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The map label for this gene is htrA [H]

Identifier: 238917543

GI number: 238917543

Start: 1679644

End: 1681029

Strand: Reverse

Name: htrA [H]

Synonym: EUBELI_01622

Alternate gene names: 238917543

Gene position: 1681029-1679644 (Counterclockwise)

Preceding gene: 238917544

Following gene: 238917542

Centisome position: 78.4

GC content: 37.3

Gene sequence:

>1386_bases
ATGATTATGTATAACGACAATAATGAGAATAATGAGAATGATTCACAGTACCGTTACAGTGGCAGTGATATACCATATAA
CAATACTAACAATGGCAGTACATCTAATAATAACACAGCATTTTCAAGTGCACCTTATGAAGCTAAGAAGCACAAGAAAC
ACAAAAGAGGATTTGCAAGGAAAGCAGCATGCTTTGTTCTTTCAGCAGTACTTTTTGGCGCAATAGCCGGTTCGGTTATG
TTTGGTGTTAATTATGCAGGTGGAAAGATTGCTGGCAGTAATAAGTCTGATGCTACAGGTGTTAATATACCAACAGTAAG
TAATAATATTTCTAATGTCGCTAAGACAGATTCTTCGCTTACAGAAGATACTAATCTTTCAGCATCAGGTAAGATGGATG
CTGAGGCAGTTGCTACAGCAGCCCTTCCTGCAATGGTTCAGCTTAATGGTACAACAACAGTTAAAAGTTCAAGTTATTTT
GGATATGGACAGAGTTATGAGGCAACATCAAGTGGTACAGGTATTATTGTAGGCAAGAGTGATACTGAATTACTTATTGT
AACTAATGCACATGTTGTTGATAATATTGATAATCTTAAATGCGTATTCTCTGATGGCACAAGTGCAAGCTGTTCTGTTA
AGGGTTCTAAGTCAGATCAGGATATTGCAGTAGCCGCAGTATCATTAAGTGATATTTCATCTGATACAGCGTCTAATATT
GCAATTGCAGAACTTGAAGATTCATCAGATATTAAAGTTGGACAGCAGGTTGTTGCCATTGGTAATGCATTAGGTGAAGG
ACAGTCAGTTACAACTGGTATAATTAGTGCAAAGGACCGTTCAATTACAGTCAACAATGTAACATTTACAGGACTTCTTA
TGACAGATGCAGCAATTAACTCTGGTAACAGTGGTGGAGCTCTTCTTAATTCTGAAGGAAAGGTTATTGCTATTAACTTT
GCAAAGACCAGCAGTGATGGTGTAGAAGGTATGGCTTATTCAATCCCTGTTTCTAATGTTAAGGATATTATCGATTCATT
AATGACTAAGCAGACAAGAAACAAGGTTTCGTCAGATAAGGCAGCATACCTTGGAATTGCAGCAGTAGATATTACAAGTA
ATTATGCATCATATTATGGATATCCTGTAGGTATTCTTATAAGAACTGTAGCTGATGATTCAGCAGCAGACAAGGCAGGA
TTAGAGACATACGACATAATTGTCGGATTTGATGACCAGACAGTTACTACTATGTCAGGACTTACTAACATGCTTCAGTA
TTATGAGGCAGGTGAAAAAGTAACTATAGATTATTATCATATGGAAGGAAGCGAGTATGTTCTTAAGAGCACGGAGGTAA
CGCTTGGCTCTAAGAAGGCATCTTAA

Upstream 100 bases:

>100_bases
GAACACATTTCGTTGTTATATTACATGTATTGACAGTGAGATGTGTTCATTTGTTATGTATGGAATCTTCATTGTCATAA
TACAATGGTAAAAGGAGAGA

Downstream 100 bases:

>100_bases
GGATATATTCCAAGTAGATATTTATGGATAATACCAATGAGAATATGACAGAAGATAAGGATATTAATAAGAATAACAAT
GGGAATTCCGATGATTATGA

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MIMYNDNNENNENDSQYRYSGSDIPYNNTNNGSTSNNNTAFSSAPYEAKKHKKHKRGFARKAACFVLSAVLFGAIAGSVM
FGVNYAGGKIAGSNKSDATGVNIPTVSNNISNVAKTDSSLTEDTNLSASGKMDAEAVATAALPAMVQLNGTTTVKSSSYF
GYGQSYEATSSGTGIIVGKSDTELLIVTNAHVVDNIDNLKCVFSDGTSASCSVKGSKSDQDIAVAAVSLSDISSDTASNI
AIAELEDSSDIKVGQQVVAIGNALGEGQSVTTGIISAKDRSITVNNVTFTGLLMTDAAINSGNSGGALLNSEGKVIAINF
AKTSSDGVEGMAYSIPVSNVKDIIDSLMTKQTRNKVSSDKAAYLGIAAVDITSNYASYYGYPVGILIRTVADDSAADKAG
LETYDIIVGFDDQTVTTMSGLTNMLQYYEAGEKVTIDYYHMEGSEYVLKSTEVTLGSKKAS

Sequences:

>Translated_461_residues
MIMYNDNNENNENDSQYRYSGSDIPYNNTNNGSTSNNNTAFSSAPYEAKKHKKHKRGFARKAACFVLSAVLFGAIAGSVM
FGVNYAGGKIAGSNKSDATGVNIPTVSNNISNVAKTDSSLTEDTNLSASGKMDAEAVATAALPAMVQLNGTTTVKSSSYF
GYGQSYEATSSGTGIIVGKSDTELLIVTNAHVVDNIDNLKCVFSDGTSASCSVKGSKSDQDIAVAAVSLSDISSDTASNI
AIAELEDSSDIKVGQQVVAIGNALGEGQSVTTGIISAKDRSITVNNVTFTGLLMTDAAINSGNSGGALLNSEGKVIAINF
AKTSSDGVEGMAYSIPVSNVKDIIDSLMTKQTRNKVSSDKAAYLGIAAVDITSNYASYYGYPVGILIRTVADDSAADKAG
LETYDIIVGFDDQTVTTMSGLTNMLQYYEAGEKVTIDYYHMEGSEYVLKSTEVTLGSKKAS
>Mature_461_residues
MIMYNDNNENNENDSQYRYSGSDIPYNNTNNGSTSNNNTAFSSAPYEAKKHKKHKRGFARKAACFVLSAVLFGAIAGSVM
FGVNYAGGKIAGSNKSDATGVNIPTVSNNISNVAKTDSSLTEDTNLSASGKMDAEAVATAALPAMVQLNGTTTVKSSSYF
GYGQSYEATSSGTGIIVGKSDTELLIVTNAHVVDNIDNLKCVFSDGTSASCSVKGSKSDQDIAVAAVSLSDISSDTASNI
AIAELEDSSDIKVGQQVVAIGNALGEGQSVTTGIISAKDRSITVNNVTFTGLLMTDAAINSGNSGGALLNSEGKVIAINF
AKTSSDGVEGMAYSIPVSNVKDIIDSLMTKQTRNKVSSDKAAYLGIAAVDITSNYASYYGYPVGILIRTVADDSAADKAG
LETYDIIVGFDDQTVTTMSGLTNMLQYYEAGEKVTIDYYHMEGSEYVLKSTEVTLGSKKAS

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=278, Percent_Identity=29.8561151079137, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI24308541, Length=274, Percent_Identity=28.4671532846715, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI22129776, Length=268, Percent_Identity=30.2238805970149, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI7019477, Length=259, Percent_Identity=28.1853281853282, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786356, Length=258, Percent_Identity=32.1705426356589, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789629, Length=280, Percent_Identity=30.3571428571429, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789630, Length=272, Percent_Identity=31.9852941176471, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646839, Length=283, Percent_Identity=28.2685512367491, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48169; Mature: 48169

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMYNDNNENNENDSQYRYSGSDIPYNNTNNGSTSNNNTAFSSAPYEAKKHKKHKRGFAR
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
KAACFVLSAVLFGAIAGSVMFGVNYAGGKIAGSNKSDATGVNIPTVSNNISNVAKTDSSL
HHHHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCC
TEDTNLSASGKMDAEAVATAALPAMVQLNGTTTVKSSSYFGYGQSYEATSSGTGIIVGKS
CCCCCCCCCCCCCHHHHHHHHCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCEEEEECC
DTELLIVTNAHVVDNIDNLKCVFSDGTSASCSVKGSKSDQDIAVAAVSLSDISSDTASNI
CCEEEEEECCHHHCCCCCEEEEEECCCCCEEEEECCCCCCCEEEEEEEEHHCCCCCCCCE
AIAELEDSSDIKVGQQVVAIGNALGEGQSVTTGIISAKDRSITVNNVTFTGLLMTDAAIN
EEEEECCCCCCHHHHHHEEEHHHCCCCCCEEEEEEECCCCEEEEECEEEEEEEEEEEECC
SGNSGGALLNSEGKVIAINFAKTSSDGVEGMAYSIPVSNVKDIIDSLMTKQTRNKVSSDK
CCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
AAYLGIAAVDITSNYASYYGYPVGILIRTVADDSAADKAGLETYDIIVGFDDQTVTTMSG
EEEEEEEEEEECCCHHHHCCCCHHEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHH
LTNMLQYYEAGEKVTIDYYHMEGSEYVLKSTEVTLGSKKAS
HHHHHHHHHCCCEEEEEEEEECCCEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MIMYNDNNENNENDSQYRYSGSDIPYNNTNNGSTSNNNTAFSSAPYEAKKHKKHKRGFAR
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
KAACFVLSAVLFGAIAGSVMFGVNYAGGKIAGSNKSDATGVNIPTVSNNISNVAKTDSSL
HHHHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCC
TEDTNLSASGKMDAEAVATAALPAMVQLNGTTTVKSSSYFGYGQSYEATSSGTGIIVGKS
CCCCCCCCCCCCCHHHHHHHHCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCEEEEECC
DTELLIVTNAHVVDNIDNLKCVFSDGTSASCSVKGSKSDQDIAVAAVSLSDISSDTASNI
CCEEEEEECCHHHCCCCCEEEEEECCCCCEEEEECCCCCCCEEEEEEEEHHCCCCCCCCE
AIAELEDSSDIKVGQQVVAIGNALGEGQSVTTGIISAKDRSITVNNVTFTGLLMTDAAIN
EEEEECCCCCCHHHHHHEEEHHHCCCCCCEEEEEEECCCCEEEEECEEEEEEEEEEEECC
SGNSGGALLNSEGKVIAINFAKTSSDGVEGMAYSIPVSNVKDIIDSLMTKQTRNKVSSDK
CCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
AAYLGIAAVDITSNYASYYGYPVGILIRTVADDSAADKAGLETYDIIVGFDDQTVTTMSG
EEEEEEEEEEECCCHHHHCCCCHHEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHH
LTNMLQYYEAGEKVTIDYYHMEGSEYVLKSTEVTLGSKKAS
HHHHHHHHHCCCEEEEEEEEECCCEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]