAGGCTGGTCGGTTTAGGTGCGGTGATGGATGGATAAAAGGT
AAAAAGTTAAAAATACGACG

Downstream 100 bases:

>100_bases
AACTATCTGTTTTCCCGTCGTCTATGGAGACAGCCCGTTCGTTGATATTCCACCTGGTGGATATCATGAATGCTGAACCG
GACAAAACGTTCAACATAGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MDKFAMIIFGASGDLTKRKLMPALYSLYRDKRLTGSFTVLGIGRTVYSDEDYRSYILGELQQFVKAEEQNLELMSSFVSH
LYYLPMDPAKVEGYSQLRERLVELTKEVDPDNLLFYLATPPSLYGVVPLHLKAAGLNTPHSRIIVEKPFGYDLESALELN
KIYSSVFDEHQIYRIDHFLGKETAQNVLAFRFANGIFEPLWNRNYIDYVEITAVENLGIEQRGGFYETAGALRDMVQNHL
IQLVALTAMEPPAVFNADNFRNEVVKVYESLTPLTETDLNEHIVRGQYTASGNKKGYREEKGVAPDSRTETYIAMKLGIS
NWRWSGVPFYIRTGKQMPTKVTEIVVHFRETPHQMFRCSGGNCPRANKLILRLQPNEGIVLKIGMKVPGAGFEVRQVTMD
FSYAQLGGVPSGDAYARLIDDCIQGDPTLFTRSDAVEASWNFFDPVLRYWKDNPDAPLYGYPAGTWGPLESEAMMHEHGA
DWTNPCKNLTNTDQYCEL

Sequences:

>Translated_498_residues
MDKFAMIIFGASGDLTKRKLMPALYSLYRDKRLTGSFTVLGIGRTVYSDEDYRSYILGELQQFVKAEEQNLELMSSFVSH
LYYLPMDPAKVEGYSQLRERLVELTKEVDPDNLLFYLATPPSLYGVVPLHLKAAGLNTPHSRIIVEKPFGYDLESALELN
KIYSSVFDEHQIYRIDHFLGKETAQNVLAFRFANGIFEPLWNRNYIDYVEITAVENLGIEQRGGFYETAGALRDMVQNHL
IQLVALTAMEPPAVFNADNFRNEVVKVYESLTPLTETDLNEHIVRGQYTASGNKKGYREEKGVAPDSRTETYIAMKLGIS
NWRWSGVPFYIRTGKQMPTKVTEIVVHFRETPHQMFRCSGGNCPRANKLILRLQPNEGIVLKIGMKVPGAGFEVRQVTMD
FSYAQLGGVPSGDAYARLIDDCIQGDPTLFTRSDAVEASWNFFDPVLRYWKDNPDAPLYGYPAGTWGPLESEAMMHEHGA
DWTNPCKNLTNTDQYCEL
>Mature_498_residues
MDKFAMIIFGASGDLTKRKLMPALYSLYRDKRLTGSFTVLGIGRTVYSDEDYRSYILGELQQFVKAEEQNLELMSSFVSH
LYYLPMDPAKVEGYSQLRERLVELTKEVDPDNLLFYLATPPSLYGVVPLHLKAAGLNTPHSRIIVEKPFGYDLESALELN
KIYSSVFDEHQIYRIDHFLGKETAQNVLAFRFANGIFEPLWNRNYIDYVEITAVENLGIEQRGGFYETAGALRDMVQNHL
IQLVALTAMEPPAVFNADNFRNEVVKVYESLTPLTETDLNEHIVRGQYTASGNKKGYREEKGVAPDSRTETYIAMKLGIS
NWRWSGVPFYIRTGKQMPTKVTEIVVHFRETPHQMFRCSGGNCPRANKLILRLQPNEGIVLKIGMKVPGAGFEVRQVTMD
FSYAQLGGVPSGDAYARLIDDCIQGDPTLFTRSDAVEASWNFFDPVLRYWKDNPDAPLYGYPAGTWGPLESEAMMHEHGA
DWTNPCKNLTNTDQYCEL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=499, Percent_Identity=36.4729458917836, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI109389365, Length=499, Percent_Identity=36.4729458917836, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI52145310, Length=492, Percent_Identity=27.6422764227642, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1788158, Length=484, Percent_Identity=40.0826446280992, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17538218, Length=496, Percent_Identity=36.6935483870968, Blast_Score=317, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=36.3070539419087, Blast_Score=293, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24643350, Length=491, Percent_Identity=34.4195519348269, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24643352, Length=489, Percent_Identity=34.3558282208589, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=30.4621848739496, Blast_Score=209, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56527; Mature: 56527

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKFAMIIFGASGDLTKRKLMPALYSLYRDKRLTGSFTVLGIGRTVYSDEDYRSYILGEL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCHHHHHHHHHH
QQFVKAEEQNLELMSSFVSHLYYLPMDPAKVEGYSQLRERLVELTKEVDPDNLLFYLATP
HHHHHHHHCCHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
PSLYGVVPLHLKAAGLNTPHSRIIVEKPFGYDLESALELNKIYSSVFDEHQIYRIDHFLG
CCCEEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHC
KETAQNVLAFRFANGIFEPLWNRNYIDYVEITAVENLGIEQRGGFYETAGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHH
IQLVALTAMEPPAVFNADNFRNEVVKVYESLTPLTETDLNEHIVRGQYTASGNKKGYREE
HHHHHHHCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEECCCCCCCCCHH
KGVAPDSRTETYIAMKLGISNWRWSGVPFYIRTGKQMPTKVTEIVVHFRETPHQMFRCSG
CCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHEECC
GNCPRANKLILRLQPNEGIVLKIGMKVPGAGFEVRQVTMDFSYAQLGGVPSGDAYARLID
CCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEEEEECCHHHHCCCCCCHHHHHHHH
DCIQGDPTLFTRSDAVEASWNFFDPVLRYWKDNPDAPLYGYPAGTWGPLESEAMMHEHGA
HHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHCCC
DWTNPCKNLTNTDQYCEL
CHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MDKFAMIIFGASGDLTKRKLMPALYSLYRDKRLTGSFTVLGIGRTVYSDEDYRSYILGEL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEECCCHHHHHHHHHH
QQFVKAEEQNLELMSSFVSHLYYLPMDPAKVEGYSQLRERLVELTKEVDPDNLLFYLATP
HHHHHHHHCCHHHHHHHHHHHEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
PSLYGVVPLHLKAAGLNTPHSRIIVEKPFGYDLESALELNKIYSSVFDEHQIYRIDHFLG
CCCEEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHC
KETAQNVLAFRFANGIFEPLWNRNYIDYVEITAVENLGIEQRGGFYETAGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHH
IQLVALTAMEPPAVFNADNFRNEVVKVYESLTPLTETDLNEHIVRGQYTASGNKKGYREE
HHHHHHHCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEECCCCCCCCCHH
KGVAPDSRTETYIAMKLGISNWRWSGVPFYIRTGKQMPTKVTEIVVHFRETPHQMFRCSG
CCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHEECC
GNCPRANKLILRLQPNEGIVLKIGMKVPGAGFEVRQVTMDFSYAQLGGVPSGDAYARLID
CCCCCCCEEEEEEECCCCEEEEECCCCCCCCCEEEEEEEECCHHHHCCCCCCHHHHHHHH
DCIQGDPTLFTRSDAVEASWNFFDPVLRYWKDNPDAPLYGYPAGTWGPLESEAMMHEHGA
HHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHCCC
DWTNPCKNLTNTDQYCEL
CHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]