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The map label for this gene is hisB

Identifier: 28199151

GI number: 28199151

Start: 1473821

End: 1474948

Strand: Reverse

Name: hisB

Synonym: PD1265

Alternate gene names: 28199151

Gene position: 1474948-1473821 (Counterclockwise)

Preceding gene: 28199152

Following gene: 28199150

Centisome position: 58.53

GC content: 56.74

Gene sequence:

>1128_bases
ATGACCCCCATCGTGTTTATTGACCGTGACGGCACGCTCATTGAAGAGCCGCCTGATTTTCAGATTGATGCCTACGAAAA
ACTGCGCCTTGTCAACGGCGTGATCCCGGCATTGCTGAAGCTCCGTGATGCCGGCTATCACTTTGTGATCGTCACCAACC
AAGATGGATTGGGCAGCCCCACGTATCCCCAAGCCAGCTTTGATGGCCCCAATGCGTTGATGCTGCAGATTTTTAGTAGC
CAAGGCATCGTCTTCCGCGATGTGCTGATCGATCGTAGCTGGCCGGCCGACAACGCGCCCACTCGTAAACCAGGCATCGG
CTTGATGGTCGCCTACCTTCAAGATCGCGACATTGATTGGGCGCGCTCGGCAATGGTGGGCGATCGCCCCACAGATCTGC
AATTTGCCGAGAATCTCAACATTCGCGGATTCCAATTACGTACCCCGCAATTTGGTGGTGACTGGGATTGGGACGGCATT
GCTCACACCTTGGCCGATGCGCCGCGCCGCGCCGTGGTACAGCGTCACACCAAGGAGACAAACATCCGTGTCGAGATTGA
TTTGGATGGCGCACCCCAGGCGCGGATCACTACCGGATTACCGTTTTTTGATCATATGCTCGAGCAGATCGCCAAACATG
CTGGCATTTCCCTACACATCAGCGCTGTTGGGGATCTGCATATCGACGAACATCACACAATAGAAGATACCGGCTTGGCG
CTAGGTCAGGCAGTGCGCCAAGCCTTGGGGGATAAACGCGGTATTGGCCGCTATGGATTCGATCCGCCCCAGCTGCCGTG
GCAGGTGAGCGGCGCGGCGGCACACGGTGGCTTTACCCTACCGATGGATGAGACCCAAGCCAGCGCTGTGTTGGACTTCA
GCGGCCGCCCGTATTTTGTCTTTGAAGGAACCTTCGTCCGTGAGCGTGTCGGCGATATGCCCACCGAACTGGTACCGCAC
TTTTTCCGCTCCCTGTGTGATGCCTCTGGGATGAACTTGCACTTGAGCGTGCATGGCGACAACGACCATCACAAAGTAGA
AGCGTGTTTCAAGGCGCTGGCGCGTGCATTGCGTCAGGCGTTACAACGCCACGGCCACGTGCTTCCTTCTACCAAGGGGG
CGTTATGA

Upstream 100 bases:

>100_bases
CCGCACCGCAGTTGCATGATGCCTTGCGGCTGACCGTGGGAACCCCCGAACAAAACACACGTCTCCTGGCCGTGTTGCGT
GACATCCAGGCGGTGCCCGC

Downstream 100 bases:

>100_bases
CCGAGGTTGCTTTGATTGATGCCGGTGGTGCCAATCTTGGTTCGGTGCGCTACGCCTTGCAGCGTTTGGGGGTAGAACCG
CGCTTAGTGTGCGATGCCCG

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSPTYPQASFDGPNALMLQIFSS
QGIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDWARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGI
AHTLADAPRRAVVQRHTKETNIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLHISAVGDLHIDEHHTIEDTGLA
LGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFVFEGTFVRERVGDMPTELVPH
FFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQALQRHGHVLPSTKGAL

Sequences:

>Translated_375_residues
MTPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSPTYPQASFDGPNALMLQIFSS
QGIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDWARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGI
AHTLADAPRRAVVQRHTKETNIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLHISAVGDLHIDEHHTIEDTGLA
LGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFVFEGTFVRERVGDMPTELVPH
FFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQALQRHGHVLPSTKGAL
>Mature_374_residues
TPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSPTYPQASFDGPNALMLQIFSSQ
GIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDWARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGIA
HTLADAPRRAVVQRHTKETNIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLHISAVGDLHIDEHHTIEDTGLAL
GQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFVFEGTFVRERVGDMPTELVPHF
FRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQALQRHGHVLPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=372, Percent_Identity=50.5376344086022, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1786399, Length=187, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324776, Length=233, Percent_Identity=41.6309012875536, Blast_Score=172, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_XYLF2 (B2I5X9)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830042.1
- ProteinModelPortal:   B2I5X9
- GeneID:   6202227
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1350
- HOGENOM:   HBG289010
- OMA:   QDGLGTP
- ProtClustDB:   PRK05446
- GO:   GO:0005737
- HAMAP:   MF_01022
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01261
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold; SSF56784 SSF56784

EC number: =3.1.3.15; =4.2.1.19

Molecular weight: Translated: 41472; Mature: 41341

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSP
CCCEEEECCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
TYPQASFDGPNALMLQIFSSQGIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDW
CCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCH
ARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGIAHTLADAPRRAVVQRHTKET
HHHHHCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCC
NIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLHISAVGDLHIDEHHTIEDTGLA
EEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEECEECCCCCCCHHHHHH
LGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCCCCCCCEEEECCCCEEEE
FEGTFVRERVGDMPTELVPHFFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQA
ECCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
LQRHGHVLPSTKGAL
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
TPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSP
CCEEEECCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
TYPQASFDGPNALMLQIFSSQGIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDW
CCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCH
ARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGIAHTLADAPRRAVVQRHTKET
HHHHHCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCC
NIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLHISAVGDLHIDEHHTIEDTGLA
EEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEEECEECCCCCCCHHHHHH
LGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEECCCCCCCCCEEEECCCCEEEE
FEGTFVRERVGDMPTELVPHFFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQA
ECCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
LQRHGHVLPSTKGAL
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA