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The map label for this gene is trxC [H]

Identifier: 238896031

GI number: 238896031

Start: 3992925

End: 3993350

Strand: Direct

Name: trxC [H]

Synonym: KP1_4162

Alternate gene names: 238896031

Gene position: 3992925-3993350 (Clockwise)

Preceding gene: 238896029

Following gene: 238896032

Centisome position: 76.08

GC content: 56.1

Gene sequence:

>426_bases
ATGAATACCGTTTGTGCCAGTTGTCAGGCTCTGAACCGCCTCCCGGACGATCGTAGCGCGGATGGCGCAAAGTGCGGACG
CTGCGGTCACGATCTTTTTGACGGCGACGTCATCAACGCGACCGGGGCAACGCTGGATAAACTCTTGAAGGACGATCTGC
CGGTCGTTGTCGATTTCTGGGCGCCATGGTGCGGACCCTGCCGTAGCTTCGCGCCGATCTTTGAAGACGTCGCGGAAGAG
CGTAGCGGGAAGATGCGTTTTGTGAAAGTCAACACCGAAGCGGAACGTGAGCTTAGCGCCCGGTTTCGTATCCGCAGCAT
CCCGACCATTATGATGTTCAAAAATGGCGAAGTGATCGACATGCTCAATGGCGCAGTGCCAAAAGCGCCATTCGATAGCT
GGCTTAACGAAGCCGGCCAACAATAA

Upstream 100 bases:

>100_bases
AAAACGCATTGTCCTCAAATAACACTTCATCGATAATATGTAACATCACAGAAACATATCGGCCACGTGCCACGTTGCAA
CCCATAACCAGAGGTTAGTT

Downstream 100 bases:

>100_bases
CCCTTCCGGGGCACCGCTTGTGCCCCGTTTTCACCTCTGCGACAATAGCGTTTTTCACTAGCGACTCCCATGACTGATAA
CGCTGTCCTTCGCCTGCGCG

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MNTVCASCQALNRLPDDRSADGAKCGRCGHDLFDGDVINATGATLDKLLKDDLPVVVDFWAPWCGPCRSFAPIFEDVAEE
RSGKMRFVKVNTEAERELSARFRIRSIPTIMMFKNGEVIDMLNGAVPKAPFDSWLNEAGQQ

Sequences:

>Translated_141_residues
MNTVCASCQALNRLPDDRSADGAKCGRCGHDLFDGDVINATGATLDKLLKDDLPVVVDFWAPWCGPCRSFAPIFEDVAEE
RSGKMRFVKVNTEAERELSARFRIRSIPTIMMFKNGEVIDMLNGAVPKAPFDSWLNEAGQQ
>Mature_141_residues
MNTVCASCQALNRLPDDRSADGAKCGRCGHDLFDGDVINATGATLDKLLKDDLPVVVDFWAPWCGPCRSFAPIFEDVAEE
RSGKMRFVKVNTEAERELSARFRIRSIPTIMMFKNGEVIDMLNGAVPKAPFDSWLNEAGQQ

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=31.5217391304348, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=36.144578313253, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI5031973, Length=87, Percent_Identity=36.7816091954023, Blast_Score=63, Evalue=9e-11,
Organism=Escherichia coli, GI1788936, Length=138, Percent_Identity=86.231884057971, Blast_Score=258, Evalue=1e-70,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=39.622641509434, Blast_Score=89, Evalue=8e-20,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=27.8846153846154, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=109, Percent_Identity=32.1100917431193, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=41.3333333333333, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=72, Percent_Identity=34.7222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=34.7222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=118, Percent_Identity=31.3559322033898, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=37.037037037037, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=105, Percent_Identity=29.5238095238095, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=105, Percent_Identity=29.5238095238095, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=40, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=105, Percent_Identity=29.5238095238095, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=33.7078651685393, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=36.5853658536585, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=33.7662337662338, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921434, Length=97, Percent_Identity=37.1134020618557, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17647799, Length=104, Percent_Identity=29.8076923076923, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15597; Mature: 15597

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVCASCQALNRLPDDRSADGAKCGRCGHDLFDGDVINATGATLDKLLKDDLPVVVDFW
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECC
APWCGPCRSFAPIFEDVAEERSGKMRFVKVNTEAERELSARFRIRSIPTIMMFKNGEVID
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHH
MLNGAVPKAPFDSWLNEAGQQ
HHCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MNTVCASCQALNRLPDDRSADGAKCGRCGHDLFDGDVINATGATLDKLLKDDLPVVVDFW
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECC
APWCGPCRSFAPIFEDVAEERSGKMRFVKVNTEAERELSARFRIRSIPTIMMFKNGEVID
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHH
MLNGAVPKAPFDSWLNEAGQQ
HHCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]