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The map label for this gene is hyuA [H]

Identifier: 238921386

GI number: 238921386

Start: 3428244

End: 3429632

Strand: Reverse

Name: hyuA [H]

Synonym: NT01EI_3530

Alternate gene names: 238921386

Gene position: 3429632-3428244 (Counterclockwise)

Preceding gene: 238921387

Following gene: 238921385

Centisome position: 89.96

GC content: 61.34

Gene sequence:

>1389_bases
ATGATGAAAAGCCTGATCAAAAACGGCACGGTGGTGAATCACAACGGCGAACGGCGCGCGGATGTGTTGATCGAACACGG
TATGATCAGCTGTCTGGAACCCGGCCTGTCGGAGGACGAGGTGGACGAAGTGATCGATGCCGAAGGGTGCTACGTGATGC
CCGGCGGAGTGGATGTACACACCCACTTTAATATCGACGTCGGCCTGGCCCGCAGCTGTGATGATTTTTTTACCGGCACC
CGCGCGGCGGCGTGTGGCGGTACAACAACCATTATCGACCATATGGGCTTTGGCCCTAAGGGCTGCTCTCTGCATCACCA
GCTGGCGGCCTACCACGGCTACGCTGCGGATAAGGCAGTGATCGACTACGGCTTTCACGGTGTGATCCAACATATCGACG
AGGCGATCCTCGACGAAATGGCCTCGATGGTGCATGACGAAGGAATCAGCAGCTTTAAGCTCTATCTGACCTACGGTTTC
AAGCTTGACGACGATGCGGTGCTGCGCGCGTTGCGCCGTCTGCATCAGGTCGGCGCGCTGACCACGGTGCACCCGGAGAA
CGATGCCGCCATCGCCCAGCGGCGCGCCCATTATCTGGCCAACGGTCAGGTGGCACCGATCTTCCATGCCCGCAGCCGTC
CACTGGAGTGCGAGGCGGAGGCCATTGCGCGCATGATCAATCTGGCGCAGCTGGCCGGGAACGCGCCGCTGTATATCGTT
CACCTTTCCAATGGGCTGGGACTGGACTACCTGCGTCTGGCCCGTGCGCGCCATCAGCCGGTGTGGGTCGAAACCTGTCC
ACAGTATTTGCTGCTGGATGAGCGCAGCTATCTGCGTGAAGACGGCCTGAAGTTTATTCTCAGTCCACCGCTGCGCAACC
TGCGCGAACAGGACGCCCTGTGGTGCGGCATCAGCGATGGTGCTATCGACGTAGTGGCCACCGACCACTGTACCTTCCCC
TACAGCCAGCGGCTGGCGCTCTCCGGCGGTAACTTCAGCCGCTGTCCCAATGGCCTGCCGGGGGTTGAAAACCGGATGCT
GCTGCTGTTCTCCGCCGGGGTGATGACCGGGCGTATCTCGCTGGCGCATTTCGTGTCGTTGACCAGCGCGACCCCGGCAC
GCCTGTTCGGTCTGTGGCCGCAGAAGGGAGTCATCGCGCCGGGCGCCGACGCCGATGTGGTGATCATCGATCCACGCCGG
ACGACGACGCTGCGCCATAGCGACTTACATGACAATGCCGACTACAGCCCCTATGAGGGCATGGTATGCCGGGGGGCCAT
TCGTCATACCCTGGCGCGCGGCGAGCGTATTTTCAGTGAGGGTGAGTTTAGCGCTGAGCCGGGGCGCGGGCGTTTCCTGA
AACGGAAGGCGTTTCAGGCACCGGTATAA

Upstream 100 bases:

>100_bases
ATGCCGCTATCCCGCTGACCTATCTTGAGCAACTGAAGAAGTAATCCATACGTTATCAACCCCGGCATCGTGCATGCCGG
GGTCTCTTTGCGGAGCCTCG

Downstream 100 bases:

>100_bases
GCAGTACGGCTGCGCCCGCATACCGCCGGGAAGCTTGCGCGACGGGATGCAGTCCGGTCCAACAACATACGAGTGAGGAT
ATGATGAAGAAAAAAATCGT

Product: phenylhydantoinase

Products: NA

Alternate protein names: Hydantoin-utilizing enzyme hyuA [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MMKSLIKNGTVVNHNGERRADVLIEHGMISCLEPGLSEDEVDEVIDAEGCYVMPGGVDVHTHFNIDVGLARSCDDFFTGT
RAAACGGTTTIIDHMGFGPKGCSLHHQLAAYHGYAADKAVIDYGFHGVIQHIDEAILDEMASMVHDEGISSFKLYLTYGF
KLDDDAVLRALRRLHQVGALTTVHPENDAAIAQRRAHYLANGQVAPIFHARSRPLECEAEAIARMINLAQLAGNAPLYIV
HLSNGLGLDYLRLARARHQPVWVETCPQYLLLDERSYLREDGLKFILSPPLRNLREQDALWCGISDGAIDVVATDHCTFP
YSQRLALSGGNFSRCPNGLPGVENRMLLLFSAGVMTGRISLAHFVSLTSATPARLFGLWPQKGVIAPGADADVVIIDPRR
TTTLRHSDLHDNADYSPYEGMVCRGAIRHTLARGERIFSEGEFSAEPGRGRFLKRKAFQAPV

Sequences:

>Translated_462_residues
MMKSLIKNGTVVNHNGERRADVLIEHGMISCLEPGLSEDEVDEVIDAEGCYVMPGGVDVHTHFNIDVGLARSCDDFFTGT
RAAACGGTTTIIDHMGFGPKGCSLHHQLAAYHGYAADKAVIDYGFHGVIQHIDEAILDEMASMVHDEGISSFKLYLTYGF
KLDDDAVLRALRRLHQVGALTTVHPENDAAIAQRRAHYLANGQVAPIFHARSRPLECEAEAIARMINLAQLAGNAPLYIV
HLSNGLGLDYLRLARARHQPVWVETCPQYLLLDERSYLREDGLKFILSPPLRNLREQDALWCGISDGAIDVVATDHCTFP
YSQRLALSGGNFSRCPNGLPGVENRMLLLFSAGVMTGRISLAHFVSLTSATPARLFGLWPQKGVIAPGADADVVIIDPRR
TTTLRHSDLHDNADYSPYEGMVCRGAIRHTLARGERIFSEGEFSAEPGRGRFLKRKAFQAPV
>Mature_462_residues
MMKSLIKNGTVVNHNGERRADVLIEHGMISCLEPGLSEDEVDEVIDAEGCYVMPGGVDVHTHFNIDVGLARSCDDFFTGT
RAAACGGTTTIIDHMGFGPKGCSLHHQLAAYHGYAADKAVIDYGFHGVIQHIDEAILDEMASMVHDEGISSFKLYLTYGF
KLDDDAVLRALRRLHQVGALTTVHPENDAAIAQRRAHYLANGQVAPIFHARSRPLECEAEAIARMINLAQLAGNAPLYIV
HLSNGLGLDYLRLARARHQPVWVETCPQYLLLDERSYLREDGLKFILSPPLRNLREQDALWCGISDGAIDVVATDHCTFP
YSQRLALSGGNFSRCPNGLPGVENRMLLLFSAGVMTGRISLAHFVSLTSATPARLFGLWPQKGVIAPGADADVVIIDPRR
TTTLRHSDLHDNADYSPYEGMVCRGAIRHTLARGERIFSEGEFSAEPGRGRFLKRKAFQAPV

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=465, Percent_Identity=36.1290322580645, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4503051, Length=460, Percent_Identity=35.4347826086957, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI62422571, Length=460, Percent_Identity=35.4347826086957, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI4503377, Length=461, Percent_Identity=35.5748373101952, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=33.4782608695652, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI190194363, Length=463, Percent_Identity=34.341252699784, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI19923821, Length=463, Percent_Identity=34.1252699784017, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI18105007, Length=404, Percent_Identity=25, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=75.0542299349241, Blast_Score=720, Evalue=0.0,
Organism=Escherichia coli, GI1786722, Length=469, Percent_Identity=32.409381663113, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71989490, Length=457, Percent_Identity=37.199124726477, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17539558, Length=459, Percent_Identity=36.6013071895425, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI86575075, Length=460, Percent_Identity=30.8695652173913, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI193204318, Length=404, Percent_Identity=25.2475247524752, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322218, Length=434, Percent_Identity=26.2672811059908, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI221377917, Length=467, Percent_Identity=35.117773019272, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17137462, Length=454, Percent_Identity=34.5814977973568, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24644287, Length=305, Percent_Identity=35.4098360655738, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24644289, Length=230, Percent_Identity=36.9565217391304, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18859883, Length=448, Percent_Identity=27.0089285714286, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24642586, Length=413, Percent_Identity=25.90799031477, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 50707; Mature: 50707

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKSLIKNGTVVNHNGERRADVLIEHGMISCLEPGLSEDEVDEVIDAEGCYVMPGGVDVH
CCHHHHCCCCEEECCCCCHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCEECCCCEEEE
THFNIDVGLARSCDDFFTGTRAAACGGTTTIIDHMGFGPKGCSLHHQLAAYHGYAADKAV
EEEEEEECCCCCCHHHHCCCCHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHH
IDYGFHGVIQHIDEAILDEMASMVHDEGISSFKLYLTYGFKLDDDAVLRALRRLHQVGAL
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCEECHHHHHHHHHHHHHHCCE
TTVHPENDAAIAQRRAHYLANGQVAPIFHARSRPLECEAEAIARMINLAQLAGNAPLYIV
EEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
HLSNGLGLDYLRLARARHQPVWVETCPQYLLLDERSYLREDGLKFILSPPLRNLREQDAL
ECCCCCCHHHHHHHHHCCCCEEHHHCCHHEEECCHHHHHHCCCEEEECCCHHHHHHCCCE
WCGISDGAIDVVATDHCTFPYSQRLALSGGNFSRCPNGLPGVENRMLLLFSAGVMTGRIS
EEECCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHCCHHH
LAHFVSLTSATPARLFGLWPQKGVIAPGADADVVIIDPRRTTTLRHSDLHDNADYSPYEG
HHHHHHHCCCCCHHHEECCCCCCEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCC
MVCRGAIRHTLARGERIFSEGEFSAEPGRGRFLKRKAFQAPV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MMKSLIKNGTVVNHNGERRADVLIEHGMISCLEPGLSEDEVDEVIDAEGCYVMPGGVDVH
CCHHHHCCCCEEECCCCCHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCEECCCCEEEE
THFNIDVGLARSCDDFFTGTRAAACGGTTTIIDHMGFGPKGCSLHHQLAAYHGYAADKAV
EEEEEEECCCCCCHHHHCCCCHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHH
IDYGFHGVIQHIDEAILDEMASMVHDEGISSFKLYLTYGFKLDDDAVLRALRRLHQVGAL
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCEECHHHHHHHHHHHHHHCCE
TTVHPENDAAIAQRRAHYLANGQVAPIFHARSRPLECEAEAIARMINLAQLAGNAPLYIV
EEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
HLSNGLGLDYLRLARARHQPVWVETCPQYLLLDERSYLREDGLKFILSPPLRNLREQDAL
ECCCCCCHHHHHHHHHCCCCEEHHHCCHHEEECCHHHHHHCCCEEEECCCHHHHHHCCCE
WCGISDGAIDVVATDHCTFPYSQRLALSGGNFSRCPNGLPGVENRMLLLFSAGVMTGRIS
EEECCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHCCHHH
LAHFVSLTSATPARLFGLWPQKGVIAPGADADVVIIDPRRTTTLRHSDLHDNADYSPYEG
HHHHHHHCCCCCHHHEECCCCCCEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCC
MVCRGAIRHTLARGERIFSEGEFSAEPGRGRFLKRKAFQAPV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA