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The map label for this gene is lrp [C]

Identifier: 29142357

GI number: 29142357

Start: 1977020

End: 1977481

Strand: Direct

Name: lrp [C]

Synonym: t1933

Alternate gene names: 29142357

Gene position: 1977020-1977481 (Clockwise)

Preceding gene: 29142355

Following gene: 29142358

Centisome position: 41.26

GC content: 48.48

Gene sequence:

>462_bases
ATGAAGCTTGACGCCTGGGATAAAAACATTCTGACATTATTGCAACGCGATAATCGTCTTTCTCAGCGGGAAATCGCCGA
ACAGGTCAATCTTTCACCTTCGGCAGTGAATCGTCGTATCGCGGCACTGGAGGAGGCGGGCATAATTAAAGGCAATGTCA
GCCTTGTTGATGCTGGCAAAGTGGGACGCCCGGTCACGATTGTGGTGCAGGTGGTGATCGAAAACGAGCGATTCAATTTA
CTGGAAGAGGCTCGTCAACGGTTTGTCAGTTGCCCGCAGGTGCAGCAGGTCTACTACGTAACGGGCGATTTCGACTTTTT
ACTGGTGCTCAATGTTCGTGACATGGCGGAATATGAAACACTTACCCGTGAGCTTTTCTTTTCCTCAGGCAATATTAAGT
CTTTTAAAACGATTGTCGTGATGCAAAACGCCAAGCAAGAGATGCGCGTCCTGATCGAGTAA

Upstream 100 bases:

>100_bases
AAATGCCCATCGTCGTGCAATTTTCACCTTTTTTTAACGGCCTGGACGCGGCAAAATTGCGCACAGTGATAGTCATCACA
TTAAAGAGGTTATTTGCGAT

Downstream 100 bases:

>100_bases
CGTGCGCAAAGCTTACAAAACCAGCCTAAATTCTCAATTGTTCGCGAGCAGGTGCGAACTTTTTACAGGTTTCTTTCTGA
AAACCTGCTTCCAGATGCGA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKLDAWDKNILTLLQRDNRLSQREIAEQVNLSPSAVNRRIAALEEAGIIKGNVSLVDAGKVGRPVTIVVQVVIENERFNL
LEEARQRFVSCPQVQQVYYVTGDFDFLLVLNVRDMAEYETLTRELFFSSGNIKSFKTIVVMQNAKQEMRVLIE

Sequences:

>Translated_153_residues
MKLDAWDKNILTLLQRDNRLSQREIAEQVNLSPSAVNRRIAALEEAGIIKGNVSLVDAGKVGRPVTIVVQVVIENERFNL
LEEARQRFVSCPQVQQVYYVTGDFDFLLVLNVRDMAEYETLTRELFFSSGNIKSFKTIVVMQNAKQEMRVLIE
>Mature_153_residues
MKLDAWDKNILTLLQRDNRLSQREIAEQVNLSPSAVNRRIAALEEAGIIKGNVSLVDAGKVGRPVTIVVQVVIENERFNL
LEEARQRFVSCPQVQQVYYVTGDFDFLLVLNVRDMAEYETLTRELFFSSGNIKSFKTIVVMQNAKQEMRVLIE

Specific function: Mediates A Global Response To Leucine. Exogenous Leucine Affects The Expression Of A Number Of Different Operons; Lrp Mediates This Effect For At Least Some Of These Operons. For Example It Is Regulator Of The Branched-Chain Amino Acid Transport Genes. [

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=151, Percent_Identity=31.1258278145695, Blast_Score=87, Evalue=5e-19,
Organism=Escherichia coli, GI87081742, Length=155, Percent_Identity=30.3225806451613, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR013196
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg; PF08279 HTH_11 [H]

EC number: NA

Molecular weight: Translated: 17503; Mature: 17503

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDAWDKNILTLLQRDNRLSQREIAEQVNLSPSAVNRRIAALEEAGIIKGNVSLVDAGK
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCEEEEECCC
VGRPVTIVVQVVIENERFNLLEEARQRFVSCPQVQQVYYVTGDFDFLLVLNVRDMAEYET
CCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECHHHHHHHH
LTRELFFSSGNIKSFKTIVVMQNAKQEMRVLIE
HHHHHHHCCCCCCCEEEEEEECCCHHHHHEECC
>Mature Secondary Structure
MKLDAWDKNILTLLQRDNRLSQREIAEQVNLSPSAVNRRIAALEEAGIIKGNVSLVDAGK
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEECCEEEEECCC
VGRPVTIVVQVVIENERFNLLEEARQRFVSCPQVQQVYYVTGDFDFLLVLNVRDMAEYET
CCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECHHHHHHHH
LTRELFFSSGNIKSFKTIVVMQNAKQEMRVLIE
HHHHHHHCCCCCCCEEEEEEECCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]