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The map label for this gene is hflK [H]

Identifier: 238892658

GI number: 238892658

Start: 447878

End: 449140

Strand: Direct

Name: hflK [H]

Synonym: KP1_0443

Alternate gene names: 238892658

Gene position: 447878-449140 (Clockwise)

Preceding gene: 238892657

Following gene: 238892659

Centisome position: 8.53

GC content: 59.86

Gene sequence:

>1263_bases
ATGGCGTGGAATCAGCCCGGTAATAACGGACAGGACCGCGACCCGTGGGGGAGCAGCAAACCTGGCGGCAACTCTGAGGG
AAATGGCAATAAAGGCGGTCGCGAGCAGGGGCCGCCGGATCTGGATGATATCTTCCGCAAGTTAAGTAAAAAACTTGGCG
GGCTCGGCGGCGGCAAGGGCGGACTGGGCGGCGGCAATAGCGCGCAGGGGCCTCGCGGACCGATGGGCGGGCGTATTGTC
GGCATCGTTGCCGCGGCGGCAGTGATTATCTGGGCGGCCAGCGGTTTCTATACCATTAAAGAGGCCGAGCGCGGCGTGGT
CACCCGTTTTGGTAAGTTCAGCCATCTGGTTGAGCCTGGCCTGAACTGGAAACCGACCTTTATCGATAACGTTCAGGCGG
TGAACGTGGAGTCGGTGCGCGAACTTGCGGCTTCCGGCGTCATGCTGACCTCTGACGAAAACGTGGTGCGCGTTGAGATG
AACGTGCAGTACCGCGTCACCGATCCGGAGCGCTATCTGTTTAGCGTGACCAGCGCGGACGACAGTCTGCGTCAGGCCAC
CGACAGCGCGCTGCGCGGCGTGATCGGCAAATACACCATGGATCGTATTCTGACCGAAGGTCGTACCGTGATCCGTAGCG
ATACCCAGCGTGAGCTGGAAGAGACGATTCGCCCGTACAACATGGGTATCACTCTGCTGGACGTCAACTTCCAGACGGCG
CGTCCGCCGGAAGAGGTGAAGGCCGCGTTTGACGATGCCATTGCCGCGCGTGAGAACGAGCAGCAGTACATTCGTGAAGC
GGAAGCGTATACCAACGAAGTCCAGCCGCGGGCGAATGGTCAGGCGCAGCGTATCCTCGAAGAGGCACGCGCCTATAAGA
CCCAGACCGTTCTGGAAGCCCAGGGTGAAGTGGCTCGCTTTGCGAAGATCCTGCCGGAATACAAAGCCGCGCCGGAAATT
ACCCGCGAGCGTCTGTATATCGAAACCATGGAAAAAGTGCTGAGCCACACCCGTAAAGTGCTGGTCAATGACAGCAAAAA
CGGCAATCTGATGGTTCTGCCGCTGGATCAGATGCTGAAAGGCGCCGCTGCGCCGGCAGCAAAGAGCGATAGTAGTGACG
CCAGCGATCTGCTGCGCCTGCCGCCAGCATCCAGCTCAAGCAGCGCCAGCACCTCATCAACCTCGAGCTCAACCGGGGGT
AGCATTATGGACCAACGCCGCGCTAACGCGCAGCGTAACGACTACCAGCGTCAGGGGGAATAA

Upstream 100 bases:

>100_bases
AGCAAGAGCCAACGCTTGTTGACTATGTGGTTTAACCTTGCAGCTTGCCTGAAGATATTGACCCCTGTGGGGATATCAAA
AACAAATATGGAGCATATAC

Downstream 100 bases:

>100_bases
CGATGCGTAAATCTGTTATCGCGATCATTGTCATCGTGCTGGTAGTGCTCTACATGTCTGTCTTTGTCGTAAAGGAAGGC
GAGCGCGGTATCACGCTGCG

Product: FtsH protease regulator HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MAWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGREQGPPDLDDIFRKLSKKLGGLGGGKGGLGGGNSAQGPRGPMGGRIV
GIVAAAAVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPGLNWKPTFIDNVQAVNVESVRELAASGVMLTSDENVVRVEM
NVQYRVTDPERYLFSVTSADDSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYNMGITLLDVNFQTA
RPPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKTQTVLEAQGEVARFAKILPEYKAAPEI
TRERLYIETMEKVLSHTRKVLVNDSKNGNLMVLPLDQMLKGAAAPAAKSDSSDASDLLRLPPASSSSSASTSSTSSSTGG
SIMDQRRANAQRNDYQRQGE

Sequences:

>Translated_420_residues
MAWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGREQGPPDLDDIFRKLSKKLGGLGGGKGGLGGGNSAQGPRGPMGGRIV
GIVAAAAVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPGLNWKPTFIDNVQAVNVESVRELAASGVMLTSDENVVRVEM
NVQYRVTDPERYLFSVTSADDSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYNMGITLLDVNFQTA
RPPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKTQTVLEAQGEVARFAKILPEYKAAPEI
TRERLYIETMEKVLSHTRKVLVNDSKNGNLMVLPLDQMLKGAAAPAAKSDSSDASDLLRLPPASSSSSASTSSTSSSTGG
SIMDQRRANAQRNDYQRQGE
>Mature_419_residues
AWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGREQGPPDLDDIFRKLSKKLGGLGGGKGGLGGGNSAQGPRGPMGGRIVG
IVAAAAVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPGLNWKPTFIDNVQAVNVESVRELAASGVMLTSDENVVRVEMN
VQYRVTDPERYLFSVTSADDSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYNMGITLLDVNFQTAR
PPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKTQTVLEAQGEVARFAKILPEYKAAPEIT
RERLYIETMEKVLSHTRKVLVNDSKNGNLMVLPLDQMLKGAAAPAAKSDSSDASDLLRLPPASSSSSASTSSTSSSTGGS
IMDQRRANAQRNDYQRQGE

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=421, Percent_Identity=88.8361045130641, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1786697, Length=283, Percent_Identity=22.9681978798587, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 45582; Mature: 45451

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGREQGPPDLDDIFRKLSKKLGGLGGGKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
GLGGGNSAQGPRGPMGGRIVGIVAAAAVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHCCC
LNWKPTFIDNVQAVNVESVRELAASGVMLTSDENVVRVEMNVQYRVTDPERYLFSVTSAD
CCCCCCHHCCCEEECHHHHHHHHHCCEEEECCCCEEEEEEEEEEEECCCHHEEEEEECCC
DSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYNMGITLLDVNFQTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHCHHHCCEEEEEECCCCC
RPPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKTQTVLEA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
QGEVARFAKILPEYKAAPEITRERLYIETMEKVLSHTRKVLVNDSKNGNLMVLPLDQMLK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEHHHHHC
GAAAPAAKSDSSDASDLLRLPPASSSSSASTSSTSSSTGGSIMDQRRANAQRNDYQRQGE
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
AWNQPGNNGQDRDPWGSSKPGGNSEGNGNKGGREQGPPDLDDIFRKLSKKLGGLGGGKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
GLGGGNSAQGPRGPMGGRIVGIVAAAAVIIWAASGFYTIKEAERGVVTRFGKFSHLVEPG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHCCC
LNWKPTFIDNVQAVNVESVRELAASGVMLTSDENVVRVEMNVQYRVTDPERYLFSVTSAD
CCCCCCHHCCCEEECHHHHHHHHHCCEEEECCCCEEEEEEEEEEEECCCHHEEEEEECCC
DSLRQATDSALRGVIGKYTMDRILTEGRTVIRSDTQRELEETIRPYNMGITLLDVNFQTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHCHHHCCEEEEEECCCCC
RPPEEVKAAFDDAIAARENEQQYIREAEAYTNEVQPRANGQAQRILEEARAYKTQTVLEA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
QGEVARFAKILPEYKAAPEITRERLYIETMEKVLSHTRKVLVNDSKNGNLMVLPLDQMLK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEHHHHHC
GAAAPAAKSDSSDASDLLRLPPASSSSSASTSSTSSSTGGSIMDQRRANAQRNDYQRQGE
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]