Click here to switch to the map view.

The map label for this gene is dnaX [H]

Identifier: 28377566

GI number: 28377566

Start: 642982

End: 644679

Strand: Direct

Name: dnaX [H]

Synonym: lp_0698

Alternate gene names: 28377566

Gene position: 642982-644679 (Clockwise)

Preceding gene: 28377565

Following gene: 28377567

Centisome position: 19.44

GC content: 46.88

Gene sequence:

>1698_bases
ATGTATCGGGCACTATATCGGGTTTGGCGTCCCCAACGCTTTGATGAGATTGTCGGGCAACAGATGATTACCCAGACACT
AAAAAATGCCATTATGACCCACCAGACGAGTCATGCGTATCTGTTTACCGGTCCCCGGGGAACTGGGAAAACGTCGGCAG
CAAAGATTTTTGCCAAGGCAATTAACTGTCACCATCTTGTTGATGGGGAACCTTGCAATGAATGTGAGACTTGTACGGCG
ATTACCAAGGGGCAACTAAATGATGTCATCGAAATTGATGCGGCTTCTAATAATGGTGTGGAAGAGATTCGTGATATTCG
GGACAAAGCGAAGTATGCTCCAACGCAAGCGGACTATAAAGTCTACATTATTGATGAAGTTCATATGTTATCGACTGGCG
CGTTTAATGCGTTGCTCAAAACGCTAGAAGAACCCCCGGCTAACGTTATATTTATCTTAGCGACAACGGAGCCCCATAAG
ATTCCATTAACGATTATTTCACGGACGCAACGGTTTGATTTTCGGCGGATTACAGCTAAGGATAGCTACGATCGGATGGT
GTACATCCTCAATGAGAAGGATGTGACCTATGATGAAAAAGCGCTACGCGTCATTGCAGCGGCTGCTGAAGGTGGAATGC
GGGATGCTTTAAGTATTCTGGATCAAGTAATTTCGTTTGGAGATAACACGGTTACGTTGGATGATGCGTTAATGGTGACG
GGAAGTGTGACCAAGCAGTTGCTGGCTAACTATGTCAGTGAGGTCACCGACCATGATACGAAGCCGGCACTAGAGACGAT
GCGACAAATCTTACAAGAAGGTAAAGATGCGAACCGTTTCATTGAAGATTTGATCAGTTATACGCGTGACGTGTTACTCT
ATCAACAGGCCCCTGAAATGGTCGATAGTGTGGCGATGGGCGAGGATGATCAACAATTTGAAGCATTTGCCAAGCAAATC
GATGCTGAAGTCCTGTATCAAATGGTCAAGACGTTGAACGATATTCAACAACAAATGCGGTTCACGACGCACCCCGACGT
TTATTTAGAAGTGTTGACGGTCAAGCTAGCTCAGTTGGATGGTCAAGCGGCCGTTCAACCGGTAGCTGCGGCAACGGTCA
ATCCTGAAGATCCCACTGTGCATAAACTGGCACAACAAGTTGAACAGTTGCAAAGCGAGGTCAAAACGTTACGTTCTCAA
GGTGGTAGTATCACTAAACCTGCACCGGCTAAGCCGCGGTCGAGTAATGGCCCGGTTGTTAAGAAGGTTAATGTCAGTCA
GATTTATCCTATTCTGGGAGCGGCAACGAAGAATGATCTCATTAAGGTGCGCGATGTTTGGACTGATTTGATGAATATTT
TGAGTGTGACGCAGCGGGCCCTAATGCACGTGGCCCAACCAGTTGCGGCCAGTTCAGAAGGTGTTGTGGTTGCGTTTGAC
TATGCGTTTGTTTATCAAAAAGCGATTGATGACCAGACCTTGATCGATGCACTCGGAAATGGTTTGGATCGGCTGATGGG
AGAGGCACCCAAGATTGTCTGTGTGCCTAAAGAACAGTGGCCACAAATTCGTAAGGATTATTTGGCCACTCACCAGCCAG
GAGGTGCAACATCAGAGCAACAAGCACCGGCCAAAGAACCGGTCGTTGAAGAAGCTAAGAATATGTTCGGTGATTTAGTT
GAAGTACAGCCGGACTAA

Upstream 100 bases:

>100_bases
GCAGCACAACCAGGAAGCTAACTGTTCAGGACGTTTAAACAATGGCTTATAATAAGTAATGATAACCAAAGTATGACTGA
TGTAAGAAAGGAAGAATCGC

Downstream 100 bases:

>100_bases
AGACGAAAGGAACTGATAATTATGATGCGTGGAATGGGCAATATGCAAAGTATGATGAAACAAATGAAGAAGATGCAGGC
GCAAATGACAGCCGAACAAG

Product: DNA-directed DNA polymerase III, gamma/tau subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MYRALYRVWRPQRFDEIVGQQMITQTLKNAIMTHQTSHAYLFTGPRGTGKTSAAKIFAKAINCHHLVDGEPCNECETCTA
ITKGQLNDVIEIDAASNNGVEEIRDIRDKAKYAPTQADYKVYIIDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPHK
IPLTIISRTQRFDFRRITAKDSYDRMVYILNEKDVTYDEKALRVIAAAAEGGMRDALSILDQVISFGDNTVTLDDALMVT
GSVTKQLLANYVSEVTDHDTKPALETMRQILQEGKDANRFIEDLISYTRDVLLYQQAPEMVDSVAMGEDDQQFEAFAKQI
DAEVLYQMVKTLNDIQQQMRFTTHPDVYLEVLTVKLAQLDGQAAVQPVAAATVNPEDPTVHKLAQQVEQLQSEVKTLRSQ
GGSITKPAPAKPRSSNGPVVKKVNVSQIYPILGAATKNDLIKVRDVWTDLMNILSVTQRALMHVAQPVAASSEGVVVAFD
YAFVYQKAIDDQTLIDALGNGLDRLMGEAPKIVCVPKEQWPQIRKDYLATHQPGGATSEQQAPAKEPVVEEAKNMFGDLV
EVQPD

Sequences:

>Translated_565_residues
MYRALYRVWRPQRFDEIVGQQMITQTLKNAIMTHQTSHAYLFTGPRGTGKTSAAKIFAKAINCHHLVDGEPCNECETCTA
ITKGQLNDVIEIDAASNNGVEEIRDIRDKAKYAPTQADYKVYIIDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPHK
IPLTIISRTQRFDFRRITAKDSYDRMVYILNEKDVTYDEKALRVIAAAAEGGMRDALSILDQVISFGDNTVTLDDALMVT
GSVTKQLLANYVSEVTDHDTKPALETMRQILQEGKDANRFIEDLISYTRDVLLYQQAPEMVDSVAMGEDDQQFEAFAKQI
DAEVLYQMVKTLNDIQQQMRFTTHPDVYLEVLTVKLAQLDGQAAVQPVAAATVNPEDPTVHKLAQQVEQLQSEVKTLRSQ
GGSITKPAPAKPRSSNGPVVKKVNVSQIYPILGAATKNDLIKVRDVWTDLMNILSVTQRALMHVAQPVAASSEGVVVAFD
YAFVYQKAIDDQTLIDALGNGLDRLMGEAPKIVCVPKEQWPQIRKDYLATHQPGGATSEQQAPAKEPVVEEAKNMFGDLV
EVQPD
>Mature_565_residues
MYRALYRVWRPQRFDEIVGQQMITQTLKNAIMTHQTSHAYLFTGPRGTGKTSAAKIFAKAINCHHLVDGEPCNECETCTA
ITKGQLNDVIEIDAASNNGVEEIRDIRDKAKYAPTQADYKVYIIDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPHK
IPLTIISRTQRFDFRRITAKDSYDRMVYILNEKDVTYDEKALRVIAAAAEGGMRDALSILDQVISFGDNTVTLDDALMVT
GSVTKQLLANYVSEVTDHDTKPALETMRQILQEGKDANRFIEDLISYTRDVLLYQQAPEMVDSVAMGEDDQQFEAFAKQI
DAEVLYQMVKTLNDIQQQMRFTTHPDVYLEVLTVKLAQLDGQAAVQPVAAATVNPEDPTVHKLAQQVEQLQSEVKTLRSQ
GGSITKPAPAKPRSSNGPVVKKVNVSQIYPILGAATKNDLIKVRDVWTDLMNILSVTQRALMHVAQPVAASSEGVVVAFD
YAFVYQKAIDDQTLIDALGNGLDRLMGEAPKIVCVPKEQWPQIRKDYLATHQPGGATSEQQAPAKEPVVEEAKNMFGDLV
EVQPD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=223, Percent_Identity=25.5605381165919, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786676, Length=335, Percent_Identity=36.7164179104478, Blast_Score=250, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71986063, Length=302, Percent_Identity=24.1721854304636, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=295, Percent_Identity=23.3898305084746, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=226, Percent_Identity=26.1061946902655, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=297, Percent_Identity=23.2323232323232, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=255, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17647857, Length=287, Percent_Identity=22.2996515679443, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921076, Length=242, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI18859927, Length=293, Percent_Identity=20.1365187713311, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62753; Mature: 62753

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRALYRVWRPQRFDEIVGQQMITQTLKNAIMTHQTSHAYLFTGPRGTGKTSAAKIFAKA
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
INCHHLVDGEPCNECETCTAITKGQLNDVIEIDAASNNGVEEIRDIRDKAKYAPTQADYK
HCHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEE
VYIIDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPHKIPLTIISRTQRFDFRRITAK
EEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEECCC
DSYDRMVYILNEKDVTYDEKALRVIAAAAEGGMRDALSILDQVISFGDNTVTLDDALMVT
CCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCHHHHH
GSVTKQLLANYVSEVTDHDTKPALETMRQILQEGKDANRFIEDLISYTRDVLLYQQAPEM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDSVAMGEDDQQFEAFAKQIDAEVLYQMVKTLNDIQQQMRFTTHPDVYLEVLTVKLAQLD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
GQAAVQPVAAATVNPEDPTVHKLAQQVEQLQSEVKTLRSQGGSITKPAPAKPRSSNGPVV
CHHHHCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
KKVNVSQIYPILGAATKNDLIKVRDVWTDLMNILSVTQRALMHVAQPVAASSEGVVVAFD
EEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
YAFVYQKAIDDQTLIDALGNGLDRLMGEAPKIVCVPKEQWPQIRKDYLATHQPGGATSEQ
HHHHHHHHCCHHHHHHHHCCHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCC
QAPAKEPVVEEAKNMFGDLVEVQPD
CCCCCCHHHHHHHHHHHCCEECCCC
>Mature Secondary Structure
MYRALYRVWRPQRFDEIVGQQMITQTLKNAIMTHQTSHAYLFTGPRGTGKTSAAKIFAKA
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
INCHHLVDGEPCNECETCTAITKGQLNDVIEIDAASNNGVEEIRDIRDKAKYAPTQADYK
HCHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEE
VYIIDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPHKIPLTIISRTQRFDFRRITAK
EEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEECCC
DSYDRMVYILNEKDVTYDEKALRVIAAAAEGGMRDALSILDQVISFGDNTVTLDDALMVT
CCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCHHHHH
GSVTKQLLANYVSEVTDHDTKPALETMRQILQEGKDANRFIEDLISYTRDVLLYQQAPEM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDSVAMGEDDQQFEAFAKQIDAEVLYQMVKTLNDIQQQMRFTTHPDVYLEVLTVKLAQLD
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
GQAAVQPVAAATVNPEDPTVHKLAQQVEQLQSEVKTLRSQGGSITKPAPAKPRSSNGPVV
CHHHHCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
KKVNVSQIYPILGAATKNDLIKVRDVWTDLMNILSVTQRALMHVAQPVAASSEGVVVAFD
EEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
YAFVYQKAIDDQTLIDALGNGLDRLMGEAPKIVCVPKEQWPQIRKDYLATHQPGGATSEQ
HHHHHHHHCCHHHHHHHHCCHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCC
QAPAKEPVVEEAKNMFGDLVEVQPD
CCCCCCHHHHHHHHHHHCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]