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The map label for this gene is aroE

Identifier: 238921404

GI number: 238921404

Start: 3458488

End: 3459303

Strand: Reverse

Name: aroE

Synonym: NT01EI_3555

Alternate gene names: 238921404

Gene position: 3459303-3458488 (Counterclockwise)

Preceding gene: 238921405

Following gene: 238921403

Centisome position: 90.74

GC content: 62.13

Gene sequence:

>816_bases
ATGCAGCAATTTGCCGTTTTTGGTCACCCGATAAAGCACAGCCAGTCGCCGCGTATCCATCGGCTCTTTGCTCAACAAAC
CGGCATTGCGCTCAGCTATGAGGCGATGCTGGCGCCGCTGGATGATTTCCCCGCCTTTGCCATGGCCTTTTTTCAGCAGG
GCGGGCGGGGCGCTAACGTCACGACTCCCTTTAAAGAGCAGGCTTGGCAGATGGCGGATGTCTTGACGCCGCGGGCCCGT
CTGGCCGGCGCGGTGAATACGCTGCATTGGCAAAACGCTCGTCTGCTGGGGGATAACACGGACGGGGTTGGGCTGGTCAG
TGATTTACATCGGCTAGCGATGATCGGTGATGCGAGTCGGGTTTTGCTGCTGGGCGCCGGTGGGGCCGCTCGCGGCGTGA
TCCTACCGCTGCTGGAACAGGGGTGCCGGATCGCGCTGGCTAATAGAACCCATGCCCGGGCACAGGCGCTGGCCGCTGCA
TTCCAGGCACAGGGGGCGATTGAGGCATTACCCTATGACGCGCTTGGCACCCACACTTTCGATCTCATTATTAACGCGAC
CGCCTCAGGGCTGCAGGGTGAGCTACCACCGCTGCCGCGCTCGATCATTCGCCCGGATTGCGCCTGTTATGACATGTTTT
ATCGTGCGGGGGCGACGCCGTTTCTGGCCTGGGTTCAGCAGCAGGGCGCGGTACGCTTGGCTGATGGCTTCGGCATGCTG
GTGGCGCAGGCGGCACACGCCTTCTCGCTGTGGCATGGCATCATGCCGCAGATAGCGCCGGTGCTGATACAGCTACGCCA
GGAGCCGGTGGGATGA

Upstream 100 bases:

>100_bases
CTCGGCTTTTCCAGTGCTGGATGCGCCGGTTGGCGGGCGCCAAAACCCATCAGAAATCCGCGATGCACTGAGCGGTGAAC
TGTTACGTCAGGGGTAAGCG

Downstream 100 bases:

>100_bases
ATCAGTCGATCCTCTTTCCCGAACTGGAGCAGTGGCAGGCGCCGTCATCGACCATCACCTTTCCGGCGATGGTCAACGGT
TTTCAGGTCACCTGTGCTAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQQFAVFGHPIKHSQSPRIHRLFAQQTGIALSYEAMLAPLDDFPAFAMAFFQQGGRGANVTTPFKEQAWQMADVLTPRAR
LAGAVNTLHWQNARLLGDNTDGVGLVSDLHRLAMIGDASRVLLLGAGGAARGVILPLLEQGCRIALANRTHARAQALAAA
FQAQGAIEALPYDALGTHTFDLIINATASGLQGELPPLPRSIIRPDCACYDMFYRAGATPFLAWVQQQGAVRLADGFGML
VAQAAHAFSLWHGIMPQIAPVLIQLRQEPVG

Sequences:

>Translated_271_residues
MQQFAVFGHPIKHSQSPRIHRLFAQQTGIALSYEAMLAPLDDFPAFAMAFFQQGGRGANVTTPFKEQAWQMADVLTPRAR
LAGAVNTLHWQNARLLGDNTDGVGLVSDLHRLAMIGDASRVLLLGAGGAARGVILPLLEQGCRIALANRTHARAQALAAA
FQAQGAIEALPYDALGTHTFDLIINATASGLQGELPPLPRSIIRPDCACYDMFYRAGATPFLAWVQQQGAVRLADGFGML
VAQAAHAFSLWHGIMPQIAPVLIQLRQEPVG
>Mature_271_residues
MQQFAVFGHPIKHSQSPRIHRLFAQQTGIALSYEAMLAPLDDFPAFAMAFFQQGGRGANVTTPFKEQAWQMADVLTPRAR
LAGAVNTLHWQNARLLGDNTDGVGLVSDLHRLAMIGDASRVLLLGAGGAARGVILPLLEQGCRIALANRTHARAQALAAA
FQAQGAIEALPYDALGTHTFDLIINATASGLQGELPPLPRSIIRPDCACYDMFYRAGATPFLAWVQQQGAVRLADGFGML
VAQAAHAFSLWHGIMPQIAPVLIQLRQEPVG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=58.7360594795539, Blast_Score=323, Evalue=6e-90,
Organism=Escherichia coli, GI1787983, Length=268, Percent_Identity=30.2238805970149, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320332, Length=290, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_EDWI9 (C5BF12)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934919.1
- ProteinModelPortal:   C5BF12
- GeneID:   7962545
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3555
- OMA:   DQYVVFG
- ProtClustDB:   PRK00258
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29122; Mature: 29122

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQFAVFGHPIKHSQSPRIHRLFAQQTGIALSYEAMLAPLDDFPAFAMAFFQQGGRGANV
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHCCCCCCHHHHHHHHHCCCCCCCC
TTPFKEQAWQMADVLTPRARLAGAVNTLHWQNARLLGDNTDGVGLVSDLHRLAMIGDASR
CCCHHHHHHHHHHHHCHHHHHHHHHHHHEECCCEEECCCCCCCHHHHHHHHHHHHCCCCE
VLLLGAGGAARGVILPLLEQGCRIALANRTHARAQALAAAFQAQGAIEALPYDALGTHTF
EEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHCCCCHHCCEEE
DLIINATASGLQGELPPLPRSIIRPDCACYDMFYRAGATPFLAWVQQQGAVRLADGFGML
EEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEECHHHHH
VAQAAHAFSLWHGIMPQIAPVLIQLRQEPVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQQFAVFGHPIKHSQSPRIHRLFAQQTGIALSYEAMLAPLDDFPAFAMAFFQQGGRGANV
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHCCCCCCHHHHHHHHHCCCCCCCC
TTPFKEQAWQMADVLTPRARLAGAVNTLHWQNARLLGDNTDGVGLVSDLHRLAMIGDASR
CCCHHHHHHHHHHHHCHHHHHHHHHHHHEECCCEEECCCCCCCHHHHHHHHHHHHCCCCE
VLLLGAGGAARGVILPLLEQGCRIALANRTHARAQALAAAFQAQGAIEALPYDALGTHTF
EEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHCCCCHHCCEEE
DLIINATASGLQGELPPLPRSIIRPDCACYDMFYRAGATPFLAWVQQQGAVRLADGFGML
EEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEECHHHHH
VAQAAHAFSLWHGIMPQIAPVLIQLRQEPVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA