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The map label for this gene is hutH [H]

Identifier: 239616535

GI number: 239616535

Start: 142019

End: 143515

Strand: Direct

Name: hutH [H]

Synonym: Kole_0127

Alternate gene names: 239616535

Gene position: 142019-143515 (Clockwise)

Preceding gene: 239616534

Following gene: 239616541

Centisome position: 6.17

GC content: 47.03

Gene sequence:

>1497_bases
TTGGTAATTATCAATGGTAACGACCTAACAGTCGAACAAGTCTACTCCGTTGCCTTTCATGGTGAAGAAGTCAGGATAGC
GGAATCAACTCTTGACGAATTGAAAAAAAAGCGACTTTTTCTCGAGGAAATGCACAATAAAGATGTCATTTACGGCATTA
ACACTGGGTTCGGAATTCTCGCAGACAAGCGAATATCGGACGACGATCTCGAAAAGCTTCAGGTAAACATAGTCAGATCT
CACGCGGCTGGTGTGGGAGAACCTCTCAAAACCGAGCTTGTAAGGGCTATCATGCTCGTTCGAGCTAACTCTCTCTGTAA
AGGTTACTCTGCTGTAAGGCCGGAGGTCGTTCAACAGCTTGTCAATTTCCTGAACAAAGGCATAGTACCAATTGTACCGG
AACAGGGATCTGTGGGGGCAAGCGGGGATCTCGCACCATTAGCGCACATAGCGCTAGCTTTGATCGGAGATGGAGAAGTA
TTCCATAATGGAAGAAAAGAAAAAGCGCTGGAAGCCATTCAAGCTGAAGGTCTTAAGCCTCTAACACTGAAAACCAAAGA
AGGATTGAGCTTGCTCAATGGGACAGCCTTCATGGCTGGAATAGGCGCATGCAGCGTGCATATAGCCGAAAAGATGTTCG
ATAAAGCTATCCTTGTAGCCGCTATGTCGGTGGACGCCCTGATGGGAAGCACTTCTCCTTTTGATCCAAGGATTCAGGAA
GCGCGACCCCATCCCGGCCAAAAATATGTTGCAAAAAAACTGAGAGAATATCTTGAAGGAAGCGAGATAAGGAGATCTCA
CCTTCACTGTGATAAAGTACAGGACGCGTACACCTTAAGAACCATCCCGCAGGTTTACGGCGCTGTTTACGACACCCTTC
AATACGTTAAATCCGTAATTACAAGAGAAATAAATTCCGCAACAGATAATCCTCTGATTTTTGATAACGGTGACGTGATC
TCCGGAGGAAACTTTCACGGGGAACCGATAGCGCTGGTACTCGATTTTCTGTCCATTGCCCTTACCGATATGGCCAACAT
GATGGAAAGGCGCGTCGACAGGCTCGTAAACCCAAAACTCAACAATTTTCCCGCTTTCCTTACCCGGGGCAAAGAAGGTC
TGAACTCCGGCTACATGATCTGGCAATACACTGCGGCAGCGCTGGCTTCTGAGAACAAAACCCTCGCGCATCCCGCGTCG
GCCGATACCATCCCCACATCCGGATTTCAGGAAGATCATGTTAGCATGGGTGCCTGGGGAGCGCGAAAGCTCTGGAAAAT
CCTAAAAAACTGGAGCAATATCCTGGCAATTGAAACCGTCCTCGCCTACAGGGCTCTTTCTTTCAGGAAACCAAAGAAAT
CCGGAAAGGCGATTGAAGGGTTTTTCAAAGAACTCTCAAATATCCTTGAAGAACACGTGGAAGACCGTTATTTCGGGAAA
GAATTCGCGGATGCGAGGGATTTCTTGTTAAAATCGCAAGGACTTAAAGGGTTTTAA

Upstream 100 bases:

>100_bases
GTCGTTCTTGCTTTCACGAAAATCCTGACAACGGTGGAGAAAAAAGTCCGTATACCTGGTTTAGAATGGAGTAGATAGCA
TATCACTGGAGGTGTCAGAC

Downstream 100 bases:

>100_bases
AGTTTCAATAAATAAATAAAAAAAGGGGGAGCAAAGCTCCCCTTTTTTGGTGCCGGAGGCGGGACTTGAACCCGCACAGG
CGTAATGCCCACATGATCCT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MVIINGNDLTVEQVYSVAFHGEEVRIAESTLDELKKKRLFLEEMHNKDVIYGINTGFGILADKRISDDDLEKLQVNIVRS
HAAGVGEPLKTELVRAIMLVRANSLCKGYSAVRPEVVQQLVNFLNKGIVPIVPEQGSVGASGDLAPLAHIALALIGDGEV
FHNGRKEKALEAIQAEGLKPLTLKTKEGLSLLNGTAFMAGIGACSVHIAEKMFDKAILVAAMSVDALMGSTSPFDPRIQE
ARPHPGQKYVAKKLREYLEGSEIRRSHLHCDKVQDAYTLRTIPQVYGAVYDTLQYVKSVITREINSATDNPLIFDNGDVI
SGGNFHGEPIALVLDFLSIALTDMANMMERRVDRLVNPKLNNFPAFLTRGKEGLNSGYMIWQYTAAALASENKTLAHPAS
ADTIPTSGFQEDHVSMGAWGARKLWKILKNWSNILAIETVLAYRALSFRKPKKSGKAIEGFFKELSNILEEHVEDRYFGK
EFADARDFLLKSQGLKGF

Sequences:

>Translated_498_residues
MVIINGNDLTVEQVYSVAFHGEEVRIAESTLDELKKKRLFLEEMHNKDVIYGINTGFGILADKRISDDDLEKLQVNIVRS
HAAGVGEPLKTELVRAIMLVRANSLCKGYSAVRPEVVQQLVNFLNKGIVPIVPEQGSVGASGDLAPLAHIALALIGDGEV
FHNGRKEKALEAIQAEGLKPLTLKTKEGLSLLNGTAFMAGIGACSVHIAEKMFDKAILVAAMSVDALMGSTSPFDPRIQE
ARPHPGQKYVAKKLREYLEGSEIRRSHLHCDKVQDAYTLRTIPQVYGAVYDTLQYVKSVITREINSATDNPLIFDNGDVI
SGGNFHGEPIALVLDFLSIALTDMANMMERRVDRLVNPKLNNFPAFLTRGKEGLNSGYMIWQYTAAALASENKTLAHPAS
ADTIPTSGFQEDHVSMGAWGARKLWKILKNWSNILAIETVLAYRALSFRKPKKSGKAIEGFFKELSNILEEHVEDRYFGK
EFADARDFLLKSQGLKGF
>Mature_498_residues
MVIINGNDLTVEQVYSVAFHGEEVRIAESTLDELKKKRLFLEEMHNKDVIYGINTGFGILADKRISDDDLEKLQVNIVRS
HAAGVGEPLKTELVRAIMLVRANSLCKGYSAVRPEVVQQLVNFLNKGIVPIVPEQGSVGASGDLAPLAHIALALIGDGEV
FHNGRKEKALEAIQAEGLKPLTLKTKEGLSLLNGTAFMAGIGACSVHIAEKMFDKAILVAAMSVDALMGSTSPFDPRIQE
ARPHPGQKYVAKKLREYLEGSEIRRSHLHCDKVQDAYTLRTIPQVYGAVYDTLQYVKSVITREINSATDNPLIFDNGDVI
SGGNFHGEPIALVLDFLSIALTDMANMMERRVDRLVNPKLNNFPAFLTRGKEGLNSGYMIWQYTAAALASENKTLAHPAS
ADTIPTSGFQEDHVSMGAWGARKLWKILKNWSNILAIETVLAYRALSFRKPKKSGKAIEGFFKELSNILEEHVEDRYFGK
EFADARDFLLKSQGLKGF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=497, Percent_Identity=42.8571428571429, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=489, Percent_Identity=42.7402862985685, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54940; Mature: 54940

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIINGNDLTVEQVYSVAFHGEEVRIAESTLDELKKKRLFLEEMHNKDVIYGINTGFGIL
CEEECCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEE
ADKRISDDDLEKLQVNIVRSHAAGVGEPLKTELVRAIMLVRANSLCKGYSAVRPEVVQQL
ECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
VNFLNKGIVPIVPEQGSVGASGDLAPLAHIALALIGDGEVFHNGRKEKALEAIQAEGLKP
HHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCC
LTLKTKEGLSLLNGTAFMAGIGACSVHIAEKMFDKAILVAAMSVDALMGSTSPFDPRIQE
EEEECHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ARPHPGQKYVAKKLREYLEGSEIRRSHLHCDKVQDAYTLRTIPQVYGAVYDTLQYVKSVI
CCCCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TREINSATDNPLIFDNGDVISGGNFHGEPIALVLDFLSIALTDMANMMERRVDRLVNPKL
HHHHHCCCCCCEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NNFPAFLTRGKEGLNSGYMIWQYTAAALASENKTLAHPASADTIPTSGFQEDHVSMGAWG
CCCHHHHHCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCH
ARKLWKILKNWSNILAIETVLAYRALSFRKPKKSGKAIEGFFKELSNILEEHVEDRYFGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
EFADARDFLLKSQGLKGF
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVIINGNDLTVEQVYSVAFHGEEVRIAESTLDELKKKRLFLEEMHNKDVIYGINTGFGIL
CEEECCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEE
ADKRISDDDLEKLQVNIVRSHAAGVGEPLKTELVRAIMLVRANSLCKGYSAVRPEVVQQL
ECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHH
VNFLNKGIVPIVPEQGSVGASGDLAPLAHIALALIGDGEVFHNGRKEKALEAIQAEGLKP
HHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCC
LTLKTKEGLSLLNGTAFMAGIGACSVHIAEKMFDKAILVAAMSVDALMGSTSPFDPRIQE
EEEECHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ARPHPGQKYVAKKLREYLEGSEIRRSHLHCDKVQDAYTLRTIPQVYGAVYDTLQYVKSVI
CCCCCCHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TREINSATDNPLIFDNGDVISGGNFHGEPIALVLDFLSIALTDMANMMERRVDRLVNPKL
HHHHHCCCCCCEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NNFPAFLTRGKEGLNSGYMIWQYTAAALASENKTLAHPASADTIPTSGFQEDHVSMGAWG
CCCHHHHHCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCH
ARKLWKILKNWSNILAIETVLAYRALSFRKPKKSGKAIEGFFKELSNILEEHVEDRYFGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
EFADARDFLLKSQGLKGF
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]