Click here to switch to the map view.

The map label for this gene is epd

Identifier: 238921226

GI number: 238921226

Start: 3255207

End: 3256232

Strand: Reverse

Name: epd

Synonym: NT01EI_3369

Alternate gene names: 238921226

Gene position: 3256232-3255207 (Counterclockwise)

Preceding gene: 238921227

Following gene: 238921225

Centisome position: 85.41

GC content: 59.16

Gene sequence:

>1026_bases
ATGACCATTCGTATCGCCATTAACGGCTTTGGTCGCATCGGCCGCAACGTACTGCGGGCGCTGTATGAGTCGGGACGACA
GACGCAGATGCGCGTCGTCGCAATCAATGAGCTGGCGGCCGCTGAAGGGATGGCACATCTACTGCAGTATGACACCTGCC
ACGGCCGGTTTGCCTGGTCGGTGCGCCAGCAGGATGACTGGTTGTGGATCGGCGACGATCGTATTCGTCTGCTGCACCGG
CCGCAGATCGCCGATCTGCCCTGGGAGGCGCTGCAGGTCGATGTGGTGCTGGAGTGTAGCGGTGTTTATGGCAGCCGGGC
TGATGGCGAGGCTCATCTTCTGGCGGGGGCCGGTAAAGTGCTGTTCTCCCACCCCGGCGGCCATGACCTTGATGCCACCG
TGGTATACGGGGTGAATCAGGAGAGTCTGTTGGCGGAGCATCGCATCGTCTCCAACGCCTCCTGTACCACCAACTGTATC
ATCCCGGTGATTAAATTGCTGGACGATGCCTTTGCCATCGAGTCGGGCGCAGTGACTACCATCCACTCGTCGATGAATGA
CCAACAGGTGATCGATGCTTACCACCCGGATCTGCGGCGGACCCGGGCTGCCAGCCACTCGATCATTCCGGTGGATACCA
AGCTGGCGGCGGGTATTGCGCGCGTGTTACCGCAGTTTCGCGATCGCTTTGAAGCGATCTCGGTACGGGTACCGACGCTG
AATGTGACCGCCATCGATCTCAGCGTCAGCGTGCGTACTCCGGTGCGGGTTGAGCAGGTGAACCACCTGCTGCAAAAGGC
GGCATCCACTGCATTTCATGGTATAGTTGACTACACAGAATTACCGCTGGTCTCGACCGACTTTAATCACGACCCGCACA
GCGCCATCGTGGACGGTACTCAGACGCGGGTCAGTGGTCGGCATTTGATTAAAACGTTGGTCTGGTGTGACAACGAATGG
GGATTCGCCAACCGGATGCTGGATACCACGCTGGCGATGGCCCGGGCAGTTTCTAATGCGTCGTAG

Upstream 100 bases:

>100_bases
AATTGATGGGGCCAGTGGCGTTTTTGCTGGCGGAGCCCGCTCCGGTGTCGCGTGCATGGATTACTCTTGGCGTCTGTTTG
TCGGACGAGGAAAGAGTAAG

Downstream 100 bases:

>100_bases
CCGCGCGCGGCGACACAGCTTAAAGCAACTTTTAGAGAATCAATGAGAGGATTCACCATGTCTGTAATTAAGATGACCGA
TTTGGATCTGGCGGGTAAAC

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTIRIAINGFGRIGRNVLRALYESGRQTQMRVVAINELAAAEGMAHLLQYDTCHGRFAWSVRQQDDWLWIGDDRIRLLHR
PQIADLPWEALQVDVVLECSGVYGSRADGEAHLLAGAGKVLFSHPGGHDLDATVVYGVNQESLLAEHRIVSNASCTTNCI
IPVIKLLDDAFAIESGAVTTIHSSMNDQQVIDAYHPDLRRTRAASHSIIPVDTKLAAGIARVLPQFRDRFEAISVRVPTL
NVTAIDLSVSVRTPVRVEQVNHLLQKAASTAFHGIVDYTELPLVSTDFNHDPHSAIVDGTQTRVSGRHLIKTLVWCDNEW
GFANRMLDTTLAMARAVSNAS

Sequences:

>Translated_341_residues
MTIRIAINGFGRIGRNVLRALYESGRQTQMRVVAINELAAAEGMAHLLQYDTCHGRFAWSVRQQDDWLWIGDDRIRLLHR
PQIADLPWEALQVDVVLECSGVYGSRADGEAHLLAGAGKVLFSHPGGHDLDATVVYGVNQESLLAEHRIVSNASCTTNCI
IPVIKLLDDAFAIESGAVTTIHSSMNDQQVIDAYHPDLRRTRAASHSIIPVDTKLAAGIARVLPQFRDRFEAISVRVPTL
NVTAIDLSVSVRTPVRVEQVNHLLQKAASTAFHGIVDYTELPLVSTDFNHDPHSAIVDGTQTRVSGRHLIKTLVWCDNEW
GFANRMLDTTLAMARAVSNAS
>Mature_340_residues
TIRIAINGFGRIGRNVLRALYESGRQTQMRVVAINELAAAEGMAHLLQYDTCHGRFAWSVRQQDDWLWIGDDRIRLLHRP
QIADLPWEALQVDVVLECSGVYGSRADGEAHLLAGAGKVLFSHPGGHDLDATVVYGVNQESLLAEHRIVSNASCTTNCII
PVIKLLDDAFAIESGAVTTIHSSMNDQQVIDAYHPDLRRTRAASHSIIPVDTKLAAGIARVLPQFRDRFEAISVRVPTLN
VTAIDLSVSVRTPVRVEQVNHLLQKAASTAFHGIVDYTELPLVSTDFNHDPHSAIVDGTQTRVSGRHLIKTLVWCDNEWG
FANRMLDTTLAMARAVSNAS

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily

Homologues:

Organism=Homo sapiens, GI7669492, Length=335, Percent_Identity=34.6268656716418, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI7657116, Length=330, Percent_Identity=35.4545454545455, Blast_Score=205, Evalue=6e-53,
Organism=Escherichia coli, GI1789295, Length=334, Percent_Identity=80.5389221556886, Blast_Score=563, Evalue=1e-162,
Organism=Escherichia coli, GI1788079, Length=329, Percent_Identity=37.9939209726444, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17534677, Length=334, Percent_Identity=36.5269461077844, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17534679, Length=334, Percent_Identity=36.2275449101796, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI32566163, Length=333, Percent_Identity=36.6366366366366, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17568413, Length=333, Percent_Identity=36.6366366366366, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6322468, Length=336, Percent_Identity=35.1190476190476, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6322409, Length=336, Percent_Identity=36.3095238095238, Blast_Score=232, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6321631, Length=336, Percent_Identity=35.4166666666667, Blast_Score=232, Evalue=6e-62,
Organism=Drosophila melanogaster, GI17933600, Length=328, Percent_Identity=34.7560975609756, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI18110149, Length=328, Percent_Identity=34.7560975609756, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI85725000, Length=328, Percent_Identity=34.4512195121951, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI22023983, Length=328, Percent_Identity=34.4512195121951, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=33.6363636363636, Blast_Score=202, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): E4PD_EDWI9 (C5BAU7)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934741.1
- GeneID:   7959668
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3369
- OMA:   IQAKAVR
- ProtClustDB:   PRK13535
- GO:   GO:0005737
- HAMAP:   MF_01640
- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01532

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.72

Molecular weight: Translated: 37550; Mature: 37419

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 155-155 BINDING 200-200 BINDING 236-236 BINDING 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRIAINGFGRIGRNVLRALYESGRQTQMRVVAINELAAAEGMAHLLQYDTCHGRFAWS
CEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEE
VRQQDDWLWIGDDRIRLLHRPQIADLPWEALQVDVVLECSGVYGSRADGEAHLLAGAGKV
EECCCCEEEECCCCEEEEECCCCCCCCHHHEEEEEEEEECCCCCCCCCCCEEEEECCCEE
LFSHPGGHDLDATVVYGVNQESLLAEHRIVSNASCTTNCIIPVIKLLDDAFAIESGAVTT
EEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
IHSSMNDQQVIDAYHPDLRRTRAASHSIIPVDTKLAAGIARVLPQFRDRFEAISVRVPTL
EECCCCCHHHHHHHCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHEEEEECCEE
NVTAIDLSVSVRTPVRVEQVNHLLQKAASTAFHGIVDYTELPLVSTDFNHDPHSAIVDGT
EEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCEEECCCCCCCCCCEECCC
QTRVSGRHLIKTLVWCDNEWGFANRMLDTTLAMARAVSNAS
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TIRIAINGFGRIGRNVLRALYESGRQTQMRVVAINELAAAEGMAHLLQYDTCHGRFAWS
EEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEE
VRQQDDWLWIGDDRIRLLHRPQIADLPWEALQVDVVLECSGVYGSRADGEAHLLAGAGKV
EECCCCEEEECCCCEEEEECCCCCCCCHHHEEEEEEEEECCCCCCCCCCCEEEEECCCEE
LFSHPGGHDLDATVVYGVNQESLLAEHRIVSNASCTTNCIIPVIKLLDDAFAIESGAVTT
EEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
IHSSMNDQQVIDAYHPDLRRTRAASHSIIPVDTKLAAGIARVLPQFRDRFEAISVRVPTL
EECCCCCHHHHHHHCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHEEEEECCEE
NVTAIDLSVSVRTPVRVEQVNHLLQKAASTAFHGIVDYTELPLVSTDFNHDPHSAIVDGT
EEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCEEECCCCCCCCCCEECCC
QTRVSGRHLIKTLVWCDNEWGFANRMLDTTLAMARAVSNAS
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA