Click here to switch to the map view.

The map label for this gene is tktA [H]

Identifier: 238921227

GI number: 238921227

Start: 3256556

End: 3258550

Strand: Reverse

Name: tktA [H]

Synonym: NT01EI_3370

Alternate gene names: 238921227

Gene position: 3258550-3256556 (Counterclockwise)

Preceding gene: 238921230

Following gene: 238921226

Centisome position: 85.47

GC content: 61.05

Gene sequence:

>1995_bases
ATGTCCTCTCGTAAAGAGCTTGCCAATGCTATCCGTGCCCTGAGCATGGATGCGGTGCAGAAGGCCAAATCCGGTCACCC
GGGCGCCCCGATGGGGATGGCAGATATCGCCGAAGTCCTGTGGCGTGATTACATGAACCATAACCCGGTCAACCCGCACT
GGGCCGATCGTGACCGTTTTGTGCTGTCCAACGGCCATGGTTCTATGCTGATTTATAGCCTGCTGCACCTTACCGGCTAT
GATCTGCCGATCTCCGAGCTGGAAAACTTCCGCCAGCTGCACTCCAGAACCCCGGGCCACCCGGAGTATGGTTATACTCC
GGGCGTTGAGACCACCACCGGTCCGCTGGGCCAGGGCATTGCCAACGCTGTCGGCATGGCCATCGCCGAGCGTACGCTGG
CCGCGCAGTTTAACCGCCCGGGGCATGACATCGTCGACCATTTCACCTATGCCTTTATGGGTGATGGCTGCATGATGGAA
GGCATCTCCCACGAGGTCTGCTCCCTGGCCGGTACCCTGAAGCTGGGCAAGCTGATTGCGTTCTACGACGATAACGGTAT
CTCCATCGACGGTCATGTTGACGGCTGGTTCACCGATGATACCGCCAAGCGTTTTGAAGCTTACGGCTGGCACGTGGTGC
GCGGCGTAGACGGTCACGACAGCGCCGCCATCAAGGCCGCTATCGAAGAGGCGCGCAGCGTAAGCGACAAGCCGTCCCTG
CTGATGTGCAAAACCGTCATTGGCTTCGGTTCGCCGAACAAGGCCGGCACCCATGACTCCCACGGCGCGCCGCTGGGCGA
TGCAGAGATCGCGGCAACCCGCGCCCAGCTGGGCTGGAACTACCCGCCGTTCGTCATCCCGCAGGAGATCTATGCCCTGT
GGGATGCCAAAGAAGCCGGTAAGGCCAAAGAGCAGGCCTGGGATGTGCGTTTCGCCGCCTATCAGGCTGCGTTCCCGCAG
CTGGCCGCCGAATTCAAACGCCGTATCAACGGCGAACTGCCGGCCAGCTGGGACAGTGAATCCCGCCAGTTTATCAAACA
GCTGCAGGCCAACCCGGCCAAGATCGCCAGCCGTAAGGCGTCGCAGAATGCGCTGGAAGCCTTTGGCAAGCTGCTGCCGG
AGTTCCTGGGCGGCTCCGCCGACCTGGCACCGAGCAACCTGACCATGTGGTCAGGGTCCAAGGCGCTGAACGAAGACGCC
GCGGGTAACTATATCCACTACGGCGTGCGTGAGTTCGGCATGACCGCTATCATCAATGGCGTTGCGTTGCACGGTGGCTT
TATCCCCTACGGTGCCACCTTCCTGATGTTCATGGAGTATGCCCGTAACGCTATGCGTATGGCTGCCCTGATGAAGATCC
GCAACATTCAGGTCTACACCCATGACTCCATCGGTCTGGGCGAGGACGGCCCGACCCATCAGCCGGTCGAGCAGATGGCC
AGCCTGCGCACCACGCCGAACATGAACACCTGGCGCCCGTGTGACCAGGTCGAGTCCGCCGTGGCATGGAAGAAGGCCAT
CGAACGTCTGGATGGGCCGTCTGCGCTGATCTTTTCCCGTCAGAACCTGACCCAGATGGATCGCAGCGCCGAGCAGCTGG
TCAACGTTGAACGTGGTGCCTATATTCTGCAGGATTGTGACGCGCAGCCGGAGCTGATCTTCATTGCCACCGGCTCTGAA
GTGGAGCTGGCGATGAAAGCCGCTGCGCAACTGAGTGCCGAAGGGCGTCAGGTTCGCGTGGTCTCCATGCCATCCACCGA
AGTGTTCGACAAGCAGGATGCCGCCTACCGTGAAGCAGTACTGCCATCCGCCGTCAGCGCCCGTGTGGCGGTCGAGGCGG
GTATCGCCGACTTCTGGTACAAGTACGTCGGTCTGAACGGCGCTGTCGTCGGTATGACCACCTTCGGTGAGTCTGCGCCG
GCCGAACAGCTGTTCGTCGAGTTCGGCTTCACTGTCGACAACGTGCTGGCCAAGGCCCGCGCACTGCTGAAGTAA

Upstream 100 bases:

>100_bases
ACTCCTTGGCTGCGCCGTGATTAAGGATTGCCGTTTTCACTCCGAGTCTGAGACAATATGGCGAACCCTTGTTTTCATAC
AATCCGACTTGGAGTAGAAC

Downstream 100 bases:

>100_bases
GCCGTACGCGGTAGAAAAAGATGAACGGGGCGTCTGCCCCGTTTTTTCTGCCGGAGTATCAGGCGCTCTCTATGCGCTGA
TTTCGCATCAAATTGTGATG

Product: transketolase 1 (TK 1)

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYMNHNPVNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPISELENFRQLHSRTPGHPEYGYTPGVETTTGPLGQGIANAVGMAIAERTLAAQFNRPGHDIVDHFTYAFMGDGCMME
GISHEVCSLAGTLKLGKLIAFYDDNGISIDGHVDGWFTDDTAKRFEAYGWHVVRGVDGHDSAAIKAAIEEARSVSDKPSL
LMCKTVIGFGSPNKAGTHDSHGAPLGDAEIAATRAQLGWNYPPFVIPQEIYALWDAKEAGKAKEQAWDVRFAAYQAAFPQ
LAAEFKRRINGELPASWDSESRQFIKQLQANPAKIASRKASQNALEAFGKLLPEFLGGSADLAPSNLTMWSGSKALNEDA
AGNYIHYGVREFGMTAIINGVALHGGFIPYGATFLMFMEYARNAMRMAALMKIRNIQVYTHDSIGLGEDGPTHQPVEQMA
SLRTTPNMNTWRPCDQVESAVAWKKAIERLDGPSALIFSRQNLTQMDRSAEQLVNVERGAYILQDCDAQPELIFIATGSE
VELAMKAAAQLSAEGRQVRVVSMPSTEVFDKQDAAYREAVLPSAVSARVAVEAGIADFWYKYVGLNGAVVGMTTFGESAP
AEQLFVEFGFTVDNVLAKARALLK

Sequences:

>Translated_664_residues
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYMNHNPVNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPISELENFRQLHSRTPGHPEYGYTPGVETTTGPLGQGIANAVGMAIAERTLAAQFNRPGHDIVDHFTYAFMGDGCMME
GISHEVCSLAGTLKLGKLIAFYDDNGISIDGHVDGWFTDDTAKRFEAYGWHVVRGVDGHDSAAIKAAIEEARSVSDKPSL
LMCKTVIGFGSPNKAGTHDSHGAPLGDAEIAATRAQLGWNYPPFVIPQEIYALWDAKEAGKAKEQAWDVRFAAYQAAFPQ
LAAEFKRRINGELPASWDSESRQFIKQLQANPAKIASRKASQNALEAFGKLLPEFLGGSADLAPSNLTMWSGSKALNEDA
AGNYIHYGVREFGMTAIINGVALHGGFIPYGATFLMFMEYARNAMRMAALMKIRNIQVYTHDSIGLGEDGPTHQPVEQMA
SLRTTPNMNTWRPCDQVESAVAWKKAIERLDGPSALIFSRQNLTQMDRSAEQLVNVERGAYILQDCDAQPELIFIATGSE
VELAMKAAAQLSAEGRQVRVVSMPSTEVFDKQDAAYREAVLPSAVSARVAVEAGIADFWYKYVGLNGAVVGMTTFGESAP
AEQLFVEFGFTVDNVLAKARALLK
>Mature_663_residues
SSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYMNHNPVNPHWADRDRFVLSNGHGSMLIYSLLHLTGYD
LPISELENFRQLHSRTPGHPEYGYTPGVETTTGPLGQGIANAVGMAIAERTLAAQFNRPGHDIVDHFTYAFMGDGCMMEG
ISHEVCSLAGTLKLGKLIAFYDDNGISIDGHVDGWFTDDTAKRFEAYGWHVVRGVDGHDSAAIKAAIEEARSVSDKPSLL
MCKTVIGFGSPNKAGTHDSHGAPLGDAEIAATRAQLGWNYPPFVIPQEIYALWDAKEAGKAKEQAWDVRFAAYQAAFPQL
AAEFKRRINGELPASWDSESRQFIKQLQANPAKIASRKASQNALEAFGKLLPEFLGGSADLAPSNLTMWSGSKALNEDAA
GNYIHYGVREFGMTAIINGVALHGGFIPYGATFLMFMEYARNAMRMAALMKIRNIQVYTHDSIGLGEDGPTHQPVEQMAS
LRTTPNMNTWRPCDQVESAVAWKKAIERLDGPSALIFSRQNLTQMDRSAEQLVNVERGAYILQDCDAQPELIFIATGSEV
ELAMKAAAQLSAEGRQVRVVSMPSTEVFDKQDAAYREAVLPSAVSARVAVEAGIADFWYKYVGLNGAVVGMTTFGESAPA
EQLFVEFGFTVDNVLAKARALLK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=646, Percent_Identity=27.3993808049536, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI4507521, Length=646, Percent_Identity=27.3993808049536, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI133778974, Length=675, Percent_Identity=25.037037037037, Blast_Score=145, Evalue=2e-34,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=82.8054298642534, Blast_Score=1181, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=72.1633888048411, Blast_Score=1044, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=583, Percent_Identity=25.9005145797599, Blast_Score=165, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=47.7611940298507, Blast_Score=600, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319593, Length=673, Percent_Identity=44.5765230312036, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45551847, Length=602, Percent_Identity=27.7408637873754, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550715, Length=602, Percent_Identity=27.7408637873754, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24645119, Length=568, Percent_Identity=26.9366197183099, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666278, Length=282, Percent_Identity=32.9787234042553, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72403; Mature: 72272

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYMNHNPVNPHWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPISELENFRQLHSRTPGHPEYGYTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGMAIAERTLAAQFNRPGHDIVDHFTYAFMGDGCMMEGISHEVCSLAGTLKLGKLIA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCEEE
FYDDNGISIDGHVDGWFTDDTAKRFEAYGWHVVRGVDGHDSAAIKAAIEEARSVSDKPSL
EECCCCEEECCCCCCEECCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
LMCKTVIGFGSPNKAGTHDSHGAPLGDAEIAATRAQLGWNYPPFVIPQEIYALWDAKEAG
EEHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHC
KAKEQAWDVRFAAYQAAFPQLAAEFKRRINGELPASWDSESRQFIKQLQANPAKIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
SQNALEAFGKLLPEFLGGSADLAPSNLTMWSGSKALNEDAAGNYIHYGVREFGMTAIING
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHH
VALHGGFIPYGATFLMFMEYARNAMRMAALMKIRNIQVYTHDSIGLGEDGPTHQPVEQMA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHHH
SLRTTPNMNTWRPCDQVESAVAWKKAIERLDGPSALIFSRQNLTQMDRSAEQLVNVERGA
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCE
YILQDCDAQPELIFIATGSEVELAMKAAAQLSAEGRQVRVVSMPSTEVFDKQDAAYREAV
EEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCHHHHHHHHH
LPSAVSARVAVEAGIADFWYKYVGLNGAVVGMTTFGESAPAEQLFVEFGFTVDNVLAKAR
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC
>Mature Secondary Structure 
SSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDYMNHNPVNPHWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPISELENFRQLHSRTPGHPEYGYTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGMAIAERTLAAQFNRPGHDIVDHFTYAFMGDGCMMEGISHEVCSLAGTLKLGKLIA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCEEE
FYDDNGISIDGHVDGWFTDDTAKRFEAYGWHVVRGVDGHDSAAIKAAIEEARSVSDKPSL
EECCCCEEECCCCCCEECCHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
LMCKTVIGFGSPNKAGTHDSHGAPLGDAEIAATRAQLGWNYPPFVIPQEIYALWDAKEAG
EEHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHC
KAKEQAWDVRFAAYQAAFPQLAAEFKRRINGELPASWDSESRQFIKQLQANPAKIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
SQNALEAFGKLLPEFLGGSADLAPSNLTMWSGSKALNEDAAGNYIHYGVREFGMTAIING
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHH
VALHGGFIPYGATFLMFMEYARNAMRMAALMKIRNIQVYTHDSIGLGEDGPTHQPVEQMA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHHH
SLRTTPNMNTWRPCDQVESAVAWKKAIERLDGPSALIFSRQNLTQMDRSAEQLVNVERGA
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCE
YILQDCDAQPELIFIATGSEVELAMKAAAQLSAEGRQVRVVSMPSTEVFDKQDAAYREAV
EEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCHHHHHHHHH
LPSAVSARVAVEAGIADFWYKYVGLNGAVVGMTTFGESAPAEQLFVEFGFTVDNVLAKAR
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]