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The map label for this gene is typA [H]

Identifier: 238924887

GI number: 238924887

Start: 2410297

End: 2412129

Strand: Direct

Name: typA [H]

Synonym: EUBREC_2538

Alternate gene names: 238924887

Gene position: 2410297-2412129 (Clockwise)

Preceding gene: 238924882

Following gene: 238924894

Centisome position: 69.87

GC content: 46.43

Gene sequence:

>1833_bases
ATGAAAACAACAAGAGACGATATTCGTAATATAGCAATTATTGCCCACGTTGATCATGGTAAAACAACACTTGTAGATGA
GCTTCTTAAGCAAAGCGGTGTGTTCCGTGACAATCAGGAAGTTCAGGATCGAGTAATGGATTCAAACGACATCGAGCGTG
AAAGAGGTATCACAATCCTCTCCAAAAACACAGCTATTCAGTATAAGGACATCAAAATCAACATCATCGACACTCCGGGT
CATGCTGACTTCGGCGGTGAGGTAGAGCGTGTTCTTAAGATGGTAAACGGAGTTATCCTCGTGGTTGATGCCTTCGAGGG
TGTTATGCCACAGACCAAGTTCGTAGTTATGAAGGCTCTTGCACTCAAGCTGCCTATCATTGTATGCGTCAACAAGATTG
ACCGTCCGGAGGCACGTCCTAATGAGGTCATCGATGAGGTATTAGAGCTCTTCATGGATCTCGATGCTTCTGAGGAGCAG
CTTGACTGCCCATTCGTTTTTGCATCAGCCAGAGACGGCTATGCCATGAAGGACTTAAACGACGAGAGAAAGGATATGAC
TCCTCTCTTCGAGACTATCGTAAACTACATCCCTGCTCCAACAGGTGATCCTGATGCCAACACACAGATTCTTATCAGTA
CAATCGACTACAACGAGTATGTAGGACGTATCGGAATCGGTAAAGTGGATAACGGTAAAATCAAGGTCAATCAGGAGGCT
GTCGTTGTAAACCACCACGACCCTGACAAGCTTGAGAAGGTCCGTATCAGCAAACTTTACGAGTTTGACGGACTCGACAA
GGTAGATGTAGCCGAGGCTAACATCGGTTCGATTGTAGCAATCTCAGGTATCGCAGATATCCACATCGGAGATACAATCT
GCTCACCGGAAGCACCGGAGGCTATTCCTTTCCAGAAGATTTCAGAGCCTACAATCTCTATGAACTTCATCGTAAACAAC
AGCCCTCTTGCAGGACAGGAAGGTAAATTTGTCACAAGCCGTCACATCCGTGACAGACTCCTTCGCGAGCTCAACACTGA
TGTTTCACTGCGTGTCGAGGATACTGACTCACCTGATTCCTTCAAGGTTTCCGGACGTGGAGAGCTTCACCTTTCAGTGC
TTATCGAGAACATGCGCCGTGAGGGTTATGAGTTCGCTGTAAGTAAGGCAGAGGTGCTCTACAAGTATGACGAAAACGGC
AAGAAGCTTGAGCCAATGGAGCTTGCTTACATCGATGTGCCTGATGAGTTTACAGGAGCTGTCATCTCAAAGCTTCAGCA
GCGCAAAGGCGAGCTTAGAAATATGGGTTCTATCGCAGGTGGCTACACCAGACTTGAATTCCATATCCCTGCACGTGGAC
TTATCGGATACCGTGGTGAGTTCATGACCGATACAAAGGGTAACGGAATCTTAAACACCATGTTTGACGGCTACGAGCCA
TACAAGGGTGAAATTGCATACCGTGCAACAGGTTCACTCATTGCCTTTGAGTCAGGTGAGGCTGTAACATACGGACTCTT
CTCTGCACAGGAGAGAGGAACACTCTTTATCGGACCAGGCGCTAAGGTTTACTCAGGAATGGTTATCGGACAGTGTGCAA
AGGCCGAGGACATCGAGCTCAATGTATGTAAGAAGAAGCATCTTACAAATACACGTTCTTCATCAGCAGATGAGGCACTC
ACACTTGTACCACCTAAAGTATTAAGCCTTGAGCAGGCTATCGACTTTATTGATACAGATGAGCTTCTTGAGGTAACACC
TGAGAGCCTTCGAATCAGAAAGAAGATTCTTGACCCTACTCTTCGTAAGAGAGCCGGTTTCAAGAAGAATTAA

Upstream 100 bases:

>100_bases
TTTTATAAAAACTTTCAATGAAAACTTGCACATTGGAAAAATTATGATAGAATAAGTTAGTTGCAAACTTAGCTTTATTT
ATTAAAGAAAGAAGGAAAAT

Downstream 100 bases:

>100_bases
ATCATGCTTTTCGCATAAAGTTTTTGTTGCTGAAAAAGTATACAGTAAATACACTTTATGTAAATTTTAATCGAGTAGGA
GGCGGTGACTAACCGCCGTC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MKTTRDDIRNIAIIAHVDHGKTTLVDELLKQSGVFRDNQEVQDRVMDSNDIERERGITILSKNTAIQYKDIKINIIDTPG
HADFGGEVERVLKMVNGVILVVDAFEGVMPQTKFVVMKALALKLPIIVCVNKIDRPEARPNEVIDEVLELFMDLDASEEQ
LDCPFVFASARDGYAMKDLNDERKDMTPLFETIVNYIPAPTGDPDANTQILISTIDYNEYVGRIGIGKVDNGKIKVNQEA
VVVNHHDPDKLEKVRISKLYEFDGLDKVDVAEANIGSIVAISGIADIHIGDTICSPEAPEAIPFQKISEPTISMNFIVNN
SPLAGQEGKFVTSRHIRDRLLRELNTDVSLRVEDTDSPDSFKVSGRGELHLSVLIENMRREGYEFAVSKAEVLYKYDENG
KKLEPMELAYIDVPDEFTGAVISKLQQRKGELRNMGSIAGGYTRLEFHIPARGLIGYRGEFMTDTKGNGILNTMFDGYEP
YKGEIAYRATGSLIAFESGEAVTYGLFSAQERGTLFIGPGAKVYSGMVIGQCAKAEDIELNVCKKKHLTNTRSSSADEAL
TLVPPKVLSLEQAIDFIDTDELLEVTPESLRIRKKILDPTLRKRAGFKKN

Sequences:

>Translated_610_residues
MKTTRDDIRNIAIIAHVDHGKTTLVDELLKQSGVFRDNQEVQDRVMDSNDIERERGITILSKNTAIQYKDIKINIIDTPG
HADFGGEVERVLKMVNGVILVVDAFEGVMPQTKFVVMKALALKLPIIVCVNKIDRPEARPNEVIDEVLELFMDLDASEEQ
LDCPFVFASARDGYAMKDLNDERKDMTPLFETIVNYIPAPTGDPDANTQILISTIDYNEYVGRIGIGKVDNGKIKVNQEA
VVVNHHDPDKLEKVRISKLYEFDGLDKVDVAEANIGSIVAISGIADIHIGDTICSPEAPEAIPFQKISEPTISMNFIVNN
SPLAGQEGKFVTSRHIRDRLLRELNTDVSLRVEDTDSPDSFKVSGRGELHLSVLIENMRREGYEFAVSKAEVLYKYDENG
KKLEPMELAYIDVPDEFTGAVISKLQQRKGELRNMGSIAGGYTRLEFHIPARGLIGYRGEFMTDTKGNGILNTMFDGYEP
YKGEIAYRATGSLIAFESGEAVTYGLFSAQERGTLFIGPGAKVYSGMVIGQCAKAEDIELNVCKKKHLTNTRSSSADEAL
TLVPPKVLSLEQAIDFIDTDELLEVTPESLRIRKKILDPTLRKRAGFKKN
>Mature_610_residues
MKTTRDDIRNIAIIAHVDHGKTTLVDELLKQSGVFRDNQEVQDRVMDSNDIERERGITILSKNTAIQYKDIKINIIDTPG
HADFGGEVERVLKMVNGVILVVDAFEGVMPQTKFVVMKALALKLPIIVCVNKIDRPEARPNEVIDEVLELFMDLDASEEQ
LDCPFVFASARDGYAMKDLNDERKDMTPLFETIVNYIPAPTGDPDANTQILISTIDYNEYVGRIGIGKVDNGKIKVNQEA
VVVNHHDPDKLEKVRISKLYEFDGLDKVDVAEANIGSIVAISGIADIHIGDTICSPEAPEAIPFQKISEPTISMNFIVNN
SPLAGQEGKFVTSRHIRDRLLRELNTDVSLRVEDTDSPDSFKVSGRGELHLSVLIENMRREGYEFAVSKAEVLYKYDENG
KKLEPMELAYIDVPDEFTGAVISKLQQRKGELRNMGSIAGGYTRLEFHIPARGLIGYRGEFMTDTKGNGILNTMFDGYEP
YKGEIAYRATGSLIAFESGEAVTYGLFSAQERGTLFIGPGAKVYSGMVIGQCAKAEDIELNVCKKKHLTNTRSSSADEAL
TLVPPKVLSLEQAIDFIDTDELLEVTPESLRIRKKILDPTLRKRAGFKKN

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=537, Percent_Identity=25.8845437616387, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=42.8571428571429, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=43.609022556391, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI4503483, Length=149, Percent_Identity=38.9261744966443, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=43.2432432432432, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=43.2432432432432, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=43.2432432432432, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI25306283, Length=144, Percent_Identity=40.9722222222222, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI19923640, Length=144, Percent_Identity=40.9722222222222, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI25306287, Length=144, Percent_Identity=40.9722222222222, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI217272892, Length=139, Percent_Identity=38.8489208633094, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI217272894, Length=139, Percent_Identity=38.8489208633094, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI34147630, Length=308, Percent_Identity=25.6493506493506, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI53729339, Length=138, Percent_Identity=36.9565217391304, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI53729337, Length=138, Percent_Identity=36.9565217391304, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI48994988, Length=599, Percent_Identity=53.5893155258765, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=516, Percent_Identity=29.0697674418605, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=43.9189189189189, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790835, Length=190, Percent_Identity=30, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790412, Length=241, Percent_Identity=29.4605809128631, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789737, Length=241, Percent_Identity=29.4605809128631, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789559, Length=171, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=232, Percent_Identity=35.7758620689655, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=42.9577464788732, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=45.1388888888889, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=37.6923076923077, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=37.6923076923077, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=161, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=38.0597014925373, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=297, Percent_Identity=28.2828282828283, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323320, Length=512, Percent_Identity=27.734375, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324707, Length=147, Percent_Identity=40.8163265306122, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=147, Percent_Identity=40.8163265306122, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=161, Percent_Identity=40.3726708074534, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=38.5135135135135, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=35, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI78706572, Length=521, Percent_Identity=26.1036468330134, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24582462, Length=145, Percent_Identity=43.448275862069, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=41.044776119403, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585711, Length=153, Percent_Identity=37.2549019607843, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585713, Length=153, Percent_Identity=37.2549019607843, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585709, Length=153, Percent_Identity=37.2549019607843, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574573, Length=144, Percent_Identity=38.8888888888889, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221458488, Length=133, Percent_Identity=47.3684210526316, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363316, Length=303, Percent_Identity=27.0627062706271, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17864358, Length=303, Percent_Identity=27.0627062706271, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921738, Length=295, Percent_Identity=26.7796610169492, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67852; Mature: 67852

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTRDDIRNIAIIAHVDHGKTTLVDELLKQSGVFRDNQEVQDRVMDSNDIERERGITIL
CCCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEE
SKNTAIQYKDIKINIIDTPGHADFGGEVERVLKMVNGVILVVDAFEGVMPQTKFVVMKAL
ECCCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHH
ALKLPIIVCVNKIDRPEARPNEVIDEVLELFMDLDASEEQLDCPFVFASARDGYAMKDLN
HHHCCHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEECCCC
DERKDMTPLFETIVNYIPAPTGDPDANTQILISTIDYNEYVGRIGIGKVDNGKIKVNQEA
CHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHCCCCCCCCCCCEEEECCEE
VVVNHHDPDKLEKVRISKLYEFDGLDKVDVAEANIGSIVAISGIADIHIGDTICSPEAPE
EEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEECCEEEEEECCCCCCCCCCC
AIPFQKISEPTISMNFIVNNSPLAGQEGKFVTSRHIRDRLLRELNTDVSLRVEDTDSPDS
CCCHHHCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEEECCCCCCC
FKVSGRGELHLSVLIENMRREGYEFAVSKAEVLYKYDENGKKLEPMELAYIDVPDEFTGA
EEECCCCCEEHHHHHHHHHHCCHHEEECCEEEEEEECCCCCCCCCEEEEEEECCCHHHHH
VISKLQQRKGELRNMGSIAGGYTRLEFHIPARGLIGYRGEFMTDTKGNGILNTMFDGYEP
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCEEEHHCCCCCC
YKGEIAYRATGSLIAFESGEAVTYGLFSAQERGTLFIGPGAKVYSGMVIGQCAKAEDIEL
CCCCEEEEECCCEEEEECCCEEEEEEEECCCCCEEEECCCHHHHCCEEEECCCCCCCCEE
NVCKKKHLTNTRSSSADEALTLVPPKVLSLEQAIDFIDTDELLEVTPESLRIRKKILDPT
EEHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCHH
LRKRAGFKKN
HHHHCCCCCC
>Mature Secondary Structure
MKTTRDDIRNIAIIAHVDHGKTTLVDELLKQSGVFRDNQEVQDRVMDSNDIERERGITIL
CCCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEE
SKNTAIQYKDIKINIIDTPGHADFGGEVERVLKMVNGVILVVDAFEGVMPQTKFVVMKAL
ECCCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHH
ALKLPIIVCVNKIDRPEARPNEVIDEVLELFMDLDASEEQLDCPFVFASARDGYAMKDLN
HHHCCHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEECCCC
DERKDMTPLFETIVNYIPAPTGDPDANTQILISTIDYNEYVGRIGIGKVDNGKIKVNQEA
CHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHCCCCCCCCCCCEEEECCEE
VVVNHHDPDKLEKVRISKLYEFDGLDKVDVAEANIGSIVAISGIADIHIGDTICSPEAPE
EEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEECCEEEEEECCCCCCCCCCC
AIPFQKISEPTISMNFIVNNSPLAGQEGKFVTSRHIRDRLLRELNTDVSLRVEDTDSPDS
CCCHHHCCCCEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEEECCCCCCC
FKVSGRGELHLSVLIENMRREGYEFAVSKAEVLYKYDENGKKLEPMELAYIDVPDEFTGA
EEECCCCCEEHHHHHHHHHHCCHHEEECCEEEEEEECCCCCCCCCEEEEEEECCCHHHHH
VISKLQQRKGELRNMGSIAGGYTRLEFHIPARGLIGYRGEFMTDTKGNGILNTMFDGYEP
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCEEEHHCCCCCC
YKGEIAYRATGSLIAFESGEAVTYGLFSAQERGTLFIGPGAKVYSGMVIGQCAKAEDIEL
CCCCEEEEECCCEEEEECCCEEEEEEEECCCCCEEEECCCHHHHCCEEEECCCCCCCCEE
NVCKKKHLTNTRSSSADEALTLVPPKVLSLEQAIDFIDTDELLEVTPESLRIRKKILDPT
EEHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCHH
LRKRAGFKKN
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]