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The map label for this gene is uhpC [H]

Identifier: 29144021

GI number: 29144021

Start: 3845244

End: 3846572

Strand: Direct

Name: uhpC [H]

Synonym: t3730

Alternate gene names: 29144021

Gene position: 3845244-3846572 (Clockwise)

Preceding gene: 29144020

Following gene: 29144022

Centisome position: 80.24

GC content: 59.74

Gene sequence:

>1329_bases
ATGCTTTCGTTTTTAAAAGCCCCGGCCAACGCGCCGCTCATCACCGATAAGCACGAGGTTGACGCCCGCTATCGCTACTG
GCGGCGGTATATCCTGATCACCATTTGGTTGGGTTACGCGCTGTTCTATTTCACCCGTAAAAGCTTTAACGCCGCCGCGC
CGGAAATCCTTGCCAGCGGTATTCTGACCCGCAGCGATATCGGCCTGCTGGCGACGCTGTTTTACATCACCTACGGGGTG
TCGAAATTTGTCTCCGGCATCGTTAGCGATCGCTCTAACGCTCGCTATTTTATGGGCATCGGGCTGATTGCGACCGGCGT
AGTGAATATTCTGTTCGGCTTCTCGACCTCGCTGTGGGCCTTTGCGCTGCTATGGGCGCTGAACGCCTTTTTCCAGGGGT
TTGGATCGCCGGTTTGCGCCCGTTTGCTGACTGCCTGGTACTCGCGTACCGAGCGCGGCGGCTGGTGGGCGTTATGGAAC
ACCGCGCATAATGTCGGCGGGGCGCTGATCCCTCTCGTTATGGCCGCTGTCGCCCTGCATTATGGCTGGCGCGTCGGGAT
GATGGTGGCCGGATTGCTTGCCATCGGGGTGGGCATGGTCCTCTGCTGGCGGCTGCGCGACCGTCCGCAGGCGATTGGTT
TACCGCCGGTAGGCGACTGGCGGCACGATGCGCTGGAGGTCGCCCAACAGCAAGAGGGCGCGGGACTAAGCCGCAAAGAA
ATCCTCGCTAAATATGTGCTGTCGAATCCCTATATCTGGCTGCTTTCGTTGTGTTATGTCTTAGTGTACGTGGTGCGCGC
GGCGATCAACGACTGGGGCAACCTGTATATGTCCGAGACGCTGGGCGTGGATTTGGTCACGGCCAACACGGCAGTATCGA
TGTTTGAGTTGGGTGGATTTATCGGCGCGCTGGTGGCGGGTTGGGGCTCGGACAAACTCTTCAACGGCAACCGCGGACCG
ATGAATTTAATCTTCGCTGCCGGGATTTTGCTCTCTGTGGGTTCGCTGTGGCTGATGCCGTTCGCCAGCTACGTCATGCA
GGCGGCCTGTTTCTTCACCACCGGTTTCTTTGTCTTCGGCCCGCAGATGCTCATTGGCATGGCGGCGGCGGAGTGCTCGC
ATAAAGAGGCGGCGGGCGCAGCCACCGGCTTTGTCGGCCTGTTCGCCTATCTCGGCGCGTCGCTTTCCGGCTGGCCGTTA
GCGAAAGTGCTGGAGATCTGGCACTGGACCGGTTTTTTTGCGGTCATCGCCATCGCGGCGGGGATCTCCGCGCTATTGCT
GCTGCCATTTCTGAACGCCCAGGCCCCACGCGAGACCCACGAAGCGTGA

Upstream 100 bases:

>100_bases
CGAACGCGTGTCGGCGCTCGGCGGGACGCTAACCATCTCTTGTACCCACGGTACGCGGGTGAGCGTCTCGTTGCCCCAGC
GTTACGTTTAAGGAAGGATA

Downstream 100 bases:

>100_bases
TACACCTCACCTTTTTGCGCTGAATGGGGCAAAACTAAGAAATTTTCCCGGTTTTGCCTGGACGCTGTCGCAGGCCCCTT
TTCCTGTGGATTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRYILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLSNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETHEA

Sequences:

>Translated_442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRYILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLSNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETHEA
>Mature_442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRYILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLSNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETHEA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=440, Percent_Identity=29.0909090909091, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4503847, Length=440, Percent_Identity=29.0909090909091, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI256219483, Length=440, Percent_Identity=29.0909090909091, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI256219543, Length=455, Percent_Identity=28.3516483516484, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI256219564, Length=371, Percent_Identity=27.7628032345013, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI46361976, Length=491, Percent_Identity=21.7922606924644, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI14150047, Length=371, Percent_Identity=21.2938005390836, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38093649, Length=470, Percent_Identity=23.4042553191489, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI223717983, Length=470, Percent_Identity=23.4042553191489, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082310, Length=438, Percent_Identity=90.1826484018265, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=447, Percent_Identity=35.1230425055928, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI2367259, Length=462, Percent_Identity=30.7359307359307, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI2367379, Length=362, Percent_Identity=21.5469613259669, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17542316, Length=462, Percent_Identity=24.2424242424242, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI133901854, Length=479, Percent_Identity=22.1294363256785, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI133901856, Length=448, Percent_Identity=22.5446428571429, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI133930953, Length=446, Percent_Identity=23.0941704035874, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17561094, Length=398, Percent_Identity=20.6030150753769, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656866, Length=414, Percent_Identity=26.8115942028986, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45550478, Length=414, Percent_Identity=26.8115942028986, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656861, Length=414, Percent_Identity=26.8115942028986, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48255; Mature: 48255

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFLKAPANAPLITDKHEVDARYRYWRRYILITIWLGYALFYFTRKSFNAAAPEILASG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ILTRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPLVMAAVALH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ILAKYVLSNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGF
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAKVLEIWHWTGFFAVIAIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISALLLLPFLNAQAPRETHEA
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLSFLKAPANAPLITDKHEVDARYRYWRRYILITIWLGYALFYFTRKSFNAAAPEILASG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ILTRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPLVMAAVALH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ILAKYVLSNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGF
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAKVLEIWHWTGFFAVIAIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISALLLLPFLNAQAPRETHEA
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]