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The map label for this gene is ung [H]

Identifier: 238896029

GI number: 238896029

Start: 3990889

End: 3991578

Strand: Direct

Name: ung [H]

Synonym: KP1_4160

Alternate gene names: 238896029

Gene position: 3990889-3991578 (Clockwise)

Preceding gene: 238896027

Following gene: 238896031

Centisome position: 76.04

GC content: 57.97

Gene sequence:

>690_bases
ATGACCACCCCTTTAACCTGGCATGACGTGCTGGCGGATGAAAAGCAACAACCCTATTTTCTCAATACTCTGAAGACCGT
CGCCGAAGAGCGCCAGTCGGGGATCACCATCTATCCACCGCAAAAAGACGTCTTCAATGCGTTTCGCTTTACTGAACTGG
GCGATGTCAAAGTCGTCATTCTCGGCCAGGACCCCTATCACGGCCCGGGTCAGGCCCACGGTCTGGCGTTCTCAGTTCGT
CCGGGCGTCGCGATCCCGCCTTCGTTGCTGAATATGTATAAAGAGCTGGAGGCCACGATCCCCGGCTTTACCCGCCCCAC
CCACGGTTATCTCGAAAGCTGGGCACGACAGGGCGTGCTGCTGCTGAATACGGTCCTGACCGTCCGCGCCGGACAGGCGC
ACTCGCACGCCAGTCTGGGCTGGGAGACCTTTACCGATAAGGTTATCGCTTTAATCAATGAGCATTGCGAGGGAGTAGTT
TTTCTGCTGTGGGGCTCTCATGCGCAGAAGAAAGGCGCGATTATCGATCGTCAGCGCCACTGCGTGCTGAAGGCGCCGCA
TCCATCACCGCTCTCTGCGCATCGCGGCTTCTTTGGCTGCAACCATTTCGTACAGACCAACCAGTGGCTGGTTGACCGCG
GCGAAACGCCGATCGACTGGATGCCGGTCCTTCCCGCTGAAAGCGAGTGA

Upstream 100 bases:

>100_bases
CAATTTTTTTTGCATAAAAGCCGGCATCAGGCCGTGCCGATTTTGTTCTATAGAAAGAAGCCGTTAAGCTATAGCGATGA
CCCTTTTGCAGGAGAGCAAG

Downstream 100 bases:

>100_bases
TTGACAGCCATAAAAAAAGCCAGCATCAGCTGGCTTTTTTGCATTCAGGCAGGCGAATCACGCCTTGTTCTGACGCCACC
ATTCCGCCAGCAGGACGCCG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTTPLTWHDVLADEKQQPYFLNTLKTVAEERQSGITIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVR
PGVAIPPSLLNMYKELEATIPGFTRPTHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVIALINEHCEGVV
FLLWGSHAQKKGAIIDRQRHCVLKAPHPSPLSAHRGFFGCNHFVQTNQWLVDRGETPIDWMPVLPAESE

Sequences:

>Translated_229_residues
MTTPLTWHDVLADEKQQPYFLNTLKTVAEERQSGITIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVR
PGVAIPPSLLNMYKELEATIPGFTRPTHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVIALINEHCEGVV
FLLWGSHAQKKGAIIDRQRHCVLKAPHPSPLSAHRGFFGCNHFVQTNQWLVDRGETPIDWMPVLPAESE
>Mature_228_residues
TTPLTWHDVLADEKQQPYFLNTLKTVAEERQSGITIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRP
GVAIPPSLLNMYKELEATIPGFTRPTHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVIALINEHCEGVVF
LLWGSHAQKKGAIIDRQRHCVLKAPHPSPLSAHRGFFGCNHFVQTNQWLVDRGETPIDWMPVLPAESE

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=58.1395348837209, Blast_Score=255, Evalue=2e-68,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=58.1395348837209, Blast_Score=254, Evalue=4e-68,
Organism=Escherichia coli, GI1788934, Length=229, Percent_Identity=91.703056768559, Blast_Score=440, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17556304, Length=221, Percent_Identity=47.9638009049774, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=239, Percent_Identity=48.5355648535565, Blast_Score=204, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25578; Mature: 25447

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLTWHDVLADEKQQPYFLNTLKTVAEERQSGITIYPPQKDVFNAFRFTELGDVKVVI
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCEEEEE
LGQDPYHGPGQAHGLAFSVRPGVAIPPSLLNMYKELEATIPGFTRPTHGYLESWARQGVL
ECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEE
LLNTVLTVRAGQAHSHASLGWETFTDKVIALINEHCEGVVFLLWGSHAQKKGAIIDRQRH
EEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCC
CVLKAPHPSPLSAHRGFFGCNHFVQTNQWLVDRGETPIDWMPVLPAESE
EEEECCCCCCCHHHCCCCCCCHHHCCCEEEEECCCCCCCEEECCCCCCC
>Mature Secondary Structure 
TTPLTWHDVLADEKQQPYFLNTLKTVAEERQSGITIYPPQKDVFNAFRFTELGDVKVVI
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCEEEEE
LGQDPYHGPGQAHGLAFSVRPGVAIPPSLLNMYKELEATIPGFTRPTHGYLESWARQGVL
ECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEE
LLNTVLTVRAGQAHSHASLGWETFTDKVIALINEHCEGVVFLLWGSHAQKKGAIIDRQRH
EEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCC
CVLKAPHPSPLSAHRGFFGCNHFVQTNQWLVDRGETPIDWMPVLPAESE
EEEECCCCCCCHHHCCCCCCCHHHCCCEEEEECCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA