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The map label for this gene is phoR [H]

Identifier: 238893324

GI number: 238893324

Start: 1165486

End: 1166781

Strand: Direct

Name: phoR [H]

Synonym: KP1_1201

Alternate gene names: 238893324

Gene position: 1165486-1166781 (Clockwise)

Preceding gene: 238893323

Following gene: 238893325

Centisome position: 22.21

GC content: 59.18

Gene sequence:

>1296_bases
GTGCTGGAACGGCTGTCATGGAAAAGGCTGGCGCTGGAGCTCTTTTTAGCGTGTATTCCGGCCCTGATTCTGGGGGCGTT
TGTGGGTCATCTGCCGTGGTTTTTACTGGCGGCAGTGACCGGTTTGCTGATCTGGCATTTCTGGAATTTGATGCGCCTGT
CGTGGTGGCTGTGGGTGGACCGGAGCATGACTCCTCCGCCTGGCCGCGGCAGTTGGGAGCCGCTGCTGTATGGTCTGCAC
CAGATGCAGATGCGTAATAAAAAGCGTCGGCGCGAGCTGGGAAGCCTGATTAAACGCTTTCGCAGCGGGGCGGAATCGCT
GCCGGATGCGGTCGTCCTGACCACGGAAGAGGGGGCTATTTTCTGGTGTAATGGCCTGGCGCAGCAGATTCTAAACCTGC
GCTGGCCGGACGACAGTGGCCAAAACATTCTTAACCTTCTGCGCTATCCCGAGTTCGCCAACTATCTGAAACAGCGCGAT
TTTTCAAAGCCGCTCAATCTGGTGCTGAATAACGCCCGTCATCTGGAAATTCGCGTGATGCCCTACAGCGACAAGCAGTG
GCTGATGGTGGCGCGCGACGTGACGCAGATGCATCAGCTGGAAGGGGCGCGGCGGAACTTTTTCGCCAACGTCAGCCATG
AGTTGCGCACCCCACTGACGGTGCTGCAGGGCTATCTGGAGATGATGCAGGAGCAGGTGCTGGAGGGGGCGACCCGAGAA
AAAGCCCTGCACACCATGCGGGAGCAAACTCAGCGTATGGAAGGTCTGGTGAAGCAGCTGCTGACGCTGTCGCGTATTGA
AGCCGCGCCGGCGCTGGCGATGAATGATCGCATCGACGTGCCGATGATGCTGCGGGTGGTGGAGCGCGAGGCGCAAACTC
TCAGCCAGGAGAAACAGACGCTGATCTTCACCGTCGATGAGCAGCTCAAGGTGCTGGGTAATGAGGAGCAACTGCGCAGC
GCCATCTCCAACCTGGTCTATAACGCGGTGAACCACACCCCGCCGGGGACCGAAATTCGCGTCAGCTGGCAGCGGACCCC
GCAGGGAGCGCTGTTCAGCGTCGAGGATAATGGGCCAGGCATTGCGCCGGAGCATATTCCCCGTCTGACCGAGCGTTTTT
ATCGGGTGGATAAAGCCCGTTCCCGGCAAACGGGGGGCAGTGGCCTGGGACTGGCGATCGTCAAACACGCGGTTAACCAT
CATGACAGCCGGCTGGAAATCGACAGCACGGTGGGCAAGGGAACCCGCTTTAGCTTCCTGCTCCCGGAACGATTAATTGC
CAAAAATGACGCCTGA

Upstream 100 bases:

>100_bases
AGCGCTGGAACACAGTGGCCATGATCGTATGGTGCAAACGGTTCGCGGCACGGGGTATCGTTTCTCCGCCCGTTTCTGAA
TTTTGACAGGAGTGTGACCC

Downstream 100 bases:

>100_bases
TCGACGCGCTGTCAGTTTATCTTGCCAATGACCAGCTTCAGCTGGTCATTTTCATTGGCAGTCGTTTTTTCTCGCCTATT
TAATGAGCGTGCGCTGCTTT

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLERLSWKRLALELFLACIPALILGAFVGHLPWFLLAAVTGLLIWHFWNLMRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQMRNKKRRRELGSLIKRFRSGAESLPDAVVLTTEEGAIFWCNGLAQQILNLRWPDDSGQNILNLLRYPEFANYLKQRD
FSKPLNLVLNNARHLEIRVMPYSDKQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQVLEGATRE
KALHTMREQTQRMEGLVKQLLTLSRIEAAPALAMNDRIDVPMMLRVVEREAQTLSQEKQTLIFTVDEQLKVLGNEEQLRS
AISNLVYNAVNHTPPGTEIRVSWQRTPQGALFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNH
HDSRLEIDSTVGKGTRFSFLLPERLIAKNDA

Sequences:

>Translated_431_residues
MLERLSWKRLALELFLACIPALILGAFVGHLPWFLLAAVTGLLIWHFWNLMRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQMRNKKRRRELGSLIKRFRSGAESLPDAVVLTTEEGAIFWCNGLAQQILNLRWPDDSGQNILNLLRYPEFANYLKQRD
FSKPLNLVLNNARHLEIRVMPYSDKQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQVLEGATRE
KALHTMREQTQRMEGLVKQLLTLSRIEAAPALAMNDRIDVPMMLRVVEREAQTLSQEKQTLIFTVDEQLKVLGNEEQLRS
AISNLVYNAVNHTPPGTEIRVSWQRTPQGALFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNH
HDSRLEIDSTVGKGTRFSFLLPERLIAKNDA
>Mature_431_residues
MLERLSWKRLALELFLACIPALILGAFVGHLPWFLLAAVTGLLIWHFWNLMRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQMRNKKRRRELGSLIKRFRSGAESLPDAVVLTTEEGAIFWCNGLAQQILNLRWPDDSGQNILNLLRYPEFANYLKQRD
FSKPLNLVLNNARHLEIRVMPYSDKQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQVLEGATRE
KALHTMREQTQRMEGLVKQLLTLSRIEAAPALAMNDRIDVPMMLRVVEREAQTLSQEKQTLIFTVDEQLKVLGNEEQLRS
AISNLVYNAVNHTPPGTEIRVSWQRTPQGALFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNH
HDSRLEIDSTVGKGTRFSFLLPERLIAKNDA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=430, Percent_Identity=86.7441860465116, Blast_Score=759, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=219, Percent_Identity=34.703196347032, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=28.515625, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=30.4347826086957, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1787894, Length=229, Percent_Identity=31.4410480349345, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789403, Length=256, Percent_Identity=32.03125, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=31.858407079646, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=25.9911894273128, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI145693157, Length=331, Percent_Identity=24.4712990936556, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=26.5765765765766, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=25.9259259259259, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=202, Percent_Identity=31.6831683168317, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790300, Length=351, Percent_Identity=27.6353276353276, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790861, Length=204, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=218, Percent_Identity=25.2293577981651, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=331, Percent_Identity=24.773413897281, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=25.6637168141593, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=27.8260869565217, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790567, Length=353, Percent_Identity=24.3626062322946, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49505; Mature: 49505

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLSWKRLALELFLACIPALILGAFVGHLPWFLLAAVTGLLIWHFWNLMRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGLHQMQMRNKKRRRELGSLIKRFRSGAESLPDAVVLTTEEGAI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQILNLRWPDDSGQNILNLLRYPEFANYLKQRDFSKPLNLVLNNARHLEIRVM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEE
PYSDKQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQVLEGATRE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
KALHTMREQTQRMEGLVKQLLTLSRIEAAPALAMNDRIDVPMMLRVVEREAQTLSQEKQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
LIFTVDEQLKVLGNEEQLRSAISNLVYNAVNHTPPGTEIRVSWQRTPQGALFSVEDNGPG
EEEEECHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCCCC
IAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHDSRLEIDSTVGKGTRFSFL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEHHCCCCCCEEEEE
LPERLIAKNDA
CHHHHHCCCCC
>Mature Secondary Structure
MLERLSWKRLALELFLACIPALILGAFVGHLPWFLLAAVTGLLIWHFWNLMRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGLHQMQMRNKKRRRELGSLIKRFRSGAESLPDAVVLTTEEGAI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQILNLRWPDDSGQNILNLLRYPEFANYLKQRDFSKPLNLVLNNARHLEIRVM
EEEHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEE
PYSDKQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQVLEGATRE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
KALHTMREQTQRMEGLVKQLLTLSRIEAAPALAMNDRIDVPMMLRVVEREAQTLSQEKQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
LIFTVDEQLKVLGNEEQLRSAISNLVYNAVNHTPPGTEIRVSWQRTPQGALFSVEDNGPG
EEEEECHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCCCC
IAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHDSRLEIDSTVGKGTRFSFL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEHHCCCCCCEEEEE
LPERLIAKNDA
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]