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The map label for this gene is mutL

Identifier: 239617975

GI number: 239617975

Start: 1719260

End: 1721068

Strand: Reverse

Name: mutL

Synonym: Kole_1603

Alternate gene names: 239617975

Gene position: 1721068-1719260 (Counterclockwise)

Preceding gene: 239617976

Following gene: 239617974

Centisome position: 74.76

GC content: 43.5

Gene sequence:

>1809_bases
ATGAAAATACATGAATTACCTCAGGAAGTGATTTTGAAGATCGCGGCAGGTGAGGTTGTTACCGGTTGTTTCTCAGTGGT
AAAGGAGCTTGTGGAAAACGCTCTCGACGCAGAAGCTACAACAGTGGAAGTAGAGATCAAAGCTGGGGGAAAAGAATATA
TAAGGGTTTCGGATAACGGTATTGGCATGCTGCCCGAGGAACTCAAAATGGCTATAAAGCCACACACCACAAGCAAAATT
CAGTGCATAGAAGATCTGGAAAGAATTCTGACATACGGATTTCGTGGCGAAGCGCTCTCAACCATCTCCAGCGTTTCAAG
AATGCGTATTTCATCGATGCCTGATAACGCTGATTTAGGGTTGACTATCGAAATCTCTGGCGGGAAAATCGTCAGGGAAA
AGTCATATATCGGACCAAAAGGGACAACCGTTGAGGTTTATGACCTGCTTTTCAATACACCTGCCAGAAGAAAATTCCTG
AAATCTCAAAGAGTTGAAGGAAGAATGGTTACAGAGATCGTGCAAAGGTTCATTCTGGCTATCCCGGACGCCGGATTCAA
ATACATTCGCGACGGTGAACTTATTTACGATCTCACCCCTGCAGAAAGAATTCTTGAAAGAATACCTGTAGTTTTTCCAG
AACTCTCTACAACCGACTTGCTGGAGGTTAAAGAAGAAACCAGCGGGATCTCAATAACAGGCTACATCACTTTCCCAGAA
AGAACCCGGTTCAACAGACTCGGTGAGATGGTGTTTGTCAACGGGCGTTATGTTAGGCAACCGGAGCTAAATTACGCCAT
AGAAAAAGGCTACGGAGAATCACTTGAAAAAGGGCGTTTCCCCTTCGCTATTCTGTTCATTTCGGTAAATCCGGAAATGA
TAGACGTAAACATCCACCCTCAAAAACTCGAGGTTCGTTTCTCCAACCCTTCCCTTGTCTTTGACGCAATCAAAAGAGCC
GTCAGAAATACTTTGCGAACGTCCGGAACATCAATCCTTCGCATAGAGAAAAGACCGTTCCCAGGTAGTTCAACCAACTA
CTCCGGAATACAACAGGACACTAAAAAACAAGAGTCTGACAACCCAGAAAAAGCCCGGGGATACGGAACACATTTGAGAG
AAACACACTGGGAACAGCGCGATCATTTTGAGAAAAGAAAAGTACCTCTACACTACCAACCAGATAATGAGTTGCTGTTG
AATATCGAAAGAACTGCTTCCAGACGCTTCGAAAAAACAGAAGCAAAAGAAACGGGTGAACCAAGATTATTCGGAGTATT
CGGCGAGCGTTATATCCTCGCCGAAACAAAAGATGGTCTACTGATAGTCGACCAGCACGCTGCACATGAAAGGCTCATTT
ATGAAAAATTAAAGAAAGCTGCAAAGATACAAAGTCAGAAATTACTTTCGCCCATCAGGTTAACCCTTGAGGATTCAAGG
AAGTCCCTTTTAAGAGAAAAGAAAAATGATGTTGAAAAACTGGGATTTCAAATTTCCTTCGAAGGTGATAGAATCTTTTT
GACGGGTATTCCTTCAATACTTTCGGAAAGTGTTGCCGTTAACGCATTGAACGAAGTCTTAGACGAGCTAAGGCTGGAAG
GACTCGAGGAACCCGAGAAGATTTTCGACCATCTTTTGTCAACGCTTGCGTGCAAATCAGCGATAAAAACCGGTGATCGT
TTGAGCGAGAGTGAAGCTAAAGAACTTTTAGAAAAGTTACTGGAAGAAGAGATACTGTTCTGTCCACACGGAAGGCCGGT
ATCGATGTTGATCCGATTTAAAGATCTGGACAGACACTTCTCAAGGTAA

Upstream 100 bases:

>100_bases
CAATGTGTGAGGGTATCGACTCGCTGAATGTTGCCGCTTCAGCAGCAATAATGCTTTTCGAGTATCGAAGGCAATGGGCT
TTGAGAGAAGGTGTGAATCC

Downstream 100 bases:

>100_bases
ACGCATAACCGGACAACAACGTCGGGATCAGGGAAACCGGTGAAAATCCGGTGCGGGCCCGCCACTGTGAGTGGGGACAA
AATCCGCAATTATGCCACTG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MKIHELPQEVILKIAAGEVVTGCFSVVKELVENALDAEATTVEVEIKAGGKEYIRVSDNGIGMLPEELKMAIKPHTTSKI
QCIEDLERILTYGFRGEALSTISSVSRMRISSMPDNADLGLTIEISGGKIVREKSYIGPKGTTVEVYDLLFNTPARRKFL
KSQRVEGRMVTEIVQRFILAIPDAGFKYIRDGELIYDLTPAERILERIPVVFPELSTTDLLEVKEETSGISITGYITFPE
RTRFNRLGEMVFVNGRYVRQPELNYAIEKGYGESLEKGRFPFAILFISVNPEMIDVNIHPQKLEVRFSNPSLVFDAIKRA
VRNTLRTSGTSILRIEKRPFPGSSTNYSGIQQDTKKQESDNPEKARGYGTHLRETHWEQRDHFEKRKVPLHYQPDNELLL
NIERTASRRFEKTEAKETGEPRLFGVFGERYILAETKDGLLIVDQHAAHERLIYEKLKKAAKIQSQKLLSPIRLTLEDSR
KSLLREKKNDVEKLGFQISFEGDRIFLTGIPSILSESVAVNALNEVLDELRLEGLEEPEKIFDHLLSTLACKSAIKTGDR
LSESEAKELLEKLLEEEILFCPHGRPVSMLIRFKDLDRHFSR

Sequences:

>Translated_602_residues
MKIHELPQEVILKIAAGEVVTGCFSVVKELVENALDAEATTVEVEIKAGGKEYIRVSDNGIGMLPEELKMAIKPHTTSKI
QCIEDLERILTYGFRGEALSTISSVSRMRISSMPDNADLGLTIEISGGKIVREKSYIGPKGTTVEVYDLLFNTPARRKFL
KSQRVEGRMVTEIVQRFILAIPDAGFKYIRDGELIYDLTPAERILERIPVVFPELSTTDLLEVKEETSGISITGYITFPE
RTRFNRLGEMVFVNGRYVRQPELNYAIEKGYGESLEKGRFPFAILFISVNPEMIDVNIHPQKLEVRFSNPSLVFDAIKRA
VRNTLRTSGTSILRIEKRPFPGSSTNYSGIQQDTKKQESDNPEKARGYGTHLRETHWEQRDHFEKRKVPLHYQPDNELLL
NIERTASRRFEKTEAKETGEPRLFGVFGERYILAETKDGLLIVDQHAAHERLIYEKLKKAAKIQSQKLLSPIRLTLEDSR
KSLLREKKNDVEKLGFQISFEGDRIFLTGIPSILSESVAVNALNEVLDELRLEGLEEPEKIFDHLLSTLACKSAIKTGDR
LSESEAKELLEKLLEEEILFCPHGRPVSMLIRFKDLDRHFSR
>Mature_602_residues
MKIHELPQEVILKIAAGEVVTGCFSVVKELVENALDAEATTVEVEIKAGGKEYIRVSDNGIGMLPEELKMAIKPHTTSKI
QCIEDLERILTYGFRGEALSTISSVSRMRISSMPDNADLGLTIEISGGKIVREKSYIGPKGTTVEVYDLLFNTPARRKFL
KSQRVEGRMVTEIVQRFILAIPDAGFKYIRDGELIYDLTPAERILERIPVVFPELSTTDLLEVKEETSGISITGYITFPE
RTRFNRLGEMVFVNGRYVRQPELNYAIEKGYGESLEKGRFPFAILFISVNPEMIDVNIHPQKLEVRFSNPSLVFDAIKRA
VRNTLRTSGTSILRIEKRPFPGSSTNYSGIQQDTKKQESDNPEKARGYGTHLRETHWEQRDHFEKRKVPLHYQPDNELLL
NIERTASRRFEKTEAKETGEPRLFGVFGERYILAETKDGLLIVDQHAAHERLIYEKLKKAAKIQSQKLLSPIRLTLEDSR
KSLLREKKNDVEKLGFQISFEGDRIFLTGIPSILSESVAVNALNEVLDELRLEGLEEPEKIFDHLLSTLACKSAIKTGDR
LSESEAKELLEKLLEEEILFCPHGRPVSMLIRFKDLDRHFSR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=345, Percent_Identity=32.463768115942, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI310128478, Length=369, Percent_Identity=27.9132791327913, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4505913, Length=369, Percent_Identity=27.9132791327913, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4505911, Length=342, Percent_Identity=28.0701754385965, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI189458898, Length=342, Percent_Identity=28.0701754385965, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI189458896, Length=325, Percent_Identity=28.6153846153846, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI263191589, Length=251, Percent_Identity=27.4900398406374, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI91992162, Length=366, Percent_Identity=25.4098360655738, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI91992160, Length=366, Percent_Identity=25.4098360655738, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI310128480, Length=326, Percent_Identity=26.3803680981595, Blast_Score=97, Evalue=6e-20,
Organism=Escherichia coli, GI1790612, Length=582, Percent_Identity=29.7250859106529, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=32.0754716981132, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=342, Percent_Identity=29.5321637426901, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=351, Percent_Identity=32.4786324786325, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=27.3480662983425, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=173, Percent_Identity=30.635838150289, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=166, Percent_Identity=33.7349397590361, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136968, Length=350, Percent_Identity=31.4285714285714, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17136970, Length=180, Percent_Identity=35.5555555555556, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_KOSOT (C5CF28)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941297.1
- GeneID:   7967835
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_1603
- ProtClustDB:   CLSK2541123
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 68523; Mature: 68523

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHELPQEVILKIAAGEVVTGCFSVVKELVENALDAEATTVEVEIKAGGKEYIRVSDNG
CCCHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCC
IGMLPEELKMAIKPHTTSKIQCIEDLERILTYGFRGEALSTISSVSRMRISSMPDNADLG
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCE
LTIEISGGKIVREKSYIGPKGTTVEVYDLLFNTPARRKFLKSQRVEGRMVTEIVQRFILA
EEEEECCCEEEEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
IPDAGFKYIRDGELIYDLTPAERILERIPVVFPELSTTDLLEVKEETSGISITGYITFPE
CCCCCCEEEECCCEEEECCHHHHHHHHCCEECCCCCCHHHHHHHHCCCCEEEEEEEECCC
RTRFNRLGEMVFVNGRYVRQPELNYAIEKGYGESLEKGRFPFAILFISVNPEMIDVNIHP
HHHHHHCCCEEEECCEEEECCCCCHHHHCCCCCHHHCCCCCEEEEEEEECCEEEEEEECC
QKLEVRFSNPSLVFDAIKRAVRNTLRTSGTSILRIEKRPFPGSSTNYSGIQQDTKKQESD
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCC
NPEKARGYGTHLRETHWEQRDHFEKRKVPLHYQPDNELLLNIERTASRRFEKTEAKETGE
CCHHHCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEHHHHHHHHHHHHHCCCC
PRLFGVFGERYILAETKDGLLIVDQHAAHERLIYEKLKKAAKIQSQKLLSPIRLTLEDSR
CEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLLREKKNDVEKLGFQISFEGDRIFLTGIPSILSESVAVNALNEVLDELRLEGLEEPEK
HHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IFDHLLSTLACKSAIKTGDRLSESEAKELLEKLLEEEILFCPHGRPVSMLIRFKDLDRHF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEECCCCCCCEEEEEEHHHHHHH
SR
CC
>Mature Secondary Structure
MKIHELPQEVILKIAAGEVVTGCFSVVKELVENALDAEATTVEVEIKAGGKEYIRVSDNG
CCCHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCC
IGMLPEELKMAIKPHTTSKIQCIEDLERILTYGFRGEALSTISSVSRMRISSMPDNADLG
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCE
LTIEISGGKIVREKSYIGPKGTTVEVYDLLFNTPARRKFLKSQRVEGRMVTEIVQRFILA
EEEEECCCEEEEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
IPDAGFKYIRDGELIYDLTPAERILERIPVVFPELSTTDLLEVKEETSGISITGYITFPE
CCCCCCEEEECCCEEEECCHHHHHHHHCCEECCCCCCHHHHHHHHCCCCEEEEEEEECCC
RTRFNRLGEMVFVNGRYVRQPELNYAIEKGYGESLEKGRFPFAILFISVNPEMIDVNIHP
HHHHHHCCCEEEECCEEEECCCCCHHHHCCCCCHHHCCCCCEEEEEEEECCEEEEEEECC
QKLEVRFSNPSLVFDAIKRAVRNTLRTSGTSILRIEKRPFPGSSTNYSGIQQDTKKQESD
CEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCC
NPEKARGYGTHLRETHWEQRDHFEKRKVPLHYQPDNELLLNIERTASRRFEKTEAKETGE
CCHHHCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEHHHHHHHHHHHHHCCCC
PRLFGVFGERYILAETKDGLLIVDQHAAHERLIYEKLKKAAKIQSQKLLSPIRLTLEDSR
CEEEEECCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLLREKKNDVEKLGFQISFEGDRIFLTGIPSILSESVAVNALNEVLDELRLEGLEEPEK
HHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IFDHLLSTLACKSAIKTGDRLSESEAKELLEKLLEEEILFCPHGRPVSMLIRFKDLDRHF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEECCCCCCCEEEEEEHHHHHHH
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA