BacMap

Definition	Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession	NC_009079
Length	2,352,693

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The map label for this gene is bdhA-2 [H]

Identifier: 126446750

GI number: 126446750

Start: 873117

End: 873905

Strand: Reverse

Name: bdhA-2 [H]

Synonym: BMA10247_A0918

Alternate gene names: 126446750

Gene position: 873905-873117 (Counterclockwise)

Preceding gene: 126446348

Following gene: 262192882

Centisome position: 37.14

GC content: 65.91

Gene sequence:

>789_bases
ATGACTTCGAACTTGAACGGGAAGGCGGCCATCGTGACGGGCGCGGCGAGCGGCATCGGCAAGGAAATCGCGCTGGAGCT
CGCGCGCGCGGGCGCGGCGGTGGCGATCGCCGATCTGAACCAGGACGGCGCGAACGCGGTGGCCGAGCTCATCGAGCAGG
CGGGCGGCCGGGCGATCGGCGTGGCGATGGACGTGACGAACGAGGACGCGGTGAACGCCGGCATCGACAAGGTCGCCCAG
ACGTTCAGCTCGGTCGACATTCTCGTGTCGAACGCGGGCATCCAGATCGTCAATCCGATCGAGAACTATGCGTTCGCCGA
CTGGAAGAAGATGCAGGCGATTCACGTCGACGGCGCGTTCCTGACGACGAAGGCCGCGCTCAAGCACATGTACAAGGACG
ATCGCGGCGGAGTGGTGATCTACATGGGCTCGGTGCATTCGCACGAGGCGTCGCCGCTGAAGTCGGCGTACGTGACGGCC
AAGCACGGGCTGCTGGGGCTTGCGCGCGTGCTGGCGAAGGAAGGCGCGAAGCACAACGTGCGCTCGCATGTGGTGTGCCC
GGGCTTCGTGCGCACGCCGCTCGTCGACAAGCAGATTCCGGAGCAGGCCAAGGAGCTCGGCATCAGCGAAGAGGAGGTGG
TGAAGAAGGTGATGCTCGGCCAGACGGTGGACGGCGTGTTCACGACGGTCGAGGACGTCGCGAAGACGGTGCTGTTCCTG
TCCGCGTTCCCGAGCGCGGCGCTCACCGGCCAGTCGTTCGTCGTCAGCCACGGCTGGTTCATGCAGTAA

Upstream 100 bases:

>100_bases
CCGCGCGGCGATAGCCGGCCATTCGGCCTATGCTGTCCGGCAGACTGGATCGAGGCCGGACGCGATGCTTTCATTGACTT
AACTGATGGAGACTTGGGGA

Downstream 100 bases:

>100_bases
GCGGCACGGAAGCGCGTGCCGAAGCGTGGCCTGGCGTACGGCCGCTTCGCTTCGCGTCGTTTTGCGTCGTTTCGGCCTTC
TCGGCTCTCCGGCAACGGGC

Product: 3-hydroxybutyrate dehydrogenase

Products: NA

Alternate protein names: BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTSNLNGKAAIVTGAASGIGKEIALELARAGAAVAIADLNQDGANAVAELIEQAGGRAIGVAMDVTNEDAVNAGIDKVAQ
TFSSVDILVSNAGIQIVNPIENYAFADWKKMQAIHVDGAFLTTKAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTA
KHGLLGLARVLAKEGAKHNVRSHVVCPGFVRTPLVDKQIPEQAKELGISEEEVVKKVMLGQTVDGVFTTVEDVAKTVLFL
SAFPSAALTGQSFVVSHGWFMQ

Sequences:

>Translated_262_residues
MTSNLNGKAAIVTGAASGIGKEIALELARAGAAVAIADLNQDGANAVAELIEQAGGRAIGVAMDVTNEDAVNAGIDKVAQ
TFSSVDILVSNAGIQIVNPIENYAFADWKKMQAIHVDGAFLTTKAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTA
KHGLLGLARVLAKEGAKHNVRSHVVCPGFVRTPLVDKQIPEQAKELGISEEEVVKKVMLGQTVDGVFTTVEDVAKTVLFL
SAFPSAALTGQSFVVSHGWFMQ
>Mature_261_residues
TSNLNGKAAIVTGAASGIGKEIALELARAGAAVAIADLNQDGANAVAELIEQAGGRAIGVAMDVTNEDAVNAGIDKVAQT
FSSVDILVSNAGIQIVNPIENYAFADWKKMQAIHVDGAFLTTKAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTAK
HGLLGLARVLAKEGAKHNVRSHVVCPGFVRTPLVDKQIPEQAKELGISEEEVVKKVMLGQTVDGVFTTVEDVAKTVLFLS
AFPSAALTGQSFVVSHGWFMQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=269, Percent_Identity=29.7397769516729, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4504505, Length=197, Percent_Identity=34.5177664974619, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=30.5555555555556, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI31542939, Length=244, Percent_Identity=31.1475409836066, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=30.2325581395349, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI142976729, Length=220, Percent_Identity=27.7272727272727, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI19923817, Length=268, Percent_Identity=27.9850746268657, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI210032110, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310128830, Length=234, Percent_Identity=29.4871794871795, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310115468, Length=234, Percent_Identity=29.4871794871795, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=30.859375, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI20149619, Length=253, Percent_Identity=26.8774703557312, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI209862901, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19923983, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=26.953125, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=30.7291666666667, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=34.1176470588235, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI40807363, Length=245, Percent_Identity=24.0816326530612, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758504, Length=210, Percent_Identity=27.6190476190476, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI10190704, Length=258, Percent_Identity=25.968992248062, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503301, Length=241, Percent_Identity=26.1410788381743, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI157739938, Length=260, Percent_Identity=25, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7706318, Length=200, Percent_Identity=27.5, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI7657478, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40254986, Length=194, Percent_Identity=28.8659793814433, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4503817, Length=194, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI126723191, Length=202, Percent_Identity=29.7029702970297, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788459, Length=257, Percent_Identity=32.6848249027237, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=30.6201550387597, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789208, Length=262, Percent_Identity=28.2442748091603, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=31.7647058823529, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=29.8449612403101, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI87082160, Length=261, Percent_Identity=28.735632183908, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790717, Length=200, Percent_Identity=28, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=29.5019157088123, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789378, Length=196, Percent_Identity=30.6122448979592, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI2367175, Length=190, Percent_Identity=33.1578947368421, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787526, Length=203, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=28.6259541984733, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=200, Percent_Identity=36, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17561402, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=263, Percent_Identity=30.0380228136882, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17564282, Length=189, Percent_Identity=30.6878306878307, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=263, Percent_Identity=26.615969581749, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=27.2373540856031, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193203117, Length=259, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=28.5171102661597, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17538182, Length=218, Percent_Identity=34.8623853211009, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982365, Length=136, Percent_Identity=34.5588235294118, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=28.1746031746032, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=24.6153846153846, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115534660, Length=241, Percent_Identity=26.5560165975104, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=273, Percent_Identity=24.5421245421245, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=134, Percent_Identity=37.3134328358209, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=27.0408163265306, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=240, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=268, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=277, Percent_Identity=26.7148014440433, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=213, Percent_Identity=27.2300469483568, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=26.1992619926199, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=26.2172284644195, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=24.9056603773585, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=26.4925373134328, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=27.5590551181102, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=26.865671641791, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=25, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=239, Percent_Identity=31.7991631799163, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324126, Length=263, Percent_Identity=24.7148288973384, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=27.319587628866, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18859837, Length=192, Percent_Identity=35.4166666666667, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24639444, Length=258, Percent_Identity=27.5193798449612, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24665243, Length=197, Percent_Identity=32.994923857868, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221331218, Length=197, Percent_Identity=32.994923857868, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24665247, Length=198, Percent_Identity=32.8282828282828, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221331216, Length=198, Percent_Identity=32.8282828282828, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=27.1317829457364, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24649181, Length=190, Percent_Identity=33.1578947368421, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24648944, Length=240, Percent_Identity=29.5833333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=29.2929292929293, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737361, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=29.5275590551181, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=31.1538461538462, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640492, Length=181, Percent_Identity=27.0718232044199, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641232, Length=221, Percent_Identity=28.0542986425339, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581726, Length=193, Percent_Identity=26.4248704663212, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357673, Length=201, Percent_Identity=30.3482587064677, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281364892, Length=236, Percent_Identity=25.4237288135593, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355631, Length=173, Percent_Identity=28.3236994219653, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21356301, Length=240, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=264, Percent_Identity=26.8939393939394, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571526, Length=264, Percent_Identity=28.030303030303, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28574402, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510726, Length=194, Percent_Identity=25.7731958762887, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584744, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007234, Length=197, Percent_Identity=29.4416243654822, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011294
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.30 [H]

Molecular weight: Translated: 27523; Mature: 27392

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNLNGKAAIVTGAASGIGKEIALELARAGAAVAIADLNQDGANAVAELIEQAGGRAIG
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEE
VAMDVTNEDAVNAGIDKVAQTFSSVDILVSNAGIQIVNPIENYAFADWKKMQAIHVDGAF
EEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCEEEECCHHHHHHHCHHHCEEEEECCHH
LTTKAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTAKHGLLGLARVLAKEGAKHNV
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RSHVVCPGFVRTPLVDKQIPEQAKELGISEEEVVKKVMLGQTVDGVFTTVEDVAKTVLFL
CCCEECCCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SAFPSAALTGQSFVVSHGWFMQ
HHCCCHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
TSNLNGKAAIVTGAASGIGKEIALELARAGAAVAIADLNQDGANAVAELIEQAGGRAIG
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEE
VAMDVTNEDAVNAGIDKVAQTFSSVDILVSNAGIQIVNPIENYAFADWKKMQAIHVDGAF
EEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCEEEECCHHHHHHHCHHHCEEEEECCHH
LTTKAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTAKHGLLGLARVLAKEGAKHNV
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RSHVVCPGFVRTPLVDKQIPEQAKELGISEEEVVKKVMLGQTVDGVFTTVEDVAKTVLFL
CCCEECCCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SAFPSAALTGQSFVVSHGWFMQ
HHCCCHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9922248; 11481431 [H]