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The map label for this gene is nuoE [H]

Identifier: 239616588

GI number: 239616588

Start: 202244

End: 202738

Strand: Direct

Name: nuoE [H]

Synonym: Kole_0180

Alternate gene names: 239616588

Gene position: 202244-202738 (Clockwise)

Preceding gene: 239616579

Following gene: 239616589

Centisome position: 8.79

GC content: 46.67

Gene sequence:

>495_bases
TTGTCACACGTTGGTTGCGAGGATCATGAAAAATTATACACCCAATTGAATGAGTACATAGACCAGGTAAAAGAAGAACC
GGGTGTGCTCATCAACGTTCTTCACAAAGCTCAGGAACTTTTTGGTTACCTCTCTGAAGAACTCCAACAGCATGTTGCTG
ATAAGTTAGGTGTGCCTCTCAGTCAGGTACATGGAGTCGTGACGTTCTACAACTTCTTCACCACCAAACCGAAGGGGAAA
CACCAGGTCAAAATCTGCCTCGGAACCGCTTGTTACGTTAGAGGGGCAGATAGAATTCTCGAACGCTTCAAAGAAGAACT
CGGGGTGGATTTAGATGAACCCACAAGTGACGGCCTTTTTTCCTTACACGGTGTAAGGTGCCTCGGCGCCTGCAGTATGG
CACCCGTTGTTCTCGTTGGGGAACGCGACTTTTATGGTAAAGTAACACCAGATGAGGTTTCAGCGATAATCAAAAAGTAC
AGGGGGGAGAAGTAA

Upstream 100 bases:

>100_bases
TCCATTTTTTATAGTTGCATGTTATAATCCAAGTGAAATAAATAACATAAATAATAACATAGCCCTATCGTATAAGAATT
TACTCAAGGAGGTGCAGGGT

Downstream 100 bases:

>100_bases
TGGCAAAGATCAAGAGCCTCGAAGAACTCATGAAAATAAAGGAGAACGCACTGAAAGAATTGAAAATGAGGGACTCTGAA
AAACGCGGAAAAATTATCGT

Product: NADH dehydrogenase (ubiquinone) 24 kDa subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSHVGCEDHEKLYTQLNEYIDQVKEEPGVLINVLHKAQELFGYLSEELQQHVADKLGVPLSQVHGVVTFYNFFTTKPKGK
HQVKICLGTACYVRGADRILERFKEELGVDLDEPTSDGLFSLHGVRCLGACSMAPVVLVGERDFYGKVTPDEVSAIIKKY
RGEK

Sequences:

>Translated_164_residues
MSHVGCEDHEKLYTQLNEYIDQVKEEPGVLINVLHKAQELFGYLSEELQQHVADKLGVPLSQVHGVVTFYNFFTTKPKGK
HQVKICLGTACYVRGADRILERFKEELGVDLDEPTSDGLFSLHGVRCLGACSMAPVVLVGERDFYGKVTPDEVSAIIKKY
RGEK
>Mature_163_residues
SHVGCEDHEKLYTQLNEYIDQVKEEPGVLINVLHKAQELFGYLSEELQQHVADKLGVPLSQVHGVVTFYNFFTTKPKGKH
QVKICLGTACYVRGADRILERFKEELGVDLDEPTSDGLFSLHGVRCLGACSMAPVVLVGERDFYGKVTPDEVSAIIKKYR
GEK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=137, Percent_Identity=36.4963503649635, Blast_Score=98, Evalue=4e-21,
Organism=Escherichia coli, GI1788621, Length=138, Percent_Identity=29.7101449275362, Blast_Score=80, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17561328, Length=151, Percent_Identity=36.4238410596026, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18859877, Length=137, Percent_Identity=36.4963503649635, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355353, Length=158, Percent_Identity=31.6455696202532, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18384; Mature: 18253

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHVGCEDHEKLYTQLNEYIDQVKEEPGVLINVLHKAQELFGYLSEELQQHVADKLGVPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SQVHGVVTFYNFFTTKPKGKHQVKICLGTACYVRGADRILERFKEELGVDLDEPTSDGLF
HHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
SLHGVRCLGACSMAPVVLVGERDFYGKVTPDEVSAIIKKYRGEK
HHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHVGCEDHEKLYTQLNEYIDQVKEEPGVLINVLHKAQELFGYLSEELQQHVADKLGVPL
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SQVHGVVTFYNFFTTKPKGKHQVKICLGTACYVRGADRILERFKEELGVDLDEPTSDGLF
HHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
SLHGVRCLGACSMAPVVLVGERDFYGKVTPDEVSAIIKKYRGEK
HHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA