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The map label for this gene is lpxP [H]

Identifier: 29140978

GI number: 29140978

Start: 529332

End: 530252

Strand: Reverse

Name: lpxP [H]

Synonym: t0457

Alternate gene names: 29140978

Gene position: 530252-529332 (Counterclockwise)

Preceding gene: 29140980

Following gene: 29140974

Centisome position: 11.07

GC content: 54.18

Gene sequence:

>921_bases
ATGTTTCCTCAAAGCAAATTTTCACGCGCGTTTTTGCACCCGCGCTACTGGCTGACGTGGTTTGGCGTTGGCGTCCTCTG
GTTACTGGTGCAGCTTCCCTACCCGGTTTTGCGTTTTCTGGGCACCCGCACCGGTAAGCTGGCGCGCCCCTTCCTGAAGC
GACGTGAGTCGATCGCTCAGAAAAACATTGAACTCTGTTTTCCGACCCTCTCCCGGGAAGAAAGGGAAAAACTGATCGCC
GAGAATTTCCACTCTCTTGGCATGGCGCTGCTTGAAACGGGCATGGCCTGGTTCTGGCCTGATAGCCGGGTTCGCAAATG
GTTTGATGTGGACGGGCTGGACAACCTTACCCGTGCGCAGGCGCAAAATCGCGGCGTAATGGTCGTTGGCGTGCATTTTA
TGTCGCTGGAATTGGGAGGCCGGGTAATGGGTCTCTGCCAGCCGATGATGGCGACCTATCGTCCGCATAACAATCCGCTC
ATGGAGTGGGTGCAGACGCGCGGTCGTATGCGCTCAAATAAAGCGATGATCGGCAGAAACAATCTGCGCGGCATTGTGGG
CGCGCTAAAAAAAGGGGAAGCCGTTTGGTTTGCTCCCGACCAGGACTACGGTCCTAAAGGCAGCTCCTTTGCGCCATTTT
TCGCGGTTGAAAACGTCGCCACCACCAACGGTACCTATGTACTGTCCAGGCTGTCTGGCGCCGCCATGCTGACCGTTACA
ATGGTAAGGAAATCCGATAACTCGGGTTATCGTCTGTATATTACCCCTGAAATGGAAGGTTACCCGGCAGATGAAAATCA
AGCCGCTGCCTATATGAATAAAATTATTGAGAAAGAGATCATGCGCGCCCCGGAGCAATATCTCTGGATTCATCGCCGTT
TCAAGACTCGCCCGTTGGGGGAAGCGTCACTCTACATCTGA

Upstream 100 bases:

>100_bases
AGCGAACGCAACTTGAAGGATGATGCGTATTTCAGAGTGTACCGCTGCGGATAATGACTCTTCTGCGATACATTATTTTC
GTATCTACAGAAGGTATTTT

Downstream 100 bases:

>100_bases
AAAAGGCCGCAAGGCCTTTTATTTTGTCATTTCGCATTGCCATAATATTCACATCGTAAATTACTCATTCCTGCTTTTAG
CGATAAGTCTCCTGTTTACA

Product: lipid A biosynthesis palmitoleoyl acyltransferase

Products: KDO2-(palmitoleoyl)-lipid IVA [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MFPQSKFSRAFLHPRYWLTWFGVGVLWLLVQLPYPVLRFLGTRTGKLARPFLKRRESIAQKNIELCFPTLSREEREKLIA
ENFHSLGMALLETGMAWFWPDSRVRKWFDVDGLDNLTRAQAQNRGVMVVGVHFMSLELGGRVMGLCQPMMATYRPHNNPL
MEWVQTRGRMRSNKAMIGRNNLRGIVGALKKGEAVWFAPDQDYGPKGSSFAPFFAVENVATTNGTYVLSRLSGAAMLTVT
MVRKSDNSGYRLYITPEMEGYPADENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPLGEASLYI

Sequences:

>Translated_306_residues
MFPQSKFSRAFLHPRYWLTWFGVGVLWLLVQLPYPVLRFLGTRTGKLARPFLKRRESIAQKNIELCFPTLSREEREKLIA
ENFHSLGMALLETGMAWFWPDSRVRKWFDVDGLDNLTRAQAQNRGVMVVGVHFMSLELGGRVMGLCQPMMATYRPHNNPL
MEWVQTRGRMRSNKAMIGRNNLRGIVGALKKGEAVWFAPDQDYGPKGSSFAPFFAVENVATTNGTYVLSRLSGAAMLTVT
MVRKSDNSGYRLYITPEMEGYPADENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPLGEASLYI
>Mature_306_residues
MFPQSKFSRAFLHPRYWLTWFGVGVLWLLVQLPYPVLRFLGTRTGKLARPFLKRRESIAQKNIELCFPTLSREEREKLIA
ENFHSLGMALLETGMAWFWPDSRVRKWFDVDGLDNLTRAQAQNRGVMVVGVHFMSLELGGRVMGLCQPMMATYRPHNNPL
MEWVQTRGRMRSNKAMIGRNNLRGIVGALKKGEAVWFAPDQDYGPKGSSFAPFFAVENVATTNGTYVLSRLSGAAMLTVT
MVRKSDNSGYRLYITPEMEGYPADENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPLGEASLYI

Specific function: Unknown

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI87082094, Length=306, Percent_Identity=91.1764705882353, Blast_Score=582, Evalue=1e-168,
Organism=Escherichia coli, GI1787292, Length=301, Percent_Identity=56.1461794019934, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1788161, Length=307, Percent_Identity=27.3615635179153, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: NA

Molecular weight: Translated: 35155; Mature: 35155

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPQSKFSRAFLHPRYWLTWFGVGVLWLLVQLPYPVLRFLGTRTGKLARPFLKRRESIAQ
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
KNIELCFPTLSREEREKLIAENFHSLGMALLETGMAWFWPDSRVRKWFDVDGLDNLTRAQ
CCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCCCCHHHHHH
AQNRGVMVVGVHFMSLELGGRVMGLCQPMMATYRPHNNPLMEWVQTRGRMRSNKAMIGRN
HHCCCEEEEEEEEEEHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCC
NLRGIVGALKKGEAVWFAPDQDYGPKGSSFAPFFAVENVATTNGTYVLSRLSGAAMLTVT
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHEECCEECCCCCEEEEHHCCCEEEEEE
MVRKSDNSGYRLYITPEMEGYPADENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPLG
EEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
EASLYI
CCCCCC
>Mature Secondary Structure
MFPQSKFSRAFLHPRYWLTWFGVGVLWLLVQLPYPVLRFLGTRTGKLARPFLKRRESIAQ
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
KNIELCFPTLSREEREKLIAENFHSLGMALLETGMAWFWPDSRVRKWFDVDGLDNLTRAQ
CCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCCCCHHHHHH
AQNRGVMVVGVHFMSLELGGRVMGLCQPMMATYRPHNNPLMEWVQTRGRMRSNKAMIGRN
HHCCCEEEEEEEEEEHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCC
NLRGIVGALKKGEAVWFAPDQDYGPKGSSFAPFFAVENVATTNGTYVLSRLSGAAMLTVT
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHEECCEECCCCCEEEEHHCCCEEEEEE
MVRKSDNSGYRLYITPEMEGYPADENQAAAYMNKIIEKEIMRAPEQYLWIHRRFKTRPLG
EEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
EASLYI
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; palmitoleoyl-ACP [C]

Specific reaction: KDO2-lipid IVA + palmitoleoyl-ACP = KDO2-(palmitoleoyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]