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The map label for this gene is xapR [H]

Identifier: 29140964

GI number: 29140964

Start: 510825

End: 511709

Strand: Direct

Name: xapR [H]

Synonym: t0437

Alternate gene names: 29140964

Gene position: 510825-511709 (Clockwise)

Preceding gene: 29140963

Following gene: 29140965

Centisome position: 10.66

GC content: 50.28

Gene sequence:

>885_bases
ATGGAACGAGCCCATCGTATTGATCTAAAGCTATTACGTTATTTCCTCGCTGTTGCAGAAGAATTGCATTTTGGCCGGGC
TGCTGCCCGGTTAAATATGTCACAACCTCCCTTGAGTATCCATATCAAAGAACTTGAACAGCAACTGGGTACATTGCTGT
TTATTCGTCATTCCCGCAGCGTTGCATTAACCCATGCCGGGAAAGTTTTAATGGAGGAGTCACGTCGCTTGTTAGCCAAT
GCAAATCAGGCGCTGGCGCGAGTGGAGCAGATTGGTCGCGGTGAAGCGGGGCGCATTGAACTGGGTGTGGTTGGTACGGC
GCTGTGGGGAAGAATGCGTCCTGCGATGCGTCACTTTTTGAAAGCAAATCCCAATGTTGAAGTACTTTTTCGCGAAAAGT
CTCCAGGTATGCAAATGGCGTTGTTAGAGCGTCGGGAACTTGATGCAGGGATCTGGCGTATGGCTATCGAACCAGCAGTC
GGTTTTACCAGCATACGTTTGCATGAATCTGCATTCATGGTTGCAGTTCCGGAAGATCACGATCTGGCATCCAGAGATTC
TGTGCCGCTGTCGGCGTTGCGCAATGAATATTTTGTTACGTTGCCTTCCGTACATTCTGATTGGGGATTTTTACAACGTG
TATGCCAACAGGCGGGTTTCTCGCCAATGATTATTCGGGAAGTGGTTGAGCCGCAAACGGTGTTGGCGATGATCAGTATG
GGGATCGGGATTACGTTGATGGCTGATGGCTATGCGCAAATGAGCTGGCCGGGTGTGGTGTTCCGTCCGTTAGAGGAACG
TATTCCGGCGGATTTGTATATTGTGTATGACCAGCAGCAGGCAACGCCAGCACTGGAGAAACTGGTGGCGGCGTTGACGG
TATGA

Upstream 100 bases:

>100_bases
TGTATTTATGTATATTGGGTATCTTGTCGTTAAATCTATTTTTTACTAGGTAATATGGTAAATTCCAGACGTTATCCCTT
ATTCCTGGAGTGCGATAGTG

Downstream 100 bases:

>100_bases
TGTCTGTGCCGGATGGCGACTAACGTCTTATCCGGCCTACGCGGCGGTGTCGTCTGTAGGCCTGATAAGCGCAGCGCATC
AGGCAAGACCCGAACCTGCG

Product: DNA-binding transcriptional activator XapR

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRSVALTHAGKVLMEESRRLLAN
ANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFLKANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAV
GFTSIRLHESAFMVAVPEDHDLASRDSVPLSALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV

Sequences:

>Translated_294_residues
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRSVALTHAGKVLMEESRRLLAN
ANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFLKANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAV
GFTSIRLHESAFMVAVPEDHDLASRDSVPLSALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV
>Mature_294_residues
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRSVALTHAGKVLMEESRRLLAN
ANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFLKANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAV
GFTSIRLHESAFMVAVPEDHDLASRDSVPLSALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=293, Percent_Identity=81.2286689419795, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI1787879, Length=284, Percent_Identity=35.9154929577465, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=28.9655172413793, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=29.5081967213115, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=31.4410480349345, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=28.9256198347107, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788748, Length=241, Percent_Identity=26.9709543568465, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787589, Length=177, Percent_Identity=35.0282485875706, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790262, Length=288, Percent_Identity=24.6527777777778, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788297, Length=256, Percent_Identity=26.5625, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081904, Length=155, Percent_Identity=33.5483870967742, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=302, Percent_Identity=25.1655629139073, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI48994962, Length=87, Percent_Identity=39.0804597701149, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32983; Mature: 32983

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCEEEEECCCC
VALTHAGKVLMEESRRLLANANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
KANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAVGFTSIRLHESAFMVAVPEDH
HCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEECCEEEEECCCCC
DLASRDSVPLSALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
CCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHH
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV
CCCEEEEECCCCCCCCCCCEECCHHHHCCCEEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MERAHRIDLKLLRYFLAVAEELHFGRAAARLNMSQPPLSIHIKELEQQLGTLLFIRHSRS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCEEEEECCCC
VALTHAGKVLMEESRRLLANANQALARVEQIGRGEAGRIELGVVGTALWGRMRPAMRHFL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
KANPNVEVLFREKSPGMQMALLERRELDAGIWRMAIEPAVGFTSIRLHESAFMVAVPEDH
HCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEECCEEEEECCCCC
DLASRDSVPLSALRNEYFVTLPSVHSDWGFLQRVCQQAGFSPMIIREVVEPQTVLAMISM
CCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHH
GIGITLMADGYAQMSWPGVVFRPLEERIPADLYIVYDQQQATPALEKLVAALTV
CCCEEEEECCCCCCCCCCCEECCHHHHCCCEEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]