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The map label for this gene is guaB [H]

Identifier: 238924894

GI number: 238924894

Start: 2418506

End: 2419963

Strand: Direct

Name: guaB [H]

Synonym: EUBREC_2545

Alternate gene names: 238924894

Gene position: 2418506-2419963 (Clockwise)

Preceding gene: 238924887

Following gene: 238924896

Centisome position: 70.11

GC content: 45.61

Gene sequence:

>1458_bases
ATGGGTACTATTATCGGCGAAGGAATTACATTTGATGACGTTCTCTTAGTTCCACAATATTCTGAGGTAACACCAAATAT
GATTGAGCTTCAGACACATCTTACTAAGAAGATTGTCCTTAACATTCCTATGATGAGTGCTGCAATGGATACAGTCACAG
AATCAAAAATGGCTATCGCAATGGCCAGACAGGGTGGTATCGGAATCATCCACAAAAATATGTCTATTGAGGCACAGGCA
GACGAAGTCGATAAGGTAAAGCGTTCAGAAAACGGCGTTATTACCGATCCGTTCTATCTTTCTCCAGACCATACATTACA
GGATGCAGACAACCTGATGGCCAAGTTCAAGATATCAGGTGTGCCAATCACAAAGGACGGCAAGCTTGTCGGCATCATCA
CAAACCGTGATCTGAAGTTTGAGACAGACTTCACAAAGAAGATTTCAGAGTCTATGACTTCTGAGAATCTCATTACAGCT
CCTGAGGGCATCACTCTCGATGAAGCAAAGAAGATTCTTGCAAAGGCAAGAAAGGAAAAGCTCCCTATCGTAGACAAGGA
CTACAACCTCAAGGGACTTATCACTATAAAGGATATCGAGAAGCAGATTAAGTATCCTCTTTCAGCAAAGGATGATCAGG
GCCGTCTCCTCTGCGGTGCCGGAGTAGGTATCACAGGCAACATGATGGAGCGTGTTGATGCTCTTGTTAAGTCTCATGTT
GATGTCATCGTTGTTGACTCAGCTCACGGACATTCAAAGAATATACTTGAGGCTGTTAAGAAGATCAAGGCTGCTTATCC
GGATCTTCAGATAATCGCCGGAAATATCGCAACAGGTGCTGCTGCCAAGGCTCTTATCGAGGCCGGTGCAGATGCAGTAA
AGGTTGGTATCGGACCTGGTTCTATCTGTACCACACGTGTCGTTGCCGGTATCGGTGTACCACAGATTACAGCTATCATG
GACTGTTACAAGGTTGCTAAGGAGTATGGAGTTCCTGTTATCGCAGATGGTGGTATCAAGTACTCAGGTGATATGACAAA
GGCTCTCGCAGCCGGTGCCAACGTATGTATGATGGGCTCAATGTTCGCAGGCTGTGATGAAGCTCCGGGAACCTTCGAGC
TTTATCAGGGAAGAAAATACAAGGTATATCGTGGCATGGGTTCTATCGCTGCTATGGAAAACGGAAGCAAGGACCGTTAC
TTCCAGGAGGGCGCTAAGAAGCTTGTTCCTGAAGGAGTTGAGGGTCGTGTAGCTTACAAGGGAACTCTTGAGGATACAGT
ATTCCAGCTTGTTGGTGGTATCCGCTCAGGAATGGGCTACTGCGGTTGCAAGACAATCGAAGATCTTAAGGAGAACGGAC
AGTTTGTCAAGATTACTGCTGCTTCTCTCAAGGAGAGCCACCCTCATGATATCCATATCACAAAAGAGGCTCCTAACTAC
AGCACAGACGATAAATAA

Upstream 100 bases:

>100_bases
ACTGCTTGACACCCACTCTTTAATTTGCTATCATCATACAAATTACATTAGTATATAAAGTATACCAGTATAATAACATA
AGAAAGAGAGGAATTTAAAA

Downstream 100 bases:

>100_bases
ACACATTTATTAATTCATATAACGAGGTAAAATATTTGGACGCTGACGACATATCGCAGATTATATTCTTATTAATACTA
TTAGCACTCTCCGCATTTTT

Product: inosine-5-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MGTIIGEGITFDDVLLVPQYSEVTPNMIELQTHLTKKIVLNIPMMSAAMDTVTESKMAIAMARQGGIGIIHKNMSIEAQA
DEVDKVKRSENGVITDPFYLSPDHTLQDADNLMAKFKISGVPITKDGKLVGIITNRDLKFETDFTKKISESMTSENLITA
PEGITLDEAKKILAKARKEKLPIVDKDYNLKGLITIKDIEKQIKYPLSAKDDQGRLLCGAGVGITGNMMERVDALVKSHV
DVIVVDSAHGHSKNILEAVKKIKAAYPDLQIIAGNIATGAAAKALIEAGADAVKVGIGPGSICTTRVVAGIGVPQITAIM
DCYKVAKEYGVPVIADGGIKYSGDMTKALAAGANVCMMGSMFAGCDEAPGTFELYQGRKYKVYRGMGSIAAMENGSKDRY
FQEGAKKLVPEGVEGRVAYKGTLEDTVFQLVGGIRSGMGYCGCKTIEDLKENGQFVKITAASLKESHPHDIHITKEAPNY
STDDK

Sequences:

>Translated_485_residues
MGTIIGEGITFDDVLLVPQYSEVTPNMIELQTHLTKKIVLNIPMMSAAMDTVTESKMAIAMARQGGIGIIHKNMSIEAQA
DEVDKVKRSENGVITDPFYLSPDHTLQDADNLMAKFKISGVPITKDGKLVGIITNRDLKFETDFTKKISESMTSENLITA
PEGITLDEAKKILAKARKEKLPIVDKDYNLKGLITIKDIEKQIKYPLSAKDDQGRLLCGAGVGITGNMMERVDALVKSHV
DVIVVDSAHGHSKNILEAVKKIKAAYPDLQIIAGNIATGAAAKALIEAGADAVKVGIGPGSICTTRVVAGIGVPQITAIM
DCYKVAKEYGVPVIADGGIKYSGDMTKALAAGANVCMMGSMFAGCDEAPGTFELYQGRKYKVYRGMGSIAAMENGSKDRY
FQEGAKKLVPEGVEGRVAYKGTLEDTVFQLVGGIRSGMGYCGCKTIEDLKENGQFVKITAASLKESHPHDIHITKEAPNY
STDDK
>Mature_484_residues
GTIIGEGITFDDVLLVPQYSEVTPNMIELQTHLTKKIVLNIPMMSAAMDTVTESKMAIAMARQGGIGIIHKNMSIEAQAD
EVDKVKRSENGVITDPFYLSPDHTLQDADNLMAKFKISGVPITKDGKLVGIITNRDLKFETDFTKKISESMTSENLITAP
EGITLDEAKKILAKARKEKLPIVDKDYNLKGLITIKDIEKQIKYPLSAKDDQGRLLCGAGVGITGNMMERVDALVKSHVD
VIVVDSAHGHSKNILEAVKKIKAAYPDLQIIAGNIATGAAAKALIEAGADAVKVGIGPGSICTTRVVAGIGVPQITAIMD
CYKVAKEYGVPVIADGGIKYSGDMTKALAAGANVCMMGSMFAGCDEAPGTFELYQGRKYKVYRGMGSIAAMENGSKDRYF
QEGAKKLVPEGVEGRVAYKGTLEDTVFQLVGGIRSGMGYCGCKTIEDLKENGQFVKITAASLKESHPHDIHITKEAPNYS
TDDK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=44.7916666666667, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=44.7916666666667, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=44.7916666666667, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=44.7916666666667, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=44.4906444906445, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=44.9367088607595, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=43.9583333333333, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=41.6666666666667, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI156104880, Length=235, Percent_Identity=37.0212765957447, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI50541956, Length=242, Percent_Identity=37.1900826446281, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541954, Length=242, Percent_Identity=37.1900826446281, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=242, Percent_Identity=37.1900826446281, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=242, Percent_Identity=37.1900826446281, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=55.9426229508197, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=219, Percent_Identity=36.0730593607306, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=497, Percent_Identity=37.2233400402414, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=40, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=258, Percent_Identity=35.2713178294574, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=43.035343035343, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=41.3934426229508, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=42.6195426195426, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6319352, Length=389, Percent_Identity=40.3598971722365, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6319353, Length=140, Percent_Identity=40.7142857142857, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=41.5800415800416, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=41.5800415800416, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=42.0091324200913, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52101; Mature: 51970

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTIIGEGITFDDVLLVPQYSEVTPNMIELQTHLTKKIVLNIPMMSAAMDTVTESKMAIA
CCCEECCCCCCCCEEEECCHHCCCCCHHHHHHHHCEEHEEECCHHHHHHHHHHHHHHEEE
MARQGGIGIIHKNMSIEAQADEVDKVKRSENGVITDPFYLSPDHTLQDADNLMAKFKISG
EECCCCEEEEEECCEEEECHHHHHHHHHCCCCEECCCEEECCCCCHHHHHHHEEEEEECC
VPITKDGKLVGIITNRDLKFETDFTKKISESMTSENLITAPEGITLDEAKKILAKARKEK
EEECCCCCEEEEEECCCEEECCHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHC
LPIVDKDYNLKGLITIKDIEKQIKYPLSAKDDQGRLLCGAGVGITGNMMERVDALVKSHV
CCEECCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCC
DVIVVDSAHGHSKNILEAVKKIKAAYPDLQIIAGNIATGAAAKALIEAGADAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCC
SICTTRVVAGIGVPQITAIMDCYKVAKEYGVPVIADGGIKYSGDMTKALAAGANVCMMGS
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEHHH
MFAGCDEAPGTFELYQGRKYKVYRGMGSIAAMENGSKDRYFQEGAKKLVPEGVEGRVAYK
HHCCCCCCCCCEEECCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEC
GTLEDTVFQLVGGIRSGMGYCGCKTIEDLKENGQFVKITAASLKESHPHDIHITKEAPNY
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEHHHCCCCCCEEEEEECCCCC
STDDK
CCCCC
>Mature Secondary Structure 
GTIIGEGITFDDVLLVPQYSEVTPNMIELQTHLTKKIVLNIPMMSAAMDTVTESKMAIA
CCEECCCCCCCCEEEECCHHCCCCCHHHHHHHHCEEHEEECCHHHHHHHHHHHHHHEEE
MARQGGIGIIHKNMSIEAQADEVDKVKRSENGVITDPFYLSPDHTLQDADNLMAKFKISG
EECCCCEEEEEECCEEEECHHHHHHHHHCCCCEECCCEEECCCCCHHHHHHHEEEEEECC
VPITKDGKLVGIITNRDLKFETDFTKKISESMTSENLITAPEGITLDEAKKILAKARKEK
EEECCCCCEEEEEECCCEEECCHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHC
LPIVDKDYNLKGLITIKDIEKQIKYPLSAKDDQGRLLCGAGVGITGNMMERVDALVKSHV
CCEECCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCC
DVIVVDSAHGHSKNILEAVKKIKAAYPDLQIIAGNIATGAAAKALIEAGADAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEECCCC
SICTTRVVAGIGVPQITAIMDCYKVAKEYGVPVIADGGIKYSGDMTKALAAGANVCMMGS
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEHHH
MFAGCDEAPGTFELYQGRKYKVYRGMGSIAAMENGSKDRYFQEGAKKLVPEGVEGRVAYK
HHCCCCCCCCCEEECCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEC
GTLEDTVFQLVGGIRSGMGYCGCKTIEDLKENGQFVKITAASLKESHPHDIHITKEAPNY
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEHHHCCCCCCEEEEEECCCCC
STDDK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]