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The map label for this gene is tyrB [H]

Identifier: 238921396

GI number: 238921396

Start: 3440865

End: 3442067

Strand: Reverse

Name: tyrB [H]

Synonym: NT01EI_3540

Alternate gene names: 238921396

Gene position: 3442067-3440865 (Counterclockwise)

Preceding gene: 238921398

Following gene: 238921395

Centisome position: 90.29

GC content: 62.59

Gene sequence:

>1203_bases
GTGTTTGAACATGTAGATGACTATGCCGGTGATCCGATCCTCTCCCTGATGGAGAGCTATAAGCGGGACGCCCGCGCGCA
AAAAGTGAATCTGAGCATCGGCCTGTACTATGACCTGCGGGGTGAGGTGCCGATGCTGGCCTCTGTCGCCACGGCACTGG
CCCGGCTGAACGCCGCGGCGCCGGCGGCCCCGCTTTATCTGCCGATGGAGGGGATGGCAGATTACCGCAGCGCGGTGCAG
TCGCTGCTGCTGGGGGCAGATCATCCCGCGCTGCGCGCGCGGCGGGTGGCGACCATCCAGACCCTGGGGGGCTCCGGCGC
GCTCAAGGTAGGCGCGGACTTTCTGCGGCGATATTTTCCGCGGGCTGAGGTCTGGGTCAGCGACCCGACCTGGGATAACC
ATGTCGCGATTTTTGAGGGTGCGGGTTTCCGGGTACATCGCTACCCCTATTTTGATCCCCAGACGCTGAGCGTTTGCTTT
GGTGCCATGCTGGAGACGCTGGAGTTGCTGCCGCCCTACAGCATCGTGCTGCTTCACCCCTGCTGCCATAACCCTACCGG
TTCGGATCTGACATTGGCGCAGTGGGATAGACTGACATCGCTGCTGCGGCGACGGGCGCTAATCCCGTTTCTGGATATTG
CCTATCAGGGTTTTGGCAGCGGCATGGATCAGGATGCCTATGCCATCCGGACGATGGCCGCCGTAGGGCTGCCATGCCTG
GTTAGCAACTCGTTCTCTAAAATTTTCTCGCTGTACGGCGAGCGTGTCGGCGGTCTGTCGGTCATGTGCAGCGATGAGGC
TGAGGCAGGACGGGTGCTGGGGCAGCTGAAGGCAATGGTGCGGCGCAACTACTCCAGTCCACCGCTGCACGGCGCTGCCT
TGGTGGCTGCAGTGTTGAATGATACCGATTTGCAGTGTCAGTGGCGTGAAGAGGTGGAGGCGATGCGCCTGCGAATCATC
GCCATGCGTGGCCAGCTGGCGTCACGCCTCAACCTAGCGCTGCCGTCGCGCCGCTTTGACTACCTGTGCCAGCAGCGGGG
CATGTTCAGCTATACCGGCCTCAGTGCACACCAGGTCGGCGAGCTACGCCGGCACGACGGTGTTTACCTGGTCGGCAGTG
GGCGCATGTGCATGGCGGGACTCAACGAGAGCAACCTCGATCGCGTGGCCGCTGCGCTGGTTCGCGTCATGGCGCTGCAG
TAA

Upstream 100 bases:

>100_bases
TTATGACGTGGAGTGCACCGACGTGCTGCCACGGCCTGTGCTGGGCTGGCCGCCGGTGACGGATCCCTTACCGTAGGACC
ACGCCAACAAGGAGCCCCTC

Downstream 100 bases:

>100_bases
TAATATCTGGGACTATGTAGATTCTACGTTTAGTAACGCGTATCTCCTCTTGTCTACGCGTTACTGACGCGGCGTCTGAC
TATCTTTACAGAACTTTCCG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFEHVDDYAGDPILSLMESYKRDARAQKVNLSIGLYYDLRGEVPMLASVATALARLNAAAPAAPLYLPMEGMADYRSAVQ
SLLLGADHPALRARRVATIQTLGGSGALKVGADFLRRYFPRAEVWVSDPTWDNHVAIFEGAGFRVHRYPYFDPQTLSVCF
GAMLETLELLPPYSIVLLHPCCHNPTGSDLTLAQWDRLTSLLRRRALIPFLDIAYQGFGSGMDQDAYAIRTMAAVGLPCL
VSNSFSKIFSLYGERVGGLSVMCSDEAEAGRVLGQLKAMVRRNYSSPPLHGAALVAAVLNDTDLQCQWREEVEAMRLRII
AMRGQLASRLNLALPSRRFDYLCQQRGMFSYTGLSAHQVGELRRHDGVYLVGSGRMCMAGLNESNLDRVAAALVRVMALQ

Sequences:

>Translated_400_residues
MFEHVDDYAGDPILSLMESYKRDARAQKVNLSIGLYYDLRGEVPMLASVATALARLNAAAPAAPLYLPMEGMADYRSAVQ
SLLLGADHPALRARRVATIQTLGGSGALKVGADFLRRYFPRAEVWVSDPTWDNHVAIFEGAGFRVHRYPYFDPQTLSVCF
GAMLETLELLPPYSIVLLHPCCHNPTGSDLTLAQWDRLTSLLRRRALIPFLDIAYQGFGSGMDQDAYAIRTMAAVGLPCL
VSNSFSKIFSLYGERVGGLSVMCSDEAEAGRVLGQLKAMVRRNYSSPPLHGAALVAAVLNDTDLQCQWREEVEAMRLRII
AMRGQLASRLNLALPSRRFDYLCQQRGMFSYTGLSAHQVGELRRHDGVYLVGSGRMCMAGLNESNLDRVAAALVRVMALQ
>Mature_400_residues
MFEHVDDYAGDPILSLMESYKRDARAQKVNLSIGLYYDLRGEVPMLASVATALARLNAAAPAAPLYLPMEGMADYRSAVQ
SLLLGADHPALRARRVATIQTLGGSGALKVGADFLRRYFPRAEVWVSDPTWDNHVAIFEGAGFRVHRYPYFDPQTLSVCF
GAMLETLELLPPYSIVLLHPCCHNPTGSDLTLAQWDRLTSLLRRRALIPFLDIAYQGFGSGMDQDAYAIRTMAAVGLPCL
VSNSFSKIFSLYGERVGGLSVMCSDEAEAGRVLGQLKAMVRRNYSSPPLHGAALVAAVLNDTDLQCQWREEVEAMRLRII
AMRGQLASRLNLALPSRRFDYLCQQRGMFSYTGLSAHQVGELRRHDGVYLVGSGRMCMAGLNESNLDRVAAALVRVMALQ

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=397, Percent_Identity=40.8060453400504, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI4504067, Length=391, Percent_Identity=40.153452685422, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI117414139, Length=387, Percent_Identity=25.0645994832041, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=67.5062972292191, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=39.5465994962217, Blast_Score=315, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI71981858, Length=393, Percent_Identity=36.3867684478371, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI25147133, Length=396, Percent_Identity=37.8787878787879, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17569539, Length=369, Percent_Identity=40.1084010840108, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=31.4578005115089, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17550384, Length=264, Percent_Identity=33.7121212121212, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147136, Length=215, Percent_Identity=33.4883720930233, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323055, Length=407, Percent_Identity=36.1179361179361, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322743, Length=428, Percent_Identity=34.5794392523364, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24580972, Length=388, Percent_Identity=41.2371134020619, Blast_Score=318, Evalue=3e-87,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=41.2371134020619, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24580970, Length=388, Percent_Identity=41.2371134020619, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24654046, Length=383, Percent_Identity=39.1644908616188, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI19922362, Length=383, Percent_Identity=39.1644908616188, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44099; Mature: 44099

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEHVDDYAGDPILSLMESYKRDARAQKVNLSIGLYYDLRGEVPMLASVATALARLNAAA
CCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
PAAPLYLPMEGMADYRSAVQSLLLGADHPALRARRVATIQTLGGSGALKVGADFLRRYFP
CCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCC
RAEVWVSDPTWDNHVAIFEGAGFRVHRYPYFDPQTLSVCFGAMLETLELLPPYSIVLLHP
CCEEEECCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
CCHNPTGSDLTLAQWDRLTSLLRRRALIPFLDIAYQGFGSGMDQDAYAIRTMAAVGLPCL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
VSNSFSKIFSLYGERVGGLSVMCSDEAEAGRVLGQLKAMVRRNYSSPPLHGAALVAAVLN
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
DTDLQCQWREEVEAMRLRIIAMRGQLASRLNLALPSRRFDYLCQQRGMFSYTGLSAHQVG
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCCHHHHH
ELRRHDGVYLVGSGRMCMAGLNESNLDRVAAALVRVMALQ
HHHHCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFEHVDDYAGDPILSLMESYKRDARAQKVNLSIGLYYDLRGEVPMLASVATALARLNAAA
CCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
PAAPLYLPMEGMADYRSAVQSLLLGADHPALRARRVATIQTLGGSGALKVGADFLRRYFP
CCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCC
RAEVWVSDPTWDNHVAIFEGAGFRVHRYPYFDPQTLSVCFGAMLETLELLPPYSIVLLHP
CCEEEECCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEC
CCHNPTGSDLTLAQWDRLTSLLRRRALIPFLDIAYQGFGSGMDQDAYAIRTMAAVGLPCL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
VSNSFSKIFSLYGERVGGLSVMCSDEAEAGRVLGQLKAMVRRNYSSPPLHGAALVAAVLN
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
DTDLQCQWREEVEAMRLRIIAMRGQLASRLNLALPSRRFDYLCQQRGMFSYTGLSAHQVG
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCCHHHHH
ELRRHDGVYLVGSGRMCMAGLNESNLDRVAAALVRVMALQ
HHHHCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]