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The map label for this gene is garR [H]

Identifier: 238896636

GI number: 238896636

Start: 4614573

End: 4615481

Strand: Reverse

Name: garR [H]

Synonym: KP1_4839

Alternate gene names: 238896636

Gene position: 4615481-4614573 (Counterclockwise)

Preceding gene: 238896637

Following gene: 238896635

Centisome position: 87.94

GC content: 56.88

Gene sequence:

>909_bases
ATGAAGAGAGAGAACATTATGACAATCAAAGTAGGTTTTATCGGTCTTGGCATTATGGGCAAACCGATGAGCAAAAATTT
GCTGAAAGCGGGTTACTCGCTGGTGGTGTCTGACCGTAACCCGGAAGCGATTGCCGACGTGATCGCCGCTGGCGCTGAGA
CCGCGACGACGCCGAAAGCGATTGCCGAACAGTGCGAGGTGATCATCACCATGCTGCCGAACTCTCCGCATGTTAAAGAG
GTGGCGCTGGGTGAAAACGGCATTATTGAAGGGGCGAAACCGGGCACCGTGGTGATCGATATGAGCTCCATTGCGCCGCT
GGCGAGTCGGGAAATCAGCGAAGCGCTGAAAGCCAAAGGTATTGATATGCTGGATGCGCCGGTGAGCGGCGGCGAACCGA
AAGCCATCGACGGCACGCTGTCGGTCATGGTCGGCGGCGATAAAGCGATCTTCGATAAATACTACGATCTGATGAAAGCG
ATGGCCGGCTCCGTAGTGCATACCGGCGATATTGGCGCGGGCAACGTCACCAAACTGGCTAACCAGGTGATTGTCGCGCT
GAACATCGCGGCGATGTCTGAAGCGCTGACCCTGGCGACTAAAGCCGGCGTCAATCCGGATCTGGTTTATCAGGCTATTC
GCGGCGGTCTGGCGGGCAGTACCGTGCTGGATGCGAAAGCCCCGATGGTGATGGACCGTAACTTCAAACCGGGTTTCCGT
ATCGACCTGCATATTAAAGATCTGGCCAATGCGTTGGATACCTCACACGGCGTGGGCGCCCAACTGCCGCTGACGGCGGC
GGTGATGGAGATGATGCAGGCGCTGCGCGCGGACGGTCTCGGCACTGCAGACCATAGCGCGCTGGCGTGCTATTACGAAA
AACTGGCGAAAGTGGAAGTCACTCGCTAA

Upstream 100 bases:

>100_bases
TGGAATGGGGCGCGACCTTCGTCGCCGTTGGCAGCGATCTGGGCGTCTTCCGTTCTGCTACCCAGAAACTTGCCGACGCG
TTTAAAAAATAATCACCAGG

Downstream 100 bases:

>100_bases
CAAGAAGGGCGCCCTGCGCGCCCTGTTATGCTTGCCTTGCGCGGCACTGTCAGGCTACAAAATTATGAAAATCGTCATTG
CCCCAGACTCTTACAAAGAA

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKRENIMTIKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETATTPKAIAEQCEVIITMLPNSPHVKE
VALGENGIIEGAKPGTVVIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKA
MAGSVVHTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFR
IDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR

Sequences:

>Translated_302_residues
MKRENIMTIKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETATTPKAIAEQCEVIITMLPNSPHVKE
VALGENGIIEGAKPGTVVIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKA
MAGSVVHTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFR
IDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR
>Mature_302_residues
MKRENIMTIKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETATTPKAIAEQCEVIITMLPNSPHVKE
VALGENGIIEGAKPGTVVIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKA
MAGSVVHTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFR
IDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEVTR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=285, Percent_Identity=34.7368421052632, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=29.0780141843972, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=97.6190476190476, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=42.9065743944637, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790315, Length=280, Percent_Identity=37.8571428571429, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17557316, Length=275, Percent_Identity=33.0909090909091, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24655230, Length=284, Percent_Identity=32.0422535211268, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922568, Length=284, Percent_Identity=32.0422535211268, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=25.531914893617, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31456; Mature: 31456

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRENIMTIKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETATTPKA
CCCCCEEEEEEEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCHHH
IAEQCEVIITMLPNSPHVKEVALGENGIIEGAKPGTVVIDMSSIAPLASREISEALKAKG
HHHHHHEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEECHHCCCHHHHHHHHHHHHCC
IDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGDIGAGNVTKLA
CCEECCCCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHH
NQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFR
HHHHHEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCE
IDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEV
EEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEC
TR
CC
>Mature Secondary Structure
MKRENIMTIKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETATTPKA
CCCCCEEEEEEEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCHHH
IAEQCEVIITMLPNSPHVKEVALGENGIIEGAKPGTVVIDMSSIAPLASREISEALKAKG
HHHHHHEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEECHHCCCHHHHHHHHHHHHCC
IDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGDIGAGNVTKLA
CCEECCCCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHH
NQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFR
HHHHHEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCE
IDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSALACYYEKLAKVEV
EEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEC
TR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]