Click here to switch to the map view.

The map label for this gene is apxIC [H]

Identifier: 238921188

GI number: 238921188

Start: 3216598

End: 3217125

Strand: Reverse

Name: apxIC [H]

Synonym: NT01EI_3329

Alternate gene names: 238921188

Gene position: 3217125-3216598 (Counterclockwise)

Preceding gene: 238921189

Following gene: 238921187

Centisome position: 84.39

GC content: 58.52

Gene sequence:

>528_bases
ATGGAGTGGCATGGATTTACCGTACAGTGCCCGCTGGTGCTGGGCGGTAGCGTGAACGAAGCCGAAGTATTGGGCGCCAC
CGTCTGGCTGTGGATGCACTCCGTGCGGCATAGAGAGGCGCCATTGGAGGCGTTGCCTGAACTGCTATTACCCGCCATCA
GACAGCGCCAGTATGTCTTGGCCTGCCAGGATAGCAGGCCCGTATTTTTTATGAGTTGGGCCTGGTTGGATGCGCAGGCT
GAACAACATTATCTCACGCGCTGGCCATTACTGGTGCCGGAGGCAGCATGGCAGAGCGGTGAGCGGATGTGGGTCATCGA
TTGGGTTGCTCCCTTTGGCCATACCCGGCAGATGACCCGACTACTGCGCAGTGAACTCTTCCCAACGCACTGCCTGCGTT
CACTCTGGCACCGGGGGGCTGAGCGCGGAAAGCGGGTGAAATGTTTTTGGGGCGATCGGGTTTCACAGGATGCGCTGCGT
ACCTGGCGGCACAATTATCCACTCTGTGCCGACGTTATCGAATGCTAA

Upstream 100 bases:

>100_bases
AGGCCGGTTACGACCTGTTTGCGGGGACTCCGTTATCCAAGCCTGATGGGCTGAAAACAGATTCGGTAACGGTCGGATTC
AGCCTCAACTGGAGTTATTG

Downstream 100 bases:

>100_bases
TAGAAAAAGTGTATTTCCCTCATTTATTGAAAAAGGAAAAAAGATGAAAAAAATACTGATAAGTCTGGCTCTGGTGAGCG
GTGTAATGGCGAGCCCTGCC

Product: RTX-I toxin-activating lysine-acyltransferase apxIC

Products: NA

Alternate protein names: APX-IC; Cytolysin IC; CLY-IC; HLY-IC; RTX-I toxin determinant C; Toxin RTX-I-activating protein C [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MEWHGFTVQCPLVLGGSVNEAEVLGATVWLWMHSVRHREAPLEALPELLLPAIRQRQYVLACQDSRPVFFMSWAWLDAQA
EQHYLTRWPLLVPEAAWQSGERMWVIDWVAPFGHTRQMTRLLRSELFPTHCLRSLWHRGAERGKRVKCFWGDRVSQDALR
TWRHNYPLCADVIEC

Sequences:

>Translated_175_residues
MEWHGFTVQCPLVLGGSVNEAEVLGATVWLWMHSVRHREAPLEALPELLLPAIRQRQYVLACQDSRPVFFMSWAWLDAQA
EQHYLTRWPLLVPEAAWQSGERMWVIDWVAPFGHTRQMTRLLRSELFPTHCLRSLWHRGAERGKRVKCFWGDRVSQDALR
TWRHNYPLCADVIEC
>Mature_175_residues
MEWHGFTVQCPLVLGGSVNEAEVLGATVWLWMHSVRHREAPLEALPELLLPAIRQRQYVLACQDSRPVFFMSWAWLDAQA
EQHYLTRWPLLVPEAAWQSGERMWVIDWVAPFGHTRQMTRLLRSELFPTHCLRSLWHRGAERGKRVKCFWGDRVSQDALR
TWRHNYPLCADVIEC

Specific function: Involved in fatty acylation of the protoxin, thereby converting it to the active toxin [H]

COG id: COG2994

COG function: function code O; ACP:hemolysin acyltransferase (hemolysin-activating protein)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RTX toxin acyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003996 [H]

Pfam domain/function: PF02794 HlyC [H]

EC number: NA

Molecular weight: Translated: 20589; Mature: 20589

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWHGFTVQCPLVLGGSVNEAEVLGATVWLWMHSVRHREAPLEALPELLLPAIRQRQYVL
CCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEE
ACQDSRPVFFMSWAWLDAQAEQHYLTRWPLLVPEAAWQSGERMWVIDWVAPFGHTRQMTR
EECCCCCEEEEEEEEECCCHHHHHHHHCCEECCHHHHCCCCEEEEEEECCCCCCHHHHHH
LLRSELFPTHCLRSLWHRGAERGKRVKCFWGDRVSQDALRTWRHNYPLCADVIEC
HHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MEWHGFTVQCPLVLGGSVNEAEVLGATVWLWMHSVRHREAPLEALPELLLPAIRQRQYVL
CCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEE
ACQDSRPVFFMSWAWLDAQAEQHYLTRWPLLVPEAAWQSGERMWVIDWVAPFGHTRQMTR
EECCCCCEEEEEEEEECCCHHHHHHHHCCEECCHHHHCCCCEEEEEEECCCCCCHHHHHH
LLRSELFPTHCLRSLWHRGAERGKRVKCFWGDRVSQDALRTWRHNYPLCADVIEC
HHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8181764; 8359891 [H]