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The map label for this gene is serA [H]

Identifier: 29346562

GI number: 29346562

Start: 1437011

End: 1437931

Strand: Reverse

Name: serA [H]

Synonym: BT_1152

Alternate gene names: 29346562

Gene position: 1437931-1437011 (Counterclockwise)

Preceding gene: 29346563

Following gene: 29346561

Centisome position: 22.97

GC content: 46.47

Gene sequence:

>921_bases
ATGAAAGTACTTGTAGCTACTGAAAAACCGTTTGCCAAAGTTGCTGTAGACGGTATCCGTAAAGAAATCGAAGCAGCCGG
ATATGAGCTTGCTTTGCTGGAGAAATATACCGATAAAGCACAGTTGCTGGATGCAGTGAAAGATGCTAATGCTATCATTA
TCCGTAGTGATATTATTGATGCAGAGGTGCTGGATGCTGCTAAAGAACTGAAGATTGTAGTTCGTGCTGGTGCCGGATAC
GATAATGTAGACCTGGCTGCCGCTACCGCTCACAATGTTTGCGTGATGAATACTCCGGGACAGAACTCCAATGCTGTTGC
CGAACTGGCTTTGGGCATGATGGTATACGCCGTTCGTAACTTCTATAACGGTACTTCCGGTACAGAATTGATGGGCAAGA
AACTGGGTATCCATGCATACGGAAACGTTGGTCGTAACGTTGCCCGTGTAGCTAAAGGCTTCGGAATGGAAGTGTACGCT
TACGACGCTTTCTGCCCGAAAGAAGTGATCGAAAAAGATGGCGTGAAGGCACTTGACTCTGCAGAAGAACTGTACAAGAC
TTGTCAGGTAGTGTCTCTTCATATCCCGGCAACTGCTGAAACGAAGAACTCTATCAACTACGCTCTGCTGAAAGATATGC
CGAAAGGCGCTATGCTGGTGAACACTGCCCGTAAGGAAGTGATCAACGAAGCCGAGCTGATCAAATTGATGGAAGACCGT
GCTGACTTCAAGTATATGACAGATATCATGCCTGCTGCTAATGCGGAATTTGCTGAGAAGTTCGCAGGACGTTATTTCTC
TACTCCGAAGAAGATGGGTGCACAGACTGCCGAAGCGAATATCAATGCCGGTATTGCTGCTGCTCAACAGATTGTCGGTT
TCCTGAAAGACGGCTGTGAGAAGTTCAGAGTAAACAAATAA

Upstream 100 bases:

>100_bases
TCACCACAGATTGCACGGATTTACACTGAAATCTTATTGAATATAGTGTGTAGGCCGGTGAAGTCTGTGGTGAATCTTTT
TTAAAAGATACAGATAAATT

Downstream 100 bases:

>100_bases
TGAGATGAATCGTAAGACTGCTTATCGTTGCTCAGTCACTTATTTGATGATAGGTGCTGGTCATTAAGCAGTATATTTAG
AAATATGTTATCAGATTTCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKVLVATEKPFAKVAVDGIRKEIEAAGYELALLEKYTDKAQLLDAVKDANAIIIRSDIIDAEVLDAAKELKIVVRAGAGY
DNVDLAAATAHNVCVMNTPGQNSNAVAELALGMMVYAVRNFYNGTSGTELMGKKLGIHAYGNVGRNVARVAKGFGMEVYA
YDAFCPKEVIEKDGVKALDSAEELYKTCQVVSLHIPATAETKNSINYALLKDMPKGAMLVNTARKEVINEAELIKLMEDR
ADFKYMTDIMPAANAEFAEKFAGRYFSTPKKMGAQTAEANINAGIAAAQQIVGFLKDGCEKFRVNK

Sequences:

>Translated_306_residues
MKVLVATEKPFAKVAVDGIRKEIEAAGYELALLEKYTDKAQLLDAVKDANAIIIRSDIIDAEVLDAAKELKIVVRAGAGY
DNVDLAAATAHNVCVMNTPGQNSNAVAELALGMMVYAVRNFYNGTSGTELMGKKLGIHAYGNVGRNVARVAKGFGMEVYA
YDAFCPKEVIEKDGVKALDSAEELYKTCQVVSLHIPATAETKNSINYALLKDMPKGAMLVNTARKEVINEAELIKLMEDR
ADFKYMTDIMPAANAEFAEKFAGRYFSTPKKMGAQTAEANINAGIAAAQQIVGFLKDGCEKFRVNK
>Mature_306_residues
MKVLVATEKPFAKVAVDGIRKEIEAAGYELALLEKYTDKAQLLDAVKDANAIIIRSDIIDAEVLDAAKELKIVVRAGAGY
DNVDLAAATAHNVCVMNTPGQNSNAVAELALGMMVYAVRNFYNGTSGTELMGKKLGIHAYGNVGRNVARVAKGFGMEVYA
YDAFCPKEVIEKDGVKALDSAEELYKTCQVVSLHIPATAETKNSINYALLKDMPKGAMLVNTARKEVINEAELIKLMEDR
ADFKYMTDIMPAANAEFAEKFAGRYFSTPKKMGAQTAEANINAGIAAAQQIVGFLKDGCEKFRVNK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=296, Percent_Identity=33.445945945946, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI145580575, Length=264, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI61743967, Length=209, Percent_Identity=28.7081339712919, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI145580578, Length=209, Percent_Identity=28.7081339712919, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557499, Length=209, Percent_Identity=28.7081339712919, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557497, Length=209, Percent_Identity=28.7081339712919, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1789279, Length=315, Percent_Identity=27.3015873015873, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787645, Length=260, Percent_Identity=30, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=29.9674267100977, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=203, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=309, Percent_Identity=26.537216828479, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=306, Percent_Identity=25.8169934640523, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=230, Percent_Identity=27.3913043478261, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=243, Percent_Identity=27.9835390946502, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=277, Percent_Identity=33.2129963898917, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=203, Percent_Identity=29.5566502463054, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646448, Length=203, Percent_Identity=29.5566502463054, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646452, Length=203, Percent_Identity=29.5566502463054, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646450, Length=203, Percent_Identity=29.5566502463054, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI62472511, Length=203, Percent_Identity=29.5566502463054, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574286, Length=272, Percent_Identity=25.3676470588235, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574284, Length=232, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585514, Length=216, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574282, Length=216, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552429, Length=216, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551003, Length=216, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=25.9541984732824, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33135; Mature: 33135

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVATEKPFAKVAVDGIRKEIEAAGYELALLEKYTDKAQLLDAVKDANAIIIRSDIID
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCC
AEVLDAAKELKIVVRAGAGYDNVDLAAATAHNVCVMNTPGQNSNAVAELALGMMVYAVRN
HHHHHHHHHEEEEEEECCCCCCCCEEHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
FYNGTSGTELMGKKLGIHAYGNVGRNVARVAKGFGMEVYAYDAFCPKEVIEKDGVKALDS
HCCCCCCHHHHHHHCCEEECCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCHHHHH
AEELYKTCQVVSLHIPATAETKNSINYALLKDMPKGAMLVNTARKEVINEAELIKLMEDR
HHHHHHHHHHEEEECCCCCCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
ADFKYMTDIMPAANAEFAEKFAGRYFSTPKKMGAQTAEANINAGIAAAQQIVGFLKDGCE
CCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHH
KFRVNK
HHCCCC
>Mature Secondary Structure
MKVLVATEKPFAKVAVDGIRKEIEAAGYELALLEKYTDKAQLLDAVKDANAIIIRSDIID
CEEEEECCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCC
AEVLDAAKELKIVVRAGAGYDNVDLAAATAHNVCVMNTPGQNSNAVAELALGMMVYAVRN
HHHHHHHHHEEEEEEECCCCCCCCEEHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
FYNGTSGTELMGKKLGIHAYGNVGRNVARVAKGFGMEVYAYDAFCPKEVIEKDGVKALDS
HCCCCCCHHHHHHHCCEEECCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCHHHHH
AEELYKTCQVVSLHIPATAETKNSINYALLKDMPKGAMLVNTARKEVINEAELIKLMEDR
HHHHHHHHHHEEEECCCCCCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
ADFKYMTDIMPAANAEFAEKFAGRYFSTPKKMGAQTAEANINAGIAAAQQIVGFLKDGCE
CCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHH
KFRVNK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]