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The map label for this gene is aphA [H]

Identifier: 239616432

GI number: 239616432

Start: 29575

End: 30540

Strand: Direct

Name: aphA [H]

Synonym: Kole_0021

Alternate gene names: 239616432

Gene position: 29575-30540 (Clockwise)

Preceding gene: 239616431

Following gene: 239616453

Centisome position: 1.28

GC content: 44.31

Gene sequence:

>966_bases
TTGAAGATTTTTTATGATCGTCGTCATCTCCTGCACATTCCAAAAAAAGAGATGGACAACGGAAAGTGGGTAGAAAATGC
CGATAAACCGGATCGTATCGAAGCGATAAGAGAAAGCCTTGAGAGACACTTTGGCTTTTCTTTCAACGAACCAAGAGACT
ACTATAGCTCTTATCTTTATCTCGTACACGATCATGATTACGTTCACTGGCTGAAGAAAAGGTCAGAAGGAGTCGAGCCA
GGAGAGGAGTACTTTCCAGAGGTTTTTGGATACGATAAGGTTTTCGATACAGGAACACCAATAACAAGAAATTCTTTTTT
TGCTGCATTGAATGCAGTTTCTGCAAGTTTGAATGCTGTGGATGAAATCCTTACGGGTGAGACAATCGTATATGCTCTCT
GCCGCCCACCCGGTCACCATGCTTCCAGCTCCCAGGCGGGTGGGTACTGTTATTTCAACAATGCCGCAATAGCAGCAAGG
TACTTCCAGAAATATACCCACGGTTACGTTGCCATACTGGATCTCGACTTTCATCATGGCAACGGAACACAGGAGATTTT
CTACGCCGACAGCACGGTTCTTTACGTATCACTGCACGGCGATCCGGAAAAATTCTATCCATGGATAAGCGGTTATGACT
GGGAGATAGGCGAAGAAGACGGTGTCGGATACAATTTCAACTTTCCTTTGCCTGGTGAAACGACAGGAACCGATTATTTG
AGAACCCTTGAGAAGGCCCTGGCAGAAATAGAGAACTTTGACCCGGATCTTCTGATTGTTTCTCTGGGTTTTGATACACA
CAAGGAAGATCCGGTAGGCCATTTCTCTCTTGAAGACAAGGATTACTATTTAATAGGAAAAGCTTTGAAAGATCTCGACT
TTTCGATCGTGCTGATTCAAGAAGGCGGATACAATCCGGACGCGAACATGCGAGCTTCAAGAAATTTCTTTGCGGGTTTG
CTATAA

Upstream 100 bases:

>100_bases
GAATCGTAGAGGTGTTCTTTGAAACCGGGTTCGAGGGTGGTCGCCACGAACGCAGAATAAGAAAGATCGATGATCTACCG
GATCTACGGAGGCGGTCTGA

Downstream 100 bases:

>100_bases
CAGGCAACAATAGAAAAAAGGGGCTTGAAAGCCCCTTTTTTGTTGTCGATTGGCTCCGATCAAAAGACCGGTCCTATTCC
GAAGAAGAAGGTTCCGGAAT

Product: Histone deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKIFYDRRHLLHIPKKEMDNGKWVENADKPDRIEAIRESLERHFGFSFNEPRDYYSSYLYLVHDHDYVHWLKKRSEGVEP
GEEYFPEVFGYDKVFDTGTPITRNSFFAALNAVSASLNAVDEILTGETIVYALCRPPGHHASSSQAGGYCYFNNAAIAAR
YFQKYTHGYVAILDLDFHHGNGTQEIFYADSTVLYVSLHGDPEKFYPWISGYDWEIGEEDGVGYNFNFPLPGETTGTDYL
RTLEKALAEIENFDPDLLIVSLGFDTHKEDPVGHFSLEDKDYYLIGKALKDLDFSIVLIQEGGYNPDANMRASRNFFAGL
L

Sequences:

>Translated_321_residues
MKIFYDRRHLLHIPKKEMDNGKWVENADKPDRIEAIRESLERHFGFSFNEPRDYYSSYLYLVHDHDYVHWLKKRSEGVEP
GEEYFPEVFGYDKVFDTGTPITRNSFFAALNAVSASLNAVDEILTGETIVYALCRPPGHHASSSQAGGYCYFNNAAIAAR
YFQKYTHGYVAILDLDFHHGNGTQEIFYADSTVLYVSLHGDPEKFYPWISGYDWEIGEEDGVGYNFNFPLPGETTGTDYL
RTLEKALAEIENFDPDLLIVSLGFDTHKEDPVGHFSLEDKDYYLIGKALKDLDFSIVLIQEGGYNPDANMRASRNFFAGL
L
>Mature_321_residues
MKIFYDRRHLLHIPKKEMDNGKWVENADKPDRIEAIRESLERHFGFSFNEPRDYYSSYLYLVHDHDYVHWLKKRSEGVEP
GEEYFPEVFGYDKVFDTGTPITRNSFFAALNAVSASLNAVDEILTGETIVYALCRPPGHHASSSQAGGYCYFNNAAIAAR
YFQKYTHGYVAILDLDFHHGNGTQEIFYADSTVLYVSLHGDPEKFYPWISGYDWEIGEEDGVGYNFNFPLPGETTGTDYL
RTLEKALAEIENFDPDLLIVSLGFDTHKEDPVGHFSLEDKDYYLIGKALKDLDFSIVLIQEGGYNPDANMRASRNFFAGL
L

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=263, Percent_Identity=36.1216730038023, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI17158039, Length=227, Percent_Identity=38.7665198237885, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI30795202, Length=227, Percent_Identity=38.7665198237885, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI30795204, Length=227, Percent_Identity=38.7665198237885, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI153085395, Length=225, Percent_Identity=38.2222222222222, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI169234807, Length=201, Percent_Identity=38.3084577114428, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148539870, Length=201, Percent_Identity=38.3084577114428, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI20070354, Length=291, Percent_Identity=31.9587628865979, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI62750349, Length=201, Percent_Identity=39.8009950248756, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI62750347, Length=201, Percent_Identity=39.8009950248756, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI226529806, Length=212, Percent_Identity=33.4905660377358, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI8923769, Length=298, Percent_Identity=26.1744966442953, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13128862, Length=283, Percent_Identity=27.208480565371, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13128860, Length=168, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073088, Length=188, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI293336691, Length=140, Percent_Identity=32.8571428571429, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI262073092, Length=218, Percent_Identity=25.2293577981651, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=291, Percent_Identity=35.0515463917526, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI193206283, Length=291, Percent_Identity=35.0515463917526, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17540332, Length=291, Percent_Identity=35.0515463917526, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI193209491, Length=200, Percent_Identity=36.5, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25154020, Length=305, Percent_Identity=28.8524590163934, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=307, Percent_Identity=28.6644951140065, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25154022, Length=305, Percent_Identity=28.8524590163934, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=171, Percent_Identity=32.1637426900585, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=168, Percent_Identity=32.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508561, Length=168, Percent_Identity=30.3571428571429, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324307, Length=279, Percent_Identity=32.6164874551971, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321244, Length=261, Percent_Identity=27.9693486590038, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323999, Length=184, Percent_Identity=29.8913043478261, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24642146, Length=298, Percent_Identity=31.5436241610738, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24642144, Length=298, Percent_Identity=31.5436241610738, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24642142, Length=298, Percent_Identity=31.5436241610738, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360899, Length=318, Percent_Identity=31.7610062893082, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24641720, Length=186, Percent_Identity=34.9462365591398, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360799, Length=186, Percent_Identity=34.9462365591398, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360801, Length=186, Percent_Identity=34.9462365591398, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644244, Length=168, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24657891, Length=167, Percent_Identity=30.5389221556886, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36735; Mature: 36735

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFYDRRHLLHIPKKEMDNGKWVENADKPDRIEAIRESLERHFGFSFNEPRDYYSSYLY
CEEEECCHHHEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCEEE
LVHDHDYVHWLKKRSEGVEPGEEYFPEVFGYDKVFDTGTPITRNSFFAALNAVSASLNAV
EEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DEILTGETIVYALCRPPGHHASSSQAGGYCYFNNAAIAARYFQKYTHGYVAILDLDFHHG
HHHHCCCEEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCEEEEEEEEEECC
NGTQEIFYADSTVLYVSLHGDPEKFYPWISGYDWEIGEEDGVGYNFNFPLPGETTGTDYL
CCCCEEEEECCEEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHH
RTLEKALAEIENFDPDLLIVSLGFDTHKEDPVGHFSLEDKDYYLIGKALKDLDFSIVLIQ
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCCEEEEEHHHHCCCEEEEEEE
EGGYNPDANMRASRNFFAGLL
CCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKIFYDRRHLLHIPKKEMDNGKWVENADKPDRIEAIRESLERHFGFSFNEPRDYYSSYLY
CEEEECCHHHEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCEEE
LVHDHDYVHWLKKRSEGVEPGEEYFPEVFGYDKVFDTGTPITRNSFFAALNAVSASLNAV
EEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DEILTGETIVYALCRPPGHHASSSQAGGYCYFNNAAIAARYFQKYTHGYVAILDLDFHHG
HHHHCCCEEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCEEEEEEEEEECC
NGTQEIFYADSTVLYVSLHGDPEKFYPWISGYDWEIGEEDGVGYNFNFPLPGETTGTDYL
CCCCEEEEECCEEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHH
RTLEKALAEIENFDPDLLIVSLGFDTHKEDPVGHFSLEDKDYYLIGKALKDLDFSIVLIQ
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCCEEEEEHHHHCCCEEEEEEE
EGGYNPDANMRASRNFFAGLL
CCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]