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The map label for this gene is hprK

Identifier: 28377613

GI number: 28377613

Start: 688895

End: 689842

Strand: Direct

Name: hprK

Synonym: lp_0754

Alternate gene names: 28377613

Gene position: 688895-689842 (Clockwise)

Preceding gene: 28377612

Following gene: 28377614

Centisome position: 20.82

GC content: 44.83

Gene sequence:

>948_bases
TTGGCAGGAAGTGTAACCGTTGCCGATTTGGTGAAAAATACGCGCCTGGATGTGTATCATGGCGCTGACTTATTAGAAAA
GAAAGATATTACAACGAGCGACATTTCACGTCCGGGGCTGGCGTTGACCGGTTACTTCAACTACTATCCTCGTGAACGGG
TGCAATTGCTAGGTAAAACTGAAACCGCTTATTCGAAAAATATGAGTCATGATGAACGACTGATGATTTTTCGTAAGATG
TGTCAGTTAACCACACCCGCGTTCGTCATTTCAACGGGGTTACCCGTTCCAGAAGAACTCGTGCAAGCCGGTGAGGAAAA
TGGCGTGCCGATTTTAGGAACGAAAATGACATCATCACGGATTCTAAGTAATATGACGAATTACTTGGAAGGTAAATTAG
CTGAACGACAATCTGTCCACGGGGTATTAGTTGACATCTATGGATTAGGTGTGCTGATTACTGGTGATTCCGGTGTTGGG
AAGAGTGAAACGGCCCTGGAATTAGTCAAACGGGGGCATCGTTTGATTGCTGATGACCGGGTCGATGTCTATCAACAGGA
TGAACAAACGCTTGTCGGTGAAGCACCCGCAATCTTGAATCACTTATTGGAGATTCGAGGTATCGGAATTATTGATGTTA
TGAATCTTTTTGGCGCTGGGGCTGTTCGTCAAGATACCGACATTGACCTTATCGTGCACCTTGAGAATTGGACGCCTGAT
AAGCAATTTGATAGACTAGGAAATGGAGAACAGAACCGGAAATTCTTTGATGTTGAAGTTCCTGAAATCTCGATTCCAGT
TAAGACTGGACGTAACCTAGCAATCATTATCGAAGCAGCGGCCATGAACTTTCGGGCCGAGAGCATGGGCTACGATGCGA
CCAAGGTCTTTGACGATAACTTGAACAAGTTGATCAAAACGAATTCCGTGCATGATTCTCACAAGTAA

Upstream 100 bases:

>100_bases
CAGTCATAAAAGTGTGGCCGCTTGAAAGGGTAGCGTAATGGCGCGACTGGACAACGCGGGCCACACTTTTTTATTAGTGG
AACAATTAGGAGGGATTCTT

Downstream 100 bases:

>100_bases
TAAGGAGATGGCAGTAGCGTGAATACCGTTTTAGGGGCACTTAACCCAATTGCACTGCGGTTAGGACCAATTCAGGTCCA
TTGGTACGGCGTCATTATTG

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKTETAYSKNMSHDERLMIFRKM
CQLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSRILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVG
KSETALELVKRGHRLIADDRVDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPD
KQFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDNLNKLIKTNSVHDSHK

Sequences:

>Translated_315_residues
MAGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKTETAYSKNMSHDERLMIFRKM
CQLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSRILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVG
KSETALELVKRGHRLIADDRVDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPD
KQFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDNLNKLIKTNSVHDSHK
>Mature_314_residues
AGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKTETAYSKNMSHDERLMIFRKMC
QLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSRILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVGK
SETALELVKRGHRLIADDRVDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPDK
QFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDNLNKLIKTNSVHDSHK

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK_LACPL (Q88YK3)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784505.1
- ProteinModelPortal:   Q88YK3
- SMR:   Q88YK3
- GeneID:   1063592
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0754
- NMPDR:   fig|220668.1.peg.639
- HOGENOM:   HBG566466
- OMA:   IHGVLVD
- ProtClustDB:   PRK05428
- BioCyc:   LPLA220668:LP_0754-MONOMER
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126
- TIGRFAMs:   TIGR00679

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 34872; Mature: 34741

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: ACT_SITE 140-140 ACT_SITE 161-161 ACT_SITE 179-179 ACT_SITE 245-245

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKT
CCCCCHHHHHHHCCCEEEEECCHHHHHCCCCHHHCCCCCEEEEEEECCCCHHHHHHHCCC
ETAYSKNMSHDERLMIFRKMCQLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSR
HHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCHHHH
ILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVGKSETALELVKRGHRLIADDR
HHHHHHHHHHHHHHHHHHHCEEEEEEEECEEEEECCCCCCCHHHHHHHHHCCCEEEECCC
VDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPD
CCHHHCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
KQFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDN
HHHHHCCCCCCCCEEEEEECCEEEEEECCCCCEEEEEEECCCCCCHHHCCCCHHHHHHHH
LNKLIKTNSVHDSHK
HHHHHHCCCCCCCCC
>Mature Secondary Structure 
AGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKT
CCCCHHHHHHHCCCEEEEECCHHHHHCCCCHHHCCCCCEEEEEEECCCCHHHHHHHCCC
ETAYSKNMSHDERLMIFRKMCQLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSR
HHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCCCEEEECCCHHHH
ILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVGKSETALELVKRGHRLIADDR
HHHHHHHHHHHHHHHHHHHCEEEEEEEECEEEEECCCCCCCHHHHHHHHHCCCEEEECCC
VDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPD
CCHHHCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
KQFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDN
HHHHHCCCCCCCCEEEEEECCEEEEEECCCCCEEEEEEECCCCCCHHHCCCCHHHHHHHH
LNKLIKTNSVHDSHK
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566