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The map label for this gene is pgcA [H]

Identifier: 238917544

GI number: 238917544

Start: 1681166

End: 1682893

Strand: Reverse

Name: pgcA [H]

Synonym: EUBELI_01623

Alternate gene names: 238917544

Gene position: 1682893-1681166 (Counterclockwise)

Preceding gene: 238917545

Following gene: 238917543

Centisome position: 78.49

GC content: 38.37

Gene sequence:

>1728_bases
ATGGGTTATATGGAAACTTACAAAGCATGGTGTGAGAATGAATATTTTGATGAAGACACACGTGCAGAACTCAAATCAAT
TGCAGGAGATGAGAAAGAGATTGAGGACAGATTCTATAAGGATCTTGAGTTTGGAACAGGCGGACTGAGAGGTGTCATAG
GCAATGGTACTAACAGAATGAATGTATACATTGTAAGAAAGGCAACTCAGGGGTTAGCTAATTTTATTATCAAGGAAGGA
ACACAGGATAAGGGTGTTGCTATTTCTCATGATAATAGAAGAATGTCAAGAGAATTTGCGCAGGAAGCAGCTCTTTGTCT
TGCGGCTAATGGCATTAAGGTATACATATTCCCTTCATTAAGACCAACACCAGAACTTTCATTTGCAGTAAGAGAACTTC
ACTGTACAGCAGGTATTATGGTTACGGCAAGCCACAATCCTCCAGAATACAATGGATATAAGGTATACTGGGATGACGGA
TGCCAGATAACAGCACCTAAGGATACACAGATTATCAATGAAGTTAAGGCTGTTACTGATTTTAATGATGTTAAGACTAT
TGATGAAGAAGAGGCTAGAGTAAGAGGCCTGTATAACATTATTGGATATGATATGGATGATGCATTTATTGCAGCATTAA
AGAAGCAGAGCCTTAACGGAGATATCATTAAGCAGGTTGCTGATGATATTAAGATTGTATACTCTCCATTCAATGGTACA
GGTAATGTTCCTGTAAGAAGAATTTTAAGAGAGTTAGGTTTCAAGAATGTATATGTTGTTCCAGAACAGGAAAAACCAGA
TCCTAACTTTACAACACTCGAGTACCCTAATCCTGAAGACCCTAAGGCATTCACATATGCATTAAGACTTGCTAAGGAAG
TTGATGCAGATATTATTCTTGCAACTGACCCTGATGCGGACAGACTTGGCGTATATTCTAAGGACACTAAATCAGGTGAG
TACAAGTCATTCACAGGTAATATGTCTGGTATGCTTATTGCAGAATACCTTCTTTCACAGAGAAAGGAGAAGGGACTTCT
TCATGAGAATGGTGCATTTGTAAAGACTATCGTATCTACTAACTTAGCTGATCTTATCGCTAAGGAATATAACTTAAAGC
TTATTGAAGTTCTTACAGGATTTAAGTATATTGGTGAGCAGATTAAGTTCTTTGAGCAGAATAATACATACGAATATGAA
TTCGGTTTTGAAGAGAGTTACGGCTGCTTGGTTGGAACTCATGCAAGAGACAAGGATGCCATCGTGGCTGTTATGGCATT
ATGTGAAGCAGCAGCTTACTATAAGTCTAAAGGCATTACTTTATGGGATCAGATGATTAATATCTTTGATAAGTACGGCT
ACTTCAAGGAAGGACAGAAGGCTGTAACTATGAAGGGTGCAGAAGGTGCTGTCCAGATTGCTAAGATGATGGATGATTTA
AGAAATAATCCACCTAAGAAGTTCGGAGCATGGAATGTTGTTGAGTTCAGAGATTATAAGAAGGATGAGTGTACAGTTAT
TGCTACAGGCGAGAAGAAGCCTACAGGACTTCCTGAATCTAACGTACTTTATTTTGAACTTAATGACCATGCATGGTGCT
GTGCAAGACCTTCAGGAACAGAGCCTAAGATTAAGTTCTATATGGGTGTTAAGGGAACAGGTCTTGAAGATGCTGATAAG
AAGTTAGAAGAACTTACTGATGCAGTATCAGAAATTGTCGGATTATAA

Upstream 100 bases:

>100_bases
AGCAGAAGGTCCGGACGAAGAAGAAGCATTGAAAGCAGTTTCTGAGAGCTTTAGAAAAGCTTTACAGGACTAATATAAAT
CAAGAAAAGAGGTAAAGGGT

Downstream 100 bases:

>100_bases
TCAGTTCAAATTTAATTAACAACTAAAACACAATATGAACACATTTCGTTGTTATATTACATGTATTGACAGTGAGATGT
GTTCATTTGTTATGTATGGA

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MGYMETYKAWCENEYFDEDTRAELKSIAGDEKEIEDRFYKDLEFGTGGLRGVIGNGTNRMNVYIVRKATQGLANFIIKEG
TQDKGVAISHDNRRMSREFAQEAALCLAANGIKVYIFPSLRPTPELSFAVRELHCTAGIMVTASHNPPEYNGYKVYWDDG
CQITAPKDTQIINEVKAVTDFNDVKTIDEEEARVRGLYNIIGYDMDDAFIAALKKQSLNGDIIKQVADDIKIVYSPFNGT
GNVPVRRILRELGFKNVYVVPEQEKPDPNFTTLEYPNPEDPKAFTYALRLAKEVDADIILATDPDADRLGVYSKDTKSGE
YKSFTGNMSGMLIAEYLLSQRKEKGLLHENGAFVKTIVSTNLADLIAKEYNLKLIEVLTGFKYIGEQIKFFEQNNTYEYE
FGFEESYGCLVGTHARDKDAIVAVMALCEAAAYYKSKGITLWDQMINIFDKYGYFKEGQKAVTMKGAEGAVQIAKMMDDL
RNNPPKKFGAWNVVEFRDYKKDECTVIATGEKKPTGLPESNVLYFELNDHAWCCARPSGTEPKIKFYMGVKGTGLEDADK
KLEELTDAVSEIVGL

Sequences:

>Translated_575_residues
MGYMETYKAWCENEYFDEDTRAELKSIAGDEKEIEDRFYKDLEFGTGGLRGVIGNGTNRMNVYIVRKATQGLANFIIKEG
TQDKGVAISHDNRRMSREFAQEAALCLAANGIKVYIFPSLRPTPELSFAVRELHCTAGIMVTASHNPPEYNGYKVYWDDG
CQITAPKDTQIINEVKAVTDFNDVKTIDEEEARVRGLYNIIGYDMDDAFIAALKKQSLNGDIIKQVADDIKIVYSPFNGT
GNVPVRRILRELGFKNVYVVPEQEKPDPNFTTLEYPNPEDPKAFTYALRLAKEVDADIILATDPDADRLGVYSKDTKSGE
YKSFTGNMSGMLIAEYLLSQRKEKGLLHENGAFVKTIVSTNLADLIAKEYNLKLIEVLTGFKYIGEQIKFFEQNNTYEYE
FGFEESYGCLVGTHARDKDAIVAVMALCEAAAYYKSKGITLWDQMINIFDKYGYFKEGQKAVTMKGAEGAVQIAKMMDDL
RNNPPKKFGAWNVVEFRDYKKDECTVIATGEKKPTGLPESNVLYFELNDHAWCCARPSGTEPKIKFYMGVKGTGLEDADK
KLEELTDAVSEIVGL
>Mature_574_residues
GYMETYKAWCENEYFDEDTRAELKSIAGDEKEIEDRFYKDLEFGTGGLRGVIGNGTNRMNVYIVRKATQGLANFIIKEGT
QDKGVAISHDNRRMSREFAQEAALCLAANGIKVYIFPSLRPTPELSFAVRELHCTAGIMVTASHNPPEYNGYKVYWDDGC
QITAPKDTQIINEVKAVTDFNDVKTIDEEEARVRGLYNIIGYDMDDAFIAALKKQSLNGDIIKQVADDIKIVYSPFNGTG
NVPVRRILRELGFKNVYVVPEQEKPDPNFTTLEYPNPEDPKAFTYALRLAKEVDADIILATDPDADRLGVYSKDTKSGEY
KSFTGNMSGMLIAEYLLSQRKEKGLLHENGAFVKTIVSTNLADLIAKEYNLKLIEVLTGFKYIGEQIKFFEQNNTYEYEF
GFEESYGCLVGTHARDKDAIVAVMALCEAAAYYKSKGITLWDQMINIFDKYGYFKEGQKAVTMKGAEGAVQIAKMMDDLR
NNPPKKFGAWNVVEFRDYKKDECTVIATGEKKPTGLPESNVLYFELNDHAWCCARPSGTEPKIKFYMGVKGTGLEDADKK
LEELTDAVSEIVGL

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=576, Percent_Identity=32.8125, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI31377548, Length=577, Percent_Identity=32.7556325823224, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1786904, Length=536, Percent_Identity=24.2537313432836, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993870, Length=558, Percent_Identity=32.4372759856631, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71993878, Length=315, Percent_Identity=35.8730158730159, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323934, Length=563, Percent_Identity=32.5044404973357, Blast_Score=243, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6323752, Length=432, Percent_Identity=28.4722222222222, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129809, Length=566, Percent_Identity=30.565371024735, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24651977, Length=438, Percent_Identity=32.8767123287671, Blast_Score=219, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24653722, Length=572, Percent_Identity=29.7202797202797, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64657; Mature: 64526

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYMETYKAWCENEYFDEDTRAELKSIAGDEKEIEDRFYKDLEFGTGGLRGVIGNGTNRM
CCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEE
NVYIVRKATQGLANFIIKEGTQDKGVAISHDNRRMSREFAQEAALCLAANGIKVYIFPSL
EEEEEECHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHEEEECCEEEEEECCC
RPTPELSFAVRELHCTAGIMVTASHNPPEYNGYKVYWDDGCQITAPKDTQIINEVKAVTD
CCCCCHHHHHHHHHEECCEEEEECCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHCC
FNDVKTIDEEEARVRGLYNIIGYDMDDAFIAALKKQSLNGDIIKQVADDIKIVYSPFNGT
CHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCEEEEEECCCCC
GNVPVRRILRELGFKNVYVVPEQEKPDPNFTTLEYPNPEDPKAFTYALRLAKEVDADIIL
CCCHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEE
ATDPDADRLGVYSKDTKSGEYKSFTGNMSGMLIAEYLLSQRKEKGLLHENGAFVKTIVST
EECCCCHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHH
NLADLIAKEYNLKLIEVLTGFKYIGEQIKFFEQNNTYEYEFGFEESYGCLVGTHARDKDA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCEEEECCCCCHHH
IVAVMALCEAAAYYKSKGITLWDQMINIFDKYGYFKEGQKAVTMKGAEGAVQIAKMMDDL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCEEEEEECCCHHHHHHHHHHHH
RNNPPKKFGAWNVVEFRDYKKDECTVIATGEKKPTGLPESNVLYFELNDHAWCCARPSGT
HCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCC
EPKIKFYMGVKGTGLEDADKKLEELTDAVSEIVGL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GYMETYKAWCENEYFDEDTRAELKSIAGDEKEIEDRFYKDLEFGTGGLRGVIGNGTNRM
CHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEE
NVYIVRKATQGLANFIIKEGTQDKGVAISHDNRRMSREFAQEAALCLAANGIKVYIFPSL
EEEEEECHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHEEEECCEEEEEECCC
RPTPELSFAVRELHCTAGIMVTASHNPPEYNGYKVYWDDGCQITAPKDTQIINEVKAVTD
CCCCCHHHHHHHHHEECCEEEEECCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHCC
FNDVKTIDEEEARVRGLYNIIGYDMDDAFIAALKKQSLNGDIIKQVADDIKIVYSPFNGT
CHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCEEEEEECCCCC
GNVPVRRILRELGFKNVYVVPEQEKPDPNFTTLEYPNPEDPKAFTYALRLAKEVDADIIL
CCCHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEE
ATDPDADRLGVYSKDTKSGEYKSFTGNMSGMLIAEYLLSQRKEKGLLHENGAFVKTIVST
EECCCCHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHH
NLADLIAKEYNLKLIEVLTGFKYIGEQIKFFEQNNTYEYEFGFEESYGCLVGTHARDKDA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCEEEECCCCCHHH
IVAVMALCEAAAYYKSKGITLWDQMINIFDKYGYFKEGQKAVTMKGAEGAVQIAKMMDDL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCEEEEEECCCHHHHHHHHHHHH
RNNPPKKFGAWNVVEFRDYKKDECTVIATGEKKPTGLPESNVLYFELNDHAWCCARPSGT
HCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCC
EPKIKFYMGVKGTGLEDADKKLEELTDAVSEIVGL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]