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The map label for this gene is uvrB

Identifier: 262192882

GI number: 262192882

Start: 867728

End: 869818

Strand: Reverse

Name: uvrB

Synonym: BMA10247_A0915

Alternate gene names: 262192882

Gene position: 869818-867728 (Counterclockwise)

Preceding gene: 126446750

Following gene: 126447698

Centisome position: 36.97

GC content: 64.47

Gene sequence:

>2091_bases
ATGTCCGAACACCACTCCGACACCCGTGACGATCTAGACGAATCGAAATTCGTGACGTTCGAAGGTTCTCCGTTTCAGCT
GTATCAGCCTTATCCGCCGTCGGGCGACCAGCCCACCGCGATCGCGACGCTCGTCGAAGGCGTCGAGGATGGCTTGTCGT
TCCAGACGCTGCTCGGCGTGACGGGCTCCGGCAAGACCTACACGATGGCGAACACGATCGCGCGGCTCGGCCGTCCGGCG
ATCGTGTTCGCGCCGAACAAGACGCTCGCCGCGCAGTTGTACGCGGAGTTCCGCGAGTTTTTCCCGCGCAACGCGGTCGA
GTACTTCGTGTCGTACTACGACTACTACCAGCCGGAAGCGTACGTGCCGCAGCGCGATCTCTTCATCGAGAAGGATTCGT
CGATCAACGAGCACATCGAGCAGATGCGGCTGTCGGCGACGAAGAGCCTGATGGAGCGGCGCGATGTCGTGATCGTCGCG
ACGGTGTCGGCGATCTACGGTATCGGCAATCCGTCCGAATACCACCAGATGATCCTCACGCTGCGCACGGGCGACAAGAT
CGGCCAGCGCGAGGTGATCGCGCGGCTGATCGCGATGCAGTACACGCGCAACGAGCAGGACTTCCAGCGCGGCACGTTTC
GCGTGCGCGGCGACACGATCGACATCTTCCCGGCCGAGCACGCGGAGATGGCGGTGCGCGTCGAGCTGTTCGACGACGAA
GTCGATACGCTGCACCTGTTCGATCCGCTGACGGGGCGCGTGCGGCAGAAGATTCCGCGCTTCACCGTCTATCCGTCGTC
GCACTACGTGACGCCGCGCGAGACTGTGATGCGCGCGGTCGAGACGATCAAGGACGAATTGCGCGAGCGTCTCGAATTCT
TCCATCGCGACGGCAAGCTCGTCGAGGCGCAGCGCCTCGAGCAGCGCACCCGGTTCGACCTCGAGATGCTGCAGGAGCTC
GGCTTCTGCAAGGGCATCGAGAATTATTCGCGGCACTTCTCCGGCGCGGCGCCGGGCGAGCCGCCGCCGACCCTCGTCGA
CTATCTGCCGCCCGACGCGCTGATGCTGCTCGACGAATCGCACGTGCTGATCGGCCAGTTGAACGGCATGTACAACGGCG
ATCGCGCGCGCAAGGAAAACCTCGTCGATTACGGGTTCCGGCTGCCGTCGGCGCTCGATAACCGGCCGCTCAAGTTTCCC
GAGTTCGAGCGCAAGATGCGCCAGGTGGTGTTCGTGTCGGCGACGCCCGCCGACTACGAGCAGCGCGTGTCCGGCCAGAC
CGCCGAGCAGGTCGTGCGGCCGACCGGGCTCGTCGATCCGCAGATCGAGGTGCGCCCGGCGAGCACGCAGGTGGACGACG
TGCTCTCCGAGATCACCGAGCGGGTGAAGGCGAACGAGCGCGTGCTGATCACCGTGCTCACGAAGCGCATGGCCGAGCAA
TTGACCGAATTCCTCGCCGACCACGGGGTCAAGGTCCGCTATCTGCACAGCGACATCGACACCGTCGAGCGCGTCGAGAT
CATCCGAGACCTGCGGCTCGGCACGTTCGACGTGCTGGTCGGGATCAACCTGCTGCGCGAGGGCCTCGACATTCCGGAAG
TGTCGCTCGTCGCGATTCTCGATGCGGACAAGGAGGGCTTCCTGCGCGCCGAGCGCTCGCTGATCCAGACGATCGGCCGC
GCGGCGCGCAACGTGAACGGCAAGGCGCTCCTGTACGCGGACCGGATCACCGATTCGATGCGCCGCGCGATCGACGAGAC
CGAGCGCCGCCGCGCAAAGCAGATCGCATACAACGAAAAGATGGGCATTACGCCGCGCGGCGTCGTGAAGCGGATCAAGG
ACATCATCGATGGCGTGTACAACGCCGACGAGGCGCGCGCCGAGCTGAAGGAGGCGCAGCAGCGCGCGAAATTCGAGGAC
ATGTCCGAGAAGCAGATCGCGAAGGAAATCAAGCGGCTCGAAAAGCAGATGGCCGATTACGCGAAAAATCTCGAGTTCGA
GAAAGCCGCGCAGACGCGCGACCAGCTCGCGCTGCTGCGCGAACGGGTGTTCGGCGCGAATGTCGGCGATCACGTGAGCG
GGGGCGAGTGA

Upstream 100 bases:

>100_bases
TTCGGTCAGCCAATCCCGAGCGCGGCGACGCGGAGCCGGCCGGGCGTCGAAGCGCTAGAATGATCCTTTGCCCGTTTCGG
CCCGCCGCCTCCGCATCCAC

Downstream 100 bases:

>100_bases
GGGCCCCCGCGGCGCCGCGCCGCAGTCGTTAATCTCGCTGTAAGCCTTGTCGGATCAGGGATTTAGCGGCATCTCCATTT
GTTTCGGAGGACGTTCGGTG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRPA
IVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVA
TVSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
VDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQRTRFDLEMLQEL
GFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFP
EFERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLITVLTKRMAEQ
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFED
MSEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE

Sequences:

>Translated_696_residues
MSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRPA
IVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVA
TVSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
VDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQRTRFDLEMLQEL
GFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFP
EFERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLITVLTKRMAEQ
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFED
MSEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE
>Mature_695_residues
SEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGVTGSGKTYTMANTIARLGRPAI
VFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVAT
VSAIYGIGNPSEYHQMILTLRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEV
DTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKLVEAQRLEQRTRFDLEMLQELG
FCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFPE
FERKMRQVVFVSATPADYEQRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLITVLTKRMAEQL
TEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRA
ARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDM
SEKQIAKEIKRLEKQMADYAKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=66.1698956780924, Blast_Score=876, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.4527687296417, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_BURMA (Q62CK6)

Other databases:

- EMBL:   CP000011
- RefSeq:   YP_105572.1
- ProteinModelPortal:   Q62CK6
- GeneID:   3086196
- GenomeReviews:   CP000011_GR
- KEGG:   bma:BMAA0880
- TIGR:   BMAA0880
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q62CK6
- ProtClustDB:   PRK05298
- BioCyc:   BMAL243160:BMA_A0880-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 79429; Mature: 79298

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGV
CCCCCCCCHHCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCC
TGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEA
CCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILT
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEEE
LRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
EECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCC
VDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKL
CCEEEECCCHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDES
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEEECCC
HVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFPEFERKMRQVVFVSATPADYE
CEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHEEEEECCCCCHH
QRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLITVLTKRMAEQ
HHHCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHH
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEK
ECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQIAKEIKRLEKQMADY
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SEHHSDTRDDLDESKFVTFEGSPFQLYQPYPPSGDQPTAIATLVEGVEDGLSFQTLLGV
CCCCCCCHHCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCC
TGSGKTYTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEA
CCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILT
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEEE
LRTGDKIGQREVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDE
EECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCC
VDTLHLFDPLTGRVRQKIPRFTVYPSSHYVTPRETVMRAVETIKDELRERLEFFHRDGKL
CCEEEECCCHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDES
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEEECCC
HVLIGQLNGMYNGDRARKENLVDYGFRLPSALDNRPLKFPEFERKMRQVVFVSATPADYE
CEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHEEEEECCCCCHH
QRVSGQTAEQVVRPTGLVDPQIEVRPASTQVDDVLSEITERVKANERVLITVLTKRMAEQ
HHHCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHH
LTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAIL
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNVNGKALLYADRITDSMRRAIDETERRRAKQIAYNEK
ECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQIAKEIKRLEKQMADY
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AKNLEFEKAAQTRDQLALLRERVFGANVGDHVSGGE
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA