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The map label for this gene is gnd [H]

Identifier: 29346632

GI number: 29346632

Start: 1520053

End: 1521528

Strand: Reverse

Name: gnd [H]

Synonym: BT_1222

Alternate gene names: 29346632

Gene position: 1521528-1520053 (Counterclockwise)

Preceding gene: 29346638

Following gene: 29346631

Centisome position: 24.3

GC content: 49.46

Gene sequence:

>1476_bases
ATGGCAAATCAGAATAAAACAGATATCGGGTTGATCGGTCTGGCAGTGATGGGTGAGAACCTTGCTTTGAATATGGAAAG
CAAGGGCTGGCACGTCTCTGTTTACAATCGTACCGTCCCCGGAGTGGAAGAAGGAGTAGTAGACCGCTTCATGAATGGTC
GTGCAAAAGGTAAAAACATTGAAGGTTTTACAGATATAAAGGCTTTTGTGGAATCAATCGCCACCCCTCGCAAGATTATG
ATGATGGTACGTGCCGGCAGTCCGGTAGACGAACTGATGGATCAGCTTTTCCCTTTGCTTTCTCCCGGAGATATTCTGAT
TGACGGTGGTAATTCTAATTACGAAGATACCAATCGCCGTGTAAAATTAGCAGAATCGAAAGGCTTCTTGTTTGTAGGAA
GCGGAGTGTCGGGCGGTGAGGAAGGTGCGTTGAACGGTGCTTCCATCATGCCCGGAGGATCGGAGAAAGCGTGGCCGGAA
GTGAAGCCTGTCTTGCAGAGCATCGCGGCGAAAGCGCCGGACGGAACTCCCTGTTGCCAGTGGGTAGGCCCTGCCGGATC
GGGACATTTTGTGAAGATGATTCACAATGGTATCGAATACGGTGATATGCAGTTGATCGCCGAGGCTTACTGGGTGATGA
AGAATCTCATTGATCTGACGAATGAGGAGATGGCGGACGTTTTTGCCCGTTGGAATGAAGGGAAGTTGCGCAGTTATCTG
ATTGAGATTACTTCTAATATTTTGCGTCACAAGGATAAATCCGGTGGGTATCTGATCGATAAGATTCTCGATGCTGCCGG
ACAGAAGGGGACGGGAAAGTGGTCTGTCATCAATGCGATGGAGTTGGGGATGCCGTTGGGCTTGATTGCCACGGCGGTGT
TCGAACGCAGTCTGTCGGCTCAGAAGGAGTTGCGTCATCTGGCTTCCAAGCAGTTCTTGTGCAAGCATACATTACCTATA
TATAATAAGGCGGAATTGGTGAAGGAGATATTTTCTGCGCTTTACGCTTCCAAGCTGGTGTCGTATGCGCAGGGTTTTGC
TGTGTTGCAGCGGGCTTCTGATTCTTTCGGATGGAATCTGGATTTGGCTTCCATTGCCCGTATGTGGCGTGGGGGATGTA
TCATCCGCAGTATTTTCCTGAATGATATAGCTGCTGCTTTTGAGGCGGCGGATAAGCCGAAGCATTTGTTGCTGGCTCCT
TACTTCCGTGAGGAGATCAAGTCTTTGCTCCCCGGATGGAAGAATCTGGTGGCGGAGGCGATGAAGGAGGAATTGCCTGT
TCCGGCTTTCTCTTCGGCTTTGAATTATTTTTATTCGCTGACTTCTGACAATTTACCTGCCAATCTGGTGCAGGCGCAAC
GAGATTATTTCGGTGCGCATACGTTTGAGAGGAAGGATGAGCTGCGCGGACAGTTCTTTCATGAGAATTGGACGGGGCAC
GGAGGGGAGACGAAGTCGGGGACTTATAATGTATGA

Upstream 100 bases:

>100_bases
TATTTGTTGACTACAAAAATAGTATTTTAATCTAAAACTAGCGAACAAATGTGCTTTTCAAGTGTTTCTTACATAAACAA
TATTTTAAAATATATAAGAT

Downstream 100 bases:

>100_bases
GTACTTTTCTTTTGCCTTGATGCAAAAGAAAGGTACCAAAAGAAAAAATCAAGGCTGCACCTACGGAGCTACTCCGGCCG
CATCTCCGGCTAAAGGGCAG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MANQNKTDIGLIGLAVMGENLALNMESKGWHVSVYNRTVPGVEEGVVDRFMNGRAKGKNIEGFTDIKAFVESIATPRKIM
MMVRAGSPVDELMDQLFPLLSPGDILIDGGNSNYEDTNRRVKLAESKGFLFVGSGVSGGEEGALNGASIMPGGSEKAWPE
VKPVLQSIAAKAPDGTPCCQWVGPAGSGHFVKMIHNGIEYGDMQLIAEAYWVMKNLIDLTNEEMADVFARWNEGKLRSYL
IEITSNILRHKDKSGGYLIDKILDAAGQKGTGKWSVINAMELGMPLGLIATAVFERSLSAQKELRHLASKQFLCKHTLPI
YNKAELVKEIFSALYASKLVSYAQGFAVLQRASDSFGWNLDLASIARMWRGGCIIRSIFLNDIAAAFEAADKPKHLLLAP
YFREEIKSLLPGWKNLVAEAMKEELPVPAFSSALNYFYSLTSDNLPANLVQAQRDYFGAHTFERKDELRGQFFHENWTGH
GGETKSGTYNV

Sequences:

>Translated_491_residues
MANQNKTDIGLIGLAVMGENLALNMESKGWHVSVYNRTVPGVEEGVVDRFMNGRAKGKNIEGFTDIKAFVESIATPRKIM
MMVRAGSPVDELMDQLFPLLSPGDILIDGGNSNYEDTNRRVKLAESKGFLFVGSGVSGGEEGALNGASIMPGGSEKAWPE
VKPVLQSIAAKAPDGTPCCQWVGPAGSGHFVKMIHNGIEYGDMQLIAEAYWVMKNLIDLTNEEMADVFARWNEGKLRSYL
IEITSNILRHKDKSGGYLIDKILDAAGQKGTGKWSVINAMELGMPLGLIATAVFERSLSAQKELRHLASKQFLCKHTLPI
YNKAELVKEIFSALYASKLVSYAQGFAVLQRASDSFGWNLDLASIARMWRGGCIIRSIFLNDIAAAFEAADKPKHLLLAP
YFREEIKSLLPGWKNLVAEAMKEELPVPAFSSALNYFYSLTSDNLPANLVQAQRDYFGAHTFERKDELRGQFFHENWTGH
GGETKSGTYNV
>Mature_490_residues
ANQNKTDIGLIGLAVMGENLALNMESKGWHVSVYNRTVPGVEEGVVDRFMNGRAKGKNIEGFTDIKAFVESIATPRKIMM
MVRAGSPVDELMDQLFPLLSPGDILIDGGNSNYEDTNRRVKLAESKGFLFVGSGVSGGEEGALNGASIMPGGSEKAWPEV
KPVLQSIAAKAPDGTPCCQWVGPAGSGHFVKMIHNGIEYGDMQLIAEAYWVMKNLIDLTNEEMADVFARWNEGKLRSYLI
EITSNILRHKDKSGGYLIDKILDAAGQKGTGKWSVINAMELGMPLGLIATAVFERSLSAQKELRHLASKQFLCKHTLPIY
NKAELVKEIFSALYASKLVSYAQGFAVLQRASDSFGWNLDLASIARMWRGGCIIRSIFLNDIAAAFEAADKPKHLLLAPY
FREEIKSLLPGWKNLVAEAMKEELPVPAFSSALNYFYSLTSDNLPANLVQAQRDYFGAHTFERKDELRGQFFHENWTGHG
GETKSGTYNV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=486, Percent_Identity=50.4115226337449, Blast_Score=483, Evalue=1e-136,
Organism=Escherichia coli, GI1788341, Length=473, Percent_Identity=49.0486257928118, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17542558, Length=488, Percent_Identity=52.2540983606557, Blast_Score=512, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321695, Length=492, Percent_Identity=52.4390243902439, Blast_Score=514, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6321977, Length=492, Percent_Identity=52.6422764227642, Blast_Score=495, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24639279, Length=486, Percent_Identity=51.2345679012346, Blast_Score=472, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 54045; Mature: 53913

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQNKTDIGLIGLAVMGENLALNMESKGWHVSVYNRTVPGVEEGVVDRFMNGRAKGKNI
CCCCCCCCHHEEEHEEECCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCC
EGFTDIKAFVESIATPRKIMMMVRAGSPVDELMDQLFPLLSPGDILIDGGNSNYEDTNRR
CCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE
VKLAESKGFLFVGSGVSGGEEGALNGASIMPGGSEKAWPEVKPVLQSIAAKAPDGTPCCQ
EEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
WVGPAGSGHFVKMIHNGIEYGDMQLIAEAYWVMKNLIDLTNEEMADVFARWNEGKLRSYL
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHH
IEITSNILRHKDKSGGYLIDKILDAAGQKGTGKWSVINAMELGMPLGLIATAVFERSLSA
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
QKELRHLASKQFLCKHTLPIYNKAELVKEIFSALYASKLVSYAQGFAVLQRASDSFGWNL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DLASIARMWRGGCIIRSIFLNDIAAAFEAADKPKHLLLAPYFREEIKSLLPGWKNLVAEA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCHHHHHHHH
MKEELPVPAFSSALNYFYSLTSDNLPANLVQAQRDYFGAHTFERKDELRGQFFHENWTGH
HHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCCCCC
GGETKSGTYNV
CCCCCCCCCCC
>Mature Secondary Structure 
ANQNKTDIGLIGLAVMGENLALNMESKGWHVSVYNRTVPGVEEGVVDRFMNGRAKGKNI
CCCCCCCHHEEEHEEECCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCC
EGFTDIKAFVESIATPRKIMMMVRAGSPVDELMDQLFPLLSPGDILIDGGNSNYEDTNRR
CCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE
VKLAESKGFLFVGSGVSGGEEGALNGASIMPGGSEKAWPEVKPVLQSIAAKAPDGTPCCQ
EEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
WVGPAGSGHFVKMIHNGIEYGDMQLIAEAYWVMKNLIDLTNEEMADVFARWNEGKLRSYL
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHH
IEITSNILRHKDKSGGYLIDKILDAAGQKGTGKWSVINAMELGMPLGLIATAVFERSLSA
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
QKELRHLASKQFLCKHTLPIYNKAELVKEIFSALYASKLVSYAQGFAVLQRASDSFGWNL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DLASIARMWRGGCIIRSIFLNDIAAAFEAADKPKHLLLAPYFREEIKSLLPGWKNLVAEA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCHHHHHHHH
MKEELPVPAFSSALNYFYSLTSDNLPANLVQAQRDYFGAHTFERKDELRGQFFHENWTGH
HHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCCCCC
GGETKSGTYNV
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]