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The map label for this gene is uhpT [H]

Identifier: 29144022

GI number: 29144022

Start: 3846715

End: 3848106

Strand: Direct

Name: uhpT [H]

Synonym: t3731

Alternate gene names: 29144022

Gene position: 3846715-3848106 (Clockwise)

Preceding gene: 29144021

Following gene: 29144023

Centisome position: 80.27

GC content: 54.53

Gene sequence:

>1392_bases
ATGCTGGCCTTCTTAAACCAGGTGCGCAAGCCGACCCTGGATCTGCCGCTCAATGTGCGGCGTAAAATGTGGTTCAAGTC
GTTCATGCAGTCCTATCTGGTGGTTTTTATCGGCTACCTGACCATGTACCTGATCCGCAAAAACTTTAACATCGCGCAGA
ACGACATGATCTCTACCTACAGGTTGAGCATGACCGAGCTGGGGATGATTGGCCTGGGCTTCTCGATCACCTACGGCGTG
GGGAAAACGCTGGTTTCCTACTACGCTGACGGTAAAAATACCAAGCAGTTTCTACCGTTTATGTTGATCCTCTCCGCTAT
CTGTATGCTCGGCTTCAGCGCCAGCATGGGCGCGGGGTCAACCAGTCTGTTTCTGATGATCGCTTTCTATGCCCTGAGCG
GTTTCTTCCAGAGTACCGGCGGATCGTGCAGCTACTCGACCATCACCAAATGGACTCCGCGTCGTAAACGCGGCACCTTT
CTCGGCTTCTGGAATATCTCCCACAACCTCGGCGGCGCGGGCGCGGCAGGCGTGGCGCTGTTCGGCGCCAACTACCTGTT
CGACGGTCACGTCATCGGCATGTTTATCTTCCCGTCGATTATCGCGCTGATTGTTGGCTTTATCGGTCTGCGTTTCGGCA
GCGACTCCCCGGAATCTTACGGTCTGGGTAAAGCTGAAGAACTGTTCGGCGAAGAGATCAGCGAAGAGGATAAAGAGACT
GAAGAAAACGAAATGACCAAGTGGCAGATCTTTGTTGAATATGTGTTGAAAAACAAAGTGATCTGGCTGCTGTGTTTCTC
CAATATCTTCCTGTATGTGGTGCGTATTGGTATCGACCAGTGGTCAACCGTCTACGCCTTCCAGGAACTGAAACTTTCTA
AAGAGGTGGCGATTCAGGGCTTTACCTTGTTTGAAGTGGGCGCGCTGGTCGGCACGTTGCTGTGGGGCTGGCTCTCTGAC
CTGGCGAACGGTCGTCGCGCGCTGGTAGCCTGTGTGGCGCTGGCGTTGATCATCGCTACCCTCGGCGTCTACCAGCACGC
CAGCAACCAGTATGTCTATCTGGCCTCGCTGTTCGCGCTCGGTTTCCTGGTGTTTGGGCCGCAGCTATTAATTGGTGTGG
CGGCTGTCGGTTTCGTACCGAAAAAAGCCATCGGCGCTGCGGACGGTATCAAGGGCACCTTCGATTATCTTATCGGCGAT
AGCTTTGCTAAGCTGGGTCTGGGCATGATTGCCGACGGCACCCCCGTTTTTGGTCTGACCGGTTGGGCGGGTACCTTCGC
CGCGCTGGACGCTGCCGCGATCGGCTGTATCTGCCTGATGGCGATGGTCGCCGTGATGGAAGAGCGCAAAATCCGCCGTG
AGAAAAAAATTCAGCAAGTCAATATCGCTTAA

Upstream 100 bases:

>100_bases
TTTTCCCGGTTTTGCCTGGACGCTGTCGCAGGCCCCTTTTCCTGTGGATTTTTACAATGCCTGCCATTCGCAGGTATAAA
AATTAGCTCAGGAGTAATCC

Downstream 100 bases:

>100_bases
ATGTGTGCATTTGGTAACGTTTTGCCCGGCTTAACGCCGGGCTTTTTTATGCCTTGCGTTCGTCAGACAGGACATCCGGT
GTCTGGCGTAAATGAAGACA

Product: sugar phosphate antiporter

Products: Proton [Cytoplasm]; glucose-6-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLAFLNQVRKPTLDLPLNVRRKMWFKSFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYRLSMTELGMIGLGFSITYGV
GKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTF
LGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRFGSDSPESYGLGKAEELFGEEISEEDKET
EENEMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD
LANGRRALVACVALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFDYLIGD
SFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAIGCICLMAMVAVMEERKIRREKKIQQVNIA

Sequences:

>Translated_463_residues
MLAFLNQVRKPTLDLPLNVRRKMWFKSFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYRLSMTELGMIGLGFSITYGV
GKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTF
LGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRFGSDSPESYGLGKAEELFGEEISEEDKET
EENEMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD
LANGRRALVACVALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFDYLIGD
SFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAIGCICLMAMVAVMEERKIRREKKIQQVNIA
>Mature_463_residues
MLAFLNQVRKPTLDLPLNVRRKMWFKSFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYRLSMTELGMIGLGFSITYGV
GKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTF
LGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRFGSDSPESYGLGKAEELFGEEISEEDKET
EENEMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD
LANGRRALVACVALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFDYLIGD
SFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAIGCICLMAMVAVMEERKIRREKKIQQVNIA

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=374, Percent_Identity=23.2620320855615, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4503847, Length=374, Percent_Identity=23.2620320855615, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI256219483, Length=374, Percent_Identity=23.2620320855615, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI2367259, Length=463, Percent_Identity=95.0323974082073, Blast_Score=868, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=459, Percent_Identity=31.8082788671024, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87082310, Length=464, Percent_Identity=32.9741379310345, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17542316, Length=475, Percent_Identity=23.7894736842105, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133930953, Length=477, Percent_Identity=20.7547169811321, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656866, Length=499, Percent_Identity=22.6452905811623, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45550478, Length=499, Percent_Identity=22.6452905811623, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24656861, Length=496, Percent_Identity=22.7822580645161, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50841; Mature: 50841

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glucose-6-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glucose-6-phosphate [Periplasm] = Proton [Cytoplasm] + glucose-6-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]